Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway

Journal of Biological Chemistry

Volumn 284, Issue 3, 2009, Pages 1612-1619

  Nakayama, Masaaki ^a   Hisatsune, Junzo ^a   Yamasaki, Eiki ^b   Isomoto, Hajime ^a   Kurazono, Hisao ^b   Hatakeyama, Masanori ^c   Azuma, Takeshi ^d   Yamaoka, Yoshio ^e   Yahiro, Kinnosuke ^f   Moss, Joel ^f   Hirayama, Toshiya ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d KOBE UNIVERSITY   (Japan)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BAFILOMYCIN; BENZOIC ACIDS; GASTRIC CANCERS; GASTRIC INJURIES; GLYCOGEN SYNTHASE; HELICOBACTER PYLORUS; LUCIFERASE REPORTER ASSAYS; MUTANT STRAINS; NUCLEAR TRANSLOCATIONS; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE; PROTEIN KINASE; SIGNALING PATHWAYS; TRANSCRIPTIONAL ACTIVITIES;

CHEMICAL REACTIONS; ENZYME ACTIVITY; PLANTS (BOTANY); SIGNALING;

PHOSPHORYLATION;

5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; BAFILOMYCIN A1; BETA CATENIN; CYCLIN D; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3BETA; LUCIFERASE; METHYL BETA CYCLODEXTRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PROTEIN KINASE B; TOPTKLUCIFERASE REPORTER PLASMID; UNCLASSIFIED DRUG; VACUOLATING TOXIN; WNT PROTEIN;

ARTICLE; BACTERIAL VIRULENCE; CELL NUCLEUS; CELL VACUOLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; GENE ACTIVITY; GENE CONTROL; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; INCUBATION TIME; INHIBITION KINETICS; INTERNALIZATION; MUTANT; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHOSPHORYLATION; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STOMACH DISEASE; STOMACH TUMOR; TRANSCRIPTION REGULATION; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTIVE TRANSPORT, CELL NUCLEUS; BACTERIAL PROTEINS; BETA CATENIN; CELL LINE, TUMOR; CELL NUCLEUS; CYCLIN D1; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MUTATION; PHOSPHOLIPASE C BETA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TRANSCRIPTIONAL ACTIVATION; WNT PROTEINS;

HELICOBACTER PYLORI;

EID: 59449108480     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806981200     Document Type: Article

References (36)

1. Atherton, J. C. (2006) Annu. Rev. Pathol. 1, 63-96
2. Kusters, J. G., van Vliet, A. H., andKuipers, E. J. (2006) Clin. Microbiol. Rev. 19, 449-490
3. D'Elios, M. M., Montecucco, C., and de Bernard, M. (2007) Clin. Chim. Acta 381, 32-38
4. Manetti, R., Massari, P., Burroni, D., de Bernard, M., Marchini, A., Olivieri, R., Papini, E., Montecucco, C., Rappuoli, R., and Telford, J. L. (1995) Infect. Immun. 63, 4476 - 4480
5. Telford, J. L., Ghiara, P., Dell'Orco, M., Comanducci, M., Burroni, D., Bugnoli, M., Tecce, M. F., Censini, S., Covacci, A., Xiang, Z. Y., Papini, E., Montecucco, C., Parente, L., and Rappuoli, R. (1994) J. Exp. Med. 179, 1653-1658
6. Fujikawa, A., Shirasaka, D., Yamamoto, S., Ota, H., Yahiro, K., Fukuda, M., Shintani, T., Wada, A., Aoyama, N., Hirayama, T., Fukamachi, H., and Noda, M. (2003) Nat. Genet. 33, 375-381
7. Cover, T. L., and Blanke, S. R. (2005) Nat. Rev. Microbiol. 3, 320 -332
8. Yamasaki, E., Wada, A., Kumatori, A., Nakagawa, I., Funao, J., Nakayama, M., Hisatsune, J., Kimura, M., Moss, J., and Hirayama, T. (2006) J. Biol. Chem. 281, 11250-11259
9. Boncristiano, M., Paccani, S. R., Barone, S., Ulivieri, C., Patrussi, L., Ilver, D., Amedei, A., D'Elios, M. M., Telford, J. L., and Baldari, C. T. (2003) J. Exp. Med. 198, 1887-1897
10. Nakayama, M., Kimura, M., Wada, A., Yahiro, K., Ogushi, K., Niidome, T., Fujikawa, A., Shirasaka, D., Aoyama, N., Kurazono, H., Noda, M., Moss, J., and Hirayama, T. (2004) J. Biol. Chem. 279, 7024-7028
11. Nakayama, M., Hisatsune, J., Yamasaki, E., Nishi, Y., Wada, A., Kurazono, H., Sap, J., Yahiro, K., Moss, J., and Hirayama, T. (2006) Infect. Immun. 74, 6571-6580
12. Hisatsune, J., Yamasaki, E., Nakayama, M., Shirasaka, D., Kurazono, H., Katagata, Y., Inoue, H., Han, J., Sap, J., Yahiro, K., Moss, J., and Hirayama, T. (2007) Infect. Immun. 75, 4472-4481
13. Hisatsune, J., Nakayama, M., Isomoto, H., Kurazono, H., Mukaida, N., Mukhopadhyay, A. K., Azuma, T., Yamaoka, Y., Sap, J., Yamasaki, E., Yahiro, K., Moss, J., and Hirayama, T. (2008) J.Immunol. 180, 5017-5027
14. Kim, L., and Kimmel, A. R. (2006) Curr. Drug Targets. 7, 1411-1419
15. Giles, R. H., van Es, J. H., and Clevers, H. (2003) Biochim. Biophys. Acta 1653, 1-2
16. Tago, K., Nakamura, T., Nishita, M., Hyodo, J., Nagai, S., Murata, Y., Adachi, S., Ohwada, S., Morishita, Y., Shibuya, H., and Akiyama, T. (2000) Genes Dev. 14, 1741-1749
17. Murata-Kamiya, N., Kurashima, Y., Teishikata, Y., Yamahashi, Y., Saito, Y., Higashi, H., Aburatani, H., Akiyama, T., Peek, R. M., Jr., Azuma, T., and Hatakeyama, M. (2007) Oncogene 26, 4617-4626
18. Kurashima, Y., Murata-Kamiya, N., Kikuchi, K., Higashi, H., Azuma, T., Kondo, S., and Hatakeyama, M. (2008) Int. J. Cancer. 122, 823-831
19. Lu, H., Wu, J. Y., Kudo, T., Ohno, T., Graham, D. Y., and Yamaoka, Y. (2005) Mol. Biol. Cell 16, 4954-4966
20. Grimes, C. A., and Jope, R. S. (2001) Prog. Neurobiol. 65, 391-426
21. Romashkova, J. A., and Makarov, S. S. (1999) Nature 401, 86 -90
22. Szabò, I., Brutsche, S., Tombola, F., Moschioni, M., Satin, B., Telford, J. L., Rappuoli, R., Montecucco, C., Papini, E., and Zoratti, M. (1999) EMBO J. 18, 5517-5527
23. Papini, E., Bugnoli, M., De Bernard, M., Figura, N., Rappuoli, R., and Mon-tecucco, C. (1993) Mol. Microbiol. 7, 323-327
24. Ricci, V., Galmiche, A., Doye, A., Necchi, V., Solcia, E., and Boquet, P. (2000) Mol. Biol. Cell 11, 3897-3909
25. Galceran, J., Hsu, S. C., and Grosschedl, R. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 8668 - 8673
26. Hovanes, K., Li, T. W., Munguia, J. E., Truong, T., Milovanovic, T., Lawrence Marsh, J., Holcombe, R. F., and Waterman, M. L. (2001) Nat. Genet. 28, 53-57
27. Salic, A., Lee, E., Mayer, L., and Kirschner, M. W. (2000) Mol. Cell. 5, 523-532
28. Moon, R. T., Bowerman, B., Boutros, M., and Perrimon, N. (2002) Science 296, 1644-1646
29. Yum, H. K., Arcaroli, J., Kupfner, J., Shenkar, R., Penninger, J. M., Sasaki, T., Yang, K. Y., Park, J. S., and Abraham, E. (2001) J. Immunol. 167, 6601-6608
30. Li, Y., Wandinger-Ness, A., Goldenring, J. R., and Cover, T. L. (2004) Mol. Biol. Cell 15, 1946-1959
31. Hoeflich, K. P., Luo, J., Rubie, E. A., Tsao, M. S., Jin, O., and Woodgett, J. R. (2000) Nature 406, 86 -90
32. Takemaru, K., Yamaguchi, S., Lee, Y. S., Zhang, Y., Carthew, R. W., and Moon, R. T. (2003) Nature 422, 905-909
33. Szabó, I. L., Pai, R., Jones, M. K., Ehring, G. R., Kawanaka, H., and Tarnawski, A. S. (2002) Exp. Biol. Med. 227, 412-424
34. Doucas, H., Garcea, G., Neal, C. P., Manson, M. M., and Berry, D. P. (2005) Eur. J. Cancer. 41, 365-379
35. Clements, W. M., Wang, J., Sarnaik, A., Kim, O. J., MacDonald, J., Fenoglio-Preiser, C., Groden, J., and Lowy, A. M. (2002) Cancer Res. 62, 3503-3506
36. Oshima, H., Matsunaga, A., Fujimura, T., Tsukamoto, T., Taketo, M. M., and Oshima, M. (2006) Gastroenterology 131, 1086-1095