Inhibition of GSK3 abolishes bacterial-induced periodontal bone loss in mice

Molecular Medicine

Volumn 18, Issue 8, 2012, Pages 1190-1196

  Adamowicz, Karina ^a,c   Wang, Huizhi ^a   Jotwani, Ravi ^a   Zeller, Iris ^a   Potempa, Jan ^a,c   Scott, David A ^a,b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

^c JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 23P40; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALVEOLAR BONE LOSS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; DRUG MECHANISM; ENZYME INHIBITION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALVEOLAR BONE LOSS; ANIMALS; GLYCOGEN SYNTHASE KINASE 3; INDOLES; INFLAMMATION; INTERLEUKIN-17; MALEIMIDES; MAXILLA; MICE; NEUTROPHIL INFILTRATION; PORPHYROMONAS GINGIVALIS; TOLL-LIKE RECEPTORS;

EID: 84870310393     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2012.00180     Document Type: Article

References (47)

1. Krauss JL, Potempa J, Lambris JD, Hajishengallis G. (2010) Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontol. 2000. 52:141-62.
2. Zhang P, et al. (2011) TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-kappaB. J. Biol. Chem. 286:24159-69.
3. Bagaitkar J, et al. (2010) Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity. PLoS One. 5:e9323.
4. Gaddis DE, Michalek SM, Katz J. (2009) Requirement of TLR4 and CD14 in dendritic cell activation by Hemagglutinin B from Porphyromonas gingivalis. Mol. Immunol. 46:2493-504.
5. Martin M, Rehani K, Jope RS, Michalek SM. (2005) Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat. Immunol. 6:777-84.
6. Wang H, Brown J, Martin M. (2011) Glycogen synthase kinase 3: a point of convergence for the host inflammatory response. Cytokine. 53:130-40.
7. Wang H, et al. (2008) IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta. J. Immunol. 181:6797-802.
8. Rehani K, Wang H, Garcia CA, Kinane DF, Martin M. (2009) Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2. J. Immunol. 182:547-53.
9. Wang H, et al. (2011) The role of glycogen synthase kinase 3 in regulating IFN-beta-mediated IL-10 production. J. Immunol. 186:675-84.
10. Antoniv TT, Ivashkiv LB. (2011) Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway. Immunology. 132:567-77.
11. Brown J, Wang H, Suttles J, Graves DT, Martin M. (2011) Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1. J. Biol. Chem. 286:44295-305.
12. Beurel E, Jope RS. (2008) Differential regulation of STAT family members by glycogen synthase kinase-3. J. Biol. Chem. 283:21934-44.
13. Rehani K, et al. (2008) Cotinine-induced convergence of the cholinergic and PI3 kinasedependent anti-inflammatory pathways in innate immune cells. Biochim. Biophys. Acta. 1783:375-82.
14. Baker PJ, Evans RT, Roopenian DC. (1994) Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice. Arch. Oral Biol. 39:1035-40.
15. Eskan MA, et al. (2012) The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nat. Immunol. 13:465-73.
16. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 378:785-9.
17. Ren F, et al. (2011) Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10- mediated immune regulatory mechanism. Hepatology. 54:687-96.
18. Hofmann C, Dunger N, Schölmerich J, Falk W, Obermeier F. (2010) Glycogen synthase kinase 3--: a master regulator of toll-like receptormediated chronic intestinal inflammation. In-flamm. Bowel Dis. 16:1850-8.
19. Li Q, Valerio MS, Kirkwood KL. (2012) MAPK usage in periodontal disease progression. J. Signal Transduct. 2012:308943.
20. Yuan H, Gupte R, Zelkha S, Amar S. (2011) Receptor activator of nuclear factor kappa B ligand antagonists inhibit tissue inflammation and bone loss in experimental periodontitis. J. Clin. Periodontol. 38:1029-36.
21. Hajishengallis G, et al. (2011) Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe. 10:497-506.
22. Barros SP, Arce RM, Galloway P, Lawter R, Offenbacher S. (2011) Therapeutic effect of a topical CCR2 antagonist on induced alveolar bone loss in mice. J. Periodontal Res. 46:246-51.
23. Cantley MD, et al. (2011) Histone deacetylase inhibitors and periodontal bone loss. J. Periodontal Res. 46:697-703.
24. Liang S, et al. (2011) The C5a receptor impairs IL- 12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J. Immunol. 186:869-77.
25. Li CH, Amar S. (2007) Inhibition of SFRP1 reduces severity of periodontitis. J. Dent. Res. 86:873-7.
26. Scott DA, Krauss JL. (2012) Neutrophils in periodontal inflammation. Front. Oral Biol. 15:56-83.
27. Bender JS, Thang H, Glogauer M. (2006) Novel rinse assay for the quantification of oral neutrophils and the monitoring of chronic periodontal disease. J. Periodontal Res. 41:214-20.
28. Ryder MI. (2010) Comparison of neutrophil functions in aggressive and chronic periodontitis. Periodontol. 2000. 53:124-37.
29. Liu RK, Cao CF, Meng HX, Gao Y. (2001) Polymorphonuclear neutrophils and their mediators in gingival tissues from generalized aggressive periodontitis. J. Periodontol. 72:1545-53.
30. Andersen E, Cimasoni G. (1993) A rapid and simpl method for counting crevicular polymorpho - nuclear leucocytes. J. Clin. Periodontol. 20:651-5.
31. Hasturk H, Kantarci A, Van Dyke TE. (2012) Paradigm shift in the pharmacological management of periodontal diseases. Front. Oral Biol. 15:160-76.
32. Okui T, Aoki Y, Ito H, Honda T, Yamazaki K. (2012) The presence of IL-17+/FOXP3+ doublepositive cells in periodontitis. J. Dent. Res. 91:574-9.
33. Khader SA. (2012) Restraining IL-17: Del-1 deals the blow. Nat. Immunol. 13:433-5.
34. Ohyama H, et al. (2009) The involvement of IL-23 and the Th17 pathway in periodontitis. J. Dent. Res. 88:633-8.
35. Beklen A, et al. (2007) MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis. J. Dent. Res. 86:347-51.
36. Braun T, Schett G. (2012) Pathways for bone loss in inflammatory disease. Curr. Osteoporos. Rep. 10:101-8.
37. Moutsopoulos NM, et al. (2012) Porphyromonasgingivalis promotes Th17 inducing pathways in chronic periodontitis. J. Autoimmun. 2012, May 3 [Epub ahead of print].
38. Yu JJ, et al. (2007) An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood. 109:3794-802.
39. Gaffen SL. (2009) The role of interleukin-17 in the pathogenesis of rheumatoid arthritis. Curr. Rheumatol. Rep. 11:365-70.
40. Silva JA, et al. (2012) Sequential IL-23 and IL-17 and increased Mmp8 and Mmp14 expression characterize the progression of an experimental model of periodontal disease in type 1 diabetes. J. Cell Physiol. 227:2441-50.
41. Tomar SL, Asma S. (2000) Smoking-attributable periodontitis in the United States: findings from NHANES III. National Health and Nutrition Examination Survey. J. Periodontol. 71:743-51.
42. Brown LJ, Loe H. (1993) Prevalence, extent, severity and progression of periodontal disease. Periodontol. 2000. 2:57-71.
43. Brown LJ, Johns BA, Wall TP. (2002) The economics of periodontal diseases. Periodontol. 2000. 29:223-34.
44. Chun YH, Chun KR, Olguin D, Wang HL. (2005) Biological foundation for periodontitis as a potential risk factor for atherosclerosis. J. Periodontal. Res. 40:87-95.
45. Teng YT, et al. (2002) Periodontal health and systemic disorders. J. Can. Dent. Assoc. 68:188-92.
46. Chen Z, O'Shea JJ. (2008) Regulation of IL-17 production in human lymphocytes. Cytokine. 41:71-8.
47. Lamont RJ. (2011) Mike Martin, A Tribute. Mol. Oral Microbiol. 26:174.