-
1
-
-
0035101914
-
Otx genes in brain morphogenesis
-
Acampora, D., Gulisano, M., Broccoli, V., et al. (2001). Otx genes in brain morphogenesis. Prog. Neurobiol. 64, 69-95.
-
(2001)
Prog. Neurobiol.
, vol.64
, pp. 69-95
-
-
Acampora, D.1
Gulisano, M.2
Broccoli, V.3
-
2
-
-
0034101021
-
The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer
-
Adams, K.A., Maida, J.M., Golden, J.A., et al. (2000). The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer. Development 127, 1857-1867.
-
(2000)
Development
, vol.127
, pp. 1857-1867
-
-
Adams, K.A.1
Maida, J.M.2
Golden, J.A.3
-
3
-
-
84871846692
-
WNT signalling pathways as therapeutic targets in cancer
-
Anastas, J.N., and Moon, R.T. (2013). WNT signalling pathways as therapeutic targets in cancer. Nat. Rev. Cancer 13, 11-26.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 11-26
-
-
Anastas, J.N.1
Moon, R.T.2
-
4
-
-
31044445499
-
Identification of intrinsic determinants of midbrain dopamine neurons
-
Andersson, E., Tryggvason, U., Deng, Q., et al. (2006a). Identification of intrinsic determinants of midbrain dopamine neurons. Cell 124, 393-405.
-
(2006)
Cell
, vol.124
, pp. 393-405
-
-
Andersson, E.1
Tryggvason, U.2
Deng, Q.3
-
5
-
-
33244474408
-
Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2
-
Andersson, E., Jensen, J.B., Parmar, M., et al. (2006b). Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2. Development 133, 507-516.
-
(2006)
Development
, vol.133
, pp. 507-516
-
-
Andersson, E.1
Jensen, J.B.2
Parmar, M.3
-
6
-
-
55849125793
-
Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo
-
Andersson, E.R., Prakash, N., Cajanek, L., et al. (2008). Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS One 3, e3517.
-
(2008)
PLoS One
, vol.3
-
-
Andersson, E.R.1
Prakash, N.2
Cajanek, L.3
-
7
-
-
84873730294
-
Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells
-
Andersson, E.R., Saltó, C., Villaescusa, J.C., et al. (2013). Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells. Proc. Natl Acad. Sci. USA 110, E602-E610.
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
-
-
Andersson, E.R.1
Saltó, C.2
Villaescusa, J.C.3
-
8
-
-
84871775384
-
The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2
-
Andre, P., Wang, Q., Wang, N., et al. (2012). The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2. J. Biol. Chem. 287, 44518-44525.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 44518-44525
-
-
Andre, P.1
Wang, Q.2
Wang, N.3
-
9
-
-
77952295552
-
Towards stem cell replacement therapies for Parkinson's disease
-
Arenas, E. (2010). Towards stem cell replacement therapies for Parkinson's disease. Biochem. Biophys. Res. Commun. 396, 152-156.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.396
, pp. 152-156
-
-
Arenas, E.1
-
10
-
-
36549040859
-
The selectivity of protein kinase inhibitors: A further update
-
Bain, J., Plater, L., Elliott, M., et al. (2007). The selectivity of protein kinase inhibitors: a further update. Biochem. J. 408, 297-315.
-
(2007)
Biochem. J.
, vol.408
, pp. 297-315
-
-
Bain, J.1
Plater, L.2
Elliott, M.3
-
11
-
-
84873558051
-
WNT signaling in bone homeostasis and disease: From human mutations to treatments
-
Baron, R., and Kneissel, M. (2013). WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat. Med. 19, 179-192.
-
(2013)
Nat. Med.
, vol.19
, pp. 179-192
-
-
Baron, R.1
Kneissel, M.2
-
12
-
-
0029114373
-
Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse
-
Bayer, S.A., Wills, K.V., Triarhou, L.C., et al. (1995). Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse. Exp. Brain Res. 105, 191-199.
-
(1995)
Exp. Brain Res.
, vol.105
, pp. 191-199
-
-
Bayer, S.A.1
Wills, K.V.2
Triarhou, L.C.3
-
13
-
-
84868156773
-
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6
-
Berwick, D.C., and Harvey, K. (2012). LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum. Mol. Genet. 21, 4966-4979.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 4966-4979
-
-
Berwick, D.C.1
Harvey, K.2
-
14
-
-
79959262926
-
Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei
-
Blaess, S., Bodea, G.O., Kabanova, A., et al. (2011). Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei. Neural Dev. 6, 29.
-
(2011)
Neural Dev.
, vol.6
, pp. 29
-
-
Blaess, S.1
Bodea, G.O.2
Kabanova, A.3
-
15
-
-
79953651370
-
Wnt5a regulates midbrain dopaminergic axon growth and guidance
-
Blakely, B.D., Bye, C.R., Fernando, C.V., et al. (2011). Wnt5a regulates midbrain dopaminergic axon growth and guidance. PLoS One 6, e18373.
-
(2011)
PLoS One
, vol.6
-
-
Blakely, B.D.1
Bye, C.R.2
Fernando, C.V.3
-
16
-
-
84880638198
-
Ryk, a receptor regulating wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons
-
Blakely, B.D., Bye, C.R., Fernando, C.V., et al. (2013). Ryk, a receptor regulating wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons. Stem Cells Dev. 22, 2132-2144.
-
(2013)
Stem Cells Dev.
, vol.22
, pp. 2132-2144
-
-
Blakely, B.D.1
Bye, C.R.2
Fernando, C.V.3
-
17
-
-
46749154758
-
Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors
-
Bonilla, S., Hall, A.C., Pinto, L., et al. (2008). Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors. Glia 56, 809-820.
-
(2008)
Glia
, vol.56
, pp. 809-820
-
-
Bonilla, S.1
Hall, A.C.2
Pinto, L.3
-
18
-
-
79961234493
-
Molecular organization and timing of Wnt1 expression define cohorts of midbrain dopamine neuron progenitors in vivo
-
Brown, A., Machan, J.T., Hayes, L., et al. (2011). Molecular organization and timing of Wnt1 expression define cohorts of midbrain dopamine neuron progenitors in vivo. J. Comp. Neurol. 519, 2978-3000.
-
(2011)
J. Comp. Neurol.
, vol.519
, pp. 2978-3000
-
-
Brown, A.1
MacHan, J.T.2
Hayes, L.3
-
19
-
-
33846235822
-
Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin
-
Bryja, V., Schulte, G., and Arenas, E. (2007). Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin. Cell Signal. 19, 610-616.
-
(2007)
Cell Signal.
, vol.19
, pp. 610-616
-
-
Bryja, V.1
Schulte, G.2
Arenas, E.3
-
20
-
-
57049149000
-
Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways
-
Bryja, V., Schambony, A., Cajánek, L., et al. (2008). Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways. EMBO Rep. 9, 1244-1250.
-
(2008)
EMBO Rep.
, vol.9
, pp. 1244-1250
-
-
Bryja, V.1
Schambony, A.2
Cajánek, L.3
-
21
-
-
64049118574
-
The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo
-
Bryja, V., Andersson, E.R., Schambony, A., et al. (2009). The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol. Biol. Cell 20, 924-936.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 924-936
-
-
Bryja, V.1
Andersson, E.R.2
Schambony, A.3
-
22
-
-
34547589477
-
Modulation of PPAR activity via phosphorylation
-
Burns, K.A., and Vanden Heuvel, J.P. (2007). Modulation of PPAR activity via phosphorylation. Biochim. Biophys. Acta 1771, 952-960.
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 952-960
-
-
Burns, K.A.1
Vanden Heuvel, J.P.2
-
23
-
-
84878226536
-
Origins and implications of pluripotent stem cell variability and heterogeneity
-
Cahan, P., and Daley, G.Q. (2013). Origins and implications of pluripotent stem cell variability and heterogeneity. Nat. Rev. Mol. Cell Biol. 14, 357-368.
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 357-368
-
-
Cahan, P.1
Daley, G.Q.2
-
24
-
-
80051674431
-
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
-
Caiazzo, M., Dell'Anno, M.T., Dvoretskova, E., et al. (2011). Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 476, 224-227.
-
(2011)
Nature
, vol.476
, pp. 224-227
-
-
Caiazzo, M.1
Dell'Anno, M.T.2
Dvoretskova, E.3
-
25
-
-
73349121619
-
Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells
-
Cajánek, L., Ribeiro, D., Liste, I., et al. (2009). Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells. Stem Cells 27, 2917-2927.
-
(2009)
Stem Cells
, vol.27
, pp. 2917-2927
-
-
Cajánek, L.1
Ribeiro, D.2
Liste, I.3
-
26
-
-
84871881514
-
Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons
-
Cajánek, L., Ganji, R.S., Henriques-Oliveira, C., et al. (2013). Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol. Cell. Biol. 33, 59-70.
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 59-70
-
-
Cajánek, L.1
Ganji, R.S.2
Henriques-Oliveira, C.3
-
27
-
-
0035798328
-
Aparadigm shift in brain research
-
Carlsson, A. (2001). Aparadigm shift in brain research. Science 294, 1021-1024.
-
(2001)
Science
, vol.294
, pp. 1021-1024
-
-
Carlsson, A.1
-
28
-
-
79960990066
-
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling
-
Carmon, K.S., Gong, X., Lin, Q., et al. (2011). R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Proc. Natl Acad. Sci. USA 108, 11452-11457.
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 11452-11457
-
-
Carmon, K.S.1
Gong, X.2
Lin, Q.3
-
29
-
-
0242363167
-
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
-
Castelo-Branco, G., Wagner, J., Rodriguez, F.J., et al. (2003). Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc. Natl Acad. Sci. USA 100, 12747-12752.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 12747-12752
-
-
Castelo-Branco, G.1
Wagner, J.2
Rodriguez, F.J.3
-
30
-
-
12344307661
-
GSK-3beta inhibition/betacatenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons
-
Castelo-Branco, G., Rawal, N., and Arenas, E. (2004). GSK-3beta inhibition/betacatenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons. J. Cell Sci. 117(Pt 24), 5731-5737.
-
(2004)
J. Cell Sci.
, vol.117
, Issue.PART 24
, pp. 5731-5737
-
-
Castelo-Branco, G.1
Rawal, N.2
Arenas, E.3
-
31
-
-
32244442041
-
Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion
-
Castelo-Branco, G., Sousa, K.M., Bryja, V., et al. (2006). Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Mol. Cell. Neurosci. 31, 251-262.
-
(2006)
Mol. Cell. Neurosci.
, vol.31
, pp. 251-262
-
-
Castelo-Branco, G.1
Sousa, K.M.2
Bryja, V.3
-
32
-
-
73949098115
-
Delayed dopaminergic neuron differentiation in Lrp6 mutant mice
-
Castelo-Branco, G., Andersson, E.R., Minina, E., et al. (2010). Delayed dopaminergic neuron differentiation in Lrp6 mutant mice. Dev. Dyn. 239, 211-221.
-
(2010)
Dev. Dyn.
, vol.239
, pp. 211-221
-
-
Castelo-Branco, G.1
Andersson, E.R.2
Minina, E.3
-
33
-
-
0041409985
-
The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
-
Chi, C.L., Martinez, S., Wurst, W., et al. (2003). The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum. Development 130, 2633-2644.
-
(2003)
Development
, vol.130
, pp. 2633-2644
-
-
Chi, C.L.1
Martinez, S.2
Wurst, W.3
-
34
-
-
70649111336
-
Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway
-
Chung, S., Leung, A., Han, B.S., et al. (2009). Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell 5, 646-658.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 646-658
-
-
Chung, S.1
Leung, A.2
Han, B.S.3
-
36
-
-
84861986053
-
Wnt/β-catenin signaling and disease
-
Clevers, H., and Nusse, R. (2012). Wnt/β-catenin signaling and disease. Cell 149, 1192-1205.
-
(2012)
Cell
, vol.149
, pp. 1192-1205
-
-
Clevers, H.1
Nusse, R.2
-
37
-
-
77951242770
-
In vitro and in vivo enhanced generation of human A9 dopamine neurons from neural stem cells by Bcl-XL
-
Courtois, E.T., Castillo, C.G., Seiz, E.G., et al. (2010). In vitro and in vivo enhanced generation of human A9 dopamine neurons from neural stem cells by Bcl-XL. J. Biol. Chem. 285, 9881-9897.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 9881-9897
-
-
Courtois, E.T.1
Castillo, C.G.2
Seiz, E.G.3
-
39
-
-
0001989283
-
Evidence for the existence of monoaminecontaining neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons
-
Dahlström, A., and Fuxe, K. (1964). Evidence for the existence of monoaminecontaining neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol. Scand. (Suppl 232), 1-55.
-
(1964)
Acta Physiol. Scand.
, Issue.SUPPL. 232
, pp. 1-55
-
-
Dahlström, A.1
Fuxe, K.2
-
40
-
-
0029742465
-
Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development
-
Danielian, P.S., and McMahon, A.P. (1996). Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature 383, 332-334.
-
(1996)
Nature
, vol.383
, pp. 332-334
-
-
Danielian, P.S.1
McMahon, A.P.2
-
41
-
-
80051926611
-
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
-
de Lau, W., Barker, N., Low, T.Y., et al. (2011). Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 476, 293-297.
-
(2011)
Nature
, vol.476
, pp. 293-297
-
-
De Lau, W.1
Barker, N.2
Low, T.Y.3
-
42
-
-
79960640766
-
Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development
-
Deng, Q., Andersson, E., Hedlund, E., et al. (2011). Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development 138, 3399-3408.
-
(2011)
Development
, vol.138
, pp. 3399-3408
-
-
Deng, Q.1
Andersson, E.2
Hedlund, E.3
-
43
-
-
84867911591
-
Glycogen synthase kinase 3b and activin/nodal inhibition in human embryonic stem cells induces a preneuroepithelial state that is required for specification to a floor plate cell lineage
-
Denham, M., Bye, C., Leung, J., et al. (2012). Glycogen synthase kinase 3b and activin/nodal inhibition in human embryonic stem cells induces a preneuroepithelial state that is required for specification to a floor plate cell lineage. Stem Cells 30, 2400-2411.
-
(2012)
Stem Cells
, vol.30
, pp. 2400-2411
-
-
Denham, M.1
Bye, C.2
Leung, J.3
-
44
-
-
78650215729
-
Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP
-
Di Salvio, M., Di Giovannantonio, L.G., Acampora, D., et al. (2010). Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP. Nat. Neurosci. 13, 1481-1488.
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 1481-1488
-
-
Di Salvio, M.1
Di Giovannantonio, L.G.2
Acampora, D.3
-
45
-
-
0035347165
-
Cell therapy in Parkinson's disease-stop or go?
-
Dunnett, S.B., Björklund, A., and Lindvall, O. (2001). Cell therapy in Parkinson's disease-stop or go? Nat. Rev. Neurosci. 2, 365-369.
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 365-369
-
-
Dunnett, S.B.1
Björklund, A.2
Lindvall, O.3
-
46
-
-
53449085169
-
Integrating positional information at the level of Smad1/5/8
-
Eivers, E., Fuentealba, L.C., and De Robertis, E.M. (2008). Integrating positional information at the level of Smad1/5/8. Curr. Opin. Genet. Dev. 18, 304-310.
-
(2008)
Curr. Opin. Genet. Dev.
, vol.18
, pp. 304-310
-
-
Eivers, E.1
Fuentealba, L.C.2
De Robertis, E.M.3
-
47
-
-
84868300421
-
Genetic dissection of midbrain dopamine neuron development in vivo
-
Ellisor, D., Rieser, C., Voelcker, B., et al. (2012). Genetic dissection of midbrain dopamine neuron development in vivo. Dev. Biol. 372, 249-262.
-
(2012)
Dev. Biol.
, vol.372
, pp. 249-262
-
-
Ellisor, D.1
Rieser, C.2
Voelcker, B.3
-
48
-
-
47949085566
-
Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density
-
Ellwanger, K., Saito, H., Clément-Lacroix, P., et al. (2008). Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol. Cell. Biol. 28, 4875-4882.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 4875-4882
-
-
Ellwanger, K.1
Saito, H.2
Clément-Lacroix, P.3
-
49
-
-
84855853673
-
Capture of neuroepithelial-like stem cells from pluripotent stemcells provides aversatile systemfor in vitro production of human neurons
-
Falk, A., Koch, P., Kesavan, J., et al. (2012). Capture of neuroepithelial-like stem cells from pluripotent stemcells provides aversatile systemfor in vitro production of human neurons. PLoS One 7, e29597.
-
(2012)
PLoS One
, vol.7
-
-
Falk, A.1
Koch, P.2
Kesavan, J.3
-
50
-
-
78649439497
-
Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem
-
Fenstermaker, A.G., Prasad, A.A., Bechara, A., et al. (2010). Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem. J. Neurosci. 30, 16053-16064.
-
(2010)
J. Neurosci.
, vol.30
, pp. 16053-16064
-
-
Fenstermaker, A.G.1
Prasad, A.A.2
Bechara, A.3
-
51
-
-
34548186224
-
Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosagedependent manner
-
Ferri, A.L., Lin, W., Mavromatakis, Y.E., et al. (2007). Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosagedependent manner. Development 134, 2761-2769.
-
(2007)
Development
, vol.134
, pp. 2761-2769
-
-
Ferri, A.L.1
Lin, W.2
Mavromatakis, Y.E.3
-
52
-
-
34347252235
-
Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain
-
Fischer, T., Guimera, J., Wurst, W., et al. (2007). Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain. Neuroscience 147, 693-711.
-
(2007)
Neuroscience
, vol.147
, pp. 693-711
-
-
Fischer, T.1
Guimera, J.2
Wurst, W.3
-
53
-
-
77951888466
-
Dishevelled: The hub of Wnt signaling
-
Gao, C., and Chen, Y.G. (2010). Dishevelled: the hub of Wnt signaling. Cell Signal. 22, 717-727.
-
(2010)
Cell Signal.
, vol.22
, pp. 717-727
-
-
Gao, C.1
Chen, Y.G.2
-
54
-
-
79751515852
-
Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2
-
Gao, B., Song, H., Bishop, K., et al. (2011). Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev. Cell 20, 163-176.
-
(2011)
Dev. Cell
, vol.20
, pp. 163-176
-
-
Gao, B.1
Song, H.2
Bishop, K.3
-
55
-
-
80053560465
-
LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling
-
Glinka, A., Dolde, C., Kirsch, N., et al. (2011). LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO Rep. 12, 1055-1061.
-
(2011)
EMBO Rep.
, vol.12
, pp. 1055-1061
-
-
Glinka, A.1
Dolde, C.2
Kirsch, N.3
-
56
-
-
79960240783
-
Planar cell polarity: Coordinating morphogenetic cell behaviors with embryonic polarity
-
Gray, R.S., Roszko, I., and Solnica-Krezel, L. (2011). Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity. Dev. Cell 21, 120-133.
-
(2011)
Dev. Cell
, vol.21
, pp. 120-133
-
-
Gray, R.S.1
Roszko, I.2
Solnica-Krezel, L.3
-
57
-
-
0035966322
-
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1
-
Habas, R., Kato, Y., and He, X. (2001). Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell 107, 843-854.
-
(2001)
Cell
, vol.107
, pp. 843-854
-
-
Habas, R.1
Kato, Y.2
He, X.3
-
58
-
-
0037439138
-
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation
-
Habas, R., Dawid, I.B., and He, X. (2003). Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev. 17, 295-309.
-
(2003)
Genes Dev.
, vol.17
, pp. 295-309
-
-
Habas, R.1
Dawid, I.B.2
He, X.3
-
59
-
-
84860765166
-
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
-
Hao, H.X., Xie, Y., Zhang, Y., et al. (2012). ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature 485, 195-200.
-
(2012)
Nature
, vol.485
, pp. 195-200
-
-
Hao, H.X.1
Xie, Y.2
Zhang, Y.3
-
60
-
-
38349164092
-
Meningeal cells induce dopaminergic neurons from embryonic stem cells
-
Hayashi, H., Morizane, A., Koyanagi, M., et al. (2008). Meningeal cells induce dopaminergic neurons from embryonic stem cells. Eur. J. Neurosci. 27, 261-268.
-
(2008)
Eur. J. Neurosci.
, vol.27
, pp. 261-268
-
-
Hayashi, H.1
Morizane, A.2
Koyanagi, M.3
-
61
-
-
79961216151
-
Timing of Sonic hedgehog and Gli1 expression segregates midbrain dopamine neurons
-
Hayes, L., Zhang, Z., Albert, P., et al. (2011). Timing of Sonic hedgehog and Gli1 expression segregates midbrain dopamine neurons. J. Comp. Neurol. 519, 3001-3018.
-
(2011)
J. Comp. Neurol.
, vol.519
, pp. 3001-3018
-
-
Hayes, L.1
Zhang, Z.2
Albert, P.3
-
62
-
-
0036205830
-
Glial cells generate neurons: The role of the transcription factor Pax6
-
Heins, N., Malatesta, P., Cecconi, F., et al. (2002). Glial cells generate neurons: the role of the transcription factor Pax6. Nat. Neurosci. 5, 308-315.
-
(2002)
Nat. Neurosci.
, vol.5
, pp. 308-315
-
-
Heins, N.1
Malatesta, P.2
Cecconi, F.3
-
63
-
-
0000058603
-
Distributional maps of tyrosine hydroxylase-immunoreactive neurons in the rat brain
-
Björklund, A., and Hökfelt, T. (eds). Amsterdam: Elsevier
-
Hökfelt, T., Matensson, R., Björklund, A., et al. (1984). Distributional maps of tyrosine hydroxylase-immunoreactive neurons in the rat brain. In: Björklund, A., and Hökfelt, T. (eds). Handbook of Chemical Neuroanatomy. Classical Transmitters in the CNS. Amsterdam: Elsevier, 277-379.
-
(1984)
Handbook of Chemical Neuroanatomy. Classical Transmitters in the CNS
, pp. 277-379
-
-
Hökfelt, T.1
Matensson, R.2
Björklund, A.3
-
64
-
-
84877929153
-
Wnt signaling in stem and cancer stem cells
-
Holland, J.D., Klaus, A., Garratt, A.N., et al. (2013). Wnt signaling in stem and cancer stem cells. Curr. Opin. Cell Biol. 25, 254-264.
-
(2013)
Curr. Opin. Cell Biol.
, vol.25
, pp. 254-264
-
-
Holland, J.D.1
Klaus, A.2
Garratt, A.N.3
-
65
-
-
80054821284
-
Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation
-
Huang, T., Xie, Z., Wang, J., et al. (2011). Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation. J. Biol. Chem. 286, 37399-37405.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 37399-37405
-
-
Huang, T.1
Xie, Z.2
Wang, J.3
-
66
-
-
77954874401
-
GSK3 signalling in neural development
-
Hur, E.M., and Zhou, F.Q. (2010). GSK3 signalling in neural development. Nat. Rev. Neurosci. 11, 539-551.
-
(2010)
Nat. Rev. Neurosci.
, vol.11
, pp. 539-551
-
-
Hur, E.M.1
Zhou, F.Q.2
-
67
-
-
0037786542
-
Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice
-
Hwang, D.Y., Ardayfio, P., Kang, U.J., et al. (2003). Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice. Brain Res. Mol. Brain Res. 114, 123-131.
-
(2003)
Brain Res. Mol. Brain Res.
, vol.114
, pp. 123-131
-
-
Hwang, D.Y.1
Ardayfio, P.2
Kang, U.J.3
-
68
-
-
0029127630
-
Induction of midbrain dopaminergic neurons by Sonic hedgehog
-
Hynes, M., Porter, J.A., Chiang, C., et al. (1995). Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron 15, 35-44.
-
(1995)
Neuron
, vol.15
, pp. 35-44
-
-
Hynes, M.1
Porter, J.A.2
Chiang, C.3
-
69
-
-
75549087261
-
Emerging roles of Wnts in the adult nervous system
-
Inestrosa, N.C., and Arenas, E. (2010). Emerging roles of Wnts in the adult nervous system. Nat. Rev. Neurosci. 11, 77-86.
-
(2010)
Nat. Rev. Neurosci.
, vol.11
, pp. 77-86
-
-
Inestrosa, N.C.1
Arenas, E.2
-
70
-
-
84863543371
-
Structural basis of Wnt recognition by Frizzled
-
Janda, C.Y., Waghray, D., Levin, A.M., et al. (2012). Structural basis of Wnt recognition by Frizzled. Science 337, 59-64.
-
(2012)
Science
, vol.337
, pp. 59-64
-
-
Janda, C.Y.1
Waghray, D.2
Levin, A.M.3
-
71
-
-
84855972240
-
Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts
-
Jellinger, K.A. (2012). Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts. Mov. Disord. 27, 8-30.
-
(2012)
Mov. Disord.
, vol.27
, pp. 8-30
-
-
Jellinger, K.A.1
-
72
-
-
58849098556
-
Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis
-
Joksimovic, M., Yun, B.A., Kittappa, R., et al. (2009a). Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat. Neurosci. 12, 125-131.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 125-131
-
-
Joksimovic, M.1
Yun, B.A.2
Kittappa, R.3
-
73
-
-
73149096463
-
Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools
-
Joksimovic, M., Anderegg, A., Roy, A., et al. (2009b). Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools. Proc. Natl Acad. Sci. USA 106, 19185-19190.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 19185-19190
-
-
Joksimovic, M.1
Anderegg, A.2
Roy, A.3
-
74
-
-
5044244757
-
R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis
-
Kazanskaya, O., Glinka, A., del Barco Barrantes, I., et al. (2004). R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev. Cell 7, 525-534.
-
(2004)
Dev. Cell
, vol.7
, pp. 525-534
-
-
Kazanskaya, O.1
Glinka, A.2
Del Barco-Barrantes, I.3
-
75
-
-
33244496187
-
Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons
-
Kele, J., Simplicio, N., Ferri, A.L., et al. (2006). Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons. Development 133, 495-505.
-
(2006)
Development
, vol.133
, pp. 495-505
-
-
Kele, J.1
Simplicio, N.2
Ferri, A.L.3
-
76
-
-
84860505844
-
SFRP1 and SFRP2 dosedependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells
-
Kele, J., Andersson, E.R., Villaescusa, J.C., et al. (2012). SFRP1 and SFRP2 dosedependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells. Stem Cells 30, 865-875.
-
(2012)
Stem Cells
, vol.30
, pp. 865-875
-
-
Kele, J.1
Andersson, E.R.2
Villaescusa, J.C.3
-
77
-
-
80054777961
-
New insights into the mechanism of Wnt signaling pathway activation
-
Kikuchi, A., Yamamoto, H., Sato, A., et al. (2011). New insights into the mechanism of Wnt signaling pathway activation. Int. Rev. Cell Mol. Biol. 291, 21-71.
-
(2011)
Int. Rev. Cell Mol. Biol.
, vol.291
, pp. 21-71
-
-
Kikuchi, A.1
Yamamoto, H.2
Sato, A.3
-
78
-
-
80755129026
-
Functional integration of dopaminergic neurons directly converted from mouse fibroblasts
-
Kim, J., Su, S.C., Wang, H., et al. (2011). Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell 9, 413-419.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 413-419
-
-
Kim, J.1
Su, S.C.2
Wang, H.3
-
79
-
-
84863094725
-
Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions
-
Kirkeby, A., Grealish, S., Wolf, D.A., et al. (2012). Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. Cell Rep. 1, 703-714.
-
(2012)
Cell Rep.
, vol.1
, pp. 703-714
-
-
Kirkeby, A.1
Grealish, S.2
Wolf, D.A.3
-
80
-
-
62549127853
-
A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration
-
Koch, P., Opitz, T., Steinbeck, J.A., et al. (2009). A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc. Natl Acad. Sci. USA 106, 3225-3230.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 3225-3230
-
-
Koch, P.1
Opitz, T.2
Steinbeck, J.A.3
-
81
-
-
84865517676
-
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
-
Koo, B.K., Spit, M., Jordens, I., et al. (2012). Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature 488, 665-669.
-
(2012)
Nature
, vol.488
, pp. 665-669
-
-
Koo, B.K.1
Spit, M.2
Jordens, I.3
-
82
-
-
84355166561
-
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease
-
Kriks, S., Shim, J.W., Piao, J., et al. (2011). Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature 480, 547-551.
-
(2011)
Nature
, vol.480
, pp. 547-551
-
-
Kriks, S.1
Shim, J.W.2
Piao, J.3
-
83
-
-
84861990748
-
Small molecules enable highly efficient neuronal conversion of human fibroblasts
-
Ladewig, J., Mertens, J., Kesavan, J., et al. (2012). Small molecules enable highly efficient neuronal conversion ofhumanfibroblasts. Nat. Methods 9,575-578.
-
(2012)
Nat. Methods
, vol.9
, pp. 575-578
-
-
Ladewig, J.1
Mertens, J.2
Kesavan, J.3
-
84
-
-
84875448554
-
Leveling Waddington: The emergence of direct programming and the loss of cell fate hierarchies
-
Ladewig, J., Koch, P., and Brüstle, O. (2013). Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies. Nat. Rev. Mol. Cell Biol. 14, 225-236.
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 225-236
-
-
Ladewig, J.1
Koch, P.2
Brüstle, O.3
-
85
-
-
66949152096
-
Parkinson's disease
-
Lees, A.J., Hardy, J., and Revesz, T. (2009). Parkinson's disease. Lancet 373, 2055-2066.
-
(2009)
Lancet
, vol.373
, pp. 2055-2066
-
-
Lees, A.J.1
Hardy, J.2
Revesz, T.3
-
86
-
-
0034925298
-
Early anterior/posterior patterning of the midbrain and cerebellum
-
Liu, A., and Joyner, A.L. (2001). Early anterior/posterior patterning of the midbrain and cerebellum. Annu. Rev. Neurosci. 24, 869-896.
-
(2001)
Annu. Rev. Neurosci.
, vol.24
, pp. 869-896
-
-
Liu, A.1
Joyner, A.L.2
-
87
-
-
21844473567
-
Cell therapy in Parkinson's disease
-
Lindvall, O., and Björklund, A. (2004). Cell therapy in Parkinson's disease. NeuroRx 1, 382-393.
-
(2004)
NeuroRx
, vol.1
, pp. 382-393
-
-
Lindvall, O.1
Björklund, A.2
-
88
-
-
80955142155
-
Cell therapeutics in Parkinson's disease
-
Lindvall, O., and Björklund, A. (2011). Cell therapeutics in Parkinson's disease. Neurotherapeutics 8, 539-548.
-
(2011)
Neurotherapeutics
, vol.8
, pp. 539-548
-
-
Lindvall, O.1
Björklund, A.2
-
89
-
-
84873802341
-
Inhibition of GSK3b-mediated BACE1 expression reduces Alzheimer-associated phenotypes
-
Ly, P.T., Wu, Y., Zou, H., et al. (2013). Inhibition of GSK3b-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J. Clin. Invest. 123, 224-235.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 224-235
-
-
Ly, P.T.1
Wu, Y.2
Zou, H.3
-
90
-
-
41549151113
-
Regulation of motor neuron specification by phosphorylation of neurogenin 2
-
Ma, Y.C., Song, M.R., Park, J.P., et al. (2008). Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron 58, 65-77.
-
(2008)
Neuron
, vol.58
, pp. 65-77
-
-
Ma, Y.C.1
Song, M.R.2
Park, J.P.3
-
91
-
-
0037030681
-
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling
-
Mao, B., Wu, W., Davidson, G., et al. (2002). Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 417, 664-667.
-
(2002)
Nature
, vol.417
, pp. 664-667
-
-
Mao, B.1
Wu, W.2
Davidson, G.3
-
92
-
-
20444376889
-
Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development
-
Maxwell, S.L., Ho, H.Y., Kuehner, E., et al. (2005). Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development. Dev. Biol. 282, 467-479.
-
(2005)
Dev. Biol.
, vol.282
, pp. 467-479
-
-
Maxwell, S.L.1
Ho, H.Y.2
Kuehner, E.3
-
93
-
-
0025188130
-
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
-
McMahon, A.P., and Bradley, A. (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073-1085.
-
(1990)
Cell
, vol.62
, pp. 1073-1085
-
-
McMahon, A.P.1
Bradley, A.2
-
94
-
-
84866102176
-
Wnt pathway regulation of embryonic stem cell self-renewal
-
Merrill, B.J. (2012). Wnt pathway regulation of embryonic stem cell self-renewal. Cold Spring Harb. Perspect. Biol. 4, a007971.
-
(2012)
Cold Spring Harb. Perspect. Biol.
, vol.4
-
-
Merrill, B.J.1
-
95
-
-
84863107502
-
Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors
-
Metzakopian, E., Lin, W., Salmon-Divon, M., et al. (2012). Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development 139, 2625-2634.
-
(2012)
Development
, vol.139
, pp. 2625-2634
-
-
Metzakopian, E.1
Lin, W.2
Salmon-Divon, M.3
-
96
-
-
33646241997
-
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context
-
Mikels, A.J., and Nusse, R. (2006). Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol. 4, e115.
-
(2006)
PLoS Biol.
, vol.4
-
-
Mikels, A.J.1
Nusse, R.2
-
97
-
-
18044399916
-
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse
-
Mukhopadhyay, M., Shtrom, S., Rodriguez-Esteban, C., et al. (2001). Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev. Cell 1, 423-434.
-
(2001)
Dev. Cell
, vol.1
, pp. 423-434
-
-
Mukhopadhyay, M.1
Shtrom, S.2
Rodriguez-Esteban, C.3
-
98
-
-
84870252814
-
The complex world of WNT receptor signalling
-
Niehrs, C. (2012). The complex world of WNT receptor signalling. Nat. Rev. Mol. Cell Biol. 13, 767-779.
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 767-779
-
-
Niehrs, C.1
-
99
-
-
0037390135
-
Pitx3 is required for development of substantia nigra dopaminergic neurons
-
Nunes, I., Tovmasian, L.T., Silva, R.M., et al. (2003). Pitx3 is required for development of substantia nigra dopaminergic neurons. Proc. Natl Acad. Sci. USA 100, 4245-4250.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 4245-4250
-
-
Nunes, I.1
Tovmasian, L.T.2
Silva, R.M.3
-
100
-
-
0020216124
-
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
-
Nusse, R., and Varmus, H.E. (1982). Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31, 99-109.
-
(1982)
Cell
, vol.31
, pp. 99-109
-
-
Nusse, R.1
Varmus, H.E.2
-
101
-
-
0026060707
-
A new nomenclature for int-1 and related genes: The Wnt gene family
-
Nusse, R., Brown, A., Papkoff, J., et al. (1991). A new nomenclature for int-1 and related genes: the Wnt gene family. Cell 64, 231.
-
(1991)
Cell
, vol.64
, pp. 231
-
-
Nusse, R.1
Brown, A.2
Papkoff, J.3
-
102
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila
-
Nüsslein-Volhard, C., and Wieschaus, E. (1980). Mutations affecting segment number and polarity in Drosophila. Nature 287, 795-801.
-
(1980)
Nature
, vol.287
, pp. 795-801
-
-
Nüsslein-Volhard, C.1
Wieschaus, E.2
-
103
-
-
79952491185
-
Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis
-
Ohkawara, B., Glinka, A., and Niehrs, C. (2011). Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis. Dev. Cell 20, 303-314.
-
(2011)
Dev. Cell
, vol.20
, pp. 303-314
-
-
Ohkawara, B.1
Glinka, A.2
Niehrs, C.3
-
104
-
-
58149214745
-
Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon
-
Omodei, D., Acampora, D., Mancuso, P., et al. (2008). Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon. Development 135, 3459-3470.
-
(2008)
Development
, vol.135
, pp. 3459-3470
-
-
Omodei, D.1
Acampora, D.2
Mancuso, P.3
-
105
-
-
2342514254
-
Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region
-
Panhuysen, M., Vogt Weisenhorn, D.M., Blanquet, V., et al. (2004). Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region. Mol. Cell. Neurosci. 26, 101-111.
-
(2004)
Mol. Cell. Neurosci.
, vol.26
, pp. 101-111
-
-
Panhuysen, M.1
Vogt Weisenhorn, D.M.2
Blanquet, V.3
-
106
-
-
38149126482
-
Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice
-
Parish, C.L., Castelo-Branco, G., Rawal, N., et al. (2008). Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. J. Clin. Invest. 118, 149-160.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 149-160
-
-
Parish, C.L.1
Castelo-Branco, G.2
Rawal, N.3
-
107
-
-
79959951387
-
Direct conversion of human fibroblasts to dopaminergic neurons
-
Pfisterer, U., Kirkeby, A., Torper, O., et al. (2011). Direct conversion of human fibroblasts to dopaminergic neurons. Proc. Natl Acad. Sci. USA 108, 10343-10348.
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 10343-10348
-
-
Pfisterer, U.1
Kirkeby, A.2
Torper, O.3
-
108
-
-
14844300927
-
The floor plate: Multiple cells, multiple signals
-
Placzek, M., and Briscoe, J. (2005). The floor plate: multiple cells, multiple signals. Nat. Rev. Neurosci. 6, 230-240.
-
(2005)
Nat. Rev. Neurosci.
, vol.6
, pp. 230-240
-
-
Placzek, M.1
Briscoe, J.2
-
109
-
-
77955617871
-
Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants
-
Politis, M., Wu, K., Loane, C., et al. (2010). Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants. Sci. Transl. Med. 2, 38ra46.
-
(2010)
Sci. Transl. Med.
, vol.2
-
-
Politis, M.1
Wu, K.2
Loane, C.3
-
110
-
-
31644448700
-
A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo
-
Prakash, N., Brodski, C., Naserke, T., et al. (2006). A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development 133, 89-98.
-
(2006)
Development
, vol.133
, pp. 89-98
-
-
Prakash, N.1
Brodski, C.2
Naserke, T.3
-
111
-
-
33646133416
-
Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain
-
Rawal, N., Castelo-Branco, G., Sousa, K.M., et al. (2006). Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain. Exp. Cell Res. 312, 1626-1636.
-
(2006)
Exp. Cell Res.
, vol.312
, pp. 1626-1636
-
-
Rawal, N.1
Castelo-Branco, G.2
Sousa, K.M.3
-
112
-
-
69749110516
-
Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling
-
Rawal, N., Corti, O., Sacchetti, P., et al. (2009). Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling. Biochem. Biophys. Res. Commun. 388, 473-478.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.388
, pp. 473-478
-
-
Rawal, N.1
Corti, O.2
Sacchetti, P.3
-
113
-
-
79951832882
-
Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis
-
Ribeiro, D., Ellwanger, K., Glagow, D., et al. (2011). Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis. PLoS One 6, e15786.
-
(2011)
PLoS One
, vol.6
-
-
Ribeiro, D.1
Ellwanger, K.2
Glagow, D.3
-
114
-
-
84866511789
-
Efficient expansion and dopaminergic differentiation ofhumanfetal ventral midbrain neuralstemcells by midbrain morphogens
-
Ribeiro, D., Laguna Goya, R., Ravindran, G., et al. (2012). Efficient expansion and dopaminergic differentiation ofhumanfetal ventral midbrain neuralstemcells by midbrain morphogens. Neurobiol. Dis. 49C, 118-127.
-
(2012)
Neurobiol. Dis.
, vol.49 C
, pp. 118-127
-
-
Ribeiro, D.1
Laguna Goya, R.2
Ravindran, G.3
-
115
-
-
0023653232
-
The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
-
Rijsewijk, F., Schuermann, M., Wagenaar, E., et al. (1987). The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50, 649-657.
-
(1987)
Cell
, vol.50
, pp. 649-657
-
-
Rijsewijk, F.1
Schuermann, M.2
Wagenaar, E.3
-
116
-
-
16644381829
-
Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
-
Rosso, S.B., Sussman, D., Wynshaw-Boris, A., et al. (2005). Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Nat. Neurosci. 8, 34-42.
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 34-42
-
-
Rosso, S.B.1
Sussman, D.2
Wynshaw-Boris, A.3
-
117
-
-
33645789040
-
A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells
-
Säfholm, A., Leandersson, K., Dejmek, J., et al. (2006). A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J. Biol. Chem. 281, 2740-2749.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 2740-2749
-
-
Säfholm, A.1
Leandersson, K.2
Dejmek, J.3
-
118
-
-
48249110960
-
Wnt signaling in neural circuit assembly
-
Salinas, P.C., and Zou, Y. (2008). Wnt signaling in neural circuit assembly. Annu. Rev. Neurosci. 31, 339-358.
-
(2008)
Annu. Rev. Neurosci.
, vol.31
, pp. 339-358
-
-
Salinas, P.C.1
Zou, Y.2
-
119
-
-
49449109011
-
Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease
-
Sanchez-Pernaute, R., Lee, H., Patterson, M., et al. (2008). Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease. Brain 131(Pt 8), 2127-2139.
-
(2008)
Brain
, vol.131
, Issue.PART 8
, pp. 2127-2139
-
-
Sanchez-Pernaute, R.1
Lee, H.2
Patterson, M.3
-
120
-
-
70349576902
-
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways
-
Sancho, R.M., Law, B.M., and Harvey, K. (2009). Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways. Hum. Mol. Genet. 18, 3955-3968.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 3955-3968
-
-
Sancho, R.M.1
Law, B.M.2
Harvey, K.3
-
121
-
-
34247589181
-
Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway
-
Schambony, A., and Wedlich, D. (2007). Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. Dev. Cell 12, 779-792.
-
(2007)
Dev. Cell
, vol.12
, pp. 779-792
-
-
Schambony, A.1
Wedlich, D.2
-
122
-
-
15244360639
-
Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation
-
Schulte, G., Bryja, V., Rawal, N., et al. (2005). Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation. J. Neurochem. 92, 1550-1553.
-
(2005)
J. Neurochem.
, vol.92
, pp. 1550-1553
-
-
Schulte, G.1
Bryja, V.2
Rawal, N.3
-
123
-
-
22844445934
-
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
-
Semënov, M., Tamai, K., and He, X. (2005). SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J. Biol. Chem. 280, 26770-26775.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26770-26775
-
-
Semënov, M.1
Tamai, K.2
He, X.3
-
124
-
-
84873453232
-
The genetics of Parkinson's disease: Progress and therapeutic implications
-
Singleton, A.B., Farrer, M.J., and Bonifati, V. (2013). The genetics of Parkinson's disease: progress and therapeutic implications. Mov. Disord. 28, 14-23.
-
(2013)
Mov. Disord.
, vol.28
, pp. 14-23
-
-
Singleton, A.B.1
Farrer, M.J.2
Bonifati, V.3
-
125
-
-
34848892735
-
Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation
-
Smelkinson, M.G., Zhou, Q., and Kalderon, D. (2007). Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation. Dev. Cell 13, 481-495.
-
(2007)
Dev. Cell
, vol.13
, pp. 481-495
-
-
Smelkinson, M.G.1
Zhou, Q.2
Kalderon, D.3
-
126
-
-
0034034739
-
A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
-
Smidt, M.P., Asbreuk, C.H., Cox, J.J., et al. (2000).A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nat. Neurosci. 3, 337-341.
-
(2000)
Nat. Neurosci.
, vol.3
, pp. 337-341
-
-
Smidt, M.P.1
Asbreuk, C.H.2
Cox, J.J.3
-
127
-
-
1642363250
-
Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
-
Smidt, M.P., Smits, S.M., Bouwmeester, H., et al. (2004). Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development 131, 1145-1155.
-
(2004)
Development
, vol.131
, pp. 1145-1155
-
-
Smidt, M.P.1
Smits, S.M.2
Bouwmeester, H.3
-
128
-
-
77951237163
-
Wnt2 regulates progenitor proliferation in the developing ventral midbrain
-
Sousa, K.M., Villaescusa, J.C., Cajanek, L., et al. (2010). Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J. Biol. Chem. 285, 7246-7253.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 7246-7253
-
-
Sousa, K.M.1
Villaescusa, J.C.2
Cajanek, L.3
-
129
-
-
84877120034
-
Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages
-
Stott, S.R., Metzakopian, E., Lin, W., et al. (2013). Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages. J. Neurosci. 33, 8022-8034.
-
(2013)
J. Neurosci.
, vol.33
, pp. 8022-8034
-
-
Stott, S.R.1
Metzakopian, E.2
Lin, W.3
-
130
-
-
73949161033
-
Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect
-
Stuebner, S., Faus-Kessler, T., Fischer, T., et al. (2010). Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect. Dev. Dyn. 239, 246-260.
-
(2010)
Dev. Dyn.
, vol.239
, pp. 246-260
-
-
Stuebner, S.1
Faus-Kessler, T.2
Fischer, T.3
-
131
-
-
37249042774
-
Lrp6 is required for convergent extension during Xenopus gastrulation
-
Tahinci, E., Thorne, C.A., Franklin, J.L., et al. (2007). Lrp6 is required for convergent extension during Xenopus gastrulation. Development 134, 4095-4106.
-
(2007)
Development
, vol.134
, pp. 4095-4106
-
-
Tahinci, E.1
Thorne, C.A.2
Franklin, J.L.3
-
132
-
-
84880620666
-
Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency
-
Tailor, J., Kittappa, R., Leto, K., et al. (2013). Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency. J Neurosci. 33, 12407-12422.
-
(2013)
J Neurosci.
, vol.33
, pp. 12407-12422
-
-
Tailor, J.1
Kittappa, R.2
Leto, K.3
-
133
-
-
33751318469
-
Monounsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion
-
Takada, R., Satomi, Y., Kurata, T., et al. (2006). Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev. Cell 11, 791-801.
-
(2006)
Dev. Cell
, vol.11
, pp. 791-801
-
-
Takada, R.1
Satomi, Y.2
Kurata, T.3
-
134
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676.
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
135
-
-
69549083403
-
Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons
-
Tang, M., Miyamoto, Y., and Huang, E.J. (2009). Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons. Development 136, 2027-2038.
-
(2009)
Development
, vol.136
, pp. 2027-2038
-
-
Tang, M.1
Miyamoto, Y.2
Huang, E.J.3
-
136
-
-
77954497673
-
Interactions of Wnt/betacatenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
-
Tang, M., Villaescusa, J.C., Luo, S.X., et al. (2010). Interactions of Wnt/betacatenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons. J. Neurosci. 30, 9280-9291.
-
(2010)
J. Neurosci.
, vol.30
, pp. 9280-9291
-
-
Tang, M.1
Villaescusa, J.C.2
Luo, S.X.3
-
137
-
-
37349004102
-
Parkinson's disease
-
Thomas, B., and Beal, M.F. (2007). Parkinson's disease. Hum. Mol. Genet. 16(Spec No. 2), R183-R194.
-
(2007)
Hum. Mol. Genet.
, vol.16
, Issue.2
-
-
Thomas, B.1
Beal, M.F.2
-
138
-
-
0025074908
-
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
-
Thomas, K.R., and Capecchi, M.R. (1990). Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346, 847-850.
-
(1990)
Nature
, vol.346
, pp. 847-850
-
-
Thomas, K.R.1
Capecchi, M.R.2
-
139
-
-
0043234811
-
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
-
Topol, L., Jiang, X., Choi, H., et al. (2003). Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J. Cell Biol. 162, 899-908.
-
(2003)
J. Cell Biol.
, vol.162
, pp. 899-908
-
-
Topol, L.1
Jiang, X.2
Choi, H.3
-
140
-
-
84876667526
-
Generation of induced neurons via direct conversion in vivo
-
Torper, O., Pfisterer, U., Wolf, D.A., et al. (2013). Generation of induced neurons via direct conversion in vivo. Proc. Natl Acad. Sci. USA 110, 7038-7043.
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 7038-7043
-
-
Torper, O.1
Pfisterer, U.2
Wolf, D.A.3
-
141
-
-
0038614833
-
Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons
-
van den Munckhof, P., Luk, K.C., Ste-Marie, L., et al. (2003). Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development 130, 2535-2542.
-
(2003)
Development
, vol.130
, pp. 2535-2542
-
-
Van Den-Munckhof, P.1
Luk, K.C.2
Ste-Marie, L.3
-
142
-
-
0041695485
-
A second canon. Functions and Mechanisms of Beta-catenin-independent Wnt Signaling
-
Veeman, M.T., Axelrod, J.D., and Moon, R.T. (2003). A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev. Cell 5, 367-377.
-
(2003)
Dev. Cell
, vol.5
, pp. 367-377
-
-
Veeman, M.T.1
Axelrod, J.D.2
Moon, R.T.3
-
143
-
-
77649162059
-
Direct conversion of fibroblasts to functional neurons by defined factors
-
Vierbuchen, T., Ostermeier, A., Pang, Z.P., et al. (2010). Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035-1041.
-
(2010)
Nature
, vol.463
, pp. 1035-1041
-
-
Vierbuchen, T.1
Ostermeier, A.2
Pang, Z.P.3
-
144
-
-
84866174640
-
Wnt signaling in mammalian development: Lessons from mouse genetics
-
Wang, J., Sinha, T., and Wynshaw-Boris, A. (2012). Wnt signaling in mammalian development: lessons from mouse genetics. Cold Spring Harb. Perspect. Biol. 4, a007963.
-
(2012)
Cold Spring Harb. Perspect. Biol.
, vol.4
-
-
Wang, J.1
Sinha, T.2
Wynshaw-Boris, A.3
-
145
-
-
0037737726
-
Wnt proteins are lipidmodified and can act as stem cell growth factors
-
Willert, K., Brown, J.D., Danenberg, E., et al. (2003). Wnt proteins are lipidmodified and can act as stem cell growth factors. Nature 423, 448-452.
-
(2003)
Nature
, vol.423
, pp. 448-452
-
-
Willert, K.1
Brown, J.D.2
Danenberg, E.3
-
146
-
-
0035257203
-
Neural plate patterning: Upstream and downstream of the isthmic organizer
-
Wurst, W., and Bally-Cuif, L. (2001). Neural plate patterning: upstream and downstream of the isthmic organizer. Nat. Rev. Neurosci. 2, 99-108.
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 99-108
-
-
Wurst, W.1
Bally-Cuif, L.2
-
147
-
-
84864353544
-
Specification of midbrain dopamine neurons from primate pluripotent stem cells
-
Xi, J., Liu, Y., Liu, H., et al. (2012). Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells 30, 1655-1663.
-
(2012)
Stem Cells
, vol.30
, pp. 1655-1663
-
-
Xi, J.1
Liu, Y.2
Liu, H.3
-
148
-
-
80052382699
-
Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors
-
Yan, C.H., Levesque, M., Claxton, S., et al. (2011). Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors. J. Neurosci. 31, 12413-12425.
-
(2011)
J. Neurosci.
, vol.31
, pp. 12413-12425
-
-
Yan, C.H.1
Levesque, M.2
Claxton, S.3
-
149
-
-
84874545497
-
Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development
-
Yang, J., Brown, A., Ellisor, D., et al. (2013a). Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development. Development 140, 1342-1352.
-
(2013)
Development
, vol.140
, pp. 1342-1352
-
-
Yang, J.1
Brown, A.2
Ellisor, D.3
-
150
-
-
84887162136
-
Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons
-
Yang, S., Edman, L., Sánchez-Alcañiz, J.A., et al. (2013b). Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons. Development 140, 4554-4564.
-
(2013)
Development
, vol.140
, pp. 4554-4564
-
-
Yang, S.1
Edman, L.2
Sánchez-Alcañiz, J.A.3
-
151
-
-
0032577445
-
FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
-
Ye, W., Shimamura, K., Rubenstein, J.L., et al. (1998). FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93, 755-766.
-
(1998)
Cell
, vol.93
, pp. 755-766
-
-
Ye, W.1
Shimamura, K.2
Rubenstein, J.L.3
-
152
-
-
0031002024
-
Dopamine neuron agenesis in Nurr1-deficient mice
-
Zetterström, R.H., Solomin, L., Jansson, L., et al. (1997). Dopamine neuron agenesis in Nurr1-deficient mice. Science 276, 248-250.
-
(1997)
Science
, vol.276
, pp. 248-250
-
-
Zetterström, R.H.1
Solomin, L.2
Jansson, L.3
-
153
-
-
84862684701
-
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation
-
Zhang, X., Abreu, J.G., Yokota, C., et al. (2012). Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell 149, 1565-1577.
-
(2012)
Cell
, vol.149
, pp. 1565-1577
-
-
Zhang, X.1
Abreu, J.G.2
Yokota, C.3
-
154
-
-
47549113841
-
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis
-
Zhu, W., Shiojima, I., Ito, Y., et al. (2008). IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 454, 345-349.
-
(2008)
Nature
, vol.454
, pp. 345-349
-
-
Zhu, W.1
Shiojima, I.2
Ito, Y.3
|