-
1
-
-
68649095434
-
Parkinson's disease: the dual hit theory revisited
-
Hawkes C.H., Del Tredici K., and Braak H. Parkinson's disease: the dual hit theory revisited. Ann. NY Acad. Sci. 1170 (2009) 615-622
-
(2009)
Ann. NY Acad. Sci.
, vol.1170
, pp. 615-622
-
-
Hawkes, C.H.1
Del Tredici, K.2
Braak, H.3
-
2
-
-
63149090431
-
Parkinson's disease: from monogenic forms to genetic susceptibility factors
-
Lesage S., and Brice A. Parkinson's disease: from monogenic forms to genetic susceptibility factors. Hum. Mol. Genet. 18 (2009) R48-R59
-
(2009)
Hum. Mol. Genet.
, vol.18
-
-
Lesage, S.1
Brice, A.2
-
3
-
-
0033491121
-
Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient
-
Piccini P., Brooks D.J., Björklund A., et al. Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient. Nat. Neurosci. 2 (1999) 1137-1140
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 1137-1140
-
-
Piccini, P.1
Brooks, D.J.2
Björklund, A.3
-
4
-
-
0035826089
-
Transplantation of embryonic dopamine neurons for severe Parkinson's disease
-
Freed C.R., Greene P.E., Breeze R.E., et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. 344 (2001) 710-719
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 710-719
-
-
Freed, C.R.1
Greene, P.E.2
Breeze, R.E.3
-
5
-
-
0042837887
-
A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease
-
Olanow C.W., Goetz C.G., Kordower J.H., et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann. Neurol. 54 (2003) 403-414
-
(2003)
Ann. Neurol.
, vol.54
, pp. 403-414
-
-
Olanow, C.W.1
Goetz, C.G.2
Kordower, J.H.3
-
6
-
-
0034921374
-
Cell survival and clinical outcome following intrastriatal transplantation in Parkinson disease
-
Hagell P., and Brundin P. Cell survival and clinical outcome following intrastriatal transplantation in Parkinson disease. J. Neuropathol. Exp. Neurol. 60 (2001) 741-752
-
(2001)
J. Neuropathol. Exp. Neurol.
, vol.60
, pp. 741-752
-
-
Hagell, P.1
Brundin, P.2
-
7
-
-
34247366072
-
Inflammation as a causative factor in the aetiology of Parkinson's disease
-
Whitton P.S. Inflammation as a causative factor in the aetiology of Parkinson's disease. Br. J. Pharmacol. 150 (2007) 963-976
-
(2007)
Br. J. Pharmacol.
, vol.150
, pp. 963-976
-
-
Whitton, P.S.1
-
8
-
-
58849107919
-
+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
-
+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J. Clin. Invest. 119 (2009) 182-192
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 182-192
-
-
Brochard, V.1
Combadière, B.2
Prigent, A.3
-
9
-
-
0036307190
-
Dyskinesias following neural transplantation in Parkinson's disease
-
Hagell P., Piccini P., Björklund A., et al. Dyskinesias following neural transplantation in Parkinson's disease. Nat. Neurosci. 5 (2002) 627-628
-
(2002)
Nat. Neurosci.
, vol.5
, pp. 627-628
-
-
Hagell, P.1
Piccini, P.2
Björklund, A.3
-
10
-
-
60149088032
-
Impact of grafted serotonin and dopamine neurons on development of l-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration
-
Carlsson T., Carta M., Muñoz A., et al. Impact of grafted serotonin and dopamine neurons on development of l-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration. Brain 132 (2009) 319-335
-
(2009)
Brain
, vol.132
, pp. 319-335
-
-
Carlsson, T.1
Carta, M.2
Muñoz, A.3
-
11
-
-
21844454972
-
Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections
-
Thompson L., Barraud P., Andersson E., et al. Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. J. Neurosci. 25 (2005) 6467-6477
-
(2005)
J. Neurosci.
, vol.25
, pp. 6467-6477
-
-
Thompson, L.1
Barraud, P.2
Andersson, E.3
-
12
-
-
43249114934
-
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
-
Kordower J.H., Chu Y., Hauser R.A., et al. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat. Med. 14 (2008) 504-506
-
(2008)
Nat. Med.
, vol.14
, pp. 504-506
-
-
Kordower, J.H.1
Chu, Y.2
Hauser, R.A.3
-
13
-
-
43249110200
-
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
-
Li J.Y., Englund E., Holton J.L., et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat. Med. 14 (2008) 501-503
-
(2008)
Nat. Med.
, vol.14
, pp. 501-503
-
-
Li, J.Y.1
Englund, E.2
Holton, J.L.3
-
14
-
-
43249085326
-
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
-
Mendez I., Viñuela A., Astradsson A., et al. Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Nat. Med. 14 (2008) 507-509
-
(2008)
Nat. Med.
, vol.14
, pp. 507-509
-
-
Mendez, I.1
Viñuela, A.2
Astradsson, A.3
-
15
-
-
70349782681
-
Protocols for generating ES cell-derived dopamine neurons
-
Kriks S., and Studer L. Protocols for generating ES cell-derived dopamine neurons. Adv. Exp. Med. Biol. 651 (2009) 101-111
-
(2009)
Adv. Exp. Med. Biol.
, vol.651
, pp. 101-111
-
-
Kriks, S.1
Studer, L.2
-
16
-
-
65349181409
-
Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease
-
Lindvall O., and Kokaia Z. Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease. Trends Pharmacol. Sci. 30 (2009) 260-267
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 260-267
-
-
Lindvall, O.1
Kokaia, Z.2
-
17
-
-
74949133926
-
Progress toward the clinical application of patient-specific pluripotent stem cells
-
Kiskinis E., and Eggan K. Progress toward the clinical application of patient-specific pluripotent stem cells. J. Clin. Invest. 120 (2010) 51-59
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 51-59
-
-
Kiskinis, E.1
Eggan, K.2
-
18
-
-
4344592974
-
Derivation of midbrain dopamine neurons from human embryonic stem cells
-
Perrier A.L., Tabar V., Barberi T., et al. Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc. Natl. Acad. Sci. USA 101 (2004) 12543-12548
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 12543-12548
-
-
Perrier, A.L.1
Tabar, V.2
Barberi, T.3
-
19
-
-
0033638174
-
Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity
-
Kawasaki H., Mizuseki K., Nishikawa S., et al. Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 28 (2000) 31-40
-
(2000)
Neuron
, vol.28
, pp. 31-40
-
-
Kawasaki, H.1
Mizuseki, K.2
Nishikawa, S.3
-
20
-
-
33750706917
-
Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
-
Roy N.S., Cleren C., Singh S.K., et al. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat. Med. 12 (2006) 1259-1268
-
(2006)
Nat. Med.
, vol.12
, pp. 1259-1268
-
-
Roy, N.S.1
Cleren, C.2
Singh, S.K.3
-
21
-
-
0032980340
-
Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes
-
Wagner J., Akerud P., Castro D.S., et al. Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes. Nat. Biotechnol. 17 (1999) 653-659
-
(1999)
Nat. Biotechnol.
, vol.17
, pp. 653-659
-
-
Wagner, J.1
Akerud, P.2
Castro, D.S.3
-
22
-
-
31044445499
-
Identification of intrinsic determinants of midbrain dopamine neurons
-
Andersson E., Tryggvason U., Deng Q., et al. Identification of intrinsic determinants of midbrain dopamine neurons. Cell 124 (2006) 393-405
-
(2006)
Cell
, vol.124
, pp. 393-405
-
-
Andersson, E.1
Tryggvason, U.2
Deng, Q.3
-
23
-
-
66149085781
-
Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells
-
Friling S., Andersson E., Thompson L.H., et al. Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells. Proc. Natl. Acad. Sci. USA 106 (2009) 7613-7618
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 7613-7618
-
-
Friling, S.1
Andersson, E.2
Thompson, L.H.3
-
24
-
-
28844441638
-
NTera2: a model system to study dopaminergic differentiation of human embryonic stem cells
-
Schwartz C.M., Spivak C.E., Baker S.C., et al. NTera2: a model system to study dopaminergic differentiation of human embryonic stem cells. Stem Cells Dev. 14 (2005) 517-534
-
(2005)
Stem Cells Dev.
, vol.14
, pp. 517-534
-
-
Schwartz, C.M.1
Spivak, C.E.2
Baker, S.C.3
-
25
-
-
32244442041
-
Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion
-
Castelo-Branco G., Sousa K.M., Bryja V., et al. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Mol. Cell. Neurosci. 31 (2006) 251-262
-
(2006)
Mol. Cell. Neurosci.
, vol.31
, pp. 251-262
-
-
Castelo-Branco, G.1
Sousa, K.M.2
Bryja, V.3
-
26
-
-
48649091029
-
Assessment of stromal-derived inducing activity in the generation of dopaminergic neurons from human embryonic stem cells
-
Vazin T., Chen J., Lee C.T., et al. Assessment of stromal-derived inducing activity in the generation of dopaminergic neurons from human embryonic stem cells. Stem Cells 26 (2008) 1517-1525
-
(2008)
Stem Cells
, vol.26
, pp. 1517-1525
-
-
Vazin, T.1
Chen, J.2
Lee, C.T.3
-
27
-
-
70349309626
-
Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells
-
Sacchetti P., Sousa K.M., Hall A.C., et al. Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell 5 (2009) 409-419
-
(2009)
Cell Stem Cell
, vol.5
, pp. 409-419
-
-
Sacchetti, P.1
Sousa, K.M.2
Hall, A.C.3
-
28
-
-
0242363167
-
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
-
Castelo-Branco G., Wagner J., Rodriguez F.J., et al. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc. Natl. Acad. Sci. USA 100 (2003) 12747-12752
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 12747-12752
-
-
Castelo-Branco, G.1
Wagner, J.2
Rodriguez, F.J.3
-
29
-
-
55849125793
-
Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo
-
Andersson E.R., Prakash N., Cajanek L., et al. Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS One 3 (2008) e3517
-
(2008)
PLoS One
, vol.3
-
-
Andersson, E.R.1
Prakash, N.2
Cajanek, L.3
-
30
-
-
38149126482
-
Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice
-
Parish C.L., Castelo-Branco G., Rawal N., et al. Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. J. Clin. Invest. 118 (2008) 149-160
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 149-160
-
-
Parish, C.L.1
Castelo-Branco, G.2
Rawal, N.3
-
31
-
-
62549127853
-
A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration
-
Koch P., Opitz T., Steinbeck J.A., et al. A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc. Natl. Acad. Sci. USA 106 (2009) 3225-3230
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 3225-3230
-
-
Koch, P.1
Opitz, T.2
Steinbeck, J.A.3
-
32
-
-
42149107420
-
Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells
-
Cho M.S., Lee Y.E., Kim J.Y., et al. Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells. Proc. Natl. Acad. Sci. USA 105 (2008) 3392-3397
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 3392-3397
-
-
Cho, M.S.1
Lee, Y.E.2
Kim, J.Y.3
-
33
-
-
62149125434
-
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
-
Chambers S.M., Fasano C.A., Papapetrou E.P., et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 27 (2009) 275-280
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 275-280
-
-
Chambers, S.M.1
Fasano, C.A.2
Papapetrou, E.P.3
-
34
-
-
50549089957
-
Disease-specific induced pluripotent stem cells
-
Park I.H., Arora N., Huo H., et al. Disease-specific induced pluripotent stem cells. Cell 134 (2008) 877-886
-
(2008)
Cell
, vol.134
, pp. 877-886
-
-
Park, I.H.1
Arora, N.2
Huo, H.3
-
35
-
-
61349100729
-
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors
-
Soldner F., Hockemeyer D., Beard C., et al. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 136 (2009) 964-977
-
(2009)
Cell
, vol.136
, pp. 964-977
-
-
Soldner, F.1
Hockemeyer, D.2
Beard, C.3
-
36
-
-
42649130264
-
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
-
Wernig M., Zhao J.P., Pruszak J., et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc. Natl. Acad. Sci. USA 105 (2008) 5856-5861
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 5856-5861
-
-
Wernig, M.1
Zhao, J.P.2
Pruszak, J.3
-
37
-
-
72749089194
-
Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming
-
Li W., and Ding S. Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends Pharmacol. Sci. 31 (2010) 36-45
-
(2010)
Trends Pharmacol. Sci.
, vol.31
, pp. 36-45
-
-
Li, W.1
Ding, S.2
-
38
-
-
69349098834
-
Stem cells: the promises and perils of p53
-
Krizhanovsky V., and Lowe S.W. Stem cells: the promises and perils of p53. Nature 460 (2009) 1085-1086
-
(2009)
Nature
, vol.460
, pp. 1085-1086
-
-
Krizhanovsky, V.1
Lowe, S.W.2
-
39
-
-
77649162059
-
Direct conversion of fibroblasts to functional neurons by defined factors
-
Vierbuchen T., Ostermeier A., Pang Z.P., et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463 (2010) 1035-1041
-
(2010)
Nature
, vol.463
, pp. 1035-1041
-
-
Vierbuchen, T.1
Ostermeier, A.2
Pang, Z.P.3
|