Cell Therapy in Parkinson's Disease

NeuroRx

Volumn 1, Issue 4, 2004, Pages 382-393

  Lindvall, Olle ^a   Björklund, Anders ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

dopamine; neural grafts; Parkinson's disease; stem cells; transplantation

Indexed keywords

DOPAMINE; LEVODOPA;

ARTICLE; CELL THERAPY; CORPUS STRIATUM; DENERVATION; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; DYSKINESIA; FRONTAL CORTEX; HUMAN; MESENCEPHALON; NERVE GRAFT; NONHUMAN; PARKINSON DISEASE; PATIENT SELECTION; POSTOPERATIVE COMPLICATION; REINNERVATION; STEM CELL TRANSPLANTATION; ANIMAL; CELL TRANSPLANTATION; CLINICAL TRIAL; FETAL TISSUE TRANSPLANTATION; PHYSIOLOGY; REVIEW;

ANIMALS; CELL TRANSPLANTATION; CLINICAL TRIALS; DOPAMINE; FETAL TISSUE TRANSPLANTATION; HUMANS; PARKINSON DISEASE; PATIENT SELECTION; STEM CELL TRANSPLANTATION;

EID: 21844473567     PISSN: 15455343     EISSN: 15455351     Source Type: Journal    
DOI: 10.1602/neurorx.1.4.382     Document Type: Article

References (65)

1. Lindvall O., Brundin P., Widner H., Rehncrona S., Gustavii B., Frackowiak R., et al. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 247 (1990) 574-577
2. Lindvall O., Widner H., Rehncrona S., Brundin P., Odin P., Gustavii B., et al. Transplantation of fetal dopamine neurons in Parkinson's disease: one-year clinical and neurophysiological observations in two patients with putaminal implants. Ann Neurol 31 (1992) 155-165
3. Lindvall O., Sawle G., Widner H., Rothwell J., Bjorklund A., Brooks D., et al. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann Neurol 35 (1994) 172-180
4. Sawle G., Bloomfield P., Bjorklund A., Brooks D., Brundin P., Leenders K., et al. Transplantation of fetal dopamine neurons in Parkinson's disease: PET [18F]6-l-fluorodopa studies in two patients with putaminal implants. Ann Neurol 31 (1992) 166-173
5. Widner H., Tetrud J., Rehncrona S., Snow B., Brundin P., Gustavii B., et al. Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). N Engl J Med 327 (1992) 1556-1563
6. Peschanski M., Defer G., N′Guyen J., Ricolfi F., Monfort J., Remy P., et al. Bilateral motor improvement and alteration of l-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon. Brain 117 (1994) 487-499
7. Freeman T., Olanow C., Hauser R., Nauert G., Smith D., Borlongan C., et al. Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease. Ann Neurol 38 (1995) 379-388
8. Remy P., Samson Y., Hantraye P., Fontaine A., Defer G., Mangin J., et al. Clinical correlates of [18F]fluorodopa uptake in five grafted parkinsonian patients. Ann Neurol 38 (1995) 580-588
9. Defer G., Geny C., Ricolfi F., Fenelon G., Monfort J., Remy P., et al. Long-term outcome of unilaterally transplanted parkinsonian patients. I. Clinical approach. Brain 119 (1996) 41-50
10. Wenning G., Odin P., Morrish P., Rehncrona S., Widner H., Brundin P., et al. Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease. Ann Neurol 42 (1997) 95-107
11. Hagell P., Schrag A., Piccini P., Jahanshahi M., Brown R., Rehncrona S., et al. Sequential bilateral transplantation in Parkinson's disease: effects of the second graft. Brain 122 (1999) 1121-1132
12. Hauser R., Freeman T., Snow B., Nauert M., Gauger L., Kordower J., et al. Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease. Arch Neurol 56 (1999) 179-187
13. Brundin P., Pogarell O., Hagell P., Piccini P., Widner H., Schrag A., et al. Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease. Brain 123 (2000) 1380-1390
14. Mendez I., Dagher A., Hong M., Hebb A., Gaudet P., Law A., et al. Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor in patients with Parkinson's disease. Report of two cases and technical considerations. J Neurosurg 92 (2000) 863-869
15. Mendez I., Dagher A., Hong M., Gaudet P., Weerasinghe S., McAlister V., et al. Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases. J Neurosurg 96 (2002) 589-596
16. Cochen V., Ribeiro M., Nguyen J., Gurruchaga J., Villafane G., Loc'h C., et al. Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue. Mov Disord 18 (2003) 928-932
17. Piccini P., Brooks D., Bjorklund A., Gunn R., Grasby P., Rimoldi O., et al. Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient. Nat Neurosci 2 (1999) 1137-1140
18. Freed C., Greene P., Breeze R., Tsai W., DuMouchel W., Kao R., et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 344 (2001) 710-719
19. Kordower J., Freeman T., Chen E., Mufson E., Sanberg P., Hauser R., et al. Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease. Mov Disord 13 (1998) 383-393
20. Kordower J., Freeman T., Snow B., Vingerhoets F., Mufson E., Sanberg P., et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med 332 (1995) 1118-1124
21. Kordower J., Rosenstein J., Collier T., Burke M., Chen E., Li J., et al. Functional fetal nigral grafts in a patient with Parkinson's disease: chemoanatomic, ultrastructural, and metabolic studies. J Comp Neurol 370 (1996) 203-230
22. Hagell P., and Brundin P. Cell survival and clinical outcome following intrastriatal transplantation in Parkinson disease. J Neuropathol Exp Neurol 60 (2001) 741-752
23. Olanow C., Goetz C., Kordower J., Stoessl A., Sossi V., Brin M., et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol 54 (2003) 403-414
24. Playford E., Jenkins I., Passingham R., Nutt J., Frackowiak R., and Brooks D. Impaired mesial frontal and putamen activation in Parkinson's disease: a positron emission tomography study. Ann Neurol 32 (1992) 151-161
25. Piccini P., Lindvall O., Bjorklund A., Brundin P., Hagell P., Ceravolo R., et al. Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts. Ann Neurol 48 (2000) 689-695
26. Cenci MA, Hagell P. Dyskinesias and neural grafting in Parkinson's disease. In: Restorative therapies in Parkinson's disease. (Olanow CW, Brundin P, eds). New York: Kluwer Academic/Plenum Publishers (in press).
27. Hagell P., Piccini P., Bjorklund A., Brundin P., Rehncrona S., Widner H., et al. Dyskinesias following neural transplantation in Parkinson's disease. Nat Neurosci 5 (2002) 627-628
28. Ma Y., Feigin A., Dhawan V., Fukuda M., Shi Q., Greene P., et al. Dyskinesia after fetal cell transplantation for parkinsonism: a PET study. Ann Neurol 52 (2002) 628-634
29. Lindvall O., and Hagell P. Clinical observations after neural transplantation in Parkinson's disease. Prog Brain Res 127 (2000) 299-320
30. Vitek J. Deep brain stimulation for Parkinson's disease. A critical re-evaluation of STN versus GPi DBS. Stereotact Funct Neurosurg 78 (2002) 119-131
31. Braak H., and Braak E. Pathoanatomy of Parkinson's disease. J Neurol 247 Suppl 2 (2000) II3-II10
32. Perl D., Olanow C., and Calne D. Alzheimer's disease and Parkinson's disease: distinct entities or extremes of a spectrum of neurodegeneration?. Ann Neurol 44 (1998) S19-S31
33. Agid Y., Javoy-Agid F., and Ruberg M. Biochemistry of neurotransmitter in PD. In: Marsden C., and Fahn S. (Eds). Movement disorders 2 (1987), Butterworth, London 166-230
34. Sortwell C., Camargo M., Pitzer M., Gyawali S., and Collier T. Diminished survival of mesencephalic dopamine neurons grafted into aged hosts occurs during the immediate postgrafting interval. Exp Neurol 169 (2001) 23-29
35. Doucet G., Brundin P., Descarries L., and Bjorklund A. Effect of prior dopamine denervation on survival and fiber outgrowth from intrastriatal fetal mesencephalic grafts. Eur J Neurosci 2 (1990) 279-290
36. Kirik D., Winkler C., and Bjorklund A. Growth and functional efficacy of intrastriatal nigral transplants depend on the extent of nigrostriatal degeneration. J Neurosci 21 (2001) 2889-2896
37. Yurek D., and Fletcher-Turner A. Temporal changes in the neurotrophic environment of the denervated striatum as determined by the survival and outgrowth of grafted fetal dopamine neurons. Brain Res 931 (2002) 126-134
38. Carvey P., Lin D., Faselis C., Notermann J., and Ling Z. Loss of striatal DA innervation increases striatal trophic activity directed at DA neurons in culture. Exp Neurol 140 (1996) 184-197
39. Ling Z., Collier T., Sortwell C., Lipton J., Vu T., Robie H., et al. Striatal trophic activity is reduced in the aged rat brain. Brain Res 856 (2000) 301-309
40. Yurek D., and Fletcher-Turner A. Lesion-induced increase of BDNF is greater in the striatum of young versus old rat brain. Exp Neurol 161 (2000) 392-396
41. Zhou J., Pliego-Rivero B., Bradford H., and Stern G. The BDNF content of postnatal and adult rat brain: the effects of 6-hydroxydopamine lesions in adult brain. Dev Brain Res 97 (1996) 297-303
42. Yurek D., and Fletcher-Turner A. Differential expression of GDNF, BDNF, and NT-3 in the aging nigrostriatal system following a neurotoxic lesion. Brain Res 891 (2001) 228-235
43. Björklund A., Stenevi U., Schmidt R., Dunnett S., and Gage F. Intracerebral grafting of neuronal cell suspensions. Acta Physiol Scand Suppl 522 (1983) 1-48
44. Dunnett S., Whishaw I., Rogers D., and Jones G. Dopamine-rich grafts ameliorate whole body motor asymmetry and sensory neglect but not independent limb use in rats with 6-hydroxydopamine lesions. Brain Res 415 (1987) 63-78
45. Mandel R., Brundin P., and Bjorklund A. The importance of graft placement and task complexity for transplant-induced recovery of simple and complex sensorimotor deficits in dopamine denervated rats. Eur J Neurosci 2 (1990) 888-894
46. Annett L., Torres E., Ridley R., Baker H., and Dunnett S. A comparison of the behavioural effects of embryonic nigral grafts in the caudate nucleus and in the putamen of marmosets with unilateral 6-OHDA lesions. Exp Brain Res 103 (1995) 355-371
47. Dunnett S., and Robbins T. The functional role of mesotelencephalic dopamine systems. Biol Rev Camb Philos Soc 67 (1992) 491-518
48. Sloan D., Baker B., Puklavec M., and Charlton H. The effect of site of transplantation and histocompatibility differences on the survival of neural tissue transplanted to the CNS of defined inbred rat strains. Prog Brain Res 82 (1990) 141-152
49. Baker-Cairns B., Sloan D., Broadwell R., Puklavec M., and Charlton H. Contributions of donor and host blood vessels in CNS allografts. Exp Neurol 142 (1996) 36-46
50. Brundin P., Barbin G., Strecker R., Isacson O., Prochiantz A., and Bjorklund A. Survival and function of dissociated rat dopamine neurones grafted at different developmental stages or after being cultured in vitro. Brain Res 467 (1988) 233-243
51. Schultzberg M., Dunnett S., Bjorklund A., Stenevi U., Hokfelt T., Dockray G., et al. Dopamine and cholecystokinin immunoreactive neurons in mesencephalic grafts reinnervating the neostriatum: evidence for selective growth regulation. Neuroscience 12 (1984) 17-32
52. Haque N., LeBlanc C., and Isacson O. Differential dissection of the rat E16 ventral mesencephalon and survival and reinnervation of the 6-OHDA-lesioned striatum by a subset of aldehyde dehydrogenase-positive TH neurons. Cell Transplant 6 (1997) 239-248
53. Isacson O., Björklund L., and Schumacher J. Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells. Ann Neurol 53 (2003) S135-S146
54. Hudson J., Hoffman A., Stromberg I., Hoffer B., and Moorhead J. Allogeneic grafts of fetal dopamine neurons: behavioral indices of immunological interactions. Neurosci Lett 171 (1994) 32-36
55. Shinoda M., Hudson J., Stromberg I., Hoffer B., Moorhead J., and Olson L. Allogeneic grafts of fetal dopamine neurons: immunological reactions following active and adoptive immunizations. Brain Res 680 (1995) 180-195
56. Shinoda M., Hudson J., Stromberg I., Hoffer B., Moorhead J., and Olson L. Microglial cell responses to fetal ventral mesencephalic tissue grafting and to active and adoptive immunizations. Exp Neurol 141 (1996) 173-180
57. Duan W., Widner H., Bjorklund A., and Brundin P. Sequential intrastriatal grafting of allogeneic embryonic dopamine-rich neuronal tissue in adult rats: will the second graft be rejected?. Neuroscience 57 (1993) 261-274
58. Barker R. Repairing the brain in Parkinson's disease: where next?. Mov Disord 17 (2002) 233-241
59. Schumacher J., Ellias S., Palmer E., Kott H., Dinsmore J., Dempsey P., et al. Transplantation of embryonic porcine mesencephalic tissue in patients with PD. Neurology 54 (2000) 1042-1050
60. Watts R., Freeman T., Hauser R., Bakay R., Ellias S., Stoessl A., et al. A double-blind, randomized, controlled, multicenter clinical trial of the safety and efficacy of stereotaxic intrastriatal implantation of fetal porcine ventral mesencephalic tissue (Neurocell™-PD) vs imitation surgery in patients with Parkinson's disease (PD). Parkinsonism Relat Disord 7 Suppl (2001) S87
61. Lindvall O., Kokaia Z., and Martinez-Serrano A. Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat Med 10 Suppl (2004) S42-S50
62. Björklund L., Sanchez-Pernaute R., Chung S., Andersson T., Chen I., McNaught K., et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci USA 99 (2002) 2344-2349
63. Kim J., Auerbach J., Rodriguez-Gomez J., Velasco I., Gavin D., Lumelsky N., et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 418 (2002) 50-56
64. Erdo F., Buhrle C., Blunk J., Hoehn M., Xia Y., Fleischmann B., et al. Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke. J Cereb Blood Flow Metab 23 (2003) 780-785
65. Steece-Collier K., Collier T., Danielson P., Kurlan R., Yurek D., and Sladek Jr. J. Embryonic mesencephalic grafts increase levodopa-induced forelimb hyperkinesia in parkinsonian rats. Mov Disord 18 (2003) 1442-1454