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Volumn 13, Issue 12, 2010, Pages 1481-1489

Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DAT PROTEIN; GIRK2 PROTEIN; PROTEIN; TRANSCRIPTION FACTOR OTX2; UNCLASSIFIED DRUG;

EID: 78650215729     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2661     Document Type: Article
Times cited : (104)

References (50)
  • 2
    • 0036454341 scopus 로고    scopus 로고
    • Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease
    • Björklund, L.M. & Isacson, O. Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease. Prog. Brain Res. 138, 411-420 (2002).
    • (2002) Prog. Brain Res. , vol.138 , pp. 411-420
    • Björklund, L.M.1    Isacson, O.2
  • 3
    • 0001989283 scopus 로고
    • Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons
    • Dahlström, A. & Fuxe, K. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol. Scand. 62, 1-55 (1964).
    • (1964) Acta Physiol. Scand. , vol.62 , pp. 1-55
    • Dahlström, A.1    Fuxe, K.2
  • 4
    • 33845746199 scopus 로고    scopus 로고
    • How to make a mesodiencephalic dopaminergic neuron
    • Smidt, M.P. & Burbach, J.P. How to make a mesodiencephalic dopaminergic neuron. Nat. Rev. Neurosci. 8, 21-32 (2007).
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 21-32
    • Smidt, M.P.1    Burbach, J.P.2
  • 5
    • 27444440377 scopus 로고    scopus 로고
    • Ontogeny of tyrosine hydroxylase mRNA expression in mid-and forebrain: Neuromeric pattern and novel positive regions
    • Marín, F., Herrero, M.T., Vyas, S. & Puelles, L. Ontogeny of tyrosine hydroxylase mRNA expression in mid-and forebrain: neuromeric pattern and novel positive regions. Dev. Dyn. 234, 709-717 (2005).
    • (2005) Dev. Dyn. , vol.234 , pp. 709-717
    • Marín, F.1    Herrero, M.T.2    Vyas, S.3    Puelles, L.4
  • 6
    • 58149214745 scopus 로고    scopus 로고
    • Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon
    • Omodei, D. et al. Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon. Development 135, 3459-3470 (2008).
    • (2008) Development , vol.135 , pp. 3459-3470
    • Omodei, D.1
  • 7
    • 21844454972 scopus 로고    scopus 로고
    • Identifcation of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression and efferent projections
    • Thompson, L., Barraud, P., Andersson, E., Kirik, D. & Björklund, A. Identifcation of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression and efferent projections. J. Neurosci. 25, 6467-6477 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 6467-6477
    • Thompson, L.1    Barraud, P.2    Andersson, E.3    Kirik, D.4    Björklund, A.5
  • 8
    • 0035233512 scopus 로고    scopus 로고
    • The pathology of Parkinson′s disease
    • Jellinger, K.A. The pathology of Parkinson′s disease. Adv. Neurol. 86, 55-72 (2001).
    • (2001) Adv. Neurol , vol.86 , pp. 55-72
    • Jellinger, K.A.1
  • 9
    • 30744461567 scopus 로고    scopus 로고
    • Development of dopaminergic neurons in the mammalian brain
    • Prakash, N. & Wurst, W. Development of dopaminergic neurons in the mammalian brain. Cell. Mol. Life Sci. 63, 187-206 (2006).
    • (2006) Cell. Mol. Life Sci , vol.63 , pp. 187-206
    • Prakash, N.1    Wurst, W.2
  • 10
    • 13144305102 scopus 로고    scopus 로고
    • Genetic control of dopaminergic neuron differentiation
    • Simeone, A. Genetic control of dopaminergic neuron differentiation. Trends Neurosci. 28, 62-65 (2005).
    • (2005) Trends Neurosci. , vol.28 , pp. 62-65
    • Simeone, A.1
  • 11
    • 0032584085 scopus 로고    scopus 로고
    • Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
    • Saucedo-Cardenas, O. et al. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA 95, 4013-4018 (1998)
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 4013-4018
    • Saucedo-Cardenas, O.1
  • 12
    • 27844547616 scopus 로고    scopus 로고
    • The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease
    • Jankovic, J., Chen, S. & Le, W.D. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog. Neurobiol. 77, 128-138 (2005).
    • (2005) Prog. Neurobiol , vol.77 , pp. 128-138
    • Jankovic, J.1    Chen, S.2    Le, W.D.3
  • 13
    • 0034034739 scopus 로고    scopus 로고
    • A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
    • Smidt, M.P. et al. A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nat. Neurosci. 3, 337-341 (2000).
    • (2000) Nat. Neurosci , vol.3 , pp. 337-341
    • Smidt, M.P.1
  • 14
    • 1642363250 scopus 로고    scopus 로고
    • Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
    • Smidt, M.P. et al. Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development 131, 1145-1155 (2004)
    • (2004) Development , vol.131 , pp. 1145-1155
    • Smidt, M.P.1
  • 15
    • 33244496187 scopus 로고    scopus 로고
    • Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons
    • Kele, J. et al. Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons. Development 133, 495-505 (2006).
    • (2006) Development , vol.133 , pp. 495-505
    • Kele, J.1
  • 16
    • 34548186224 scopus 로고    scopus 로고
    • Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner
    • Ferri, A.L. et al. Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development 134, 2761-2769 (2007).
    • (2007) Development , vol.134 , pp. 2761-2769
    • Ferri, A.L.1
  • 17
    • 33244474408 scopus 로고    scopus 로고
    • Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2
    • Andersson, E., Jensen, J.B., Parmar, M., Guillemot, F. & Björklund, A. Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2. Development 133, 507-516 (2006).
    • (2006) Development , vol.133 , pp. 507-516
    • Andersson, E.1    Jensen, J.B.2    Parmar, M.3    Guillemot, F.4    Björklund, A.5
  • 18
    • 31044445499 scopus 로고    scopus 로고
    • Identifcation of intrinsic determinants of midbrain dopamine neurons
    • Andersson, E. et al. Identifcation of intrinsic determinants of midbrain dopamine neurons. Cell 124, 393-405 (2006).
    • (2006) Cell , vol.124 , pp. 393-405
    • Andersson, E.1
  • 19
    • 34848896595 scopus 로고    scopus 로고
    • Differences in neurogenic potential in foor plate cells along an anteroposterior location: Midbrain dopaminergic neurons originate from mesencephalic foor plate cells
    • Ono, Y. et al. Differences in neurogenic potential in foor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic foor plate cells. Development 134, 3213-3225 (2007).
    • (2007) Development , vol.134 , pp. 3213-3225
    • Ono, Y.1
  • 20
    • 0038614833 scopus 로고    scopus 로고
    • Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons
    • van den Munckhof, P. et al. Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development 130, 2535-2542 (2003).
    • (2003) Development , vol.130 , pp. 2535-2542
    • Van Den Munckhof, P.1
  • 22
    • 0035341443 scopus 로고    scopus 로고
    • Fate of midbrain dopaminergic neurons controlled by the engrailed genes
    • Simon, H.H., Saueressig, H., Wurst, W., Goulding, M.D. & O'Leary, D.D. Fate of midbrain dopaminergic neurons controlled by the engrailed genes. J. Neurosci. 21, 3126-3134 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 3126-3134
    • Simon, H.H.1    Saueressig, H.2    Wurst, W.3    Goulding, M.D.4    O'Leary, D.D.5
  • 23
    • 33846804054 scopus 로고    scopus 로고
    • Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1
    • Sonnier, L. et al. Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. J. Neurosci. 27, 1063-1071 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 1063-1071
    • Sonnier, L.1
  • 24
    • 33750061314 scopus 로고    scopus 로고
    • Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice
    • Sgadò, P. et al. Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proc. Natl. Acad. Sci. USA 103, 15242-15247 (2006)
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 15242-15247
    • Sgadò, P.1
  • 25
    • 0031002024 scopus 로고    scopus 로고
    • Dopamine neuron agenesis in Nurr1-defcient mice
    • Zetterström, R.H. et al. Dopamine neuron agenesis in Nurr1-defcient mice. Science 276, 248-250 (1997).
    • (1997) Science , vol.276 , pp. 248-250
    • Zetterström, R.H.1
  • 26
    • 0242363167 scopus 로고    scopus 로고
    • Differential regulation of dopaminergic neuron development by Wnt-1 Wnt-3a and Wnt-5a
    • Castelo-Branco, G. et al. Differential regulation of dopaminergic neuron development by Wnt-1, Wnt-3a and Wnt-5a. Proc. Natl. Acad. Sci. USA 100, 12747-12752 (2003)
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12747-12752
    • Castelo-Branco, G.1
  • 27
    • 0037406899 scopus 로고    scopus 로고
    • Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain
    • Puelles, E. et al. Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat. Neurosci. 6, 453-460 (2003).
    • (2003) Nat. Neurosci , vol.6 , pp. 453-460
    • Puelles, E.1
  • 28
    • 2542628846 scopus 로고    scopus 로고
    • Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain
    • Puelles, E. et al. Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain. Development 131, 2037-2048 (2004).
    • (2004) Development , vol.131 , pp. 2037-2048
    • Puelles, E.1
  • 29
    • 31644448700 scopus 로고    scopus 로고
    • A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo
    • Prakash, N. et al. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development 133, 89-98 (2006).
    • (2006) Development , vol.133 , pp. 89-98
    • Prakash, N.1
  • 30
    • 70350341194 scopus 로고    scopus 로고
    • Dopamine transporter glycosylation correlates with the vulnerability of midbrain dopaminergic cells in Parkinson's disease
    • Afonso-Oramas, D. et al. Dopamine transporter glycosylation correlates with the vulnerability of midbrain dopaminergic cells in Parkinson's disease. Neurobiol. Dis. 36, 494-508 (2009).
    • (2009) Neurobiol. Dis , vol.36 , pp. 494-508
    • Afonso-Oramas, D.1
  • 31
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • Dauer, W. & Przedborski, S. Parkinson's disease: mechanisms and models. Neuron 39, 889-909 (2003).
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 32
    • 0028784523 scopus 로고
    • Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1 2 3,6-tetrahydropyridine
    • Jackson-Lewis, V., Jakowec, M., Burke, R.E. & Przedborski, S. Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration 4, 257-269 (1995)
    • (1995) Neurodegeneration , vol.4 , pp. 257-269
    • Jackson-Lewis, V.1    Jakowec, M.2    Burke, R.E.3    Przedborski, S.4
  • 33
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • Blum, D. et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog. Neurobiol. 65, 135-172 (2001).
    • (2001) Prog. Neurobiol , vol.65 , pp. 135-172
    • Blum, D.1
  • 34
    • 26444529541 scopus 로고    scopus 로고
    • Cell type-specifc gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection
    • Chung, C.Y. et al. Cell type-specifc gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Hum. Mol. Genet. 14, 1709-1725 (2005).
    • (2005) Hum. Mol. Genet , vol.14 , pp. 1709-1725
    • Chung, C.Y.1
  • 35
    • 11844262742 scopus 로고    scopus 로고
    • Gene expression profling of rat midbrain dopamine neurons: Implications for selective vulnerability in parkinsonism
    • Greene, J.G., Dingledine, R. & Greenamyre, J.T. Gene expression profling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism. Neurobiol. Dis. 18, 19-31 (2005).
    • (2005) Neurobiol. Dis , vol.18 , pp. 19-31
    • Greene, J.G.1    Dingledine, R.2    Greenamyre, J.T.3
  • 36
    • 0030861479 scopus 로고    scopus 로고
    • An immunocytochemical study on the distribution of two G-protein-gated inward rectifer potassium channels (GIRK2 and GIRK4) in the adult rat brain
    • Murer, G. et al. An immunocytochemical study on the distribution of two G-protein-gated inward rectifer potassium channels (GIRK2 and GIRK4) in the adult rat brain. Neuroscience 80, 345-357 (1997).
    • (1997) Neuroscience , vol.80 , pp. 345-357
    • Murer, G.1
  • 37
    • 0032535637 scopus 로고    scopus 로고
    • Girk2 expression in the ventral midbrain, cerebellum, and olfactory bulb and its relationship to the murine mutation weaver
    • Schein, J.C., Hunter, D.D. & Roffer-Tarlov, S. Girk2 expression in the ventral midbrain, cerebellum, and olfactory bulb and its relationship to the murine mutation weaver. Dev. Biol. 204, 432-450 (1998).
    • (1998) Dev. Biol , vol.204 , pp. 432-450
    • Schein, J.C.1    Hunter, D.D.2    Roffer-Tarlov, S.3
  • 38
    • 77956022861 scopus 로고    scopus 로고
    • Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain
    • Di Salvio, M., Di Giovannantonio, L.G., Omodei, D., Acampora, D. & Simeone, A. Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain. Int. J. Dev. Biol. 54, 939-945 (2010).
    • (2010) Int. J. Dev. Biol , vol.54 , pp. 939-945
    • Di Salvio, M.1    Di Giovannantonio, L.G.2    Omodei, D.3    Acampora, D.4    Simeone, A.5
  • 39
    • 0030513477 scopus 로고    scopus 로고
    • Midbrain dopaminergic neurons in the mouse that contain calbindin-D28k exhibit reduced vulnerability to MPTP-induced neurodegeneration
    • Liang, C.L., Sinton, C.M., Sonsalla, P.K. & German, D.C. Midbrain dopaminergic neurons in the mouse that contain calbindin-D28k exhibit reduced vulnerability to MPTP-induced neurodegeneration. Neurodegeneration 5, 313-318 (1996).
    • (1996) Neurodegeneration , vol.5 , pp. 313-318
    • Liang, C.L.1    Sinton, C.M.2    Sonsalla, P.K.3    German, D.C.4
  • 40
  • 41
    • 33748637350 scopus 로고    scopus 로고
    • Characterization of a mouse strain expressing Cre recombinase from the 3′ untranslated region of the dopamine transporter locus
    • Bäckman, C.M. et al. Characterization of a mouse strain expressing Cre recombinase from the 3′ untranslated region of the dopamine transporter locus. Genesis 44, 383-390 (2006).
    • (2006) Genesis , vol.44 , pp. 383-390
    • Bäckman, C.M.1
  • 42
    • 70349512750 scopus 로고    scopus 로고
    • Selective inactivation of Otx2 mRNA isoforms reveals isoform-specifc requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm
    • Acampora, D., Di Giovannantonio, L.G., Di Salvio, M., Mancuso, P. & Simeone, A. Selective inactivation of Otx2 mRNA isoforms reveals isoform-specifc requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech. Dev. 126, 882-897 (2009).
    • (2009) Mech. Dev , vol.126 , pp. 882-897
    • Acampora, D.1    Di Giovannantonio, L.G.2    Di Salvio, M.3    Mancuso, P.4    Simeone, A.5
  • 43
    • 38549159511 scopus 로고    scopus 로고
    • The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age
    • Kittappa, R., Chang, W.W., Awatramani, R.B. & McKay, R.D. The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol. 5, e325 (2007).
    • (2007) PLoS Biol , vol.5
    • Kittappa, R.1    Chang, W.W.2    Awatramani, R.B.3    McKay, R.D.4
  • 44
    • 2442637536 scopus 로고    scopus 로고
    • The role of N-glycosylation in function and surface traffcking of the human dopamine transporter
    • Li, L.B. et al. The role of N-glycosylation in function and surface traffcking of the human dopamine transporter. J. Biol. Chem. 279, 21012-21020 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 21012-21020
    • Li, L.B.1
  • 45
    • 0037462827 scopus 로고    scopus 로고
    • Oligomerization and traffcking of the human dopamine transporter. Mutational analysis identifes critical domains important for the functional expression of the transporter
    • Torres, G.E. et al. Oligomerization and traffcking of the human dopamine transporter. Mutational analysis identifes critical domains important for the functional expression of the transporter. J. Biol. Chem. 278, 2731-2739 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 2731-2739
    • Torres, G.E.1
  • 46
    • 0032977408 scopus 로고    scopus 로고
    • Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter
    • Bezard, E. et al. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter. Exp. Neurol. 155, 268-273 (1999).
    • (1999) Exp. Neurol , vol.155 , pp. 268-273
    • Bezard, E.1
  • 47
    • 0027454020 scopus 로고
    • Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium
    • Pif, C., Giros, B. & Caron, M.G. Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. J. Neurosci. 13, 4246-4253 (1993).
    • (1993) J. Neurosci. , vol.13 , pp. 4246-4253
    • Pif, C.1    Giros, B.2    Caron, M.G.3
  • 48
    • 70349906874 scopus 로고    scopus 로고
    • Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifes tectal fate without induction of a secondary midbrain-hindbrain boundary organizer
    • Agoston, Z. & Schulte, D. Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifes tectal fate without induction of a secondary midbrain-hindbrain boundary organizer. Development 136, 3311-3322 (2009).
    • (2009) Development , vol.136 , pp. 3311-3322
    • Agoston, Z.1    Schulte, D.2
  • 49
    • 72449191782 scopus 로고    scopus 로고
    • Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons
    • Kadkhodaei, B. et al. Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J. Neurosci. 29, 15923-15932 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 15923-15932
    • Kadkhodaei, B.1
  • 50
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21, 70-71 (1999).
    • (1999) Nat. Genet , vol.21 , pp. 70-71
    • Soriano, P.1


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