Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage

Stem Cells

Volumn 30, Issue 11, 2012, Pages 2400-2411

  Denham, Mark ^a   Bye, Chris ^b   Leung, Jessie ^a   Conley, Brock J ^a   Thompson, Lachlan H ^b   Dottori, Mirella ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

Floor plate; FOXA2; GLI; Human embryonic stem cells; Sonic hedgehog

Indexed keywords

ACTIVIN; GLYCOGEN SYNTHASE KINASE 3BETA; HEPATOCYTE NUCLEAR FACTOR 3BETA; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX2;

ARTICLE; CELL FATE; CELL LINEAGE; CELL SELECTION; DOPAMINERGIC NERVE CELL; EMBRYONIC STEM CELL; ENZYME INHIBITION; FLOOR PLATE CELL LINEAGE; HUMAN; HUMAN CELL; MESENCEPHALON; NERVE CELL INHIBITION; NERVOUS SYSTEM DEVELOPMENT; NEURAL TUBE; NEUROEPITHELIUM; PROTEIN EXPRESSION; UPREGULATION;

ACTIVINS; ANTIGENS, DIFFERENTIATION; BENZAMIDES; BODY PATTERNING; CELL LINEAGE; CELLS, CULTURED; CYCLOHEXYLAMINES; DIOXOLES; DOPAMINERGIC NEURONS; EMBRYONIC STEM CELLS; EYE PROTEINS; GLYCOGEN SYNTHASE KINASE 3; HEDGEHOG PROTEINS; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HOMEODOMAIN PROTEINS; HUMANS; NEURAL TUBE; NEUROEPITHELIAL CELLS; NEUROGENESIS; NODAL PROTEIN; NUCLEAR PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PYRIDINES; PYRIMIDINES; RECEPTORS, G-PROTEIN-COUPLED; REPRESSOR PROTEINS; SOXB1 TRANSCRIPTION FACTORS; THIOPHENES; TRANSCRIPTION FACTORS;

EID: 84867911591     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1204     Document Type: Article

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