Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons

Development

Volumn 130, Issue 11, 2003, Pages 2535-2542

  van den Munckhof, Pepijn ^a   Luk, Kelvin C ^b   Ste Marie, Line ^c   Montgomery, Jane ^c   Blanchet, Pierre J ^d   Sadikot, Abbas F ^b   Drouin, Jacques ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Dopamine; Homeobox; Midbrain; Pitx3 (Ptx3); Transcription factor

Indexed keywords

DOPAMINE; HOMEODOMAIN PROTEIN; PROTEIN PITX3; UNCLASSIFIED DRUG;

AKINESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APHAKIA; APOPTOSIS; BEHAVIOR; BRAIN DEVELOPMENT; CELL LOSS; CELL SUBPOPULATION; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; HYPOKINESIA; LOCOMOTION; MALE; MESENCEPHALON; MOTOR ACTIVITY; MOTOR DYSFUNCTION; MOUSE; MOUSE MUTANT; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; REVIEW; STRIATE CORTEX; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM;

ANIMALIA;

EID: 0038614833     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.00464     Document Type: Review

References (38)

1. Amendt, B. A., Sutherland, L. B., Semina, E. V. and Russo, A. F. (1998). The molecular basis of Rieger syndrome. analysis of Pitx2 homeodomain protein activities. J. Biol. Chem. 273, 20066-20072.
2. Bayer, S. A., Wills, K. V., Triarhou, L. C., Verina, T., Thomas, J. D. and Ghetti, B. (1995). Selective vulnerability of late-generated dopaminergic neurons of the substantia nigra in weaver mutant mice. Proc. Natl. Acad. Sci. USA 92, 9137-9140.
3. Björklund, A. and Lindvall, O., eds (1984). Dopamine containing systems in the CNS. In Handbook of Chemical Neuroanatomy, pp. 55-122. Amsterdam: Elsevier.
4. Chen, H., Lun, Y., Ovchinnikov, D., Kokubo, H., Oberg, K. C., Pepicelli, C. V., Gan, L., Lee, B. and Johnson, R. L. (1998). Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat. Genet. 19, 51-55.
5. Dawson, T., Mandir, A. and Lee, M. (2002). Animal models. of PD: pieces of the same puzzle? Neuron 35, 219-222.
6. Egan, M. F. and Weinberger, D. R. (1997). Neurobiology of schizophrenia. Curr. Opin. Neurobiol. 7, 701-707.
7. Fearnley, J. M. and Lees, A. J. (1991). Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 114, 2283-2301.
8. Franklin, K. B. J. and Paxinos, G. (1997). The Mouse Brain in Stereotaxic Coordinates. New York: Academic Press.
9. Hynes, M. and Rosenthal, A. (1999). Specification of dopaminergic and serotonergic neurons in the vertebrate CNS. Curr. Neurol. 9, 26-36.
10. Jackson-Lewis, V., Vila, M., Djaldetti, R., Guegan, C., Liberatore, G., Liu, J., O'Malley, K. L., Burke, R. E. and Przedborski, S. (2000). Developmental cell death in dopaminergic neurons of the substantia nigra of mice. J. Comp Neurol. 424, 476-488.
11. Jellinger, K. A. (2001). The pathology of Parkinson's disease. In Parkinson's Disease: Advances in Neurology. Vol. 86 (ed. D. Calne and S. Calne), pp. 55-72. Philadelphia, PA: Lippincott, Williams and Wilkins..
12. King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., Turek, F. W. and Takahashi, J. S. (1997). Positional cloning of the mouse circadian clock gene. Cell 89, 641-653.
13. Kish, S. J., Shannak, K. and Hornykiewicz, O. (1988). Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications. New Engl. J. Med. 318, 876-880.
14. Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y. and Shimizu, N. (1998). Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605-608.
15. Lebel, M., Gauthier, Y., Moreau, A. and Drouin, J. (2001). Pitx3 activates mouse tyrosine hydroxylase promoter via a high affinity binding site. J. Neurochem. 76, 1-11.
16. Montgomery, E. B., Jr, Baker, K. B., Lyons, K. and Koller, W. C. (1999). Abnormal performance on the PD test battery by asymptomatic first-degree relatives. Neurology 52, 757-762.
17. Piccini, P., Burn, D. J., Ceravolo, R., Maraganore, D. and Brooks, D. J. (1999). The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twins. Ann. Neurol. 45, 577-582.
18. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R. et al. (1997). Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047.
19. Rieger, D. K., Reichenberger, E., McLean, W., Sidow, A. and Olsen, B. R. (2001 ). A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice. Genomics 72, 61-72.
20. Saucedo-Cardenas, O., Quintana-Hau, J. D., Le, W. D., Smidt, M. P., Cox, J. J., DeMayo, F., Burbach, J. P. H. and Conneely, O. M. (1998). Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA 95, 4013-4018.
21. Semina, E. V., Reiter, R. S. and Murray, J. (1997). Isolation of a new homeobox gene belonging to the Pitx/Rieg family: expression during lens development and mapping to the aphakia region on mouse chromosome 19. Hum. Mol. Genet. 6, 2109-2116.
22. Semina, E. V., Ferrell, R. E., Mintz-Hittner, H. A., Bitoun, P., Alward, W. L. M., Reiter, R. S., Funkhauser, C., Daack-Hirsch, S. and Murray, J. C. (1998). A novel homeobox gene PITX3 is mutated in families with amosomal-dominant cataracts and ASMD. Nat. Genet. 19, 167-170.
23. Semina, E. V., Murray, J. C., Reiter, R. and Hrstka, R. F. G. J. (2000). Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice. Hum. Mol. Genet. 9, 1575-1585.
24. Smidt, M., van, Schaick, H. S. A., Lanctôt, C., Tremblay, J. J., Cox, J. J., van, der, Kleij, A. A. M., Wolterink, G., Drouin, J. and Burbach, P. H. (1997). A homeodomain gene PTX3 has highly restricted brain expression in mesencephalic dopaminergic neurons. Proc. Natl. Acad. Sci. USA 94, 13305-13310.
25. Smidt, M. P., Asbreuk, C. H., Cox, J. J., Chen, H. and Johnson, R. L. (2000). A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nat. Neurosci. 3, 337-341.
26. Ste-Marie, L., Vachon, L., Bemeur, C., Lambert, J. and Montgomery, J. (1999). Local striatal infusion of MPP+ does not result in increased hydroxylation after systemic administration of 4-hydroxybenzoate. Free Radic. Biol. Med. 27, 997-1007.
27. Sveinbjornsdottir, S., Hicks, A. A., Jonsson, T., Petursson, H., Gugmundsson, G., Frigge, M. L., Kong, A., Gulcher, J. R. and Stefansson, K. (2000). Familial aggregation of Parkinson's disease in Iceland. New Engl. J. Med. 343, 1765-1770.
28. Swanson, D. J., Zellmer, E. and Lewis, E. J. (1998). AP1 proteins mediate the cAMP response of the dopamine beta-hydroxylase gene. J. Biol. Chem. 273, 24065-24074.
29. Tanner, C. M., Ottman, R., Goldman, S. M., Ellenberg, J., Chan, P., Mayeux, R. and Langston, J. W. (1999). Parkinson disease in twins: an etiologic study. J. Am. Med. Assoc. 281, 341-346.
30. Tvrdik, P., Asadi, A., Kozak, L. P., Nedergaard, J., Cannon, B. and Jacobsson, A. (1997). Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue. J. Biol. Chem. 272, 31738-31746.
31. Varnum, D. S. and Stevens, L. C. (1968). Aphakia, a new mutation in the Mouse. J. Hered. 59, 147-150.
32. West, M. J. (1993). New stereological methods for counting neurons. Neurobiol. Aging 14, 275-285.
33. West, M. J. and Gundersen, H. J. (1990). Unbiased stereological estimation of the number of neurons in the human hippocampus. J. Comp Neurol. 296, 1-22.
34. Witta, J., Baffi, J. S., Palkovits, M., Mezey, E., Castillo, S. O. and Nikodem, V. M. (2000). Nigrostriatal innervation is preserved in Nurr1-null mice, although dopaminergic neuron precursors are arrested from terminal differentiation. Mol. Brain Res. 84, 67-78.
35. Ye, W., Shimamura, K., Rubenstein, J. L., Hynes, M. A. and Rosenthal, A. (1998). FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93, 755-766.
36. Zetterstrom, R. H., Williams, R., Perlmann, T. and Olson, L. (1996). Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system. Mol Brain Res 41, 111-120.
37. Zetterstrom, R. H., Solomin, L., Jansson, L., Hoffer, B. J., Olson, L. and Perlmann, T. (1997). Dopamine neuron agenesis in Nurr1-deficient mice. Science 276, 248-250.
38. Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A. and Lee, C. C. (2001). Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105, 683-694.