Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect

Developmental Dynamics

Volumn 239, Issue 1, 2010, Pages 246-260

  Stuebner, Sebastian ^a   Faus Kessler, Theresa ^a   Fischer, Thomas ^a   Wurst, Wolfgang ^a,b   Prakash, Nilima ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Dopaminergic neurons; Fzd3; Fzd6; Midbrain; Mouse; Schizophrenia; Wnt1

Indexed keywords

BETA CATENIN; FRIZZLED PROTEIN; FRIZZLED PROTEIN FZD3; FRIZZLED PROTEIN FZD6; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN NERVE CELL; BRAIN REGION; BRAIN VENTRICLE DILATATION; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DOPAMINERGIC NERVE CELL; EMBRYO; EMBRYO DEVELOPMENT; KNOCKOUT MOUSE; MESENCEPHALON; MORPHOGENESIS; MOUSE; MOUSE MUTANT; NEURAL TUBE; NEUROEPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; RHOMBENCEPHALON;

ANALYSIS OF VARIANCE; ANIMALS; BROMODEOXYURIDINE; FRIZZLED RECEPTORS; GENE DOSAGE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MESENCEPHALON; MICE; MICE, KNOCKOUT; MORPHOGENESIS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 73949161033     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22127     Document Type: Article

References (52)

1. Andersson E, Tryggvason U, Deng Q, Friling S, Alekseenko Z, Robert B, Perlmann T, Ericson J. 2006. Identification of intrinsic determinants of midbrain dopamine neurons. Cell 124:393-405.
2. Andersson ER, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L, Yamaguchi TP, Hall AC, Wurst W, Arenas E. 2008. Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS ONE 3:e3517.
3. Ang S-L. 2006. Transcriptional control of midbrain dopaminergic neuron development. Development 133:3499- 3506.
4. Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, McMahon AP, Sommer L, Boussadia O, Kemler R. 2001. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128:1253-1264.
5. Brodski C, Weisenhorn DM, Signore M, Sillaber I, Oesterheld M, Broccoli V, Acampora D, Simeone A, Wurst W. 2003. Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer. J Neurosci 23:4199-4207.
6. Castelo-Branco G, Andersson ER, Minina E, Sousa KM, Ribeiro D, Kokubu C, Imai K, Prakash N, Wurst W, Arenas E. 2009. Delayed dopaminergic neuron differentiation in Lrp6 mutant mice. Dev Dyn 239:211-221.
7. Chizhikov VV, Millen KJ. 2004a. Control of roof plate development and signaling by Lmx1b in the caudal vertebrate CNS. J Neurosci 24:5694-5703.
8. Chizhikov VV, Millen KJ. 2004b. Control of roof plate formation by Lmx1a in the developing spinal cord. Development 131:2693-2705.
9. Copp AJ, Greene NDE, Murdoch JN. 2003. Dishevelled: linking convergent extension with neural tube closure. Trends Neurosci 26:453-455.
10. De Ferrari GV, Moon RT. 2006. The ups and downs of Wnt signaling in prevalent neurological disorders. Oncogene 25:7545-7553.
11. Deardorff MA, Tan C, Saint-Jeannet JP, Klein PS. 2001. A role for frizzled 3 in neural crest development. Development 128:3655-3663.
12. Fedtsova NG, Turner EE. 1995. Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors. Mech Dev 53:291-304.
13. Fischer T, Guimera J, Wurst W, Prakash N. 2007. Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain. Neuroscience 147:693-711.
14. Gates MA, Torres EM, White A, Fricker-Gates RA, Dunnett SB. 2006. Re-examining the ontogeny of substantia nigra dopamine neurons. Eur J Neurosci 23:1384-1390.
15. Golan T, Yaniv A, Bafico A, Liu G, Gazit A. 2004. The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt/β-catenin signaling cascade. J Biol Chem 279:14879-14888.
16. Guo N, Hawkins C, Nathans J. 2004. Frizzled6 controls hair patterning in mice. Proc Natl Acad Sci USA 101: 9277-9281.
17. Holm S. 1979. A simple sequentially rejective multiple test procedure. Scand. J Statistics 6:65-70.
18. Huang H, He X. 2008. Wnt/beta-catenin signaling: new (and old) players and new insights. Curr Opin Cell Biol 20:119-125.
19. Huang HC, Klein PS. 2004. The Frizzled family: receptors for multiple signal transduction pathways. Genome Biol 5: 234.231-234.237.
20. Ille F, Sommer L. 2005. Wnt signaling: multiple functions in neural development. Cell Mol Life Sci 62:1-9.
21. Joksimovic M, Yun BA, Kittappa R, Anderegg AM, Chang WW, Taketo MM, McKay RD, Awatramani RB. 2009. Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis Nat Neurosci 12:125-131.
22. Kele J, Simplicio N, Ferri ALM, Mira H, Guillemot F, Arenas E, Ang S-L. 2006. Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons. Development 133:495-505.
23. Kittappa R, Chang WW, Awatramani RB, McKay RDG. 2007. The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol 5:e325.
24. Logan CY, Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20: 781-810.
25. Lyuksyutova AI, Lu CC, Milanesio N, King LA, Guo N, Wang Y, Nathans J, Tessier-Lavigne M, Zou Y. 2003. Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling. Science 302:1984-1988.
26. Martinez S. 2001. The isthmic organizer and brain regionalization. Int J Dev Biol 45:367-371.
27. McMahon AP, Bradley A. 1990. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62:1073-1085.
28. Megason SG, McMahon AP. 2002. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 129:2087-2098.
29. Millonig JH, Millen KJ, Hatten ME. 2000. The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS. Nature 403: 764-769.
30. Nakatani T, Minaki Y, Kumai M, Ono Y. 2007. Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon. Development 134:2783-2793.
31. Niederreither K, Fraulob V, Garnier J-M, Chambon P, Dolle P. 2002. Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse. Mech Dev 110:165-171.
32. Ono Y, Nakatani T, Sakamoto Y, Mizuhara E, Minaki Y, Kumai M, Hamaguchi A, Nishimura M, Inoue Y, Hayashi H, Takahashi J, Imai T. 2007. Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells. Development 134:3213-3225.
33. Perlmann T, Wallen-Mackenzie A. 2004. Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells. Cell Tissue Res 318:45-52.
34. Pinheiro J, Bates D, DebRoy S, Sarkar D, R Core team. 2008. nlme: Linear and Nonlinear Mixed Effects Models. R package version 3.1-89.
35. Prakash N, Brodski C, Naserke T, Puelles E, Gogoi R, Hall A, Panhuysen M, Echevarria D, Sussel L, Weisenhorn DMV, Martinez S, Arenas E, Simeone A, Wurst W. 2006. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development 133: 89-98.
36. Prakash N, Puelles E, Freude K, Trumbach D, Omodei D, Di Salvio M, Sussel L, Ericson J, Sander M, Simeone A, Wurst W. 2009. Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development 136:2545-2555.
37. Puelles E, Acampora D, Lacroix E, Signore M, Annino A, Tuorto F, Filosa S, Corte G, Wurst W, Ang SL, Simeone A. 2003. Otx dose-dependent integrated control of antero-posterior and dorsoventral patterning of midbrain. Nat Neurosci 6:453-460.
38. R Development Core Team 2008. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.
39. Seifert JR, Mlodzik M. 2007. Frizzled/ PCP signalling: a conserved mechanism regulating cell polarity and directed motility. Nat Rev Genet 8:126-138.
40. Smidt MP, Asbreuk CH, Cox JJ, Chen H, Johnson RL, Burbach JP. 2000. A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nat Neurosci 3:337-341.
41. Smidt MP, Smits SM, Burbach JPH. 2004. Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigra. Cell Tissue Res 318:35-43.
42. Tang M, Miyamoto Y, Huang EJ. 2009. Multiple roles of β-catenin in controlling the neurogenic niche for midbrain dopamine neurons. Development 136: 2027-2038.
43. Thomas KR, Capecchi MR. 1990. Targeted disruption of the murine int-1 protooncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346:847-850.
44. van Amerongen R, Mikels A, Nusse R. 2008. Alternative wnt signaling is initiated by distinct receptors. Sci Signal 1: re9.
45. Wallen A, Zetterstrom RH, Solomin L, Arvidsson M, Olson L, Perlmann T. 1999. Fate of mesencephalic AHD2-expressing dopamine progenitor cells in Nurr1 mutant mice. Exp Cell Res 253: 737-746.
46. Wallingford JB. 2005. Neural tube closure and neural tube defects: Studies in animal models reveal known knowns and known unknowns. Am J Med Genet C Semin Med Genet 135C:59-68.
47. Wang Y, Thekdi N, Smallwood PM, Macke JP, Nathans J. 2002. Frizzled-3 is required for the development of major fiber tracts in the rostral CNS. J Neurosci 22:8563-8573.
48. Wang Y, Guo N, Nathans J. 2006a. The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J Neurosci 26:2147-2156.
49. Wang Y, Zhang J, Mori S, Nathans J. 2006b. Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neuro filament staining, and geneti-cally directed cell labeling. J Neurosci 26: 355-364.
50. Wilkinson DG, Bailes JA, McMahon AP. 1987. Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell 50:79-88.
51. Wurst W, Bally-Cuif L. 2001. Neural plate patterning: upstream and downstream of the isthmic organizer. Nat Rev Neurosci 2:99-108.
52. Zervas M, Millet S, Ahn S, Joyner AL. 2004. Cell behaviors and genetic lineages of the mesencephalon and rhombomere 1. Neuron 43:345-357.