Early anterior/posterior patterning of the midbrain and cerebellum

Annual Review of Neuroscience

Volumn 24, Issue , 2001, Pages 869-896

  Liu, A ^a   Joyner, A L ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Engrailed; Fibroblast growth factor; Gbx2; Midbrain hindbrain organizer; Otx2

Indexed keywords

FIBROBLAST GROWTH FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GBX2; TRANSCRIPTION FACTOR OTX2; UNCLASSIFIED DRUG;

BRAIN REGION; CEREBELLUM; CHICKEN; EMBRYO PATTERN FORMATION; EMBRYO TRANSFER; EMBRYONIC STRUCTURES; FEEDBACK SYSTEM; GENE EXPRESSION; MESENCEPHALON; MOLECULAR GENETICS; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; BODY PATTERNING; CEREBELLUM; CHICK EMBRYO; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MESENCEPHALON; VERTEBRATES;

EID: 0034925298     PISSN: 0147006X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.neuro.24.1.869     Document Type: Review

References (130)

1. Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
2. Genetic control of brain morphogenesis through Otx gene dosage requirement
3. Forebrain and midbrain regions are deleted in Otx2-/-mutants due to a defective anterior neuroectoderm specification during gastrulation
4. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis
5. The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer
6. Fate and potentialities of the avian mesencephalic/metencephalic neuroepithelium
7. A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
8. Engrailed defines the position of dorsal di-mesencephalic boundary by repressing diencephalic fate
9. Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development
10. Fgfr2 is required for limb out-growth and lung-branching morphogenesis
11. Involvement of Wnt-1 in the formation of the mes/metencephalic boundary
12. The FGF family of growth factors and oncogenes
13. Axis development and early asymmetry in mammals
14. Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands
15. Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development
16. Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells
17. Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain
18. The caudal limit of Otx2 expression positions the isthmic organizer
19. Graded interference with FGF signalling reveals its dorsoventral asymmetry at the mid-hindbrain boundary
20. Expression of sprouty2 during early development of the chick embryo is coincident with known sites of FGF signalling
21. Differential display of genes expressed at the midbrain-hindbrain junction identifies sprouty2: An FGF8-inducible member of a family of intracellular FGF antagonists
22. Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome
23. Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: A role for FGFR1 in morphogenetic movement through the primitive streak
24. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
25. Of worms and men: An evolutionary perspective on the fibroblast growth factor (FGF) and FGF receptor families
26. The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo
27. Midbrain development induced by FGF8 in the chick embryo
28. Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development
29. Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development
30. Murine FGFR-1 is required for early postimplantation growth and axial organization
31. Fibroblast growth factor receptor 3 is a negative regulator of bone growth
32. Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system
33. The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renalcoloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney
34. Requirement of FGF-4 for postimplantation mouse development
35. Retroviral misexpression of engrailed genes in the chick optic tectum perturbs the topographic targeting of retinal axons
36. Role of Pax-5 in the regulation of a mid-hindbrain organizer's activity
37. Patterning signals acting in the spinal cord override the organizing activity of the isthmus
38. Pax in development
39. A series of normal stages in the development of the chick embryo
40. Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2
41. Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development
42. FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
43. Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system
44. Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon
45. The molecular genetic basis of positional information in insect segments
46. Regeneration of isthmic tissue is the result of a specific and direct interaction between rhombomere 1 and mid-brain
47. Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression
48. Establishment of rostrocaudal polarity in tectal primordium: Engrailed expression and subsequent tectal polarity
49. A role for gradient en expression in positional specification on the optic tectum
50. Active repression of transcription by the engrailed homeodomain protein
51. Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox
52. Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer
53. En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: Expression during embryogenesis
54. Interaction between Otx2 and Gbx2 defines the organizing center for the optic tectum
55. Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus
56. Zebrafish pax[b] is involved in the formation of the midbrain-hindbrain boundary
57. Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain
58. EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region
59. FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate
60. Two enhancer regions in the mouse En-2 locus direct expression to the mid/hindbrain region and mandibular myoblasts
61. Rostral optic tectum acquires caudal characteristics following ectopic engrailed expression
62. A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary
63. FGF-8 isoforms differ in NIH3T3 cell transforming potential
64. FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development
65. Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
66. FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression
67. Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en
68. Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo
69. Early deletion of neuromeres in Wnt-1-/- mutant mice: Evaluation by morphological and molecular markers
70. Mouse Otx2 functions in the formation and patterning of rostral head
71. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
72. The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1-mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum
73. Cell determination boundaries as organizing regions for secondary embryonic fields
74. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
75. A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum
76. Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants
77. The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: A study using in situ hybridisation and chick/quail homotopic grafts
78. A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
79. Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
80. Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed
81. Reorganizing the organizer 75 years on
82. Wnt genes
83. Roles of Pax-2 in initiation of the chick tectal development
84. Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)
85. The genetic basis of patterned baldness in Drosophila
86. Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis
87. Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse
88. Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary
89. Characterization of three novel members of the zebrafish Pax2/5/8 family: Dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function
90. Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection
91. Structural basis for FGF receptor dimerization and activation
92. Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis
93. Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification
94. The midbrain-hindbrain boundary genetic cascade is activated ectopically in the diencephalon in response to the widespread expression of one of its components, the medaka gene Ol-eng2
95. Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1
96. Pax2/5 and Pax6 subdivide the early neural tube into three domains
97. Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: Evidence from targeted mutations
98. Fgf10 is essential for limb and lung formation
99. Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation of the midbrain
100. Inductive interactions direct early regionalization of the mouse forebrain
101. Nested expression domains of four homeobox genes in developing rostral brain
102. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
103. The role of fibroblast growth factors in early Xenopus development
104. A conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2- and msh-class homeoproteins, mediates active transcriptional repression in vivo
105. Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene
106. Two Pax2/5/8-binding sites in Engrailed-2 are required for proper initiation of endogenous mid-hindbrain expression
107. FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse
108. Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain
109. Functional equivalency between Otx2 and Otx1 in development of the rostral head
110. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
111. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells
112. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
113. Swaying is a mutant allele of the proto-oncogene Wnt-1
114. Pax2 contributes to inner ear patterning and optic nerve trajectory
115. Cooperation of Pax2 and Pax5 in midbrain and cerebellum development
116. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
117. Expression of FGFR1, FGFR2 and FGFR3 during early neural development in the chick embryo
118. Pax-6, a murine paired box gene, is expressed in the developing CNS
119. Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function
120. Early mesencephalon/metencephalon patterning and development of the cerebellum
121. FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung
122. Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo
123. The role of the rhombic lip in avian cerebellum development
124. Multiple developmental defects in Engrailed-1 mutant mice: An early mid-hindbrain deletion and patterning defects in forelimbs and sternum
125. Genomic structure, mapping, activity and expression of fibroblast growth factor 17
126. Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures
127. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
128. Expression of the fibroblast growth factor receptor FGFR-1/flg during gastrulation and segmentation in the mouse embryo
129. fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation
130. The spatial and temporal pattern of C-Lmx1 expression in the neuroectoderm during chick neurulation