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Volumn 1310, Issue 1, 2014, Pages 98-110

Topoisomerase II and leukemia

Author keywords

Acute myeloid leukemia; Acute promyelocytic leukemia; Anticancer drug; Chromosomal translocation; Topoisomerase II poison

Indexed keywords

CURCUMIN; CYTOCHROME P450 3A4; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; EPIGALLOCATECHIN; ETOPOSIDE; GENISTEIN; MITOXANTRONE; TURMERIC;

EID: 84896305694     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12358     Document Type: Article
Times cited : (159)

References (149)
  • 1
    • 34548391416 scopus 로고    scopus 로고
    • DNA topoisomerase II, genotoxicity, and cancer
    • McClendon, A.K. & N. Osheroff. 2007. DNA topoisomerase II, genotoxicity, and cancer. Mutat. Res. 623: 83-97.
    • (2007) Mutat. Res. , vol.623 , pp. 83-97
    • McClendon, A.K.1    Osheroff, N.2
  • 2
    • 63349086953 scopus 로고    scopus 로고
    • The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing
    • Deweese, J.E. & N. Osheroff. 2009. The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Res. 37: 738-748.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 738-748
    • Deweese, J.E.1    Osheroff, N.2
  • 3
    • 64649105115 scopus 로고    scopus 로고
    • DNA topoisomerase II and its growing repertoire of biological functions
    • Nitiss, J.L. 2009. DNA topoisomerase II and its growing repertoire of biological functions. Nat. Rev. Cancer 9: 327-337.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 327-337
    • Nitiss, J.L.1
  • 5
    • 81855198087 scopus 로고    scopus 로고
    • All tangled up: how cells direct, manage and exploit topoisomerase function
    • Vos, S.M., E.M. Tretter, B.H. Schmidt & J.M. Berger. 2011. All tangled up: how cells direct, manage and exploit topoisomerase function. Nat. Rev. Mol. Cell. Biol. 12: 827-841.
    • (2011) Nat. Rev. Mol. Cell. Biol. , vol.12 , pp. 827-841
    • Vos, S.M.1    Tretter, E.M.2    Schmidt, B.H.3    Berger, J.M.4
  • 6
    • 85029829734 scopus 로고    scopus 로고
    • DNA topoisomerases: type II
    • quot; In. W.J. Lennarz and M.D. Lane, Eds.: - Waltham, MA: Academic Press.
    • Gentry, A.C. 2013. "DNA topoisomerases: type II." In The Encyclopedia of Biological Chemistry. W.J. Lennarz and M.D. Lane, Eds.: 163-168. Waltham, MA: Academic Press.
    • (2013) The Encyclopedia of Biological Chemistry , pp. 163-168
    • Gentry, A.C.1
  • 7
    • 64649090292 scopus 로고    scopus 로고
    • Targeting DNA topoisomerase II in cancer chemotherapy
    • Nitiss, J.L. 2009. Targeting DNA topoisomerase II in cancer chemotherapy. Nat. Rev. Cancer 9: 338-350.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 338-350
    • Nitiss, J.L.1
  • 8
    • 84855347756 scopus 로고    scopus 로고
    • Interfacial inhibitors: targeting macromolecular complexes
    • Pommier, Y. & C. Marchand. 2012. Interfacial inhibitors: targeting macromolecular complexes. Nat. Rev. Drug Discov. 11: 25-36.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 25-36
    • Pommier, Y.1    Marchand, C.2
  • 9
    • 84872547120 scopus 로고    scopus 로고
    • Drugging topoisomerases: lessons and challenges
    • Pommier, Y. 2013. Drugging topoisomerases: lessons and challenges. ACS Chem. Biol. 8: 82-95.
    • (2013) ACS Chem. Biol. , vol.8 , pp. 82-95
    • Pommier, Y.1
  • 10
    • 33747892853 scopus 로고    scopus 로고
    • Topoisomerase II and the etiology of chromosomal translocations
    • Felix, C.A., C.P. Kolaris & N. Osheroff. 2006. Topoisomerase II and the etiology of chromosomal translocations. DNA Repair (Amst.) 5: 1093-1108.
    • (2006) DNA Repair (Amst.) , vol.5 , pp. 1093-1108
    • Felix, C.A.1    Kolaris, C.P.2    Osheroff, N.3
  • 11
    • 76049113976 scopus 로고    scopus 로고
    • Molecular biology of therapy-related leukaemias
    • Joannides, M. & D. Grimwade. 2010. Molecular biology of therapy-related leukaemias. Clin. Transl. Oncol. 12: 8-14.
    • (2010) Clin. Transl. Oncol. , vol.12 , pp. 8-14
    • Joannides, M.1    Grimwade, D.2
  • 13
    • 84863228471 scopus 로고    scopus 로고
    • Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents
    • Cowell, I.G. & A.C. Austin. 2012. Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents. Int. J. Environ. Res. Public. Health. 9: 2075-2091.
    • (2012) Int. J. Environ. Res. Public. Health. , vol.9 , pp. 2075-2091
    • Cowell, I.G.1    Austin, A.C.2
  • 14
    • 84863867276 scopus 로고    scopus 로고
    • Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor
    • Ezoe, S. 2012. Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor. Int. J. Environ. Res. Public Health 9: 2444-2453.
    • (2012) Int. J. Environ. Res. Public Health , vol.9 , pp. 2444-2453
    • Ezoe, S.1
  • 15
    • 84878815434 scopus 로고    scopus 로고
    • Therapy-related acute promyelocytic leukemia: a systematic review
    • Rashidi, A. & I.S. Fisher. 2013. Therapy-related acute promyelocytic leukemia: a systematic review. Med. Oncol. 30: 625.
    • (2013) Med. Oncol. , vol.30 , pp. 625
    • Rashidi, A.1    Fisher, I.S.2
  • 16
    • 0032032797 scopus 로고    scopus 로고
    • Eukaryotic DNA topoisomerase IIβ
    • Austin, C.A. & L.K. Marsh. 1998. Eukaryotic DNA topoisomerase IIβ. Bioessays 20: 215-226.
    • (1998) Bioessays , vol.20 , pp. 215-226
    • Austin, C.A.1    Marsh, L.K.2
  • 17
    • 57649134962 scopus 로고    scopus 로고
    • Bimodal recognition of DNA geometry by human topoisomerase IIα: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain
    • McClendon, A.K., A.C. Gentry, J.S. Dickey, et al. 2008. Bimodal recognition of DNA geometry by human topoisomerase IIα: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain. Biochemistry 47: 13169-13178.
    • (2008) Biochemistry , vol.47 , pp. 13169-13178
    • McClendon, A.K.1    Gentry, A.C.2    Dickey, J.S.3
  • 18
    • 28244433817 scopus 로고    scopus 로고
    • Human topoisomerase IIα rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks
    • McClendon, A.K., A.C. Rodriguez & N. Osheroff. 2005. Human topoisomerase IIα rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks. J. Biol. Chem. 280: 39337-39345.
    • (2005) J. Biol. Chem. , vol.280 , pp. 39337-39345
    • McClendon, A.K.1    Rodriguez, A.C.2    Osheroff, N.3
  • 19
    • 0026147704 scopus 로고
    • Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells
    • Woessner, R.D., M.R. Mattern, C.K. Mirabelli, et al. 1991. Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells. Cell Growth Differ. 2: 209-214.
    • (1991) Cell Growth Differ. , vol.2 , pp. 209-214
    • Woessner, R.D.1    Mattern, M.R.2    Mirabelli, C.K.3
  • 20
    • 18444387711 scopus 로고    scopus 로고
    • Dynamics of human DNA topoisomerases IIα and IIβ in living cells
    • Christensen, M.O., M.K. Larsen, H.U. Barthelmes, et al. 2002. Dynamics of human DNA topoisomerases IIα and IIβ in living cells. J. Cell Biol. 157: 31-44.
    • (2002) J. Cell Biol. , vol.157 , pp. 31-44
    • Christensen, M.O.1    Larsen, M.K.2    Barthelmes, H.U.3
  • 21
    • 0034614266 scopus 로고    scopus 로고
    • DNA topoisomerase IIβ and neural development
    • Yang, X., W. Li, E.D. Prescott, et al. 2000. DNA topoisomerase IIβ and neural development. Science 287: 131-134.
    • (2000) Science , vol.287 , pp. 131-134
    • Yang, X.1    Li, W.2    Prescott, E.D.3
  • 22
    • 78650182756 scopus 로고    scopus 로고
    • The function of DNA topoisomerase IIβ in neuronal development
    • Heng, X. & W.D. Le. 2010. The function of DNA topoisomerase IIβ in neuronal development. Neurosci. Bull. 26: 411-416.
    • (2010) Neurosci. Bull. , vol.26 , pp. 411-416
    • Heng, X.1    Le, W.D.2
  • 23
    • 33745255099 scopus 로고    scopus 로고
    • A topoisomerase IIβ-mediated dsDNA break required for regulated transcription
    • Ju, B.G., V.V. Lunyak, V. Perissi, et al. 2006. A topoisomerase IIβ-mediated dsDNA break required for regulated transcription. Science 312: 1798-1802.
    • (2006) Science , vol.312 , pp. 1798-1802
    • Ju, B.G.1    Lunyak, V.V.2    Perissi, V.3
  • 24
    • 84861850399 scopus 로고    scopus 로고
    • Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity
    • Cowell, I.G., Z. Sondka, K. Smith, et al. 2012. Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity. Proc. Natl. Acad. Sci. USA 109: 8989-8994.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 8989-8994
    • Cowell, I.G.1    Sondka, Z.2    Smith, K.3
  • 25
    • 50649101663 scopus 로고    scopus 로고
    • DNA topoisomerases: harnessing and constraining energy to govern chromosome topology
    • Schoeffler, A.J. & J.M. Berger. 2008. DNA topoisomerases: harnessing and constraining energy to govern chromosome topology. Q. Rev. Biophys. 41: 41-101.
    • (2008) Q. Rev. Biophys. , vol.41 , pp. 41-101
    • Schoeffler, A.J.1    Berger, J.M.2
  • 26
    • 77953229439 scopus 로고    scopus 로고
    • A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases
    • Schmidt, B.H., A.B. Burgin, J.E. Deweese, et al. 2010. A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature 465: 641-644.
    • (2010) Nature , vol.465 , pp. 641-644
    • Schmidt, B.H.1    Burgin, A.B.2    Deweese, J.E.3
  • 27
    • 77954679766 scopus 로고    scopus 로고
    • The use of divalent metal ions by type II topoisomerases
    • Deweese, J.E. & N. Osheroff. 2010. The use of divalent metal ions by type II topoisomerases. Metallomics 2: 450-459.
    • (2010) Metallomics , vol.2 , pp. 450-459
    • Deweese, J.E.1    Osheroff, N.2
  • 28
    • 84869094439 scopus 로고    scopus 로고
    • Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity
    • Schmidt, B.H., N. Osheroff & J.M. Berger. 2012. Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat. Struct. Mol. Biol. 19: 1147-1154.
    • (2012) Nat. Struct. Mol. Biol. , vol.19 , pp. 1147-1154
    • Schmidt, B.H.1    Osheroff, N.2    Berger, J.M.3
  • 29
    • 80055065448 scopus 로고    scopus 로고
    • The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks
    • Bates, A.D., J.M. Berger & A. Maxwell. 2011. The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks. Nucleic Acids Res. 39: 6327-6339.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 6327-6339
    • Bates, A.D.1    Berger, J.M.2    Maxwell, A.3
  • 30
    • 84863168027 scopus 로고    scopus 로고
    • DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA
    • Lee, S., S.R. Jung, K. Heo, et al. 2012. DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA. Proc. Natl. Acad. Sci. U.S.A. 109: 2925-2930.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 2925-2930
    • Lee, S.1    Jung, S.R.2    Heo, K.3
  • 31
    • 0021099691 scopus 로고
    • Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster
    • Sander, M. & T. Hsieh. 1983. Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster. J. Biol. Chem. 258: 8421-8428.
    • (1983) J. Biol. Chem. , vol.258 , pp. 8421-8428
    • Sander, M.1    Hsieh, T.2
  • 32
    • 0021112878 scopus 로고
    • Cleavage of DNA by mammalian DNA topoisomerase II
    • Liu, L.F., T.C. Rowe, L. Yang, et al. 1983. Cleavage of DNA by mammalian DNA topoisomerase II. J. Biol. Chem. 258: 15365-15370.
    • (1983) J. Biol. Chem. , vol.258 , pp. 15365-15370
    • Liu, L.F.1    Rowe, T.C.2    Yang, L.3
  • 33
    • 0024339376 scopus 로고
    • Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate
    • Zechiedrich, E.L., K. Christiansen, A.H. Andersen, et al. 1989. Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate. Biochemistry 28: 6229-6236.
    • (1989) Biochemistry , vol.28 , pp. 6229-6236
    • Zechiedrich, E.L.1    Christiansen, K.2    Andersen, A.H.3
  • 34
    • 22144486601 scopus 로고    scopus 로고
    • Interfacial inhibitors of protein-nucleic acid interactions
    • Pommier, Y. & C. Marchand. 2005. Interfacial inhibitors of protein-nucleic acid interactions. Curr. Med. Chem. Anti-Cancer Agents 5: 421-429.
    • (2005) Curr. Med. Chem. Anti-Cancer Agents , vol.5 , pp. 421-429
    • Pommier, Y.1    Marchand, C.2
  • 36
    • 67650682519 scopus 로고    scopus 로고
    • DNA topoisomerase I inhibitors: chemistry, biology, and interfacial inhibition
    • Pommier, Y. 2009. DNA topoisomerase I inhibitors: chemistry, biology, and interfacial inhibition. Chem. Rev. 109: 2894-2902.
    • (2009) Chem. Rev. , vol.109 , pp. 2894-2902
    • Pommier, Y.1
  • 37
    • 77954187741 scopus 로고    scopus 로고
    • DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
    • Pommier, Y., E. Leo, H. Zhang & C. Marchand. 2010. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem. Biol. 17: 421-433.
    • (2010) Chem. Biol. , vol.17 , pp. 421-433
    • Pommier, Y.1    Leo, E.2    Zhang, H.3    Marchand, C.4
  • 38
    • 84896296195 scopus 로고    scopus 로고
    • Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons. In press.
    • Ketron, A.C. & N. Osheroff. 2013. Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons. In press.
    • (2013)
    • Ketron, A.C.1    Osheroff, N.2
  • 39
    • 79960676884 scopus 로고    scopus 로고
    • Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide
    • Wu, C.C., T.K. Li, L. Farh, et al. 2011. Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide. Science 333: 459-462.
    • (2011) Science , vol.333 , pp. 459-462
    • Wu, C.C.1    Li, T.K.2    Farh, L.3
  • 40
    • 0035916938 scopus 로고    scopus 로고
    • Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation
    • Wang, H., Y. Mao, A.Y. Chen, et al. 2001. Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation. Biochemistry 40: 3316-3323.
    • (2001) Biochemistry , vol.40 , pp. 3316-3323
    • Wang, H.1    Mao, Y.2    Chen, A.Y.3
  • 42
    • 33747466075 scopus 로고    scopus 로고
    • Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIα: altering enzyme function by blocking the N-terminal protein gate
    • Bender, R.P., H.J. Lehmler, L.W. Robertson, et al. 2006. Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIα: altering enzyme function by blocking the N-terminal protein gate. Biochemistry 45: 10140-10152.
    • (2006) Biochemistry , vol.45 , pp. 10140-10152
    • Bender, R.P.1    Lehmler, H.J.2    Robertson, L.W.3
  • 43
    • 33947198738 scopus 로고    scopus 로고
    • Quinone-induced enhancement of DNA cleavage by human topoisomerase IIα: adduction of cysteine residues 392 and 405
    • Bender, R.P., A.J. Ham & N. Osheroff. 2007. Quinone-induced enhancement of DNA cleavage by human topoisomerase IIα: adduction of cysteine residues 392 and 405. Biochemistry 46: 2856-2864.
    • (2007) Biochemistry , vol.46 , pp. 2856-2864
    • Bender, R.P.1    Ham, A.J.2    Osheroff, N.3
  • 44
    • 34447136194 scopus 로고    scopus 로고
    • Mutation of cysteine residue 455 to alanine in human topoisomerase IIα confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate
    • Bender, R.P. & N. Osheroff. 2007. Mutation of cysteine residue 455 to alanine in human topoisomerase IIα confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chem. Res. Toxicol. 20: 975-981.
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 975-981
    • Bender, R.P.1    Osheroff, N.2
  • 45
    • 80053039106 scopus 로고    scopus 로고
    • Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα
    • Lin, R.K., N. Zhou, Y.L. Lyu, et al. 2011. Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα. J. Biol. Chem. 286: 33591-33600.
    • (2011) J. Biol. Chem. , vol.286 , pp. 33591-33600
    • Lin, R.K.1    Zhou, N.2    Lyu, Y.L.3
  • 46
    • 54049153246 scopus 로고    scopus 로고
    • Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis
    • Hasan, S.K., A.N. Mays, T. Ottone, et al. 2008. Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis. Blood 112: 3383-3390.
    • (2008) Blood , vol.112 , pp. 3383-3390
    • Hasan, S.K.1    Mays, A.N.2    Ottone, T.3
  • 47
    • 0032756225 scopus 로고    scopus 로고
    • Murine transgenic cells lacking DNA topoisomerase IIβ are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation
    • Errington, F., E. Willmore, M.J. Tilby, et al. 1999. Murine transgenic cells lacking DNA topoisomerase IIβ are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation. Mol. Pharmacol. 56: 1309-1316.
    • (1999) Mol. Pharmacol. , vol.56 , pp. 1309-1316
    • Errington, F.1    Willmore, E.2    Tilby, M.J.3
  • 48
    • 0032222419 scopus 로고    scopus 로고
    • Absence of topoisomerase IIβ in an amsacrine-resistant human leukemia cell line with mutant topoisomerase IIα
    • Herzog, C.E., K.A. Holmes, L.M. Tuschong, et al. 1998. Absence of topoisomerase IIβ in an amsacrine-resistant human leukemia cell line with mutant topoisomerase IIα. Cancer Res. 58: 5298-5300.
    • (1998) Cancer Res. , vol.58 , pp. 5298-5300
    • Herzog, C.E.1    Holmes, K.A.2    Tuschong, L.M.3
  • 49
    • 34250785684 scopus 로고    scopus 로고
    • Cells lacking DNA topoisomerase IIβ are resistant to genistein
    • Lopez-Lazaro, M., E. Willmore & C.A. Austin. 2007. Cells lacking DNA topoisomerase IIβ are resistant to genistein. J. Nat. Prod. 70: 763-767.
    • (2007) J. Nat. Prod. , vol.70 , pp. 763-767
    • Lopez-Lazaro, M.1    Willmore, E.2    Austin, C.A.3
  • 50
    • 53049090988 scopus 로고    scopus 로고
    • NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform
    • Toyoda, E., S. Kagaya, I.G. Cowell, et al. 2008. NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J. Biol. Chem. 283: 23711-23720.
    • (2008) J. Biol. Chem. , vol.283 , pp. 23711-23720
    • Toyoda, E.1    Kagaya, S.2    Cowell, I.G.3
  • 51
    • 67649958842 scopus 로고    scopus 로고
    • Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management
    • Yeh, E.T. & C.L. Bickford. 2009. Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J. Am. Coll. Cardiol. 53: 2231-2247.
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 2231-2247
    • Yeh, E.T.1    Bickford, C.L.2
  • 52
    • 79551610758 scopus 로고    scopus 로고
    • Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes
    • Force, T. & K.L. Kolaja. 2011. Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes. Nat. Rev. Drug. Discov. 10: 111-126.
    • (2011) Nat. Rev. Drug. Discov. , vol.10 , pp. 111-126
    • Force, T.1    Kolaja, K.L.2
  • 53
    • 0032563825 scopus 로고    scopus 로고
    • Doxorubicin-induced cardiomyopathy
    • Singal, P.K. & N. Iliskovic. 1998. Doxorubicin-induced cardiomyopathy. N. Engl. J. Med. 339: 900-905.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 900-905
    • Singal, P.K.1    Iliskovic, N.2
  • 54
    • 57449120634 scopus 로고    scopus 로고
    • Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy
    • Martin, E., A.V. Thougaard, M. Grauslund, et al. 2009. Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy. Toxicology 255: 72-79.
    • (2009) Toxicology , vol.255 , pp. 72-79
    • Martin, E.1    Thougaard, A.V.2    Grauslund, M.3
  • 55
    • 0020583667 scopus 로고
    • A randomized controlled trial assessing the prevention of doxorubicin cardiomyopathy by N-acetylcysteine
    • Myers, C., R. Bonow, S. Palmeri, et al. 1983. A randomized controlled trial assessing the prevention of doxorubicin cardiomyopathy by N-acetylcysteine. Semin. Oncol. 10: 53-55.
    • (1983) Semin. Oncol. , vol.10 , pp. 53-55
    • Myers, C.1    Bonow, R.2    Palmeri, S.3
  • 56
    • 0026793298 scopus 로고
    • Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development
    • Capranico, G., S. Tinelli, C.A. Austin, et al. 1992. Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development. Biochim. Biophys. Acta 1132: 43-48.
    • (1992) Biochim. Biophys. Acta , vol.1132 , pp. 43-48
    • Capranico, G.1    Tinelli, S.2    Austin, C.A.3
  • 57
    • 34547462435 scopus 로고    scopus 로고
    • Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies
    • Azarova, A.M., Y.L. Lyu, C.P. Lin, et al. 2007. Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies. Proc. Natl. Acad. Sci. U.S.A. 104: 11014-11019.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 11014-11019
    • Azarova, A.M.1    Lyu, Y.L.2    Lin, C.P.3
  • 58
    • 84869209094 scopus 로고    scopus 로고
    • Identification of the molecular basis of doxorubicin-induced cardiotoxicity
    • Zhang, S., X. Liu, T. Bawa-Khalfe, et al. 2012. Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat. Med. 18: 1639-1642.
    • (2012) Nat. Med. , vol.18 , pp. 1639-1642
    • Zhang, S.1    Liu, X.2    Bawa-Khalfe, T.3
  • 59
    • 0023550131 scopus 로고
    • Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung
    • Ratain, M.J., L.S. Kaminer, J.D. Bitran, et al. 1987. Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung. Blood 70: 1412-1417.
    • (1987) Blood , vol.70 , pp. 1412-1417
    • Ratain, M.J.1    Kaminer, L.S.2    Bitran, J.D.3
  • 60
    • 0024554675 scopus 로고
    • Therapy-related acute nonlymphocytic leukemia with monocytic features and rearrangement of chromosome 11q
    • DeVore, R., J. Whitlock, J.D. Hainsworth & H.D. Johnson. 1989. Therapy-related acute nonlymphocytic leukemia with monocytic features and rearrangement of chromosome 11q. Ann. Intern. Med. 110: 740-742.
    • (1989) Ann. Intern. Med. , vol.110 , pp. 740-742
    • DeVore, R.1    Whitlock, J.2    Hainsworth, J.D.3    Johnson, H.D.4
  • 61
    • 33747882412 scopus 로고    scopus 로고
    • Etoposide and illegitimate DNA double-strand break repair in the generation of MLL translocations: new insights and new questions
    • Sung, P.A., J. Libura & C. Richardson. 2006. Etoposide and illegitimate DNA double-strand break repair in the generation of MLL translocations: new insights and new questions. DNA Repair (Amst.) 5: 1109-1118.
    • (2006) DNA Repair (Amst.) , vol.5 , pp. 1109-1118
    • Sung, P.A.1    Libura, J.2    Richardson, C.3
  • 62
    • 18744373853 scopus 로고    scopus 로고
    • MLL targets SET domain methyltransferase activity to Hox gene promoters
    • Milne, T.A., S.D. Briggs, H.W. Brock, et al. 2002. MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol. Cell 10: 1107-1117.
    • (2002) Mol. Cell , vol.10 , pp. 1107-1117
    • Milne, T.A.1    Briggs, S.D.2    Brock, H.W.3
  • 63
    • 4644220954 scopus 로고    scopus 로고
    • MLL: a histone methyltransferase disrupted in leukemia
    • Hess, J.L. 2004. MLL: a histone methyltransferase disrupted in leukemia. Trends Mol. Med. 10: 500-507.
    • (2004) Trends Mol. Med. , vol.10 , pp. 500-507
    • Hess, J.L.1
  • 64
    • 35348849015 scopus 로고    scopus 로고
    • Hox genes in hematopoiesis and leukemogenesis
    • Argiropoulos, B. & K.R. Humphries. 2007. Hox genes in hematopoiesis and leukemogenesis. Oncogene 26: 6766-6776.
    • (2007) Oncogene , vol.26 , pp. 6766-6776
    • Argiropoulos, B.1    Humphries, K.R.2
  • 65
    • 78650333017 scopus 로고    scopus 로고
    • Mechanisms of leukemogenesis by MLL fusion proteins
    • Marschalek, R. 2011. Mechanisms of leukemogenesis by MLL fusion proteins. Br. J. Haematol. 152: 141-154.
    • (2011) Br. J. Haematol. , vol.152 , pp. 141-154
    • Marschalek, R.1
  • 66
    • 84856916060 scopus 로고    scopus 로고
    • The pathogenesis of mixed-lineage leukemia
    • Muntean, A.G. & L.J. Hess. 2012. The pathogenesis of mixed-lineage leukemia. Annu. Rev. Pathol. 7: 283-301.
    • (2012) Annu. Rev. Pathol. , vol.7 , pp. 283-301
    • Muntean, A.G.1    Hess, L.J.2
  • 67
    • 0034234515 scopus 로고    scopus 로고
    • DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis
    • Strissel, P.L., R. Strick, R.J. Tomek, et al. 2000. DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis. Hum. Mol. Genet. 9: 1671-1679.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 1671-1679
    • Strissel, P.L.1    Strick, R.2    Tomek, R.J.3
  • 68
    • 0037022636 scopus 로고    scopus 로고
    • Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia
    • Zhang, Y., P. Strissel, R. Strick, et al. 2002. Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia. Proc. Natl. Acad. Sci. U.S.A. 99: 3070-3075.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 3070-3075
    • Zhang, Y.1    Strissel, P.2    Strick, R.3
  • 69
    • 84885806263 scopus 로고    scopus 로고
    • Evaluation of prognostic factors in patients with therapy-related acute myeloid leukemia
    • Park, S.H., H.S. Chi, Y.U. Cho, et al. 2013. Evaluation of prognostic factors in patients with therapy-related acute myeloid leukemia. Blood Res. 48: 185-192.
    • (2013) Blood Res. , vol.48 , pp. 185-192
    • Park, S.H.1    Chi, H.S.2    Cho, Y.U.3
  • 70
    • 0028326283 scopus 로고
    • The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation
    • Pedersen-Bjergaard, J. & D.J. Rowley. 1994. The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation. Blood 83: 2780-2786.
    • (1994) Blood , vol.83 , pp. 2780-2786
    • Pedersen-Bjergaard, J.1    Rowley, D.J.2
  • 71
    • 0036934475 scopus 로고    scopus 로고
    • Pooled analysis of clinical and cytogenetic features in treatment-related and de novo adult acute myeloid leukemia and myelodysplastic syndromes based on a consecutive series of 761 patients analyzed 1976-1993 and on 5098 unselected cases reported in the literature 1974-2001
    • Mauritzson, N., M. Albin, L. Rylander, et al. 2002. Pooled analysis of clinical and cytogenetic features in treatment-related and de novo adult acute myeloid leukemia and myelodysplastic syndromes based on a consecutive series of 761 patients analyzed 1976-1993 and on 5098 unselected cases reported in the literature 1974-2001. Leukemia 16: 2366-2378.
    • (2002) Leukemia , vol.16 , pp. 2366-2378
    • Mauritzson, N.1    Albin, M.2    Rylander, L.3
  • 72
    • 2942706074 scopus 로고    scopus 로고
    • Prognosis in therapy-related acute myeloid leukemia and impact of karyotype
    • Kern, W., T. Haferlach, S. Schnittger, et al. 2004. Prognosis in therapy-related acute myeloid leukemia and impact of karyotype. J. Clin. Oncol. 22: 2510-2511.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2510-2511
    • Kern, W.1    Haferlach, T.2    Schnittger, S.3
  • 73
    • 0026079804 scopus 로고
    • Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia
    • Pui, C.H., R.C. Ribeiro, M.L. Hancock, et al. 1991. Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. N. Engl. J. Med. 325: 1682-1687.
    • (1991) N. Engl. J. Med. , vol.325 , pp. 1682-1687
    • Pui, C.H.1    Ribeiro, R.C.2    Hancock, M.L.3
  • 74
    • 0028332667 scopus 로고
    • Therapy-related acute myeloid leukemia following treatment with epipodophyllotoxins: estimating the risks
    • Smith, M.A., L. Rubinstein & S.R. Ungerleider. 1994. Therapy-related acute myeloid leukemia following treatment with epipodophyllotoxins: estimating the risks. Med. Pediatr. Oncol. 23: 86-98.
    • (1994) Med. Pediatr. Oncol. , vol.23 , pp. 86-98
    • Smith, M.A.1    Rubinstein, L.2    Ungerleider, S.R.3
  • 75
    • 0031884608 scopus 로고    scopus 로고
    • Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia
    • Relling, M.V., Y. Yanishevski, J. Nemec, et al. 1998. Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia. Leukemia 12: 346-352.
    • (1998) Leukemia , vol.12 , pp. 346-352
    • Relling, M.V.1    Yanishevski, Y.2    Nemec, J.3
  • 76
    • 0033008437 scopus 로고    scopus 로고
    • Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins
    • Smith, M.A., L. Rubinstein, J.R. Anderson, et al. 1999. Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins. J. Clin. Oncol. 17: 569-577.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 569-577
    • Smith, M.A.1    Rubinstein, L.2    Anderson, J.R.3
  • 77
    • 0032189081 scopus 로고    scopus 로고
    • Secondary leukemias induced by topoisomerase-targeted drugs
    • Felix, C.A. 1998. Secondary leukemias induced by topoisomerase-targeted drugs. Biochim. Biophys. Acta 1400: 233-255.
    • (1998) Biochim. Biophys. Acta , vol.1400 , pp. 233-255
    • Felix, C.A.1
  • 78
    • 66149120646 scopus 로고    scopus 로고
    • A safer regimen for high-risk neuroblastoma
    • Felix, C.A. 2009. A safer regimen for high-risk neuroblastoma. Pediatr. Blood Cancer 53: 3-6.
    • (2009) Pediatr. Blood Cancer , vol.53 , pp. 3-6
    • Felix, C.A.1
  • 79
    • 0030772421 scopus 로고    scopus 로고
    • Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias
    • Megonigal, M.D., E.F. Rappaport, D.H. Jones, et al. 1997. Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias. Proc. Natl. Acad. Sci. U.S.A. 94: 11583-11588.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 11583-11588
    • Megonigal, M.D.1    Rappaport, E.F.2    Jones, D.H.3
  • 80
    • 43549112363 scopus 로고    scopus 로고
    • Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome
    • Robinson, B.W., N.K. Cheung, C.P. Kolaris, et al. 2008. Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome. Blood 111: 3802-3812.
    • (2008) Blood , vol.111 , pp. 3802-3812
    • Robinson, B.W.1    Cheung, N.K.2    Kolaris, C.P.3
  • 81
    • 0035814808 scopus 로고    scopus 로고
    • Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints
    • Lovett, B.D., D. Strumberg, I.A. Blair, et al. 2001. Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints. Biochemistry 40: 1159-1170.
    • (2001) Biochemistry , vol.40 , pp. 1159-1170
    • Lovett, B.D.1    Strumberg, D.2    Blair, I.A.3
  • 82
    • 0035859820 scopus 로고    scopus 로고
    • Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation
    • Lovett, B.D., L. Lo Nigro, E.F. Rappaport, et al. 2001. Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation. Proc. Natl. Acad. Sci. U.S. A. 98: 9802-9807.
    • (2001) Proc. Natl. Acad. Sci. U.S. A. , vol.98 , pp. 9802-9807
    • Lovett, B.D.1    Lo Nigro, L.2    Rappaport, E.F.3
  • 83
    • 0346753588 scopus 로고    scopus 로고
    • Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing
    • Whitmarsh, R.J., C. Saginario, Y. Zhuo, et al. 2003. Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing. Oncogene 22: 8448-8459.
    • (2003) Oncogene , vol.22 , pp. 8448-8459
    • Whitmarsh, R.J.1    Saginario, C.2    Zhuo, Y.3
  • 84
    • 0030041634 scopus 로고    scopus 로고
    • Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites
    • Broeker, P.L., H.G. Super, M.J. Thirman, et al. 1996. Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites. Blood 87: 1912-1922.
    • (1996) Blood , vol.87 , pp. 1912-1922
    • Broeker, P.L.1    Super, H.G.2    Thirman, M.J.3
  • 85
    • 0034791454 scopus 로고    scopus 로고
    • Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992
    • Andersen, M.K., D.H. Christiansen, B.A. Jensen, et al. 2001. Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992. Br. J. Haematol. 114: 539-543.
    • (2001) Br. J. Haematol. , vol.114 , pp. 539-543
    • Andersen, M.K.1    Christiansen, D.H.2    Jensen, B.A.3
  • 86
    • 0035056832 scopus 로고    scopus 로고
    • Leukemias related to treatment with DNA topoisomerase II inhibitors
    • Felix, C.A. 2001. Leukemias related to treatment with DNA topoisomerase II inhibitors. Med. Pediatr. Oncol. 36: 525-535.
    • (2001) Med. Pediatr. Oncol. , vol.36 , pp. 525-535
    • Felix, C.A.1
  • 87
    • 28544437234 scopus 로고    scopus 로고
    • Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity
    • Betti, C.J., M.J. Villalobos, Q. Jiang, et al. 2005. Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity. Leukemia 19: 2289-2295.
    • (2005) Leukemia , vol.19 , pp. 2289-2295
    • Betti, C.J.1    Villalobos, M.J.2    Jiang, Q.3
  • 88
    • 33749469891 scopus 로고    scopus 로고
    • Role of apoptotic nuclease caspase-activated DNase in etoposide-induced treatment-related acute myelogenous leukemia
    • Hars, E.S., Y.L. Lyu, C.P. Lin & L.F. Liu, 2006. Role of apoptotic nuclease caspase-activated DNase in etoposide-induced treatment-related acute myelogenous leukemia. Cancer Res. 66: 8975-8979.
    • (2006) Cancer Res. , vol.66 , pp. 8975-8979
    • Hars, E.S.1    Lyu, Y.L.2    Lin, C.P.3    Liu, L.F.4
  • 89
    • 33751072676 scopus 로고    scopus 로고
    • Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot
    • Mirault, M.E., P. Boucher & A. Tremblay, 2006. Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot. Am. J. Hum. Genet. 79: 779-791.
    • (2006) Am. J. Hum. Genet. , vol.79 , pp. 779-791
    • Mirault, M.E.1    Boucher, P.2    Tremblay, A.3
  • 90
    • 0031011855 scopus 로고    scopus 로고
    • DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis
    • Stanulla, M., J. Wang, D.S. Chervinsky, et al. 1997. DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis. Mol. Cell. Biol. 17: 4070-4079.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4070-4079
    • Stanulla, M.1    Wang, J.2    Chervinsky, D.S.3
  • 91
    • 0035360796 scopus 로고    scopus 로고
    • Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system
    • Betti, C.J., M.J. Villalobos, M.O. Diaz & A.T. Vaughan. 2001. Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system. Cancer Res. 61: 4550-4555.
    • (2001) Cancer Res. , vol.61 , pp. 4550-4555
    • Betti, C.J.1    Villalobos, M.J.2    Diaz, M.O.3    Vaughan, A.T.4
  • 92
    • 68549135307 scopus 로고    scopus 로고
    • Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding
    • Le, H., S. Singh, S.J. Shih, et al. 2009. Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding. Genes Chrom. Cancer 48: 806-815.
    • (2009) Genes Chrom. Cancer , vol.48 , pp. 806-815
    • Le, H.1    Singh, S.2    Shih, S.J.3
  • 94
    • 0026635651 scopus 로고
    • Human cytochrome P450 metabolism of teniposide and etoposide
    • Relling, M.V., R. Evans, C. Dass, et al. 1992. Human cytochrome P450 metabolism of teniposide and etoposide. J. Pharmacol. Exp. Ther. 261: 491-496.
    • (1992) J. Pharmacol. Exp. Ther. , vol.261 , pp. 491-496
    • Relling, M.V.1    Evans, R.2    Dass, C.3
  • 95
    • 0028009274 scopus 로고
    • O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4
    • Relling, M.V., J. Nemec, E.G. Schuetz, et al. 1994. O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4. Mol. Pharmacol. 45: 352-358.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 352-358
    • Relling, M.V.1    Nemec, J.2    Schuetz, E.G.3
  • 96
    • 4143090798 scopus 로고    scopus 로고
    • Kinetics and regulation of cytochrome P450-mediated etoposide metabolism
    • Zhuo, X., N. Zheng, C.A. Felix & I.A. Blair. 2004. Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug. Metab. Dispos. 32: 993-1000.
    • (2004) Drug. Metab. Dispos. , vol.32 , pp. 993-1000
    • Zhuo, X.1    Zheng, N.2    Felix, C.A.3    Blair, I.A.4
  • 97
    • 13144282667 scopus 로고    scopus 로고
    • Association of CYP3A4 genotype with treatment-related leukemia
    • Felix, C.A., A.H. Walker, B.J. Lange, et al. 1998. Association of CYP3A4 genotype with treatment-related leukemia. Proc. Natl. Acad. Sci. U.S. A. 95: 13176-13181.
    • (1998) Proc. Natl. Acad. Sci. U.S. A. , vol.95 , pp. 13176-13181
    • Felix, C.A.1    Walker, A.H.2    Lange, B.J.3
  • 98
    • 0030854622 scopus 로고    scopus 로고
    • Considerable plasma levels of a cytotoxic etoposide metabolite in patients undergoing high-dose chemotherapy
    • Stremetzne, S., U. Jaehde, R. Kasper, et al. 1997. Considerable plasma levels of a cytotoxic etoposide metabolite in patients undergoing high-dose chemotherapy. Eur. J. Cancer 33: 978-979.
    • (1997) Eur. J. Cancer , vol.33 , pp. 978-979
    • Stremetzne, S.1    Jaehde, U.2    Kasper, R.3
  • 99
    • 0034902032 scopus 로고    scopus 로고
    • Simultaneous determination of etoposide and its catechol metabolite in the plasma of pediatric patients by liquid chromatography/tandem mass spectrometry
    • Pang, S., N. Zheng, C.A. Felix, et al. 2001. Simultaneous determination of etoposide and its catechol metabolite in the plasma of pediatric patients by liquid chromatography/tandem mass spectrometry. J. Mass. Spectrom. 36: 771-781.
    • (2001) J. Mass. Spectrom. , vol.36 , pp. 771-781
    • Pang, S.1    Zheng, N.2    Felix, C.A.3
  • 100
    • 0031466176 scopus 로고    scopus 로고
    • Determination of the cytotoxic catechol metabolite of etoposide (3'O-demethyletoposide) in human plasma by high-performance liquid chromatography
    • Stremetzne, S., U. Jaehde & W. Schunack. 1997. Determination of the cytotoxic catechol metabolite of etoposide (3'O-demethyletoposide) in human plasma by high-performance liquid chromatography. J. Chromatogr. B: Biomed. Sci. Appl. 703: 209-215.
    • (1997) J. Chromatogr. B: Biomed. Sci. Appl. , vol.703 , pp. 209-215
    • Stremetzne, S.1    Jaehde, U.2    Schunack, W.3
  • 101
    • 2442616994 scopus 로고    scopus 로고
    • Plasma etoposide catechol increases in pediatric patients undergoing multiple-day chemotherapy with etoposide
    • Zheng, N., C.A. Felix, S. Pang, et al. 2004. Plasma etoposide catechol increases in pediatric patients undergoing multiple-day chemotherapy with etoposide. Clin. Cancer Res. 10: 2977-2985.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2977-2985
    • Zheng, N.1    Felix, C.A.2    Pang, S.3
  • 102
    • 0031559562 scopus 로고    scopus 로고
    • Inhibition of the topoisomerase II-DNA cleavable complex by the ortho-quinone derivative of the antitumor drug etoposide (VP-16)
    • Gantchev, T.G. & D.J. Hunting. 1997. Inhibition of the topoisomerase II-DNA cleavable complex by the ortho-quinone derivative of the antitumor drug etoposide (VP-16). Biochem. Biophys. Res. Commun. 237: 24-27.
    • (1997) Biochem. Biophys. Res. Commun. , vol.237 , pp. 24-27
    • Gantchev, T.G.1    Hunting, D.J.2
  • 103
    • 0031978752 scopus 로고    scopus 로고
    • The ortho-quinone metabolite of the anticancer drug etoposide (VP-16) is a potent inhibitor of the topoisomerase II/DNA cleavable complex
    • Gantchev, T.G. & D.J. Hunting. 1998. The ortho-quinone metabolite of the anticancer drug etoposide (VP-16) is a potent inhibitor of the topoisomerase II/DNA cleavable complex. Mol. Pharmacol. 53: 422-428.
    • (1998) Mol. Pharmacol. , vol.53 , pp. 422-428
    • Gantchev, T.G.1    Hunting, D.J.2
  • 104
    • 0022536877 scopus 로고
    • Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26)
    • Haim, N., J. Roman, J. Nemec & B.K. Sinha. 1986. Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem. Biophys. Res. Commun. 135: 215-220.
    • (1986) Biochem. Biophys. Res. Commun. , vol.135 , pp. 215-220
    • Haim, N.1    Roman, J.2    Nemec, J.3    Sinha, B.K.4
  • 105
    • 79959464133 scopus 로고    scopus 로고
    • Etoposide quinone is a redox-dependent topoisomerase II poison
    • Jacob, D.A., S.L. Mercer, N. Osheroff & J.E. Deweese. 2011. Etoposide quinone is a redox-dependent topoisomerase II poison. Biochemistry 50: 5660-5667.
    • (2011) Biochemistry , vol.50 , pp. 5660-5667
    • Jacob, D.A.1    Mercer, S.L.2    Osheroff, N.3    Deweese, J.E.4
  • 106
    • 0032868183 scopus 로고    scopus 로고
    • Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach
    • Kagan, V.E., J.C. Yalowich, G.G. Borisenko, et al. 1999. Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach. Mol. Pharmacol. 56: 494-506.
    • (1999) Mol. Pharmacol. , vol.56 , pp. 494-506
    • Kagan, V.E.1    Yalowich, J.C.2    Borisenko, G.G.3
  • 107
    • 33746211294 scopus 로고    scopus 로고
    • Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells
    • Fan, Y., E.M. Schreiber, A. Giorgianni, et al. 2006. Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells. Chem. Res. Toxicol. 19: 937-943.
    • (2006) Chem. Res. Toxicol. , vol.19 , pp. 937-943
    • Fan, Y.1    Schreiber, E.M.2    Giorgianni, A.3
  • 108
    • 0025046910 scopus 로고
    • Structure-activity relations, cytotoxicity and topoisomerase II dependent cleavage induced by pendulum ring analogues of etoposide
    • Sinha, B.K., P.M. Politi, H.M. Eliot, et al. 1990. Structure-activity relations, cytotoxicity and topoisomerase II dependent cleavage induced by pendulum ring analogues of etoposide. Eur. J. Cancer 26: 590-593.
    • (1990) Eur. J. Cancer , vol.26 , pp. 590-593
    • Sinha, B.K.1    Politi, P.M.2    Eliot, H.M.3
  • 109
    • 5444243359 scopus 로고    scopus 로고
    • Active genes dynamically colocalize to shared sites of ongoing transcription
    • Osborne, C.S., L. Chakalova, K.E. Brown, et al. 2004. Active genes dynamically colocalize to shared sites of ongoing transcription. Nat. Genet. 36: 1065-1071.
    • (2004) Nat. Genet. , vol.36 , pp. 1065-1071
    • Osborne, C.S.1    Chakalova, L.2    Brown, K.E.3
  • 110
    • 70450222694 scopus 로고    scopus 로고
    • A model for all genomes: the role of transcription factories
    • Cook, P.R. 2010. A model for all genomes: the role of transcription factories. J. Mol. Biol. 395: 1-10.
    • (2010) J. Mol. Biol. , vol.395 , pp. 1-10
    • Cook, P.R.1
  • 111
    • 33750301347 scopus 로고    scopus 로고
    • Role of topoisomerase IIβ in the expression of developmentally regulated genes
    • Lyu, Y.L., C.P. Lin, A.M. Azarova, et al. 2006. Role of topoisomerase IIβ in the expression of developmentally regulated genes. Mol. Cell. Biol. 26: 7929-7941.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 7929-7941
    • Lyu, Y.L.1    Lin, C.P.2    Azarova, A.M.3
  • 112
    • 0031406189 scopus 로고    scopus 로고
    • Infant cancer in the U.S.: histology-specific incidence and trends, 1973 to 1992
    • Gurney, J.G., J.A. Ross, D.A. Wall, et al. 1997. Infant cancer in the U.S.: histology-specific incidence and trends, 1973 to 1992. J. Pediatr. Hematol. Oncol. 19: 428-432.
    • (1997) J. Pediatr. Hematol. Oncol. , vol.19 , pp. 428-432
    • Gurney, J.G.1    Ross, J.A.2    Wall, D.A.3
  • 113
    • 0033023073 scopus 로고    scopus 로고
    • Leukemia in infants
    • Felix, C.A. & B.J. Lange. 1999. Leukemia in infants. Oncologist 4: 225-240.
    • (1999) Oncologist , vol.4 , pp. 225-240
    • Felix, C.A.1    Lange, B.J.2
  • 114
    • 0037063170 scopus 로고    scopus 로고
    • MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site
    • Slater, D.J., E. Hilgenfeld, E.F. Rappaport, et al. 2002. MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site. Oncogene 21: 4706-4714.
    • (2002) Oncogene , vol.21 , pp. 4706-4714
    • Slater, D.J.1    Hilgenfeld, E.2    Rappaport, E.F.3
  • 116
    • 21344472782 scopus 로고    scopus 로고
    • The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia
    • De Braekeleer, M., F. Morel, Le Bris, et al. 2005. The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia. Anticancer Res. 25: 1931-1944.
    • (2005) Anticancer Res. , vol.25 , pp. 1931-1944
    • De Braekeleer, M.1    Morel, F.2    Bris, L.3
  • 117
    • 11544323440 scopus 로고    scopus 로고
    • t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes
    • Megonigal, M.D., E.F. Rappaport, D.H. Jones, et al. 1998. t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes. Proc. Natl. Acad. Sci. U.S. A. 95: 6413-6418.
    • (1998) Proc. Natl. Acad. Sci. U.S. A. , vol.95 , pp. 6413-6418
    • Megonigal, M.D.1    Rappaport, E.F.2    Jones, D.H.3
  • 118
    • 0009886478 scopus 로고
    • Clonal, nonconstitutional rearrangements of the MLL gene in infant twins with acute lymphoblastic leukemia: in utero chromosome rearrangement of 11q23
    • Gill Super, H.J., P.G. Rothberg, H. Kobayashi, et al. 1994. Clonal, nonconstitutional rearrangements of the MLL gene in infant twins with acute lymphoblastic leukemia: in utero chromosome rearrangement of 11q23. Blood 83: 641-644.
    • (1994) Blood , vol.83 , pp. 641-644
    • Gill Super, H.J.1    Rothberg, P.G.2    Kobayashi, H.3
  • 119
    • 0029056308 scopus 로고
    • Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites
    • Felix, C.A., B.J. Lange, M.R. Hosler, et al. 1995. Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites. Cancer Res. 55: 4287-4292.
    • (1995) Cancer Res. , vol.55 , pp. 4287-4292
    • Felix, C.A.1    Lange, B.J.2    Hosler, M.R.3
  • 120
    • 0034712748 scopus 로고    scopus 로고
    • Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia
    • Strick, R., P.L. Strissel, S. Borgers, et al. 2000. Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia. Proc. Natl. Acad. Sci. U.S. A. 97: 4790-4795.
    • (2000) Proc. Natl. Acad. Sci. U.S. A. , vol.97 , pp. 4790-4795
    • Strick, R.1    Strissel, P.L.2    Borgers, S.3
  • 121
    • 20144389914 scopus 로고    scopus 로고
    • Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: a report from the children's oncology group
    • Spector, L.G., Y. Xie, L.L. Robison, et al. 2005. Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: a report from the children's oncology group. Cancer Epidemiol. Biomarkers Prev. 14: 651-655.
    • (2005) Cancer Epidemiol. Biomarkers Prev. , vol.14 , pp. 651-655
    • Spector, L.G.1    Xie, Y.2    Robison, L.L.3
  • 122
    • 0026574138 scopus 로고
    • Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives
    • Austin, C.A., S. Patel, K. Ono, et al. 1992. Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives. Biochem. J. 282: 883-889.
    • (1992) Biochem. J. , vol.282 , pp. 883-889
    • Austin, C.A.1    Patel, S.2    Ono, K.3
  • 123
    • 34249317605 scopus 로고    scopus 로고
    • Bioflavonoids as poisons of human topoisomerase IIα and IIβ
    • Bandele, O.J. & N. Osheroff. 2007. Bioflavonoids as poisons of human topoisomerase IIα and IIβ. Biochemistry 46: 6097-6108.
    • (2007) Biochemistry , vol.46 , pp. 6097-6108
    • Bandele, O.J.1    Osheroff, N.2
  • 124
    • 43149124005 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases
    • Bandele, O.J. & N. Osheroff. 2008. (-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases. Chem. Res. Toxicol. 21: 936-943.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 936-943
    • Bandele, O.J.1    Osheroff, N.2
  • 125
    • 47049094564 scopus 로고    scopus 로고
    • Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement
    • Bandele, O.J., S.J. Clawson & N. Osheroff. 2008. Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement. Chem. Res. Toxicol. 21: 1253-1260.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 1253-1260
    • Bandele, O.J.1    Clawson, S.J.2    Osheroff, N.3
  • 127
    • 0025043959 scopus 로고
    • The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus
    • de The, H., C. Chomienne, M. Lanotte, et al. 1990. The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature 347: 558-561.
    • (1990) Nature , vol.347 , pp. 558-561
    • de The, H.1    Chomienne, C.2    Lanotte, M.3
  • 128
    • 0025780876 scopus 로고
    • Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML
    • Kakizuka, A., W.H. Miller, Jr., K. Umesono, et al. 1991. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML. Cell 66: 663-674.
    • (1991) Cell , vol.66 , pp. 663-674
    • Kakizuka, A.1    Miller Jr, W.H.2    Umesono, K.3
  • 129
    • 0037301145 scopus 로고    scopus 로고
    • Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia
    • Reiter, A., S. Saussele, D. Grimwade, et al. 2003. Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia. Genes Chromosomes Cancer 36: 175-188.
    • (2003) Genes Chromosomes Cancer , vol.36 , pp. 175-188
    • Reiter, A.1    Saussele, S.2    Grimwade, D.3
  • 130
    • 0037868159 scopus 로고    scopus 로고
    • Therapy-related acute promyelocytic leukemia
    • Beaumont, M., M. Sanz, P.M. Carli, et al. 2003. Therapy-related acute promyelocytic leukemia. J. Clin. Oncol. 21: 2123-2137.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2123-2137
    • Beaumont, M.1    Sanz, M.2    Carli, P.M.3
  • 131
    • 79958706507 scopus 로고    scopus 로고
    • The role of PML in the nervous system
    • Salomoni, P. & J. Betts-Henderson. 2011. The role of PML in the nervous system. Mol. Neurobiol. 43: 114-123.
    • (2011) Mol. Neurobiol. , vol.43 , pp. 114-123
    • Salomoni, P.1    Betts-Henderson, J.2
  • 132
    • 80051770868 scopus 로고    scopus 로고
    • The role of PML in the control of apoptotic cell fate: a new key player at ER-mitochondria sites
    • Pinton, P., C. Giorgi & P.P. Pandolfi. 2011. The role of PML in the control of apoptotic cell fate: a new key player at ER-mitochondria sites. Cell Death Differ. 18: 1450-1456.
    • (2011) Cell Death Differ. , vol.18 , pp. 1450-1456
    • Pinton, P.1    Giorgi, C.2    Pandolfi, P.P.3
  • 133
    • 84865468924 scopus 로고    scopus 로고
    • The role of PML ubiquitination in human malignancies
    • Chen, R.H., Y.R. Lee & W.C. Yuan 2012. The role of PML ubiquitination in human malignancies. J. Biomed. Sci. 19: 81.
    • (2012) J. Biomed. Sci. , vol.19 , pp. 81
    • Chen, R.H.1    Lee, Y.R.2    Yuan, W.C.3
  • 134
    • 84865074686 scopus 로고    scopus 로고
    • The cell biology of disease: acute promyelocytic leukemia, arsenic, and PML bodies
    • de The, H., Le Bras, M. & V. Lallemand-Breitenbach. 2012. The cell biology of disease: acute promyelocytic leukemia, arsenic, and PML bodies. J. Cell. Biol. 198: 11-21.
    • (2012) J. Cell. Biol. , vol.198 , pp. 11-21
    • de The, H.1    Le Bras, M.2    Lallemand-Breitenbach, V.3
  • 136
    • 36448975490 scopus 로고    scopus 로고
    • Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
    • Bernardi, R. & P.P. Pandolfi. 2007. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat. Rev. Mol. Cell. Biol. 8: 1006-1016.
    • (2007) Nat. Rev. Mol. Cell. Biol. , vol.8 , pp. 1006-1016
    • Bernardi, R.1    Pandolfi, P.P.2
  • 138
    • 77958510339 scopus 로고    scopus 로고
    • Acute promyelocytic leukaemia: novel insights into the mechanisms of cure
    • de The, H. & Z. Chen. 2010. Acute promyelocytic leukaemia: novel insights into the mechanisms of cure. Nat. Rev. Cancer. 10: 775-783.
    • (2010) Nat. Rev. Cancer. , vol.10 , pp. 775-783
    • de The, H.1    Chen, Z.2
  • 139
    • 0001483546 scopus 로고
    • Acute promyelocytic leukemia
    • Hillestad, L.K. 1957. Acute promyelocytic leukemia. Acta. Med. Scand. 159: 189-194.
    • (1957) Acta. Med. Scand. , vol.159 , pp. 189-194
    • Hillestad, L.K.1
  • 141
    • 0037409182 scopus 로고    scopus 로고
    • The molecular pathogenesis of acute promyelocytic leukaemia: implications for the clinical management of the disease
    • Mistry, A.R., E.W. Pedersen, E. Solomon & D. Grimwade. 2003. The molecular pathogenesis of acute promyelocytic leukaemia: implications for the clinical management of the disease. Blood Rev. 17: 71-97.
    • (2003) Blood Rev. , vol.17 , pp. 71-97
    • Mistry, A.R.1    Pedersen, E.W.2    Solomon, E.3    Grimwade, D.4
  • 142
    • 41949111045 scopus 로고    scopus 로고
    • Acute promyelocytic leukemia: from highly fatal to highly curable
    • Wang, Z.Y. & Z. Chen. 2008. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 111: 2505-2515.
    • (2008) Blood , vol.111 , pp. 2505-2515
    • Wang, Z.Y.1    Chen, Z.2
  • 143
    • 20144388623 scopus 로고    scopus 로고
    • DNA topoisomerase II in therapy-related acute promyelocytic leukemia
    • Mistry, A.R., C.A. Felix, R.J. Whitmarsh, et al. 2005. DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N. Engl. J. Med. 352: 1529-1538.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 1529-1538
    • Mistry, A.R.1    Felix, C.A.2    Whitmarsh, R.J.3
  • 144
    • 75649084232 scopus 로고    scopus 로고
    • Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia
    • Mays, A.N., N. Osheroff, Y. Xiao, et al. 2010. Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood 115: 326-330.
    • (2010) Blood , vol.115 , pp. 326-330
    • Mays, A.N.1    Osheroff, N.2    Xiao, Y.3
  • 145
    • 84896312164 scopus 로고    scopus 로고
    • Therapy related acute leukaemia with mitoxantrone: 4 years on, what is the risk and can it be limited?
    • Ellis, R.J., S. Brown & M. Boggild. 2013. Therapy related acute leukaemia with mitoxantrone: 4 years on, what is the risk and can it be limited? J. Neurol. Neurosurg. Psychiatr. 84: e2.
    • (2013) J. Neurol. Neurosurg. Psychiatr. , vol.84
    • Ellis, R.J.1    Brown, S.2    Boggild, M.3
  • 146
    • 0036783808 scopus 로고    scopus 로고
    • A study of therapy-related acute leukaemia after mitoxantrone therapy for multiple sclerosis
    • Ghalie, R.G., E. Mauch, G. Edan, et al. 2002. A study of therapy-related acute leukaemia after mitoxantrone therapy for multiple sclerosis. Mult. Scler. 8: 441-445.
    • (2002) Mult. Scler. , vol.8 , pp. 441-445
    • Ghalie, R.G.1    Mauch, E.2    Edan, G.3
  • 147
    • 0033628701 scopus 로고    scopus 로고
    • Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice
    • Fortune, J.M. & N. Osheroff. 2000. Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. Prog. Nucleic Acid Res. Mol. Biol. 64: 221-253.
    • (2000) Prog. Nucleic Acid Res. Mol. Biol. , vol.64 , pp. 221-253
    • Fortune, J.M.1    Osheroff, N.2
  • 148
    • 84880415836 scopus 로고    scopus 로고
    • PARP1 is required for chromosomal translocations
    • Wray, J., E.A. Williamson, S.B. Singh, et al. 2013. PARP1 is required for chromosomal translocations. Blood 121: 4359-4365.
    • (2013) Blood , vol.121 , pp. 4359-4365
    • Wray, J.1    Williamson, E.A.2    Singh, S.B.3
  • 149
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • Wang, M., W. Wu, B. Rosidi, et al. 2006. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res. 34: 6170-6182.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 6170-6182
    • Wang, M.1    Wu, W.2    Rosidi, B.3


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