A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

Nature

Volumn 465, Issue 7298, 2010, Pages 641-644

  Schmidt, Bryan H ^a   Burgin, Alex B ^b   Deweese, Joseph E ^c   Osheroff, Neil ^c   Berger, James M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Emerald BioStructures   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE 1A; SINGLE STRANDED DNA; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID; ANTIBIOTICS; BIOCHEMISTRY; CANCER; CATALYSIS; CHROMOSOME; DNA; ENZYME ACTIVITY; LESION; MUTATION; YEAST;

ALLOSTERISM; ARTICLE; CATALYSIS; CHROMOSOME; CONTROLLED STUDY; DNA BINDING; DNA CLEAVAGE; DNA PROTEIN COMPLEX; DNA STRAND BREAKAGE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ESCHERICHIA COLI; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; SACCHAROMYCES CEREVISIAE;

ALLOSTERIC REGULATION; BASE SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA; DNA TOPOISOMERASES, TYPE I, EUKARYOTIC; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SACCHAROMYCES CEREVISIAE; TYROSINE;

SACCHAROMYCES CEREVISIAE;

EID: 77953229439     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08974     Document Type: Article

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