DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg 2+-mediated dynamic bending of gate-DNA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 8, 2012, Pages 2925-2930

  Lee, Sanghwa ^a   Jung, Seung Ryoung ^a   Heo, Kang ^a   Byl, Jo Ann W ^b   Deweese, Joseph E ^b   Osheroff, Neil ^b,c   Hohng, Sungchul ^a  

^a Seoul National University   (South Korea)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LIPSCOMB UNIVERSITY   (United States)

Author keywords

G segment selection; Indirect readout; N gate clamping; Single molecule FRET; Type II topoisomerase

Indexed keywords

CURVED DNA; DNA PRIMASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE (ATP HYDROLYSING) ALPHA; DOUBLE STRANDED DNA; MAGNESIUM ION; UNCLASSIFIED DRUG;

ARTICLE; DNA CLEAVAGE; DNA STRAND BREAKAGE; FLUORESCENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; REGULATORY MECHANISM;

AMINO ACIDS, ACIDIC; ANTIGENS, NEOPLASM; BASE SEQUENCE; CATIONS, DIVALENT; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA CLEAVAGE; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; HUMANS; MAGNESIUM; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION;

EID: 84863168027     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1115704109     Document Type: Article

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