Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide

Science

Volumn 333, Issue 6041, 2011, Pages 459-462

  Wu, Chyuan Chuan ^a   Li, Tsai Kun ^a,b   Farh, Lynn ^c   Lin, Li Ying ^a,d   Lin, Te Sheng ^a,d   Yu, Yu Jen ^a   Yen, Tien Jui ^a   Chiang, Chia Wang ^a,d   Chan, Nei Li ^a,d  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL PINGTUNG UNIVERSITY   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE;

CANCER; CHROMOSOME; CRYSTAL STRUCTURE; DRUG; ENZYME ACTIVITY; INHIBITION; MOLECULAR ANALYSIS; MUTATION; PROTEIN; TOPOLOGY;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DNA CLEAVAGE; DRUG BINDING; DRUG TARGETING; ENZYME INHIBITION; GENE MUTATION; HUMAN; MOLECULAR INTERACTION; PRIORITY JOURNAL;

BASE PAIRING; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; HUMANS; MODELS, MOLECULAR; MUTANT PROTEINS; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

EID: 79960676884     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1204117     Document Type: Article

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