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Volumn 21, Issue 30, 2002, Pages 4706-4714

MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site

(11) Slater, Diana J a Hilgenfeld, Eva c,g Rappaport, Eric F a Shah, Narayan d Meek, Rita G e Williams, Wendy Reed a Lovett, Brian D a,h Osheroff, Neil f Autar, Reshma S a,i Ried, Thomas c Felix, Carolyn A a,b

a CHILDREN S HOSPITAL OF PHILADELPHIA (United States)

b UNIVERSITY OF PENNSYLVANIA (United States)

c NATIONAL CANCER INSTITUTE (United States)

d GEISINGER MEDICAL CENTER (United States)

e NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN (United States)

f VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (United States)

g UNIVERSITY OF MÜNSTER (Germany)

h PENN STATE COLLEGE OF MEDICINE (United States)

i UNIVERSITY OF AMSTERDAM (Netherlands)

Author keywords

Complex translocation; DNA topoisomerase II; Infant leukaemia; MLL; SEPTIN6; Spectral karyotype

Indexed keywords

CELL CYCLE PROTEIN; COMPLEMENTARY DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); MIXED LINEAGE LEUKEMIA PROTEIN; SEPTIN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE MYELOMONOCYTIC LEUKEMIA; ARTICLE; CARCINOGENESIS; CASE REPORT; CHROMOSOME 11Q; CHROMOSOME 3; CHROMOSOME BANDING PATTERN; CHROMOSOME INSERTION; CHROMOSOME TRANSLOCATION; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION X; CHROMOSOME XQ; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME DEGRADATION; EXON; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FUNCTION; GENE FUSION; GENE IDENTIFICATION; GENE PROBE; GENE REARRANGEMENT; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HUMAN; IN VITRO STUDY; INFANT; INTRON; KARYOTYPE; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REGULATORY MECHANISM; SOUTHERN BLOTTING; X CHROMOSOME ABERRATION;

ACUTE DISEASE; BASE SEQUENCE; CHROMOSOME BREAKAGE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 3; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; GTP-BINDING PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; LEUKEMIA, MYELOID; LEUKEMIA, MYELOMONOCYTIC, ACUTE; MOLECULAR SEQUENCE DATA; MYELOID-LYMPHOID LEUKEMIA PROTEIN; PROTO-ONCOGENES; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; X CHROMOSOME;

INSERTION SEQUENCES;

EID: 0037063170 PISSN: 09509232 EISSN: None Source Type: Journal
DOI: 10.1038/sj.onc.1205572 Document Type: Article

Times cited : (52)

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