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Volumn 395, Issue 1, 2010, Pages 1-10

A Model for all Genomes: The Role of Transcription Factories

Author keywords

chromatin loop; chromosome; RNA polymerase; transcription factor; transcription factory

Indexed keywords

RNA POLYMERASE; TRANSCRIPTION FACTOR;

EID: 70450222694     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.10.031     Document Type: Review
Times cited : (201)

References (62)
  • 1
    • 0029148589 scopus 로고
    • A chromomeric model for nuclear and chromosome structure
    • Cook P.R. A chromomeric model for nuclear and chromosome structure. J. Cell Sci. 108 (1995) 2927-2935
    • (1995) J. Cell Sci. , vol.108 , pp. 2927-2935
    • Cook, P.R.1
  • 2
    • 67649766870 scopus 로고    scopus 로고
    • Transcription factories: gene expression in unions?
    • Sutherland H., and Bickmore W.A. Transcription factories: gene expression in unions?. Nat. Rev. Genet. 10 (2009) 457-466
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 457-466
    • Sutherland, H.1    Bickmore, W.A.2
  • 3
    • 0021708056 scopus 로고
    • A structural analysis of the role of the nuclear matrix and DNA loops in the organization of the nucleus and chromosome
    • Pienta K.J., and Coffey D.S. A structural analysis of the role of the nuclear matrix and DNA loops in the organization of the nucleus and chromosome. J. Cell Sci. Suppl. 1 (1984) 123-135
    • (1984) J. Cell Sci. Suppl. , vol.1 , pp. 123-135
    • Pienta, K.J.1    Coffey, D.S.2
  • 4
    • 33750512774 scopus 로고    scopus 로고
    • Nucleoid organization and the maintenance of DNA integrity in E. coli, B. subtilis and D. radiodurans
    • Frenkiel-Krispin D., and Minsky A. Nucleoid organization and the maintenance of DNA integrity in E. coli, B. subtilis and D. radiodurans. J. Struct. Biol. 156 (2006) 311-319
    • (2006) J. Struct. Biol. , vol.156 , pp. 311-319
    • Frenkiel-Krispin, D.1    Minsky, A.2
  • 5
    • 0035889085 scopus 로고    scopus 로고
    • The concept of self-organization in cellular architecture
    • Misteli T. The concept of self-organization in cellular architecture. J. Cell Biol. 155 (2001) 181-185
    • (2001) J. Cell Biol. , vol.155 , pp. 181-185
    • Misteli, T.1
  • 6
    • 0036842123 scopus 로고    scopus 로고
    • Predicting three-dimensional genome structure from transcriptional activity
    • Cook P.R. Predicting three-dimensional genome structure from transcriptional activity. Nat. Genet. 32 (2002) 347-352
    • (2002) Nat. Genet. , vol.32 , pp. 347-352
    • Cook, P.R.1
  • 7
  • 8
    • 0000105298 scopus 로고
    • The initiation of vaccinia infection
    • Cairns J. The initiation of vaccinia infection. Virology 11 (1960) 603-623
    • (1960) Virology , vol.11 , pp. 603-623
    • Cairns, J.1
  • 10
    • 0027311843 scopus 로고
    • Visualization of replication factories attached to a nucleoskeleton
    • Hozák P., Hassan A.B., Jackson D.A., and Cook P.R. Visualization of replication factories attached to a nucleoskeleton. Cell 73 (1993) 361-373
    • (1993) Cell , vol.73 , pp. 361-373
    • Hozák, P.1    Hassan, A.B.2    Jackson, D.A.3    Cook, P.R.4
  • 11
    • 0027499230 scopus 로고
    • Visualization of focal sites of transcription within human nuclei
    • Jackson D.A., Hassan A.B., Errington R.J., and Cook P.R. Visualization of focal sites of transcription within human nuclei. EMBO J. 12 (1993) 1059-1065
    • (1993) EMBO J. , vol.12 , pp. 1059-1065
    • Jackson, D.A.1    Hassan, A.B.2    Errington, R.J.3    Cook, P.R.4
  • 12
    • 0028308290 scopus 로고
    • Sites in human nuclei where DNA damaged by ultra-violet light is repaired: visualization and localization relative to the nucleoskeleton
    • Jackson D.A., Balajee A.S., Mullenders L., and Cook P.R. Sites in human nuclei where DNA damaged by ultra-violet light is repaired: visualization and localization relative to the nucleoskeleton. J. Cell Sci. 107 (1994) 1745-1752
    • (1994) J. Cell Sci. , vol.107 , pp. 1745-1752
    • Jackson, D.A.1    Balajee, A.S.2    Mullenders, L.3    Cook, P.R.4
  • 13
    • 0033546210 scopus 로고    scopus 로고
    • The organization of replication and transcription
    • Cook P.R. The organization of replication and transcription. Science 284 (1999) 1790-1795
    • (1999) Science , vol.284 , pp. 1790-1795
    • Cook, P.R.1
  • 14
    • 0019830601 scopus 로고
    • RNA is synthesised at the nuclear cage
    • Jackson D.A., McCready S.J., and Cook P.R. RNA is synthesised at the nuclear cage. Nature 292 (1981) 552-555
    • (1981) Nature , vol.292 , pp. 552-555
    • Jackson, D.A.1    McCready, S.J.2    Cook, P.R.3
  • 15
    • 50149109300 scopus 로고    scopus 로고
    • Single-molecule studies of RNA polymerase: motoring along
    • Herbert K.M., Greenleaf W.J., and Block S.M. Single-molecule studies of RNA polymerase: motoring along. Annu. Rev. Biochem. 77 (2008) 149-176
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 149-176
    • Herbert, K.M.1    Greenleaf, W.J.2    Block, S.M.3
  • 16
    • 0035668536 scopus 로고    scopus 로고
    • Making contacts on a nucleic acid polymer
    • Rippe K. Making contacts on a nucleic acid polymer. Trends Biochem. Sci. 26 (2001) 733-740
    • (2001) Trends Biochem. Sci. , vol.26 , pp. 733-740
    • Rippe, K.1
  • 17
    • 33845295824 scopus 로고    scopus 로고
    • The depletion attraction: an underappreciated force driving cellular organization
    • Marenduzzo D., Finan K., and Cook P.R. The depletion attraction: an underappreciated force driving cellular organization. J. Cell Biol. 175 (2006) 681-686
    • (2006) J. Cell Biol. , vol.175 , pp. 681-686
    • Marenduzzo, D.1    Finan, K.2    Cook, P.R.3
  • 19
    • 41949121201 scopus 로고    scopus 로고
    • The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions
    • Jhunjhunwala S., van Zelm M.C., Peak M.M., Cutchin S., Riblet R., van Dongen J.J., et al. The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions. Cell 133 (2008) 265-279
    • (2008) Cell , vol.133 , pp. 265-279
    • Jhunjhunwala, S.1    van Zelm, M.C.2    Peak, M.M.3    Cutchin, S.4    Riblet, R.5    van Dongen, J.J.6
  • 22
    • 0000359208 scopus 로고
    • Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity
    • Hopfield J.J. Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. Proc. Natl Acad. Sci. USA 71 (1974) 4135-4139
    • (1974) Proc. Natl Acad. Sci. USA , vol.71 , pp. 4135-4139
    • Hopfield, J.J.1
  • 23
    • 0037049641 scopus 로고    scopus 로고
    • The transcription cycle of RNA polymerase II in living cells
    • Kimura H., Sugaya K., and Cook P.R. The transcription cycle of RNA polymerase II in living cells. J. Cell Biol. 159 (2002) 777-782
    • (2002) J. Cell Biol. , vol.159 , pp. 777-782
    • Kimura, H.1    Sugaya, K.2    Cook, P.R.3
  • 25
    • 0001436751 scopus 로고    scopus 로고
    • The nucleoid
    • Neidhardt F.C., Curtiss R., Ingraham J.L., Lin E.C.C., Brooks Low K., Magasanik B., Reznifoff W.S., Riley M., Schaechter M., and Umbarger H.E. (Eds), ASM Press, Washington, DC
    • Pettijohn D.E. The nucleoid. In: Neidhardt F.C., Curtiss R., Ingraham J.L., Lin E.C.C., Brooks Low K., Magasanik B., Reznifoff W.S., Riley M., Schaechter M., and Umbarger H.E. (Eds). Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology (1996), ASM Press, Washington, DC 158-166
    • (1996) Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology , pp. 158-166
    • Pettijohn, D.E.1
  • 26
    • 25144495578 scopus 로고    scopus 로고
    • Organization of supercoil domains and their reorganization by transcription
    • Deng S., Stein R.A., and Higgins N.P. Organization of supercoil domains and their reorganization by transcription. Mol. Microbiol. 57 (2005) 1511-1521
    • (2005) Mol. Microbiol. , vol.57 , pp. 1511-1521
    • Deng, S.1    Stein, R.A.2    Higgins, N.P.3
  • 27
    • 33845669025 scopus 로고    scopus 로고
    • Many expressed genes in bacteria and yeast are transcribed only once per cell cycle
    • Bon M., McGowan S.J., and Cook P.R. Many expressed genes in bacteria and yeast are transcribed only once per cell cycle. FASEB J. 20 (2006) 1721-1723
    • (2006) FASEB J. , vol.20 , pp. 1721-1723
    • Bon, M.1    McGowan, S.J.2    Cook, P.R.3
  • 28
    • 0024323320 scopus 로고
    • Transcription mapping of the Escherichia coli chromosome by electron microscopy
    • French S.L., and Miller O.L. Transcription mapping of the Escherichia coli chromosome by electron microscopy. J. Bacteriol. 171 (1989) 4207-4216
    • (1989) J. Bacteriol. , vol.171 , pp. 4207-4216
    • French, S.L.1    Miller, O.L.2
  • 29
    • 33750529760 scopus 로고    scopus 로고
    • Coupling the distribution of RNA polymerase to global gene regulation and the dynamic structure of the bacterial nucleoid in Escherichia coli
    • Jin D.J., and Cabrera J.E. Coupling the distribution of RNA polymerase to global gene regulation and the dynamic structure of the bacterial nucleoid in Escherichia coli. J. Struct. Biol 156 (2006) 284-291
    • (2006) J. Struct. Biol , vol.156 , pp. 284-291
    • Jin, D.J.1    Cabrera, J.E.2
  • 30
    • 34250619055 scopus 로고    scopus 로고
    • Genomic analysis of protein-DNA interactions in bacteria: insights into transcription and chromosome organization
    • Wade J.T., Struhl K., Busby S.J., and Grainger D.C. Genomic analysis of protein-DNA interactions in bacteria: insights into transcription and chromosome organization. Mol. Microbiol. 65 (2007) 21-26
    • (2007) Mol. Microbiol. , vol.65 , pp. 21-26
    • Wade, J.T.1    Struhl, K.2    Busby, S.J.3    Grainger, D.C.4
  • 32
    • 0021699624 scopus 로고
    • Replication and transcription depend on attachment of DNA to the nuclear cage
    • Jackson D.A., McCready S.J., and Cook P.R. Replication and transcription depend on attachment of DNA to the nuclear cage. J. Cell Sci. Suppl. 1 (1984) 59-79
    • (1984) J. Cell Sci. Suppl. , vol.1 , pp. 59-79
    • Jackson, D.A.1    McCready, S.J.2    Cook, P.R.3
  • 33
    • 0018962604 scopus 로고
    • Torsional tension in the DNA double helix measured with trimethylpsoralen in living E. coli cells, analogous measurements in insect and human cells
    • Sinden R.R., Carlson J.O., and Pettijohn D.E. Torsional tension in the DNA double helix measured with trimethylpsoralen in living E. coli cells, analogous measurements in insect and human cells. Cell 21 (1980) 773-783
    • (1980) Cell , vol.21 , pp. 773-783
    • Sinden, R.R.1    Carlson, J.O.2    Pettijohn, D.E.3
  • 34
    • 4444234129 scopus 로고    scopus 로고
    • Visualization of unconstrained negative supercoils of DNA on polytene chromosomes of Drosophila
    • Matsumoto K., and Hirose S. Visualization of unconstrained negative supercoils of DNA on polytene chromosomes of Drosophila. J. Cell Sci. 117 (2004) 3797-3805
    • (2004) J. Cell Sci. , vol.117 , pp. 3797-3805
    • Matsumoto, K.1    Hirose, S.2
  • 35
    • 33847205083 scopus 로고    scopus 로고
    • What are the molecular ties that maintain genomic loops?
    • Marenduzzo D., Faro-Trindade I., and Cook P.R. What are the molecular ties that maintain genomic loops?. Trends Genet. 23 (2007) 126-133
    • (2007) Trends Genet. , vol.23 , pp. 126-133
    • Marenduzzo, D.1    Faro-Trindade, I.2    Cook, P.R.3
  • 36
    • 39049092286 scopus 로고    scopus 로고
    • Beta-globin regulation and long-range interactions
    • Palstra R.J., de Laat W., and Grosveld F. Beta-globin regulation and long-range interactions. Adv. Genet. 61 (2008) 107-142
    • (2008) Adv. Genet. , vol.61 , pp. 107-142
    • Palstra, R.J.1    de Laat, W.2    Grosveld, F.3
  • 37
    • 35648930913 scopus 로고    scopus 로고
    • The role of transcription factories in large-scale structure and dynamics of interphase chromatin
    • Sexton T., Umlauf D., Kurukuti S., and Fraser P. The role of transcription factories in large-scale structure and dynamics of interphase chromatin. Semin. Cell Dev. Biol. 18 (2007) 691-697
    • (2007) Semin. Cell Dev. Biol. , vol.18 , pp. 691-697
    • Sexton, T.1    Umlauf, D.2    Kurukuti, S.3    Fraser, P.4
  • 38
    • 53249124651 scopus 로고    scopus 로고
    • FISH-eyed and genome-wide views on the spatial organisation of gene expression
    • Simonis M., and de Laat W. FISH-eyed and genome-wide views on the spatial organisation of gene expression. Biochim. Biophys. Acta 1783 (2008) 2052-2060
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 2052-2060
    • Simonis, M.1    de Laat, W.2
  • 39
    • 38149133051 scopus 로고    scopus 로고
    • Transcription factories are nuclear subcompartments that remain in the absence of transcription
    • Mitchell J., and Fraser P. Transcription factories are nuclear subcompartments that remain in the absence of transcription. Genes Dev. 22 (2008) 20-25
    • (2008) Genes Dev. , vol.22 , pp. 20-25
    • Mitchell, J.1    Fraser, P.2
  • 40
    • 45749154811 scopus 로고    scopus 로고
    • Maintenance of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription
    • Palstra R.J., Simonis M., Klous P., Brasset E., Eijkelkamp B., and de Laat W. Maintenance of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription. PLoS ONE e1661 (2008) 3
    • (2008) PLoS ONE , vol.e1661 , pp. 3
    • Palstra, R.J.1    Simonis, M.2    Klous, P.3    Brasset, E.4    Eijkelkamp, B.5    de Laat, W.6
  • 41
    • 33746472337 scopus 로고    scopus 로고
    • Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification
    • Cléard F., Moshkin Y., Karch F., and Maeda R. Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification. Nat. Genet 38 (2006) 931-935
    • (2006) Nat. Genet , vol.38 , pp. 931-935
    • Cléard, F.1    Moshkin, Y.2    Karch, F.3    Maeda, R.4
  • 42
  • 43
    • 0033561153 scopus 로고    scopus 로고
    • Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III
    • Pombo A., Jackson D.A., Hollinshead M., Wang Z., Roeder R.G., and Cook P.R. Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III. EMBO J. 18 (1999) 2241-2253
    • (1999) EMBO J. , vol.18 , pp. 2241-2253
    • Pombo, A.1    Jackson, D.A.2    Hollinshead, M.3    Wang, Z.4    Roeder, R.G.5    Cook, P.R.6
  • 44
    • 0031813779 scopus 로고    scopus 로고
    • Numbers and organization of RNA polymerases, nascent transcripts and transcription units in HeLa nuclei
    • Jackson D.A., Iborra F.J., Manders E.M.M., and Cook P.R. Numbers and organization of RNA polymerases, nascent transcripts and transcription units in HeLa nuclei. Mol. Biol. Cell 9 (1998) 1523-1536
    • (1998) Mol. Biol. Cell , vol.9 , pp. 1523-1536
    • Jackson, D.A.1    Iborra, F.J.2    Manders, E.M.M.3    Cook, P.R.4
  • 45
    • 33745632115 scopus 로고    scopus 로고
    • A conserved organization of transcription during embryonic stem cell differentiation and in cells with high C value
    • Faro-Trindade I., and Cook P.R. A conserved organization of transcription during embryonic stem cell differentiation and in cells with high C value. Mol. Biol. Cell 17 (2006) 2910-2920
    • (2006) Mol. Biol. Cell , vol.17 , pp. 2910-2920
    • Faro-Trindade, I.1    Cook, P.R.2
  • 46
    • 47649111278 scopus 로고    scopus 로고
    • RNA polymerase II activity is located on the surface of ∼87 nm protein-rich transcription factories
    • Eskiw C.H., Rapp A., Carter D.R.F., and Cook P.R. RNA polymerase II activity is located on the surface of ∼87 nm protein-rich transcription factories. J. Cell Sci. 121 (2008) 1999-2007
    • (2008) J. Cell Sci. , vol.121 , pp. 1999-2007
    • Eskiw, C.H.1    Rapp, A.2    Carter, D.R.F.3    Cook, P.R.4
  • 47
    • 0028923173 scopus 로고
    • Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells
    • Hozák P., Sasseville A.M.-J., Raymond Y., and Cook P.R. Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells. J. Cell Sci. 108 (1995) 635-644
    • (1995) J. Cell Sci. , vol.108 , pp. 635-644
    • Hozák, P.1    Sasseville, A.M.-J.2    Raymond, Y.3    Cook, P.R.4
  • 48
    • 44149106396 scopus 로고    scopus 로고
    • Similar active genes cluster in specialized transcription factories
    • Xu M., and Cook P.R. Similar active genes cluster in specialized transcription factories. J. Cell Biol. 181 (2008) 615-623
    • (2008) J. Cell Biol. , vol.181 , pp. 615-623
    • Xu, M.1    Cook, P.R.2
  • 49
    • 37249087838 scopus 로고    scopus 로고
    • Coordinate gene regulation during hematopoiesis is related to genomic organization
    • Kosak S.T., Scalzo D., Alworth S.V., Li F., Palmer S., Enver T., et al. Coordinate gene regulation during hematopoiesis is related to genomic organization. PLoS Biol. e309 (2007) 5
    • (2007) PLoS Biol. , vol.e309 , pp. 5
    • Kosak, S.T.1    Scalzo, D.2    Alworth, S.V.3    Li, F.4    Palmer, S.5    Enver, T.6
  • 50
    • 32044450311 scopus 로고    scopus 로고
    • Modeling a self-avoiding chromatin loop: relation to the packing problem, action-at-a-distance, and nuclear context
    • Bon M., Marenduzzo D., and Cook P.R. Modeling a self-avoiding chromatin loop: relation to the packing problem, action-at-a-distance, and nuclear context. Structure 14 (2006) 197-204
    • (2006) Structure , vol.14 , pp. 197-204
    • Bon, M.1    Marenduzzo, D.2    Cook, P.R.3
  • 51
    • 0344897665 scopus 로고    scopus 로고
    • Nongenic transcription, gene regulation and action at a distance
    • Cook P.R. Nongenic transcription, gene regulation and action at a distance. J. Cell Sci. 116 (2003) 4483-4491
    • (2003) J. Cell Sci. , vol.116 , pp. 4483-4491
    • Cook, P.R.1
  • 52
    • 0024334963 scopus 로고
    • An enhancer stimulates transcription in trans when attached to the promoter via a protein bridge
    • Müeller-Storm H., Sogo J., and Schaffner W. An enhancer stimulates transcription in trans when attached to the promoter via a protein bridge. Cell 58 (1989) 767-777
    • (1989) Cell , vol.58 , pp. 767-777
    • Müeller-Storm, H.1    Sogo, J.2    Schaffner, W.3
  • 53
    • 0027267914 scopus 로고
    • Transcriptionally-active minichromosomes are attached transiently in nuclei through transcription units
    • Jackson D.A., and Cook P.R. Transcriptionally-active minichromosomes are attached transiently in nuclei through transcription units. J. Cell Sci. 105 (1993) 1143-1150
    • (1993) J. Cell Sci. , vol.105 , pp. 1143-1150
    • Jackson, D.A.1    Cook, P.R.2
  • 54
    • 43049152845 scopus 로고    scopus 로고
    • Poised RNA polymerase II gives pause for thought
    • Margaritis T., and Holstege F.C. Poised RNA polymerase II gives pause for thought. Cell 133 (2008) 581-584
    • (2008) Cell , vol.133 , pp. 581-584
    • Margaritis, T.1    Holstege, F.C.2
  • 55
    • 0028256471 scopus 로고
    • Site of transcription of ribosomal RNA and intranucleolar structure in HeLa cells
    • Hozák P., Cook P., Schöfer C., Mosgöller W., and Wachtler F. Site of transcription of ribosomal RNA and intranucleolar structure in HeLa cells. J. Cell Sci. 107 (1994) 639-648
    • (1994) J. Cell Sci. , vol.107 , pp. 639-648
    • Hozák, P.1    Cook, P.2    Schöfer, C.3    Mosgöller, W.4    Wachtler, F.5
  • 56
    • 0035986870 scopus 로고    scopus 로고
    • Lampbrush chromosomes and associated bodies: new insights into principles of nuclear structure and function
    • Morgan G.T. Lampbrush chromosomes and associated bodies: new insights into principles of nuclear structure and function. Chromosome Res. 10 (2002) 177-200
    • (2002) Chromosome Res. , vol.10 , pp. 177-200
    • Morgan, G.T.1
  • 57
    • 0031897697 scopus 로고    scopus 로고
    • Assembly of lampbrush chromosomes from sperm chromatin
    • Gall J.G., and Murphy C. Assembly of lampbrush chromosomes from sperm chromatin. Mol. Biol. Cell 9 (1998) 733-747
    • (1998) Mol. Biol. Cell , vol.9 , pp. 733-747
    • Gall, J.G.1    Murphy, C.2
  • 58
    • 70349944662 scopus 로고    scopus 로고
    • Entropic organization of interphase chromosomes
    • Cook P.R., and Marenduzzo D. Entropic organization of interphase chromosomes. J. Cell Biol. 186 (2009) 825-834
    • (2009) J. Cell Biol. , vol.186 , pp. 825-834
    • Cook, P.R.1    Marenduzzo, D.2
  • 59
    • 53249083943 scopus 로고    scopus 로고
    • The role of specialized transcription factories in chromosome pairing
    • Xu M., and Cook P.R. The role of specialized transcription factories in chromosome pairing. Biochem. Biophys. Acta 1783 (2008) 2155-2160
    • (2008) Biochem. Biophys. Acta , vol.1783 , pp. 2155-2160
    • Xu, M.1    Cook, P.R.2
  • 61
    • 0030006048 scopus 로고    scopus 로고
    • The rDNA transcription machinery is assembled during mitosis in active NORs and absent in inactive NORs
    • Roussel P., André C., Comai L., and Hernandez-Verdun D. The rDNA transcription machinery is assembled during mitosis in active NORs and absent in inactive NORs. J. Cell Biol. 133 (1996) 235-246
    • (1996) J. Cell Biol. , vol.133 , pp. 235-246
    • Roussel, P.1    André, C.2    Comai, L.3    Hernandez-Verdun, D.4


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