Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 23, 2012, Pages 8989-8994

  Cowell, Ian G ^a   Sondka, Zbyslaw ^a   Smith, Kayleigh ^a   Lee, Ka Cheong ^a   Manville, Catriona M ^a   Sidorczuk Lesthuruge, Malgorzata ^a   Rance, Holly Ashlene ^a   Padget, Kay ^c   Jackson, Graham Hunter ^b   Adachi, Noritaka ^d   Austin, Caroline A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c NORTHUMBRIA UNIVERSITY   (United Kingdom)

^d YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Acute leukemia; Nuclear organization; TOP2

Indexed keywords

DNA TOPOISOMERASE; ETOPOSIDE; MIXED LINEAGE LEUKEMIA PROTEIN; TOPOISOMERASE II BETA; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DNA STRAND BREAKAGE; GENE CLUSTER; GENE TRANSLOCATION; GENETIC STABILITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

CHROMATIN IMMUNOPRECIPITATION; DNA BREAKS, DOUBLE-STRANDED; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; ETOPOSIDE; FLUORESCENCE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, ACUTE; MICRONUCLEUS TESTS; MODELS, BIOLOGICAL; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NEOPLASMS, SECOND PRIMARY; TRANSLOCATION, GENETIC;

EID: 84861850399     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1204406109     Document Type: Article

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