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Volumn 12, Issue 1, 2010, Pages 8-14

Molecular biology of therapy-related leukaemias

Author keywords

Alkylating agents; Therapy related AML; Topoisomerase

Indexed keywords

ALKYLATING AGENT; CELL DNA; CHLORMETHINE; CYCLOPHOSPHAMIDE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; EARLY GROWTH RESPONSE FACTOR 1; EPIRUBICIN; GYRASE INHIBITOR; MELPHALAN; MITOXANTRONE; MIXED LINEAGE LEUKEMIA PROTEIN; ONCOPROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR RUNX1;

EID: 76049113976     PISSN: 1699048X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12094-010-0460-5     Document Type: Review
Times cited : (35)

References (62)
  • 1
    • 0031978239 scopus 로고    scopus 로고
    • Risk of secondary myeloid leukemia and myelodysplastic syndrome following standard-dose chemotherapy or high-dose chemotherapy with stem cell support in patients with potentially curable malignancies
    • DOI 10.1007/s004320050156
    • C. Kollmannsberger J.T. Hartman L. Kanz C. Bokemeyer 1998 Risk of secondary myeloid leukaemia and myelodysplastic syndrome following standard-dose chemotherapy or high-dose chemotherapy with stem cell support in patients with potentially curable malignancies J Cancer Res Clin Oncol 124 207 214 10.1007/s004320050156 1:CAS:528:DyaK1cXlslOisrw%3D 9619748 (Pubitemid 28216233)
    • (1998) Journal of Cancer Research and Clinical Oncology , vol.124 , Issue.3-4 , pp. 207-214
    • Kollmannsberger, C.1    Hartmann, J.T.2    Kanz, L.3    Bokemeyer, C.4
  • 2
    • 0017708202 scopus 로고
    • Nonrandom chromosomal abnormalities in acute nonlymphocytic leukemia in patients treated for Hodgkin's disease and non-Hodgkin's lymphoma
    • J.D. Rowley H.M. Golomb J.W. Vardiman 1977 Nonrandom chromosomal abnormalities in acute nonlymphocytic leukemia in patients treated for Hodgkin's disease and non-Hodgkin's lymphoma Blood 50 759 770
    • (1977) Blood , vol.50 , pp. 759-770
    • Rowley, J.D.1    Golomb, H.M.2    Vardiman, J.W.3
  • 3
    • 0032752216 scopus 로고    scopus 로고
    • The incidence of secondary leukaemias
    • 1:STN:280:DyaK1MvjvFOnsA%3D%3D 10509043
    • G. Leone M. Luca P. Alessandro, et al. 1999 The incidence of secondary leukaemias Haematologica 84 937 945 1:STN:280:DyaK1MvjvFOnsA%3D%3D 10509043
    • (1999) Haematologica , vol.84 , pp. 937-945
    • Leone, G.1    Luca, M.2    Alessandro, P.3
  • 4
    • 0037085745 scopus 로고    scopus 로고
    • Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia
    • DOI 10.1182/blood.V99.6.1909
    • J. Pedersen-Bjergaard M.K. Andersen D.H. Christiansen C. Nerlov 2002 Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia Blood 99 1909 1912 10.1182/blood.V99.6.1909 1:CAS:528:DC%2BD38XitF2ntrk%3D 11877259 (Pubitemid 34525468)
    • (2002) Blood , vol.99 , Issue.6 , pp. 1909-1912
    • Pedersen-Bjergaard, J.1    Andersen, M.K.2    Christiansen, D.H.3    Nerlov, C.4
  • 5
    • 0032784783 scopus 로고    scopus 로고
    • World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting. Airlie House, Virginia, November 1997
    • 1:STN:280:DC%2BD3c%2FksVyltQ%3D%3D 10577857
    • N.L. Harris E.S. Jaffe J. Diebold, et al. 1999 World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting. Airlie House, Virginia, November 1997 J Clin Oncol 17 3835 3849 1:STN:280:DC%2BD3c%2FksVyltQ%3D%3D 10577857
    • (1999) J Clin Oncol , vol.17 , pp. 3835-3849
    • Harris, N.L.1    Jaffe, E.S.2    Diebold, J.3
  • 6
    • 0036197483 scopus 로고    scopus 로고
    • International Workshop on the relationship of prior therapy to balanced chromosome aberrations in therapy-related myelodysplastic syndromes and acute leukemia: Overview report
    • DOI 10.1002/gcc.10040
    • J.D. Rowley H. Olney 2002 International workshop on the relationship of prior therapy to balanced chromosome aberrations in therapy related myelodysplastic syndromes and acute leukemia: overview report Genes Chromosomes Cancer 33 331 345 10.1002/gcc.10040 11921269 (Pubitemid 34208796)
    • (2002) Genes Chromosomes and Cancer , vol.33 , Issue.4 , pp. 331-345
    • Rowley, J.D.1    Olney, H.J.2
  • 7
    • 0033847847 scopus 로고    scopus 로고
    • Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations
    • DOI 10.1002/1098-2264(2000)9999:9999<::AID-GCC1013>3.0.CO;2-T
    • H.G. Ahuja C.A. Felix P.D. Aplan 2000 Potential role of DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations Genes Chromosomes Cancer 29 96 105 10.1002/1098-2264(2000)9999:9999<::AID- GCC1013>3.0.CO;2-T 1:CAS:528:DC%2BD3cXntVWiurw%3D 10959088 (Pubitemid 30679667)
    • (2000) Genes Chromosomes and Cancer , vol.29 , Issue.2 , pp. 96-105
    • Ahuja, H.G.1    Felix, C.A.2    Aplan, P.D.3
  • 8
    • 39149093029 scopus 로고    scopus 로고
    • Genetics of therapy-related myelodysplasia and acute myeloid leukemia
    • DOI 10.1038/sj.leu.2405078, PII 2405078
    • J. Pedersen-Bjergaard M.K. Andersen M.T. Andersen D.H. Christiansen 2008 Genetics of therapy related myelodysplasia and acute myeloid leukemia Leukemia 22 240 248 10.1038/sj.leu.2405078 1:CAS:528:DC%2BD1cXhvVyltb4%3D 18200041 (Pubitemid 351250527)
    • (2008) Leukemia , vol.22 , Issue.2 , pp. 240-248
    • Pedersen-Bjergaard, J.1    Andersen, M.K.2    Andersen, M.T.3    Christiansen, D.H.4
  • 10
    • 0034084812 scopus 로고    scopus 로고
    • Increase therapy-related leukemia secondary to breast cancer
    • 10.1038/sj.leu.2401787 1:CAS:528:DC%2BD3cXksVCmurg%3D 10865966
    • P.M. Carli C. Sgro N. Parchin-Geneste, et al. 2000 Increase therapy-related leukemia secondary to breast cancer Leukemia 14 1014 1017 10.1038/sj.leu.2401787 1:CAS:528:DC%2BD3cXksVCmurg%3D 10865966
    • (2000) Leukemia , vol.14 , pp. 1014-1017
    • Carli, P.M.1    Sgro, C.2    Parchin-Geneste, N.3
  • 12
    • 61949441174 scopus 로고    scopus 로고
    • Management of acute promyelocytic leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet
    • 10.1182/blood-2008-04-150250 1:CAS:528:DC%2BD1MXivVaqsLY%3D 18812465
    • M.A. Sanz D. Grimwade M.S. Tallman, et al. 2009 Management of acute promyelocytic leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet Blood 113 1875 1891 10.1182/blood-2008-04-150250 1:CAS:528:DC%2BD1MXivVaqsLY%3D 18812465
    • (2009) Blood , vol.113 , pp. 1875-1891
    • Sanz, M.A.1    Grimwade, D.2    Tallman, M.S.3
  • 15
    • 0026178922 scopus 로고
    • Catalytic function of DNA topoisomerase II
    • 10.1002/bies.950130603 1:CAS:528:DyaK3MXltlSgtLk%3D 1654050
    • N. Osheroff L.E. Zechiedrich K.C. Gale 1991 Catalytic function of DNA topoisomerase II BioEssays 13 269 273 10.1002/bies.950130603 1:CAS:528:DyaK3MXltlSgtLk%3D 1654050
    • (1991) BioEssays , vol.13 , pp. 269-273
    • Osheroff, N.1    Zechiedrich, L.E.2    Gale, K.C.3
  • 16
    • 34548391416 scopus 로고    scopus 로고
    • DNA topoisomerase II, genotoxicity, and cancer
    • K. McClendin N. Osheroff 2007 DNA topoisomerase II, genotoxicity, and cancer Mutat Res 623 83 97
    • (2007) Mutat Res , vol.623 , pp. 83-97
    • McClendin, K.1    Osheroff, N.2
  • 17
    • 0032190561 scopus 로고    scopus 로고
    • Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme
    • 1:CAS:528:DyaK1cXmtFWisrg%3D 9748545
    • A. Burden N. Osheroff 1998 Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme Biochim Biophys Acta 1400 139 154 1:CAS:528:DyaK1cXmtFWisrg%3D 9748545
    • (1998) Biochim Biophys Acta , vol.1400 , pp. 139-154
    • Burden, A.1    Osheroff, N.2
  • 18
    • 0025647116 scopus 로고
    • Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers
    • 1:CAS:528:DyaK3MXnslGrtQ%3D%3D 2176156
    • E.L. Zechiedrich N. Osheroff 1990 Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers EMBO J 9 4555 4562 1:CAS:528:DyaK3MXnslGrtQ%3D%3D 2176156
    • (1990) EMBO J , vol.9 , pp. 4555-4562
    • Zechiedrich, E.L.1    Osheroff, N.2
  • 19
    • 0023746243 scopus 로고
    • Flexibility of DNA
    • 10.1146/annurev.bb.17.060188.001405 1:CAS:528:DyaL1cXltVKmtbw%3D
    • P.J. Hagerman 1988 Flexibility of DNA Annu Rev Biophys Chem 17 265 286 10.1146/annurev.bb.17.060188.001405 1:CAS:528:DyaL1cXltVKmtbw%3D
    • (1988) Annu Rev Biophys Chem , vol.17 , pp. 265-286
    • Hagerman, P.J.1
  • 20
    • 0023902435 scopus 로고
    • A consensus sequence for cleavage by vertebrate DNA topoisomerase II
    • 10.1093/nar/16.12.5533 1:CAS:528:DyaL1cXlt1Crtb4%3D 2838820
    • J.R. Spitzner M.T. Muller 1988 A consensus sequence for cleavage by vertebrate DNA topoisomerase II Nucleic Acids Res 16 5533 5556 10.1093/nar/16.12.5533 1:CAS:528:DyaL1cXlt1Crtb4%3D 2838820
    • (1988) Nucleic Acids Res , vol.16 , pp. 5533-5556
    • Spitzner, J.R.1    Muller, M.T.2
  • 21
    • 63349086953 scopus 로고    scopus 로고
    • The DNA cleavage reaction of topoisomerase II: Wolf in sheep's clothing
    • 10.1093/nar/gkn937 19042970
    • J.E. Deweese N. Osheroff 2008 The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing Nucleic Acids Res 37 738 748 10.1093/nar/gkn937 19042970
    • (2008) Nucleic Acids Res , vol.37 , pp. 738-748
    • Deweese, J.E.1    Osheroff, N.2
  • 22
    • 61449115991 scopus 로고    scopus 로고
    • DNA topology and topoisomerases: Teaching a knotty subject
    • 10.1002/bmb.20244 1:CAS:528:DC%2BD1MXhs1Kms7s%3D
    • J.E. Deweese M.A. Osheroff N. Osheroff 2009 DNA topology and topoisomerases: teaching a knotty subject Biochem Mol Biol Educ 37 2 10 10.1002/bmb.20244 1:CAS:528:DC%2BD1MXhs1Kms7s%3D
    • (2009) Biochem Mol Biol Educ , vol.37 , pp. 2-10
    • Deweese, J.E.1    Osheroff, M.A.2    Osheroff, N.3
  • 23
    • 0032189963 scopus 로고    scopus 로고
    • Mutagenetic properties of topoisomerase-targeted drugs
    • 1:CAS:528:DyaK1cXmtFWis7g%3D 9748584
    • B.C. Baguley L.R. Ferguson 1998 Mutagenetic properties of topoisomerase-targeted drugs Biochim Biophys Acta 1400 213 222 1:CAS:528:DyaK1cXmtFWis7g%3D 9748584
    • (1998) Biochim Biophys Acta , vol.1400 , pp. 213-222
    • Baguley, B.C.1    Ferguson, L.R.2
  • 24
    • 0021099691 scopus 로고
    • Double strand DNA cleavage by type ll DNA topoisomerase from Drosophila melanogaster
    • M. Sander T. Hsieh 1982 Double strand DNA cleavage by type ll DNA topoisomerase from Drosophila melanogaster J Biol Chem 285 8421 8428
    • (1982) J Biol Chem , vol.285 , pp. 8421-8428
    • Sander, M.1    Hsieh, T.2
  • 25
    • 0023807667 scopus 로고
    • Single-strand DNA cleavages by eukaryotic topoisomerase II
    • DOI 10.1021/bi00422a012
    • B.U. Muller J.R. Spitzner J.A. DiDonato, et al. 1988 Single-strand DNA cleaves by eukaryotic topoisomerase ll Biochemistry 27 8369 8379 10.1021/bi00422a012 1:CAS:528:DyaL1cXlvVKjs7g%3D 2853964 (Pubitemid 18262756)
    • (1988) Biochemistry , vol.27 , Issue.22 , pp. 8369-8379
    • Muller, M.T.1    Spitzner, J.R.2    DiDonato, J.A.3    Mehta, V.B.4    Tsutsui, K.5    Tsutsui, K.6
  • 26
    • 0021112878 scopus 로고
    • Cleavage of DNA by mammalian DNA topoisomerase ll
    • 1:CAS:528:DyaL3sXmtVylurw%3D 6317692
    • L.F. Liu T.C. Rowe L. Yang, et al. 1983 Cleavage of DNA by mammalian DNA topoisomerase ll J Biol Chem 258 15365 15370 1:CAS:528:DyaL3sXmtVylurw%3D 6317692
    • (1983) J Biol Chem , vol.258 , pp. 15365-15370
    • Liu, L.F.1    Rowe, T.C.2    Yang, L.3
  • 27
    • 0035056832 scopus 로고    scopus 로고
    • Leukemias related to treatment with DNA topoisomerase II inhibitors
    • DOI 10.1002/mpo.1125
    • C.A. Felix 2001 Leukemias related to treatment with DNA topoisomerase II inhibitors Med Pediatr Oncol 36 525 535 10.1002/mpo.1125 1:STN:280: DC%2BD3MzgvFGitA%3D%3D 11340607 (Pubitemid 32336557)
    • (2001) Medical and Pediatric Oncology , vol.36 , Issue.5 , pp. 525-535
    • Felix, C.A.1
  • 28
    • 28944450748 scopus 로고    scopus 로고
    • Mechanisms of therapy related carcinogenesis
    • 1:CAS:528:DC%2BD2MXht1ykurbJ
    • J.M. Allan L.B. Travis 2005 Mechanisms of therapy related carcinogenesis Nat Rev 5 943 955 1:CAS:528:DC%2BD2MXht1ykurbJ
    • (2005) Nat Rev , vol.5 , pp. 943-955
    • Allan, J.M.1    Travis, L.B.2
  • 30
    • 0037105525 scopus 로고    scopus 로고
    • Transcription of AML1/ETO in bone marrow and cord blood of individuals without acute myelogenous leukemia [2]
    • DOI 10.1182/blood-2002-06-1673
    • J. Basecke L. Cepek C. Mannhalter, et al. 2002 Transcription of AML1/ETO in bone marrow and cord blood of individuals without acute myelogenous leukemia Blood 100 2267 2268 10.1182/blood-2002-06-1673 1:CAS:528:DC%2BD38Xnt1yhtro%3D 12229881 (Pubitemid 35001270)
    • (2002) Blood , vol.100 , Issue.6 , pp. 2267-2268
    • Basecke, J.1    Cepek, L.2    Mannhalter, C.3    Krauter, J.4    Hildenhagen, S.5    Brittinger, G.6    Trumper, L.7    Griesinger, F.8
  • 31
    • 0031011855 scopus 로고    scopus 로고
    • DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis
    • 1:CAS:528:DyaK2sXktFOhurc%3D 9199342
    • M. Stanulla J. Wang D.S. Chervinsky, et al. 1997 DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis Mol Cell Biol 17 4070 4079 1:CAS:528:DyaK2sXktFOhurc%3D 9199342
    • (1997) Mol Cell Biol , vol.17 , pp. 4070-4079
    • Stanulla, M.1    Wang, J.2    Chervinsky, D.S.3
  • 32
    • 0035360796 scopus 로고    scopus 로고
    • Apoptotic triggers initiate translocations within the MLL gene involving non-homologous end joining repair system
    • 1:CAS:528:DC%2BD3MXktlWjsLw%3D 11389089
    • C.J. Betti M.J. Villalobos M.O. Diaz A.T. Vaughan 2001 Apoptotic triggers initiate translocations within the MLL gene involving non-homologous end joining repair system Cancer Res 61 4550 4555 1:CAS:528:DC%2BD3MXktlWjsLw%3D 11389089
    • (2001) Cancer Res , vol.61 , pp. 4550-4555
    • Betti, C.J.1    Villalobos, M.J.2    Diaz, M.O.3    Vaughan, A.T.4
  • 33
    • 0035943687 scopus 로고    scopus 로고
    • Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis
    • 10.1074/jbc.M103962200 1:CAS:528:DC%2BD3MXms1Snu70%3D 11406628
    • S.P. Sim L.F. Liu 2001 Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis J Biol Chem 276 31590 31595 10.1074/jbc.M103962200 1:CAS:528:DC%2BD3MXms1Snu70%3D 11406628
    • (2001) J Biol Chem , vol.276 , pp. 31590-31595
    • Sim, S.P.1    Liu, L.F.2
  • 34
    • 0037444282 scopus 로고    scopus 로고
    • Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of division
    • 1:CAS:528:DC%2BD3sXit1Sgurs%3D 12649202
    • C.J. Betti M.J. Villalobos M.O. Diaz A.T. Vaughan 2003 Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of division Cancer Res 63 1377 1381 1:CAS:528:DC%2BD3sXit1Sgurs%3D 12649202
    • (2003) Cancer Res , vol.63 , pp. 1377-1381
    • Betti, C.J.1    Villalobos, M.J.2    Diaz, M.O.3    Vaughan, A.T.4
  • 35
    • 33747892853 scopus 로고    scopus 로고
    • Topoisomerase II and the etiology of chromosomal translocations
    • DOI 10.1016/j.dnarep.2006.05.031, PII S1568786406001716, Mechanisms of Chromosomal Translocations
    • C.A. Felix C.P. Kolaris N. Osheroff 2006 Topoisomerase II and the etiology of chromosomal translocations DNA Repair (Amst) 5 1093 1108 10.1016/j.dnarep.2006.05.031 1:CAS:528:DC%2BD28XptFSrtr8%3D (Pubitemid 44291622)
    • (2006) DNA Repair , vol.5 , Issue.9-10 , pp. 1093-1108
    • Felix, C.A.1    Kolaris, C.P.2    Osheroff, N.3
  • 38
    • 0346753588 scopus 로고    scopus 로고
    • Reciprocal DNA topoisomerase II cleavage events at 5′-TATTA- 3′ sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing
    • DOI 10.1038/sj.onc.1207052
    • R.J. Whitmarsh C. Saginario Y. Zhuo, et al. 2003 Reciprocal DNA topoisomerase II cleavage events at 5′-TATTA-3′ sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing Oncogene 22 8448 8459 10.1038/sj.onc.1207052 1:CAS:528: DC%2BD3sXptVOrtL8%3D 14627986 (Pubitemid 37523897)
    • (2003) Oncogene , vol.22 , Issue.52 , pp. 8448-8459
    • Whitmarsh, R.J.1    Saginario, C.2    Zhuo, Y.3    Hilgenfeld, E.4    Rappaport, E.F.5    Megonigal, M.D.6    Carroll, M.7    Liu, M.8    Osheroff, N.9    Cheung, N.-K.V.10    Slater, D.J.11    Ried, T.12    Knutsen, T.13    Blair, I.A.14    Felix, C.A.15
  • 40
    • 0033628701 scopus 로고    scopus 로고
    • Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice
    • 10.1016/S0079-6603(00)64006-0 1:CAS:528:DC%2BD3cXivVCnsLw%3D 10697411
    • J.M. Fortune N. Osheroff 2000 Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice Prog Nucleic Acid Res Mol Biol 64 221 253 10.1016/S0079-6603(00)64006-0 1:CAS:528:DC%2BD3cXivVCnsLw%3D 10697411
    • (2000) Prog Nucleic Acid Res Mol Biol , vol.64 , pp. 221-253
    • Fortune, J.M.1    Osheroff, N.2
  • 41
    • 54049153246 scopus 로고    scopus 로고
    • Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis
    • 10.1182/blood-2007-10-115600 1:CAS:528:DC%2BD1cXht1Omur3L 18650449
    • S.K. Hasan A.N. Mays T. Ottone, et al. 2008 Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis Blood 112 3383 3390 10.1182/blood-2007-10- 115600 1:CAS:528:DC%2BD1cXht1Omur3L 18650449
    • (2008) Blood , vol.112 , pp. 3383-3390
    • Hasan, S.K.1    Mays, A.N.2    Ottone, T.3
  • 42
    • 76049123781 scopus 로고    scopus 로고
    • Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia
    • [Epub ahead of print]
    • Mays AN, Osheroff N, Xiao Y et al (2009) Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood [Epub ahead of print]
    • (2009) Blood
    • Mays, A.N.1    Osheroff, N.2    Xiao, Y.3
  • 44
    • 0023264243 scopus 로고
    • Risk of therapy-related leukaemia and preleukaemia after Hodgkins disease. Relation to age, cumulative dose of alkylating agents and time from chemotherapy
    • 10.1016/S0140-6736(87)92744-9 1:STN:280:DyaL2s3ls1GjtA%3D%3D 2885581
    • J. Pedersen-Bjergaard L. Specht S.O. Larsen, et al. 1987 Risk of therapy-related leukaemia and preleukaemia after Hodgkins disease. Relation to age, cumulative dose of alkylating agents and time from chemotherapy Lancet 2 83 88 10.1016/S0140-6736(87)92744-9 1:STN:280:DyaL2s3ls1GjtA%3D%3D 2885581
    • (1987) Lancet , vol.2 , pp. 83-88
    • Pedersen-Bjergaard, J.1    Specht, L.2    Larsen, S.O.3
  • 45
    • 0022399410 scopus 로고
    • Mechanisms of carcinogenesis induced by alkylating agents
    • 1:CAS:528:DyaL28Xhs1Wgsg%3D%3D 3907708
    • R. Saffhill G.P. Margison P.J. O'Connor 1985 Mechanisms of carcinogenesis induced by alkylating agents Biochim Biophys Acta 823 111 145 1:CAS:528:DyaL28Xhs1Wgsg%3D%3D 3907708
    • (1985) Biochim Biophys Acta , vol.823 , pp. 111-145
    • Saffhill, R.1    Margison, G.P.2    O'Connor, P.J.3
  • 46
    • 0035064546 scopus 로고    scopus 로고
    • Therapy-related leukemia associated with alkylating agents
    • DOI 10.1002/mpo.1126
    • S.M. Davis 2001 Therapy-related leukemia associated with alkylating agents Med Paediatr Oncol 36 536 540 10.1002/mpo.1126 (Pubitemid 32336558)
    • (2001) Medical and Pediatric Oncology , vol.36 , Issue.5 , pp. 536-540
    • Davies, S.M.1
  • 47
    • 33645018128 scopus 로고    scopus 로고
    • Deregulation of homologous recombination DNA repair in alkylating agent-treated stem cell clones: A possible role in the aetiology of chemotherapy-induced leukaemia
    • 10.1038/sj.onc.1209208 1:CAS:528:DC%2BD28XitlKntbs%3D 16278672
    • L.J. Worrillow J.M. Allan 2006 Deregulation of homologous recombination DNA repair in alkylating agent-treated stem cell clones: a possible role in the aetiology of chemotherapy-induced leukaemia Oncogene 25 1709 1720 10.1038/sj.onc.1209208 1:CAS:528:DC%2BD28XitlKntbs%3D 16278672
    • (2006) Oncogene , vol.25 , pp. 1709-1720
    • Worrillow, L.J.1    Allan, J.M.2
  • 48
    • 0001253917 scopus 로고
    • The reaction of mono- and di-functional alkylating agents with nucleic acids
    • P. Brooks P.D. Lawley 1961 The reaction of mono- and di-functional alkylating agents with nucleic acids Biochem J 80 496 503
    • (1961) Biochem J , vol.80 , pp. 496-503
    • Brooks, P.1    Lawley, P.D.2
  • 49
    • 0029762815 scopus 로고    scopus 로고
    • DNA repair: Enzymatic mechanism and relevance to drug response
    • 10.1093/jnci/88.19.1346 1:CAS:528:DyaK28XmsFOkt7k%3D 8827012
    • S.G. Chaney A. Sancar 1996 DNA repair: enzymatic mechanism and relevance to drug response J Natl Cancer Inst 88 1346 1360 10.1093/jnci/88.19.1346 1:CAS:528:DyaK28XmsFOkt7k%3D 8827012
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1346-1360
    • Chaney, S.G.1    Sancar, A.2
  • 51
    • 0035032231 scopus 로고    scopus 로고
    • Biology and therapy of secondary leukaemias
    • DOI 10.1053/beha.2000.0119
    • E.J. Dann R.M. Rowe 2001 Biology and therapy of secondary leukaemias Best Pract Res Clin Haematol 14 119 137 10.1053/beha.2000.0119 1:CAS:528: DC%2BD38XhvFagtg%3D%3D 11355927 (Pubitemid 32372403)
    • (2001) Best Practice and Research in Clinical Haematology , vol.14 , Issue.1 , pp. 119-137
    • Dann, E.J.1    Rowe, J.M.2
  • 52
    • 0016434094 scopus 로고
    • Multiple myeloma and acute leukaemia associated with alkylating agents
    • 10.1001/archinte.135.1.185 1:STN:280:DyaE2M%2FovFKiuw%3D%3D 1053891
    • R.A. Kyle R.V. Pierre E.D. Bayrd 1975 Multiple myeloma and acute leukaemia associated with alkylating agents Arch Intern Med 135 185 192 10.1001/archinte.135.1.185 1:STN:280:DyaE2M%2FovFKiuw%3D%3D 1053891
    • (1975) Arch Intern Med , vol.135 , pp. 185-192
    • Kyle, R.A.1    Pierre, R.V.2    Bayrd, E.D.3
  • 53
    • 0942289903 scopus 로고    scopus 로고
    • Human mismatch repair, drug-induced DNA damage, and secondary cancer
    • DOI 10.1016/j.biochi.2003.10.007
    • P. Karran J. Offman M. Bignami 2003 Human mismatch repair, drug-induced DNA damage, and secondary cancer Biochemie 85 1149 1160 10.1016/j.biochi.2003. 10.007 1:CAS:528:DC%2BD2cXjsVyqsg%3D%3D (Pubitemid 38142368)
    • (2003) Biochimie , vol.85 , Issue.11 , pp. 1149-1160
    • Karran, P.1    Offman, J.2    Bignami, M.3
  • 54
    • 0029929429 scopus 로고    scopus 로고
    • The secondary leukemias: Challenges and research directions
    • DOI 10.1093/jnci/88.7.407
    • M.A. Smith R.P. McCaffrey J.E. Karp 1996 The secondary leukaemias: challenges and research directions J Natl Cancer Inst 88 407 413 10.1093/jnci/88.7.407 1:STN:280:DyaK287nslyqsg%3D%3D 8618232 (Pubitemid 26097057)
    • (1996) Journal of the National Cancer Institute , vol.88 , Issue.7 , pp. 407-418
    • Smith, M.A.1    McCaffrey, R.P.2    Karp, J.E.3
  • 55
    • 67650859652 scopus 로고    scopus 로고
    • Deletion 5q in myelodysplastic syndrome: A paradigm for the study of hemizygous deletions in cancer
    • 10.1038/leu.2009.53 1:CAS:528:DC%2BD1MXoslOhs7o%3D 19322210
    • B.L. Ebert 2009 Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer Leukemia 23 1252 1256 10.1038/leu.2009.53 1:CAS:528:DC%2BD1MXoslOhs7o%3D 19322210
    • (2009) Leukemia , vol.23 , pp. 1252-1256
    • Ebert, B.L.1
  • 57
    • 38349088899 scopus 로고    scopus 로고
    • Identification of RPS14 as a 5q-syndrome gene by RNA interference screen
    • 10.1038/nature06494 1:CAS:528:DC%2BD1cXnt1Gjtw%3D%3D 18202658
    • B.L. Ebert J. Pretz J. Bosco, et al. 2008 Identification of RPS14 as a 5q-syndrome gene by RNA interference screen Nature 451 335 339 10.1038/nature06494 1:CAS:528:DC%2BD1cXnt1Gjtw%3D%3D 18202658
    • (2008) Nature , vol.451 , pp. 335-339
    • Ebert, B.L.1    Pretz, J.2    Bosco, J.3
  • 58
    • 76049097120 scopus 로고    scopus 로고
    • Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype
    • [Epub ahead of print]
    • Starczynowski DT, Kuchenbauer F, Argiropoulos B et al (2009) Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype. Nat Med [Epub ahead of print]
    • (2009) Nat Med
    • Starczynowski, D.T.1    Kuchenbauer, F.2    Argiropoulos, B.3
  • 59
    • 0035281739 scopus 로고    scopus 로고
    • Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukaemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype and poor prognosis
    • 1:CAS:528:DC%2BD3MXit1ertL8%3D 11230485
    • D.H. Christiansen M.K. Andersen J. Pedersen-Bjergaard 2001 Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukaemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype and poor prognosis J Clin Oncol 19 1405 1413 1:CAS:528:DC%2BD3MXit1ertL8%3D 11230485
    • (2001) J Clin Oncol , vol.19 , pp. 1405-1413
    • Christiansen, D.H.1    Andersen, M.K.2    Pedersen-Bjergaard, J.3
  • 60
    • 0026079804 scopus 로고
    • Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia
    • 1:STN:280:DyaK38%2FkvFKiuw%3D%3D 1944468
    • C.H. Pui C. Riberio M.L. Hancock, et al. 1991 Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia N Engl J Med 325 1682 1687 1:STN:280:DyaK38%2FkvFKiuw%3D%3D 1944468
    • (1991) N Engl J Med , vol.325 , pp. 1682-1687
    • Pui, C.H.1    Riberio, C.2    Hancock, M.L.3
  • 62
    • 34249275300 scopus 로고    scopus 로고
    • Advances in the understanding of susceptibility to treatment-related acute myeloid leukaemia
    • DOI 10.1111/j.1365-2141.2007.06613.x
    • C. Seedhouse N. Russell 2007 Advances in the understanding of susceptibility to treatment-related acute myeloid leukaemia Br J Haematol 137 513 529 10.1111/j.1365-2141.2007.06613.x 1:CAS:528:DC%2BD2sXot1KqsLw%3D 17539774 (Pubitemid 46817341)
    • (2007) British Journal of Haematology , vol.137 , Issue.6 , pp. 513-529
    • Seedhouse, C.1    Russell, N.2


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