메뉴 건너뛰기




Volumn 66, Issue 2, 2014, Pages 231-241

The interleukin-23/interleukin-17 axis in spondyloarthritis pathogenesis: Th17 and beyond

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; CASPASE RECRUITMENT DOMAIN PROTEIN 9; CD4 ANTIGEN; HLA B27 ANTIGEN; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 27; INTERLEUKIN 6 RECEPTOR; PROTEIN KINASE TYK2; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 84896285523     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38291     Document Type: Review
Times cited : (191)

References (132)
  • 1
    • 79959359494 scopus 로고    scopus 로고
    • Spondyloarthritis
    • Dougados M, Baeten D. Spondyloarthritis. Lancet 2011;377: 2127-37.
    • (2011) Lancet , vol.377 , pp. 2127-2137
    • Dougados, M.1    Baeten, D.2
  • 2
    • 84863191813 scopus 로고    scopus 로고
    • Prevalence of axial spondylarthritis in the United States: Estimates from a crosssectional survey
    • Reveille JD, Witter JP, Weisman MH. Prevalence of axial spondylarthritis in the United States: estimates from a crosssectional survey. Arthritis Care Res (Hoboken) 2012;64: 905-10.
    • (2012) Arthritis Care Res (Hoboken) , vol.64 , pp. 905-910
    • Reveille, J.D.1    Witter, J.P.2    Weisman, M.H.3
  • 3
    • 0021272107 scopus 로고
    • Evaluation of diagnostic criteria for ankylosing spondylitis: A proposal for modification of the New York criteria
    • Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum 1984;27: 361-8.
    • (1984) Arthritis Rheum , vol.27 , pp. 361-368
    • Van Der Linden, S.1    Valkenburg, H.A.2    Cats, A.3
  • 4
    • 78650679234 scopus 로고    scopus 로고
    • The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general
    • Rudwaleit M, van der Heijde D, Landewe R, Akkoc N, Brandt J, Chou CT, et al. The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis 2011;70: 25-31.
    • (2011) Ann Rheum Dis , vol.70 , pp. 25-31
    • Rudwaleit, M.1    Van Der Heijde, D.2    Landewe, R.3    Akkoc, N.4    Brandt, J.5    Chou, C.T.6
  • 5
    • 67449128733 scopus 로고    scopus 로고
    • The development of Assessment of Spondylo-Arthritis international Society classification criteria for axial spondyloarthritis (part II): Validation and final selection
    • Rudwaleit M, van der Heijde D, Landewe R, Listing J, Akkoc N, Brandt J, et al. The development of Assessment of Spondylo-Arthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis 2009;68: 777-83.
    • (2009) Ann Rheum Dis , vol.68 , pp. 777-783
    • Rudwaleit, M.1    Van Der Heijde, D.2    Landewe, R.3    Listing, J.4    Akkoc, N.5    Brandt, J.6
  • 6
    • 84860572793 scopus 로고    scopus 로고
    • Developments in therapies for spondyloarthritis
    • Sieper J. Developments in therapies for spondyloarthritis. Nat Rev Rheumatol 2012;8: 280-7.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 280-287
    • Sieper, J.1
  • 7
    • 84861837660 scopus 로고    scopus 로고
    • Motion for debate: The development of ankylosis in ankylosing spondylitis is largely dependent on inflammation
    • Maksymowych WP, Elewaut D, Schett G. Motion for debate: the development of ankylosis in ankylosing spondylitis is largely dependent on inflammation. Arthritis Rheum 2012;64: 1713-9.
    • (2012) Arthritis Rheum , vol.64 , pp. 1713-1719
    • Maksymowych, W.P.1    Elewaut, D.2    Schett, G.3
  • 8
    • 84885126123 scopus 로고    scopus 로고
    • The impact of tumor necrosis factor - Inhibitors on radiographic progression in ankylosing spondylitis
    • Haroon N, Inman RD, Learch TJ, Weisman MH, Lee M, Rahbar MH, et al. The impact of tumor necrosis factor - inhibitors on radiographic progression in ankylosing spondylitis. Arthritis Rheum 2013;65: 2645-54.
    • (2013) Arthritis Rheum , vol.65 , pp. 2645-2654
    • Haroon, N.1    Inman, R.D.2    Learch, T.J.3    Weisman, M.H.4    Lee, M.5    Rahbar, M.H.6
  • 9
    • 69349093225 scopus 로고    scopus 로고
    • Interleukin-17 and type 17 helper T cells
    • Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med 2009;361: 888-98.
    • (2009) N Engl J Med , vol.361 , pp. 888-898
    • Miossec, P.1    Korn, T.2    Kuchroo, V.K.3
  • 10
    • 77954143695 scopus 로고    scopus 로고
    • Innate IL-17-producing cells: The sentinels of the immune system
    • Cua DJ, Tato CM. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol 2010;10: 479-89.
    • (2010) Nat Rev Immunol , vol.10 , pp. 479-489
    • Cua, D.J.1    Tato, C.M.2
  • 11
    • 84866934694 scopus 로고    scopus 로고
    • Targeting IL-17 and TH17 cells in chronic inflammation
    • Miossec P, Kolls JK. Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Disc 2012;11: 763-76.
    • (2012) Nat Rev Drug Disc , vol.11 , pp. 763-776
    • Miossec, P.1    Kolls, J.K.2
  • 12
    • 84873635866 scopus 로고    scopus 로고
    • Th17 cell development: From the cradle to the grave
    • Zuniga LA, Jain R, Haines C, Cua DJ. Th17 cell development: from the cradle to the grave. Immunol Rev 2013;252: 78-88.
    • (2013) Immunol Rev , vol.252 , pp. 78-88
    • Zuniga, L.A.1    Jain, R.2    Haines, C.3    Cua, D.J.4
  • 13
    • 35748981184 scopus 로고    scopus 로고
    • Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    • Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007;39: 1329-37.
    • (2007) Nat Genet , vol.39 , pp. 1329-1337
    • Burton, P.R.1    Clayton, D.G.2    Cardon, L.R.3    Craddock, N.4    Deloukas, P.5    Duncanson, A.6
  • 14
    • 75749085686 scopus 로고    scopus 로고
    • Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
    • Reveille JD, Sims AM, Danoy P, Evans DM, Leo P, Pointon JJ, et al. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet 2010;42: 123-7.
    • (2010) Nat Genet , vol.42 , pp. 123-127
    • Reveille, J.D.1    Sims, A.M.2    Danoy, P.3    Evans, D.M.4    Leo, P.5    Pointon, J.J.6
  • 15
    • 79960899377 scopus 로고    scopus 로고
    • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
    • Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G, et al. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet 2011;43: 761-7.
    • (2011) Nat Genet , vol.43 , pp. 761-767
    • Evans, D.M.1    Spencer, C.C.2    Pointon, J.J.3    Su, Z.4    Harvey, D.5    Kochan, G.6
  • 16
    • 84879691837 scopus 로고    scopus 로고
    • Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
    • International Genetics of Ankylosing Spondylitis Consortium (IGAS)
    • International Genetics of Ankylosing Spondylitis Consortium (IGAS), Cortes A, Hadler J, Pointon JP, Robinson PC, Karaderi T, et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet 2013;45: 730-8.
    • (2013) Nat Genet , vol.45 , pp. 730-738
    • Cortes, A.1    Hadler, J.2    Pointon, J.P.3    Robinson, P.C.4    Karaderi, T.5
  • 17
    • 69449086287 scopus 로고    scopus 로고
    • HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats
    • DeLay ML, Turner MJ, Klenk EI, Smith JA, Sowders DP, Colbert RA. HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheum 2009;60: 2633-43.
    • (2009) Arthritis Rheum , vol.60 , pp. 2633-2643
    • Delay, M.L.1    Turner, M.J.2    Klenk, E.I.3    Smith, J.A.4    Sowders, D.P.5    Colbert, R.A.6
  • 18
    • 84855254473 scopus 로고    scopus 로고
    • Proinflammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritis-prone HLA-B27-transgenic rats
    • Glatigny S, Fert I, Blaton MA, Lories RJ, Araujo LM, Chiocchia G, et al. Proinflammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritis-prone HLA-B27-transgenic rats. Arthritis Rheum 2012;64: 110-20.
    • (2012) Arthritis Rheum , vol.64 , pp. 110-120
    • Glatigny, S.1    Fert, I.2    Blaton, M.A.3    Lories, R.J.4    Araujo, L.M.5    Chiocchia, G.6
  • 19
    • 84863697312 scopus 로고    scopus 로고
    • IL-23 induces spondyloarthropathy by acting on ROR - CD3-CD4-CD8- entheseal resident T cells
    • Sherlock JP, Joyce-Shaikh B, Turner SP, Chao CC, Sathe M, Grein J, et al. IL-23 induces spondyloarthropathy by acting on ROR - CD3-CD4-CD8- entheseal resident T cells. Nat Med 2012;18: 1069-76.
    • (2012) Nat Med , vol.18 , pp. 1069-1076
    • Sherlock, J.P.1    Joyce-Shaikh, B.2    Turner, S.P.3    Chao, C.C.4    Sathe, M.5    Grein, J.6
  • 21
    • 79951835541 scopus 로고    scopus 로고
    • Th17 cells expressing KIR3DL2- and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis
    • Bowness P, Ridley A, Shaw J, Chan AT, Wong-Baeza I, Fleming M, et al. Th17 cells expressing KIR3DL2- and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis. J Immunol 2011;186: 2672-80.
    • (2011) J Immunol , vol.186 , pp. 2672-2680
    • Bowness, P.1    Ridley, A.2    Shaw, J.3    Chan, A.T.4    Wong-Baeza, I.5    Fleming, M.6
  • 22
    • 79959207913 scopus 로고    scopus 로고
    • Analysis of IL-17- cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response
    • Appel H, Maier R, Wu P, Scheer R, Hempfing A, Kayser R, et al. Analysis of IL-17- cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther 2011;13:R95.
    • (2011) Arthritis Res Ther , vol.13
    • Appel, H.1    Maier, R.2    Wu, P.3    Scheer, R.4    Hempfing, A.5    Kayser, R.6
  • 23
    • 84878527072 scopus 로고    scopus 로고
    • In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis
    • Appel H, Maier R, Bleil J, Hempfing A, Loddenkemper C, Schlichting U, et al. In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis. Arthritis Rheum 2013;65: 1522-9.
    • (2013) Arthritis Rheum , vol.65 , pp. 1522-1529
    • Appel, H.1    Maier, R.2    Bleil, J.3    Hempfing, A.4    Loddenkemper, C.5    Schlichting, U.6
  • 25
    • 84887992906 scopus 로고    scopus 로고
    • Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: A randomised, double-blind, placebo-controlled trial
    • Baeten D, Baraliakos X, Braun J, Sieper J, Emery P, van der Heijde D, et al. Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial. Lancet 2013; 382: 1705-13.
    • (2013) Lancet , vol.382 , pp. 1705-1713
    • Baeten, D.1    Baraliakos, X.2    Braun, J.3    Sieper, J.4    Emery, P.5    Van Der Heijde, D.6
  • 26
    • 47049123836 scopus 로고    scopus 로고
    • The interleukin-23/interleukin-17 axis in spondyloarthritis
    • Layh-Schmitt G, Colbert RA. The interleukin-23/interleukin-17 axis in spondyloarthritis. Curr Opin Rheumatol 2008;20: 392-7.
    • (2008) Curr Opin Rheumatol , vol.20 , pp. 392-397
    • Layh-Schmitt, G.1    Colbert, R.A.2
  • 27
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003;278: 1910-4.
    • (2003) J Biol Chem , vol.278 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    De Sauvage, F.J.4    Gurney, A.L.5
  • 28
  • 29
    • 34247247352 scopus 로고    scopus 로고
    • Interferon - Regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17
    • Chu CQ, Swart D, Alcorn D, Tocker J, Elkon KB. Interferon - regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17. Arthritis Rheum 2007;56: 1145-51.
    • (2007) Arthritis Rheum , vol.56 , pp. 1145-1151
    • Chu, C.Q.1    Swart, D.2    Alcorn, D.3    Tocker, J.4    Elkon, K.B.5
  • 30
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003;421: 744-8.
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6
  • 31
    • 60749107176 scopus 로고    scopus 로고
    • The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
    • McGeachy MJ, Chen Y, Tato CM, Laurence A, Joyce-Shaikh B, Blumenschein WM, et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol 2009;10: 314-24.
    • (2009) Nat Immunol , vol.10 , pp. 314-324
    • McGeachy, M.J.1    Chen, Y.2    Tato, C.M.3    Laurence, A.4    Joyce-Shaikh, B.5    Blumenschein, W.M.6
  • 35
    • 77956222219 scopus 로고    scopus 로고
    • Human Th17 cells comprise heterogeneous subsets including IFN - Producing cells with distinct properties from the Th1 lineage
    • Boniface K, Blumenschein WM, Brovont-Porth K, McGeachy MJ, Basham B, Desai B, et al. Human Th17 cells comprise heterogeneous subsets including IFN - producing cells with distinct properties from the Th1 lineage. J Immunol 2010;185: 679-87.
    • (2010) J Immunol , vol.185 , pp. 679-687
    • Boniface, K.1    Blumenschein, W.M.2    Brovont-Porth, K.3    McGeachy, M.J.4    Basham, B.5    Desai, B.6
  • 36
    • 64549126102 scopus 로고    scopus 로고
    • Interleukin-17 and interferon - Are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells
    • Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, et al. Interleukin-17 and interferon - are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation 2009;119: 1424-32.
    • (2009) Circulation , vol.119 , pp. 1424-1432
    • Eid, R.E.1    Rao, D.A.2    Zhou, J.3    Lo, S.F.4    Ranjbaran, H.5    Gallo, A.6
  • 37
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4- T cells
    • O'Shea JJ, Paul WE. Mechanisms underlying lineage commitment and plasticity of helper CD4- T cells. Science 2010;327: 1098-102.
    • (2010) Science , vol.327 , pp. 1098-1102
    • O'Shea, J.J.1    Paul, W.E.2
  • 39
    • 33747089041 scopus 로고    scopus 로고
    • Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
    • Uhlig HH, McKenzie BS, Hue S, Thompson C, Joyce-Shaikh B, Stepankova R, et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 2006; 25: 309-18.
    • (2006) Immunity , vol.25 , pp. 309-318
    • Uhlig, H.H.1    McKenzie, B.S.2    Hue, S.3    Thompson, C.4    Joyce-Shaikh, B.5    Stepankova, R.6
  • 40
    • 68649088121 scopus 로고    scopus 로고
    • Interleukin-1 and IL-23 induce innate IL-17 production from - T cells, amplifying Th17 responses and autoimmunity
    • Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH. Interleukin-1 and IL-23 induce innate IL-17 production from - T cells, amplifying Th17 responses and autoimmunity. Immunity 2009;31: 331-41.
    • (2009) Immunity , vol.31 , pp. 331-341
    • Sutton, C.E.1    Lalor, S.J.2    Sweeney, C.M.3    Brereton, C.F.4    Lavelle, E.C.5    Mills, K.H.6
  • 42
    • 78650711124 scopus 로고    scopus 로고
    • Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease
    • Danoy P, Pryce K, Hadler J, Bradbury LA, Farrar C, Pointon J, et al. Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS Gen 2010;6:e1001195.
    • (2010) PLoS Gen , vol.6
    • Danoy, P.1    Pryce, K.2    Hadler, J.3    Bradbury, L.A.4    Farrar, C.5    Pointon, J.6
  • 43
    • 84655176642 scopus 로고    scopus 로고
    • A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis
    • Lin Z, Bei JX, Shen M, Li Q, Liao Z, Zhang Y, et al. A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. Nat Genet 2012;44: 73-7.
    • (2012) Nat Genet , vol.44 , pp. 73-77
    • Lin, Z.1    Bei, J.X.2    Shen, M.3    Li, Q.4    Liao, Z.5    Zhang, Y.6
  • 44
    • 84860585350 scopus 로고    scopus 로고
    • Genetics of spondyloarthritis-beyond the MHC
    • Reveille JD. Genetics of spondyloarthritis-beyond the MHC. Nat Rev Rheumatol 2012;8: 296-304.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 296-304
    • Reveille, J.D.1
  • 45
    • 84867760885 scopus 로고    scopus 로고
    • The genetics of ankylosing spondylitis and axial spondyloarthritis
    • Robinson PC, Brown MA. The genetics of ankylosing spondylitis and axial spondyloarthritis. Rheum Dis Clin North Am 2012;38: 539-53.
    • (2012) Rheum Dis Clin North Am , vol.38 , pp. 539-553
    • Robinson, P.C.1    Brown, M.A.2
  • 46
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006;314: 1461-3.
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3    Rioux, J.D.4    Silverberg, M.S.5    Daly, M.J.6
  • 47
    • 33846608131 scopus 로고    scopus 로고
    • A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
    • Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 2007;80: 273-90.
    • (2007) Am J Hum Genet , vol.80 , pp. 273-290
    • Cargill, M.1    Schrodi, S.J.2    Chang, M.3    Garcia, V.E.4    Brandon, R.5    Callis, K.P.6
  • 48
    • 79952066088 scopus 로고    scopus 로고
    • The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans
    • Di Meglio P, Di Cesare A, Laggner U, Chu CC, Napolitano L, Villanova F, et al. The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans. PLoS One 2011;6:e17160.
    • (2011) PLoS One , vol.6
    • Di Meglio, P.1    Di Cesare, A.2    Laggner, U.3    Chu, C.C.4    Napolitano, L.5    Villanova, F.6
  • 49
    • 67449105675 scopus 로고    scopus 로고
    • IL-23R polymorphisms in patients with ankylosing spondylitis in Korea
    • Sung IH, Kim TH, Bang SY, Kim TJ, Lee B, Peddle L, et al. IL-23R polymorphisms in patients with ankylosing spondylitis in Korea. J Rheumatol 2009;36: 1003-5.
    • (2009) J Rheumatol , vol.36 , pp. 1003-1005
    • Sung, I.H.1    Kim, T.H.2    Bang, S.Y.3    Kim, T.J.4    Lee, B.5    Peddle, L.6
  • 50
    • 70350525335 scopus 로고    scopus 로고
    • Association of ERAP1, but not IL23R, with ankylosing spondy- litis in a Han Chinese population
    • Davidson SI, Wu X, Liu Y, Wei M, Danoy PA, Thomas G, et al. Association of ERAP1, but not IL23R, with ankylosing spondy- litis in a Han Chinese population. Arthritis Rheum 2009;60: 3263-8.
    • (2009) Arthritis Rheum , vol.60 , pp. 3263-3268
    • Davidson, S.I.1    Wu, X.2    Liu, Y.3    Wei, M.4    Danoy, P.A.5    Thomas, G.6
  • 51
    • 84879855609 scopus 로고    scopus 로고
    • High-throughput sequencing of IL23R reveals a low-frequency, nonsynonymous single-nucleotide polymorphism that is associated with ankylosing spondylitis in a Han Chinese population
    • Davidson SI, Jiang L, Cortes A, Wu X, Glazov EA, Zheng Y, et al. High-throughput sequencing of IL23R reveals a low-frequency, nonsynonymous single-nucleotide polymorphism that is associated with ankylosing spondylitis in a Han Chinese population. Arthritis Rheum 2013;65: 1747-52.
    • (2013) Arthritis Rheum , vol.65 , pp. 1747-1752
    • Davidson, S.I.1    Jiang, L.2    Cortes, A.3    Wu, X.4    Glazov, E.A.5    Zheng, Y.6
  • 53
    • 80051795590 scopus 로고    scopus 로고
    • The role of Dectin-1 in the host defence against fungal infections
    • Drummond RA, Brown GD. The role of Dectin-1 in the host defence against fungal infections. Curr Opin Microbiol 2011;14: 392-9.
    • (2011) Curr Opin Microbiol , vol.14 , pp. 392-399
    • Drummond, R.A.1    Brown, G.D.2
  • 54
    • 34249026701 scopus 로고    scopus 로고
    • Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
    • LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 2007;8: 630-8.
    • (2007) Nat Immunol , vol.8 , pp. 630-638
    • Leibund Gut-Landmann, S.1    Gross, O.2    Robinson, M.J.3    Osorio, F.4    Slack, E.C.5    Tsoni, S.V.6
  • 55
    • 60549104110 scopus 로고    scopus 로고
    • Differential use of CARD9 by Dectin-1 in macrophages and dendritic cells
    • Goodridge HS, Shimada T, Wolf AJ, Hsu YM, Becker CA, Lin X, et al. Differential use of CARD9 by Dectin-1 in macrophages and dendritic cells. J Immunol 2009;182: 1146-54.
    • (2009) J Immunol , vol.182 , pp. 1146-1154
    • Goodridge, H.S.1    Shimada, T.2    Wolf, A.J.3    Hsu, Y.M.4    Becker, C.A.5    Lin, X.6
  • 56
    • 84872065897 scopus 로고    scopus 로고
    • JAKs and STATs in immunity, immunodeficiency, and cancer
    • O'Shea JJ, Holland SM, Staudt LM. JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med 2013; 368: 161-70.
    • (2013) N Engl J Med , vol.368 , pp. 161-170
    • O'Shea, J.J.1    Holland, S.M.2    Staudt, L.M.3
  • 57
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 2006;7: 929-36.
    • (2006) Nat Immunol , vol.7 , pp. 929-936
    • Batten, M.1    Li, J.2    Yi, S.3    Kljavin, N.M.4    Danilenko, D.M.5    Lucas, S.6
  • 58
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    • Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM, et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 2006;7: 937-45.
    • (2006) Nat Immunol , vol.7 , pp. 937-945
    • Stumhofer, J.S.1    Laurence, A.2    Wilson, E.H.3    Huang, E.4    Tato, C.M.5    Johnson, L.M.6
  • 59
    • 41449110468 scopus 로고    scopus 로고
    • Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
    • Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM, et al. Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 2008;452: 773-6.
    • (2008) Nature , vol.452 , pp. 773-776
    • Milner, J.D.1    Brenchley, J.M.2    Laurence, A.3    Freeman, A.F.4    Hill, B.J.5    Elias, K.M.6
  • 60
    • 84856405512 scopus 로고    scopus 로고
    • The mystery of missing heritability: Genetic interactions create phantom heritability
    • Zuk O, Hechter E, Sunyaev SR, Lander ES. The mystery of missing heritability: genetic interactions create phantom heritability. Proc Natl Acad Sci U S A 2012;109: 1193-8.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 1193-1198
    • Zuk, O.1    Hechter, E.2    Sunyaev, S.R.3    Lander, E.S.4
  • 61
    • 84882449068 scopus 로고    scopus 로고
    • Genetic insights into common pathways and complex relationships among immune- mediated diseases
    • Parkes M, Cortes A, van Heel DA, Brown MA. Genetic insights into common pathways and complex relationships among immune- mediated diseases. Nat Rev Gen 2013;14: 661-73.
    • (2013) Nat Rev Gen , vol.14 , pp. 661-673
    • Parkes, M.1    Cortes, A.2    Van Heel, D.A.3    Brown, M.A.4
  • 62
    • 34248178540 scopus 로고    scopus 로고
    • Serum IL-17, BMP-7, and bone turnover markers in patients with ankylosing spondylitis
    • Wendling D, Cedoz JP, Racadot E, Dumoulin G. Serum IL-17, BMP-7, and bone turnover markers in patients with ankylosing spondylitis. Joint Bone Spine 2007;74: 304-5.
    • (2007) Joint Bone Spine , vol.74 , pp. 304-305
    • Wendling, D.1    Cedoz, J.P.2    Racadot, E.3    Dumoulin, G.4
  • 63
    • 35948937642 scopus 로고    scopus 로고
    • Th1/Th17 cytokine profiles in patients with reactive arthritis/ undifferentiated spondyloarthropathy
    • Singh R, Aggarwal A, Misra R. Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy. J Rheumatol 2007;34: 2285-90.
    • (2007) J Rheumatol , vol.34 , pp. 2285-2290
    • Singh, R.1    Aggarwal, A.2    Misra, R.3
  • 64
    • 77949444874 scopus 로고    scopus 로고
    • Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis
    • Melis L, Vandooren B, Kruithof E, Jacques P, De Vos M, Mielants H, et al. Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis. Ann Rheum Dis 2010;69: 618-23.
    • (2010) Ann Rheum Dis , vol.69 , pp. 618-623
    • Melis, L.1    Vandooren, B.2    Kruithof, E.3    Jacques, P.4    De Vos, M.5    Mielants, H.6
  • 65
    • 84864093247 scopus 로고    scopus 로고
    • Association of serum interleukin-17 and interleukin-23 levels with disease activity in Chinese patients with ankylosing spondylitis
    • Chen WS, Chang YS, Lin KC, Lai CC, Wang SH, Hsiao KH, et al. Association of serum interleukin-17 and interleukin-23 levels with disease activity in Chinese patients with ankylosing spondylitis. J Chin Med Assoc 2012;75: 303-8.
    • (2012) J Chin Med Assoc , vol.75 , pp. 303-308
    • Chen, W.S.1    Chang, Y.S.2    Lin, K.C.3    Lai, C.C.4    Wang, S.H.5    Hsiao, K.H.6
  • 66
    • 79954450170 scopus 로고    scopus 로고
    • Increased serum IL-17 and IL-23 in the patient with ankylosing spondylitis
    • Mei Y, Pan F, Gao J, Ge R, Duan Z, Zeng Z, et al. Increased serum IL-17 and IL-23 in the patient with ankylosing spondylitis. Clin Rheumatol 2011;30: 269-73.
    • (2011) Clin Rheumatol , vol.30 , pp. 269-273
    • Mei, Y.1    Pan, F.2    Gao, J.3    Ge, R.4    Duan, Z.5    Zeng, Z.6
  • 67
    • 84876437435 scopus 로고    scopus 로고
    • Levels of circulating Th17 cells and regulatory T cells in ankylosing spondylitis patients with an inadequate response to anti-TNF - Therapy
    • Xueyi L, Lina C, Zhenbiao W, Qing H, Qiang L, Zhu P. Levels of circulating Th17 cells and regulatory T cells in ankylosing spondylitis patients with an inadequate response to anti-TNF - therapy. J Clin Immunol 2013;33: 151-61.
    • (2013) J Clin Immunol , vol.33 , pp. 151-161
    • Xueyi, L.1    Lina, C.2    Zhenbiao, W.3    Qing, H.4    Qiang, L.5    Zhu, P.6
  • 68
    • 49449115544 scopus 로고    scopus 로고
    • Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides
    • Jandus C, Bioley G, Rivals JP, Dudler J, Speiser D, Romero P. Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum 2008;58: 2307-17.
    • (2008) Arthritis Rheum , vol.58 , pp. 2307-2317
    • Jandus, C.1    Bioley, G.2    Rivals, J.P.3    Dudler, J.4    Speiser, D.5    Romero, P.6
  • 69
    • 66449133523 scopus 로고    scopus 로고
    • Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis
    • Shen H, Goodall JC, Hill Gaston JS. Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. Arthritis Rheum 2009;60: 1647-56.
    • (2009) Arthritis Rheum , vol.60 , pp. 1647-1656
    • Shen, H.1    Goodall, J.C.2    Hill Gaston, J.S.3
  • 70
    • 77957886710 scopus 로고    scopus 로고
    • Frequency and phenotype of T helper 17 cells in peripheral blood and synovial fluid of patients with reactive arthritis
    • Shen H, Goodall JC, Hill Gaston JS. Frequency and phenotype of T helper 17 cells in peripheral blood and synovial fluid of patients with reactive arthritis. J Rheumatol 2010;37: 2096-9.
    • (2010) J Rheumatol , vol.37 , pp. 2096-2099
    • Shen, H.1    Goodall, J.C.2    Hill Gaston, J.S.3
  • 71
    • 84859237495 scopus 로고    scopus 로고
    • Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis
    • Zhang L, Li YG, Li YH, Qi L, Liu XG, Yuan CZ, et al. Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis. PLoS One 2012;7:e31000.
    • (2012) PLoS One , vol.7
    • Zhang, L.1    Li, Y.G.2    Li, Y.H.3    Qi, L.4    Liu, X.G.5    Yuan, C.Z.6
  • 72
    • 84858644639 scopus 로고    scopus 로고
    • Enrichment of circulating interleukin- 17-secreting interleukin-23 receptor-positive -/- T cells in patients with active ankylosing spondylitis
    • Kenna TJ, Davidson SI, Duan R, Bradbury LA, McFarlane J, Smith M, et al. Enrichment of circulating interleukin- 17-secreting interleukin-23 receptor-positive -/- T cells in patients with active ankylosing spondylitis. Arthritis Rheum 2012; 64: 1420-9.
    • (2012) Arthritis Rheum , vol.64 , pp. 1420-1429
    • Kenna, T.J.1    Davidson, S.I.2    Duan, R.3    Bradbury, L.A.4    McFarlane, J.5    Smith, M.6
  • 73
    • 84873830962 scopus 로고    scopus 로고
    • Decreased Th17 and Th1 cells in the peripheral blood of patients with early non-radiographic axial spondyloarthritis: A marker of disease activity in HLA-B27- patients
    • Bautista-Caro MB, Arroyo-Villa I, Castillo-Gallego C, de Miguel E, Peiteado D, Puig-Kroger A, et al. Decreased Th17 and Th1 cells in the peripheral blood of patients with early non-radiographic axial spondyloarthritis: a marker of disease activity in HLA-B27- patients. Rheumatology (Oxford) 2013;52: 352-62.
    • (2013) Rheumatology (Oxford) , vol.52 , pp. 352-362
    • Bautista-Caro, M.B.1    Arroyo-Villa, I.2    Castillo-Gallego, C.3    De Miguel, E.4    Peiteado, D.5    Puig-Kroger, A.6
  • 74
    • 82455210509 scopus 로고    scopus 로고
    • Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response
    • Zeng L, Lindstrom MJ, Smith JA. Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response. Arthritis Rheum 2011;63: 3807-17.
    • (2011) Arthritis Rheum , vol.63 , pp. 3807-3817
    • Zeng, L.1    Lindstrom, M.J.2    Smith, J.A.3
  • 75
    • 84867213800 scopus 로고    scopus 로고
    • Cytokine secretion by pathogen recognition receptor-stimulated dendritic cells in rheumatoid arthritis and ankylosing spondylitis
    • Prevosto C, Goodall JC, Hill Gaston JS. Cytokine secretion by pathogen recognition receptor-stimulated dendritic cells in rheumatoid arthritis and ankylosing spondylitis. J Rheumatol 2012; 39: 1918-28.
    • (2012) J Rheumatol , vol.39 , pp. 1918-1928
    • Prevosto, C.1    Goodall, J.C.2    Hill Gaston, J.S.3
  • 76
    • 0026003027 scopus 로고
    • The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy
    • and the European Spondylarthropathy Study Group
    • Dougados M, van der Linden S, Juhlin R, Huitfeldt B, Amor B, Calin A, et al, and the European Spondylarthropathy Study Group. The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum 1991;34: 1218-27.
    • (1991) Arthritis Rheum , vol.34 , pp. 1218-1227
    • Dougados, M.1    Van Der Linden, S.2    Juhlin, R.3    Huitfeldt, B.4    Amor, B.5    Calin, A.6
  • 77
    • 65249152431 scopus 로고    scopus 로고
    • Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis
    • Ciccia F, Bombardieri M, Principato A, Giardina A, Tripodo C, Porcasi R, et al. Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis. Arthritis Rheum 2009;60: 955-65.
    • (2009) Arthritis Rheum , vol.60 , pp. 955-965
    • Ciccia, F.1    Bombardieri, M.2    Principato, A.3    Giardina, A.4    Tripodo, C.5    Porcasi, R.6
  • 78
    • 84861796578 scopus 로고    scopus 로고
    • Interleukin-22 and interleukin-22-producing NKp44- natural killer cells in subclinical gut inflammation in ankylosing spondylitis
    • Ciccia F, Accardo-Palumbo A, Alessandro R, Rizzo A, Principe S, Peralta S, et al. Interleukin-22 and interleukin-22-producing NKp44- natural killer cells in subclinical gut inflammation in ankylosing spondylitis. Arthritis Rheum 2012;64: 1869-78.
    • (2012) Arthritis Rheum , vol.64 , pp. 1869-1878
    • Ciccia, F.1    Accardo-Palumbo, A.2    Alessandro, R.3    Rizzo, A.4    Principe, S.5    Peralta, S.6
  • 79
  • 81
    • 77956190936 scopus 로고    scopus 로고
    • Imbalance of NKp44-NKp46- and NKp44- NKp46- natural killer cells in the intestinal mucosa of patients with Crohn's disease
    • 892.e1-3
    • Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, et al. Imbalance of NKp44-NKp46- and NKp44- NKp46- natural killer cells in the intestinal mucosa of patients with Crohn's disease. Gastroenterology 2010;139:882-92, 892.e1-3.
    • (2010) Gastroenterology , vol.139 , pp. 882-892
    • Takayama, T.1    Kamada, N.2    Chinen, H.3    Okamoto, S.4    Kitazume, M.T.5    Chang, J.6
  • 82
    • 84878612188 scopus 로고    scopus 로고
    • Combinatorial control of Th17 and Th1 cell functions by genetic variations in genes associated with the interleukin-23 signaling pathway in spondyloarthritis
    • Coffre M, Roumier M, Rybczynska M, Sechet E, Law HK, Gossec L, et al. Combinatorial control of Th17 and Th1 cell functions by genetic variations in genes associated with the interleukin-23 signaling pathway in spondyloarthritis. Arthritis Rheum 2013;65: 1510-21.
    • (2013) Arthritis Rheum , vol.65 , pp. 1510-1521
    • Coffre, M.1    Roumier, M.2    Rybczynska, M.3    Sechet, E.4    Law, H.K.5    Gossec, L.6
  • 83
    • 45349092221 scopus 로고    scopus 로고
    • Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon - Dysregulation
    • Smith JA, Barnes MD, Hong D, DeLay ML, Inman RD, Colbert RA. Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon - dysregulation. Arthritis Rheum 2008;58: 1640-9.
    • (2008) Arthritis Rheum , vol.58 , pp. 1640-1649
    • Smith, J.A.1    Barnes, M.D.2    Hong, D.3    Delay, M.L.4    Inman, R.D.5    Colbert, R.A.6
  • 84
    • 0035170976 scopus 로고    scopus 로고
    • Low T cell production of TNF- and IFN- in ankylosing spondylitis: Its relation to HLA-B27 and influence of the TNF- 308 gene polymorphism
    • Rudwaleit M, Siegert S, Yin Z, Eick J, Thiel A, Radbruch A, et al. Low T cell production of TNF- and IFN- in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF- 308 gene polymorphism. Ann Rheum Dis 2001;60: 36-42.
    • (2001) Ann Rheum Dis , vol.60 , pp. 36-42
    • Rudwaleit, M.1    Siegert, S.2    Yin, Z.3    Eick, J.4    Thiel, A.5    Radbruch, A.6
  • 85
    • 0025234494 scopus 로고
    • Guilt by association: HLA-B27 and ankylosing spondylitis
    • Benjamin RJ, Parham P. Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol Today 1990;11: 137-42.
    • (1990) Immunol Today , vol.11 , pp. 137-142
    • Benjamin, R.J.1    Parham, P.2
  • 86
    • 0030060392 scopus 로고    scopus 로고
    • T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLAB27 transgenic rats
    • Breban M, Fernandez-Sueiro JL, Richardson JA, Hadavand RR, Maika SD, Hammer RE, et al. T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLAB27 transgenic rats. J Immunol 1996;156: 794-803.
    • (1996) J Immunol , vol.156 , pp. 794-803
    • Breban, M.1    Fernandez-Sueiro, J.L.2    Richardson, J.A.3    Hadavand, R.R.4    Maika, S.D.5    Hammer, R.E.6
  • 88
    • 0037438486 scopus 로고    scopus 로고
    • CD8 - T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats
    • May E, Dorris ML, Satumtira N, Iqbal I, Rehman MI, Lightfoot E, et al. CD8 - T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. J Immunol 2003; 170: 1099-105.
    • (2003) J Immunol , vol.170 , pp. 1099-1105
    • May, E.1    Dorris, M.L.2    Satumtira, N.3    Iqbal, I.4    Rehman, M.I.5    Lightfoot, E.6
  • 89
    • 67650074528 scopus 로고    scopus 로고
    • Spondylarthritis in HLA-B27/human -2- microglobulin-transgenic rats is not prevented by lack of CD8
    • Taurog JD, Dorris ML, Satumtira N, Tran TM, Sharma R, Dressel R, et al. Spondylarthritis in HLA-B27/human -2- microglobulin-transgenic rats is not prevented by lack of CD8. Arthritis Rheum 2009;60: 1977-84.
    • (2009) Arthritis Rheum , vol.60 , pp. 1977-1984
    • Taurog, J.D.1    Dorris, M.L.2    Satumtira, N.3    Tran, T.M.4    Sharma, R.5    Dressel, R.6
  • 90
    • 0028003794 scopus 로고
    • The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats
    • Taurog JD, Richardson JA, Croft JT, Simmons WA, Zhou M, Fernandez-Sueiro JL, et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 1994;180: 2359-64.
    • (1994) J Exp Med , vol.180 , pp. 2359-2364
    • Taurog, J.D.1    Richardson, J.A.2    Croft, J.T.3    Simmons, W.A.4    Zhou, M.5    Fernandez-Sueiro, J.L.6
  • 91
    • 9544226450 scopus 로고    scopus 로고
    • Normal luminal bacteria, especially bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLAB27/ human -2 microglobulin transgenic rats
    • Rath HC, Herfarth HH, Ikeda JS, Grenther WB, Hamm TE Jr, Balish E, et al. Normal luminal bacteria, especially bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLAB27/ human -2 microglobulin transgenic rats. J Clin Invest 1996; 98: 945-53.
    • (1996) J Clin Invest , vol.98 , pp. 945-953
    • Rath, H.C.1    Herfarth, H.H.2    Ikeda, J.S.3    Grenther, W.B.4    Hamm Jr., T.E.5    Balish, E.6
  • 92
    • 80155130269 scopus 로고    scopus 로고
    • Time for a gut check: Evidence for the hypothesis that HLA-B27 predisposes to ankylosing spondylitis by altering the microbiome
    • Rosenbaum JT, Davey MP. Time for a gut check: evidence for the hypothesis that HLA-B27 predisposes to ankylosing spondylitis by altering the microbiome. Arthritis Rheum 2011;63: 3195-8.
    • (2011) Arthritis Rheum , vol.63 , pp. 3195-3198
    • Rosenbaum, J.T.1    Davey, M.P.2
  • 93
    • 0032742012 scopus 로고    scopus 로고
    • Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies
    • Mear JP, Schreiber KL, Munz C, Zhu X, Stevanovic S, Rammensee HG, et al. Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies. J Immunol 1999;163: 6665-70.
    • (1999) J Immunol , vol.163 , pp. 6665-6670
    • Mear, J.P.1    Schreiber, K.L.2    Munz, C.3    Zhu, X.4    Stevanovic, S.5    Rammensee, H.G.6
  • 94
    • 0033136630 scopus 로고    scopus 로고
    • HLAB27 can form a novel -2-microglobulin-free heavy chain homodimer structure
    • Allen RL, O'Callaghan CA, McMichael AJ, Bowness P. HLAB27 can form a novel -2-microglobulin-free heavy chain homodimer structure. J Immunol 1999;162: 5045-8.
    • (1999) J Immunol , vol.162 , pp. 5045-5048
    • Allen, R.L.1    O'Callaghan, C.A.2    McMichael, A.J.3    Bowness, P.4
  • 95
  • 96
    • 84884416127 scopus 로고    scopus 로고
    • The biochemistry and immunology of non-canonical forms of HLA-B27
    • Shaw J, Hatano H, Kollnberger S. The biochemistry and immunology of non-canonical forms of HLA-B27. Mol Immunol 2014;57: 52-8.
    • (2014) Mol Immunol , vol.57 , pp. 52-58
    • Shaw, J.1    Hatano, H.2    Kollnberger, S.3
  • 97
    • 33846194065 scopus 로고    scopus 로고
    • HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis- like disease
    • Turner MJ, DeLay ML, Bai S, Klenk E, Colbert RA. HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: implications for the pathogenesis of spondylarthritis- like disease. Arthritis Rheum 2007;56: 215-23.
    • (2007) Arthritis Rheum , vol.56 , pp. 215-223
    • Turner, M.J.1    Delay, M.L.2    Bai, S.3    Klenk, E.4    Colbert, R.A.5
  • 98
    • 23444431837 scopus 로고    scopus 로고
    • HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response
    • Turner MJ, Sowders DP, DeLay ML, Mohapatra R, Bai S, Smith JA, et al. HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response. J Immunol 2005;175: 2438-48.
    • (2005) J Immunol , vol.175 , pp. 2438-2448
    • Turner, M.J.1    Sowders, D.P.2    Delay, M.L.3    Mohapatra, R.4    Bai, S.5    Smith, J.A.6
  • 99
    • 84856111924 scopus 로고    scopus 로고
    • The unfolded protein response: Controlling cell fate decisions under ER stress and beyond
    • Hetz C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 2012;13: 89-102.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 89-102
    • Hetz, C.1
  • 100
    • 77951290227 scopus 로고    scopus 로고
    • TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
    • Martinon F, Chen X, Lee AH, Glimcher LH. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 2010;11: 411-8.
    • (2010) Nat Immunol , vol.11 , pp. 411-418
    • Martinon, F.1    Chen, X.2    Lee, A.H.3    Glimcher, L.H.4
  • 101
  • 102
    • 47049098902 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN - Induction via X-box binding protein 1
    • Smith JA, Turner MJ, DeLay ML, Klenk EI, Sowders DP, Colbert RA. Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN - induction via X-box binding protein 1. Eur J Immunol 2008;38: 1194-203.
    • (2008) Eur J Immunol , vol.38 , pp. 1194-1203
    • Smith, J.A.1    Turner, M.J.2    Delay, M.L.3    Klenk, E.I.4    Sowders, D.P.5    Colbert, R.A.6
  • 103
    • 77956917631 scopus 로고    scopus 로고
    • XBP-1 couples endoplasmic reticulum stress to augmented IFN - Induction via a cis-acting enhancer in macrophages
    • Zeng L, Liu YP, Sha H, Chen H, Qi L, Smith JA. XBP-1 couples endoplasmic reticulum stress to augmented IFN - induction via a cis-acting enhancer in macrophages. J Immunol 2010;185: 2324-30.
    • (2010) J Immunol , vol.185 , pp. 2324-2330
    • Zeng, L.1    Liu, Y.P.2    Sha, H.3    Chen, H.4    Qi, L.5    Smith, J.A.6
  • 104
    • 78049271424 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression
    • Goodall JC, Wu C, Zhang Y, McNeill L, Ellis L, Saudek V, et al. Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci U S A 2010;107: 17698-703.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 17698-17703
    • Goodall, J.C.1    Wu, C.2    Zhang, Y.3    McNeill, L.4    Ellis, L.5    Saudek, V.6
  • 105
    • 84867911096 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress regulates the innate immunity critical transcription factor IRF3
    • Liu YP, Zeng L, Tian A, Bomkamp A, Rivera D, Gutman D, et al. Endoplasmic reticulum stress regulates the innate immunity critical transcription factor IRF3. J Immunol 2012;189: 4630-9.
    • (2012) J Immunol , vol.189 , pp. 4630-4639
    • Liu, Y.P.1    Zeng, L.2    Tian, A.3    Bomkamp, A.4    Rivera, D.5    Gutman, D.6
  • 106
    • 84881362894 scopus 로고    scopus 로고
    • HLA-B27 alters the response to tumor necrosis factor - And promotes osteoclastogenesis in bone marrow monocytes from HLA-B27- transgenic rats
    • Layh-Schmitt G, Yang EY, Kwon G, Colbert RA. HLA-B27 alters the response to tumor necrosis factor - and promotes osteoclastogenesis in bone marrow monocytes from HLA-B27- transgenic rats. Arthritis Rheum 2013;65: 2123-31.
    • (2013) Arthritis Rheum , vol.65 , pp. 2123-2131
    • Layh-Schmitt, G.1    Yang, E.Y.2    Kwon, G.3    Colbert, R.A.4
  • 107
    • 84903890646 scopus 로고    scopus 로고
    • Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation
    • E-pub ahead of print
    • Ciccia F, Accardo-Palumbo A, Rizzo A, Guggino G, Raimondo S, Giardina A, et al. Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. Ann Rheum Dis 2013. E-pub ahead of print.
    • (2013) Ann Rheum Dis
    • Ciccia, F.1    Accardo-Palumbo, A.2    Rizzo, A.3    Guggino, G.4    Raimondo, S.5    Giardina, A.6
  • 108
    • 27744513659 scopus 로고    scopus 로고
    • Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin-like receptor KIR3DL2 in spondylarthritis
    • Chan AT, Kollnberger SD, Wedderburn LR, Bowness P. Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin-like receptor KIR3DL2 in spondylarthritis. Arthritis Rheum 2005;52: 3586-95.
    • (2005) Arthritis Rheum , vol.52 , pp. 3586-3595
    • Chan, A.T.1    Kollnberger, S.D.2    Wedderburn, L.R.3    Bowness, P.4
  • 110
    • 3242798755 scopus 로고    scopus 로고
    • HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors
    • Kollnberger S, Bird LA, Roddis M, Hacquard-Bouder C, Kubagawa H, Bodmer HC, et al. HLA-B27 heavy chain homodimers are expressed in HLA-B27 transgenic rodent models of spondyloarthritis and are ligands for paired Ig-like receptors. J Immunol 2004;173: 1699-710.
    • (2004) J Immunol , vol.173 , pp. 1699-1710
    • Kollnberger, S.1    Bird, L.A.2    Roddis, M.3    Hacquard-Bouder, C.4    Kubagawa, H.5    Bodmer, H.C.6
  • 111
    • 84867525970 scopus 로고    scopus 로고
    • Expression of HLA-B27 causes loss of migratory dendritic cells in a rat model of spondylarthritis
    • Utriainen L, Firmin D, Wright P, Cerovic V, Breban M, McInnes I, et al. Expression of HLA-B27 causes loss of migratory dendritic cells in a rat model of spondylarthritis. Arthritis Rheum 2012;64: 3199-209.
    • (2012) Arthritis Rheum , vol.64 , pp. 3199-3209
    • Utriainen, L.1    Firmin, D.2    Wright, P.3    Cerovic, V.4    Breban, M.5    McInnes, I.6
  • 112
    • 34248589191 scopus 로고    scopus 로고
    • Alteration of antigen-independent immunologic synapse formation between dendritic cells from HLA-B27- transgenic rats and CD4- T cells: Selective impairment of costimulatory molecule engagement by mature HLA-B27
    • Hacquard-Bouder C, Chimenti MS, Giquel B, Donnadieu E, Fert I, Schmitt A, et al. Alteration of antigen-independent immunologic synapse formation between dendritic cells from HLA-B27- transgenic rats and CD4- T cells: selective impairment of costimulatory molecule engagement by mature HLA-B27. Arthritis Rheum 2007;56: 1478-89.
    • (2007) Arthritis Rheum , vol.56 , pp. 1478-1489
    • Hacquard-Bouder, C.1    Chimenti, M.S.2    Giquel, B.3    Donnadieu, E.4    Fert, I.5    Schmitt, A.6
  • 113
    • 69449083847 scopus 로고    scopus 로고
    • Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics, class II major histocompatibility complex expression, and viability
    • Dhaenens M, Fert I, Glatigny S, Haerinck S, Poulain C, Donnadieu E, et al. Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics, class II major histocompatibility complex expression, and viability. Arthritis Rheum 2009;60: 2622-32.
    • (2009) Arthritis Rheum , vol.60 , pp. 2622-2632
    • Dhaenens, M.1    Fert, I.2    Glatigny, S.3    Haerinck, S.4    Poulain, C.5    Donnadieu, E.6
  • 114
    • 70349564251 scopus 로고    scopus 로고
    • The enthesis organ concept and its relevance to the spondyloarthropathies
    • Benjamin M, McGonagle D. The enthesis organ concept and its relevance to the spondyloarthropathies. Adv Exp Med Biol 2009;649: 57-70.
    • (2009) Adv Exp Med Biol , vol.649 , pp. 57-70
    • Benjamin, M.1    McGonagle, D.2
  • 115
    • 79960492398 scopus 로고    scopus 로고
    • IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass
    • Adamopoulos IE, Tessmer M, Chao CC, Adda S, Gorman D, Petro M, et al. IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass. J Immunol 2011;187: 951-9.
    • (2011) J Immunol , vol.187 , pp. 951-959
    • Adamopoulos, I.E.1    Tessmer, M.2    Chao, C.C.3    Adda, S.4    Gorman, D.5    Petro, M.6
  • 117
    • 0026039673 scopus 로고
    • Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis
    • Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 1991;10: 4025-31.
    • (1991) EMBO J , vol.10 , pp. 4025-4031
    • Keffer, J.1    Probert, L.2    Cazlaris, H.3    Georgopoulos, S.4    Kaslaris, E.5    Kioussis, D.6
  • 118
    • 84879123832 scopus 로고    scopus 로고
    • Interleukin-23: A promising therapeutic target in seronegative spondyloarthropathy
    • Sherlock JP, Cua DJ. Interleukin-23: a promising therapeutic target in seronegative spondyloarthropathy. Curr Opinion Pharmacol 2013;13: 445-8.
    • (2013) Curr Opinion Pharmacol , vol.13 , pp. 445-448
    • Sherlock, J.P.1    Cua, D.J.2
  • 119
    • 84859499638 scopus 로고    scopus 로고
    • Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis
    • Wada Y, Cardinale I, Khatcherian A, Chu J, Kantor AB, Gottlieb AB, et al. Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis. PLoS One 2012;7:e35069.
    • (2012) PLoS One , vol.7
    • Wada, Y.1    Cardinale, I.2    Khatcherian, A.3    Chu, J.4    Kantor, A.B.5    Gottlieb, A.B.6
  • 120
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
    • Papp KA, Langley RG, Lebwohl M, Krueger GG, Szapary P, Yeilding N, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 2008;371: 1675-84.
    • (2008) Lancet , vol.371 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3    Krueger, G.G.4    Szapary, P.5    Yeilding, N.6
  • 121
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin- 12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    • Leonardi CL, Kimball AB, Papp KA, Yeilding N, Guzzo C, Wang Y, et al. Efficacy and safety of ustekinumab, a human interleukin- 12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 2008;371: 1665-74.
    • (2008) Lancet , vol.371 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3    Yeilding, N.4    Guzzo, C.5    Wang, Y.6
  • 122
    • 60249084148 scopus 로고    scopus 로고
    • Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: Randomised, double-blind, placebo- controlled, crossover trial
    • Gottlieb A, Menter A, Mendelsohn A, Shen YK, Li S, Guzzo C, et al. Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo- controlled, crossover trial. Lancet 2009;373: 633-40.
    • (2009) Lancet , vol.373 , pp. 633-640
    • Gottlieb, A.1    Menter, A.2    Mendelsohn, A.3    Shen, Y.K.4    Li, S.5    Guzzo, C.6
  • 123
    • 84883134297 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial
    • McInnes IB, Kavanaugh A, Gottlieb AB, Puig L, Rahman P, Ritchlin C, et al. Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial. Lancet 2013;382: 780-9.
    • (2013) Lancet , vol.382 , pp. 780-789
    • McInnes, I.B.1    Kavanaugh, A.2    Gottlieb, A.B.3    Puig, L.4    Rahman, P.5    Ritchlin, C.6
  • 124
  • 127
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL- 17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebocontrolled trial
    • Hueber W, Sands BE, Lewitzky S, Vandemeulebroecke M, Reinisch W, Higgins PD, et al. Secukinumab, a human anti-IL- 17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebocontrolled trial. Gut 2012;61: 1693-700.
    • (2012) Gut , vol.61 , pp. 1693-1700
    • Hueber, W.1    Sands, B.E.2    Lewitzky, S.3    Vandemeulebroecke, M.4    Reinisch, W.5    Higgins, P.D.6
  • 128
    • 84868689685 scopus 로고    scopus 로고
    • Seventeen in Crohn's disease: Less prime than we thought?
    • Raine T, Kaser A. Seventeen in Crohn's disease: less prime than we thought? Gut 2012;61: 1653-4.
    • (2012) Gut , vol.61 , pp. 1653-1654
    • Raine, T.1    Kaser, A.2
  • 129
    • 84877603562 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in patients with rheumatoid arthritis: A phase II, dose-finding, double-blind, randomised, placebo controlled study
    • Genovese MC, Durez P, Richards HB, Supronik J, Dokoupilova E, Mazurov V, et al. Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study. Ann Rheum Dis 2013;72: 863-9.
    • (2013) Ann Rheum Dis , vol.72 , pp. 863-869
    • Genovese, M.C.1    Durez, P.2    Richards, H.B.3    Supronik, J.4    Dokoupilova, E.5    Mazurov, V.6
  • 130
    • 84891740105 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate- to-severe psoriatic arthritis: A 24-week, randomised, double- blind, placebo-controlled, phase II proof-of-concept trial
    • E-pub ahead of print
    • McInnes IB, Sieper J, Braun J, Emery P, van der Heijde D, Isaacs JD, et al. Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate- to-severe psoriatic arthritis: a 24-week, randomised, double- blind, placebo-controlled, phase II proof-of-concept trial. Ann Rheum Dis 2013. E-pub ahead of print.
    • (2013) Ann Rheum Dis
    • McInnes, I.B.1    Sieper, J.2    Braun, J.3    Emery, P.4    Van Der Heijde, D.5    Isaacs, J.D.6
  • 131
    • 84888003170 scopus 로고    scopus 로고
    • 17 and 23: Prime numbers for ankylosing spondylitis?
    • E-pub ahead of print
    • Colbert RA, Ward MM. 17 and 23: prime numbers for ankylosing spondylitis? Lancet 2013. E-pub ahead of print.
    • (2013) Lancet
    • Colbert, R.A.1    Ward, M.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.