Interleukin-23: A promising therapeutic target in seronegative spondyloarthropathy

Current Opinion in Pharmacology

Volumn 13, Issue 3, 2013, Pages 445-448

  Sherlock, Jonathan P ^a,b   Cua, Daniel J ^c  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B27 ANTIGEN; INTERLEUKIN 23;

ANKYLOSING SPONDYLITIS; CROHN DISEASE; CYTOKINE PRODUCTION; ENTERITIS; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; REGULATORY T LYMPHOCYTE; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SPONDYLOARTHROPATHY; TH17 CELL; UPREGULATION;

ANIMALS; HUMANS; INTERLEUKIN-23; SPONDYLARTHROPATHIES;

EID: 84879123832     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2013.03.002     Document Type: Review

References (27)

1. X. Wang, Z. Lin, Q. Wei, Y. Jiang, and J. Gu Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis Rheumatol Int 29 2009 1343 1347
2. D. Wendling IL-23 and IL-17 in ankylosing spondylitis Rheumatol Int 30 2010 1547
3. Y. Mei, F. Pan, J. Gao, R. Ge, Z. Duan, Z. Zeng, F. Liao, G. Xia, S. Wang, and S. Xu Increased serum IL-17 and IL-23 in the patient with ankylosing spondylitis Clin Rheumatol 30 2011 269 273
4. H. Mielants, E.M. Veys, C. Cuvelier, M. de Vos, S. Goemaere, L. de Clercq, L. Schatteman, and D. Elewaut The evolution of spondyloarthropathies in relation to gut histology. II. Histological aspects J Rheumatol 22 1995 2273 2278
5. F. Ciccia, M. Bombardieri, A. Principato, A. Giardina, C. Tripodo, R. Porcasi, S. Peralta, V. Franco, E. Giardina, and A. Craxi Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis Arthritis Rheum 60 2009 955 965
6. F. Ciccia, A. Accardo-Palumbo, A. Giardina, P. Di Maggio, A. Principato, M. Bombardieri, A. Rizzo, R. Alessandro, A. Ferrante, and S. Principe Expansion of intestinal CD4+CD25(high) Treg cells in patients with ankylosing spondylitis: a putative role for interleukin-10 in preventing intestinal Th17 response Arthritis Rheum 62 2010 3625 3634
7. F. Ciccia, A. Accardo-Palumbo, R. Alessandro, A. Rizzo, S. Principe, S. Peralta, F. Raiata, A. Giardina, G. De Leo, and G. Triolo Interleukin-22 and interleukin-22-producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis Arthritis Rheum 64 2012 1869 1878
8. M. de Vries, I. van der Horst-Bruinsma, I. van Hoogstraten, A. van Bodegraven, B.M.E. Blomberg von, M. Blomberg von, H. Ratnawati, and B. Dijkmans pANCA, ASCA, and OmpC antibodies in patients with ankylosing spondylitis without inflammatory bowel disease J Rheumatol 37 2010 2340 2344
9. R.E. Hammer, S.D. Maika, J.A. Richardson, J.P. Tang, and J.D. Taurog Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders Cell 63 1990 1099 1112
10. R.L. Allen, C.A. O'Callaghan, A.J. McMichael, and P. Bowness Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure J Immunol 162 1999 5045 5048
11. N. Gregersen, P. Bross, S. Vang, and J.H. Christensen Protein misfolding and human disease Annu Rev Genomics Hum Genet 7 2006 103 124
12. M.J. Turner, D.P. Sowders, M.L. DeLay, R. Mohapatra, S. Bai, J.A. Smith, J.R. Brandewie, J.D. Taurog, and R.A. Colbert HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response J Immunol 175 2005 2438 2448
13. M.L. DeLay, M.J. Turner, E.I. Klenk, J.A. Smith, D.P. Sowders, and R.A. Colbert HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats Arthritis Rheum 60 2009 2633 2643
14. J. Goodall, C. Wu, Y. Zhang, L. McNeill, L. Ellis, V. Saudek, and J. Gaston Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression Proc Natl Acad Sci U S A 107 2010 17698 17703
15. J.D. Taurog, C. Rival, L.M. van Duivenvoorde, N. Satumtira, M.L. Dorris, M. Sun, J.M. Shelton, J.A. Richardson, F.K. Hamra, and R.E. Hammer Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats Arthritis Rheum 64 2012 2518 2528
16. P. Burton, D. Clayton, L. Cardon, N. Craddock, P. Deloukas, A. Duncanson, D. Kwiatkowski, M. McCarthy, W. Ouwehand, and N. Samani Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants Nat Genet 39 2007 1329 1337
17. J.D. Reveille, A.-M. Sims, P. Danoy, D.M. Evans, P. Leo, J.J. Pointon, R. Jin, X. Zhou, L.A. Bradbury, and L.H. Appleton Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci Nat Genet 42 2010 123 127
18. P. Di Meglio, A. Di Cesare, U. Laggner, C.-C. Chu, L. Napolitano, F. Villanova, I. Tosi, F. Capon, R.C. Trembath, and K. Peris The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans PLoS ONE 6 2011 e17160
19. R.L. Allen, T. Raine, A. Haude, J. Trowsdale, and M.J. Wilson Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures J Immunol 167 2001 5543 5547
20. P. Hansasuta, T. Dong, H. Thananchai, M. Weekes, C. Willberg, H. Aldemir, S. Rowland-Jones, and V.M. Braud Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific Eur J Immunol 34 2004 1673 1679
21. S. Kollnberger, L. Bird, M.-Y. Sun, C. Retiere, V.M. Braud, A. McMichael, and P. Bowness Cell-surface expression and immune receptor recognition of HLA-B27 homodimers Arthritis Rheum 46 2002 2972 2982
22. A.T. Chan, S.D. Kollnberger, L.R. Wedderburn, and P. Bowness Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin-like receptor KIR3DL2 in spondylarthritis Arthritis Rheum 52 2005 3586 3595
23. P. Bowness, A. Ridley, J. Shaw, A.T. Chan, I. Wong-Baeza, M. Fleming, F. Cummings, A. McMichael, and S. Kollnberger Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis J Immunol 186 2011 2672 2680
24. J. Ball Enthesopathy of rheumatoid and ankylosing spondylitis Ann Rheum Dis 30 1971 213 223
25. D. McGonagle, W. Gibbon, and P. Emery Classification of inflammatory arthritis by enthesitis Lancet 352 1998 1137 1140
26. J.P. Sherlock, B. Joyce-Shaikh, S.P. Turner, C.-C. Chao, M. Sathe, J. Grein, D.M. Gorman, E.P. Bowman, T.K. McClanahan, and J.H. Yearley IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells Nat Med 18 2012 1069 1076
27. A. Gottlieb, A. Menter, A. Mendelsohn, Y.-K. Shen, S. Li, C. Guzzo, S. Fretzin, R. Kunynetz, and A. Kavanaugh Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial Lancet 373 2009 633 640