메뉴 건너뛰기




Volumn 98, Issue 4, 1996, Pages 945-953

Normal luminal bacteria, especially bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human β2 microglobulin transgenic rats

Author keywords

Bacteroides; experimental colitis; germfree; specific pathogen free

Indexed keywords

BETA 2 MICROGLOBULIN; HLA B27 ANTIGEN;

EID: 9544226450     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118878     Document Type: Article
Times cited : (717)

References (57)
  • 1
    • 0029114193 scopus 로고
    • Current concepts of etiology and pathogenesis of ulcerative colitis and Crohn's disease
    • Sartor, R.B. 1995. Current concepts of etiology and pathogenesis of ulcerative colitis and Crohn's disease. Gastroenterol. Clin. North Am. 24:475-506.
    • (1995) Gastroenterol. Clin. North Am. , vol.24 , pp. 475-506
    • Sartor, R.B.1
  • 2
    • 0002696589 scopus 로고
    • Microbial factors in the pathogenesis of Crohn's disease, ulcerative colitis and experimental intestinal inflammation
    • J.B. Kirsncr and R.G. Shorter, editors. Williams & Wilkins, Baltimore, MD
    • Sartor, R.B. 1995. Microbial factors in the pathogenesis of Crohn's disease, ulcerative colitis and experimental intestinal inflammation. In Inflammatory Bowel Disease. J.B. Kirsncr and R.G. Shorter, editors. Williams & Wilkins, Baltimore, MD. 96-124.
    • (1995) Inflammatory Bowel Disease , pp. 96-124
    • Sartor, R.B.1
  • 4
    • 0027437451 scopus 로고
    • Is there a role for antibiotics as primary therapy in Crohn's ileitis?
    • Peppercorn, M.A. 1993. Is there a role for antibiotics as primary therapy in Crohn's ileitis? J. Clin. Gastroenterol. 17:235-237.
    • (1993) J. Clin. Gastroenterol. , vol.17 , pp. 235-237
    • Peppercorn, M.A.1
  • 5
    • 0000614417 scopus 로고
    • Prolonged remission in Crohn's disease following therapy for Mycobacterium paratuberculosis infection
    • Abstr.
    • Graham, D.Y., M.T. Al-Assi, and M. Robinson. 1995. Prolonged remission in Crohn's disease following therapy for Mycobacterium paratuberculosis infection. Gastroenterology. 108:826a. (Abstr.)
    • (1995) Gastroenterology , vol.108
    • Graham, D.Y.1    Al-Assi, M.T.2    Robinson, M.3
  • 6
    • 0001301124 scopus 로고
    • A double-blind, placebo-controlled, six-month ciprofloxacin treatment improves prognosis in ulcerative colitis
    • Abstr.
    • Turunen, U. 1994. A double-blind, placebo-controlled, six-month ciprofloxacin treatment improves prognosis in ulcerative colitis. Gastroenterology. 106:786a. (Abstr.)
    • (1994) Gastroenterology , vol.106
    • Turunen, U.1
  • 7
    • 0028327808 scopus 로고
    • Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats
    • McCall, R.D., S. Haskill, E.M. Zimmermann, P.K. Lund, R.C. Thompson, and R.B. Sartor. 1994. Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats. Gastroenterology. 106:960-972.
    • (1994) Gastroenterology , vol.106 , pp. 960-972
    • McCall, R.D.1    Haskill, S.2    Zimmermann, E.M.3    Lund, P.K.4    Thompson, R.C.5    Sartor, R.B.6
  • 8
    • 0021924786 scopus 로고
    • Granulomatous enterocolitis induced in rats by purified bacterial cell wall fragments
    • Sartor, R.B., W.J. Cromartie, D.W. Powell, and J.H. Schwab. 1985. Granulomatous enterocolitis induced in rats by purified bacterial cell wall fragments. Gastroenterology. 89:587-595.
    • (1985) Gastroenterology , vol.89 , pp. 587-595
    • Sartor, R.B.1    Cromartie, W.J.2    Powell, D.W.3    Schwab, J.H.4
  • 9
    • 0025964069 scopus 로고
    • Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline
    • Lichtman, S.N., J. Keku, J.H. Schwab, and R.B. Sartor. 1991. Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline. Gastroenterology. 100:513-519.
    • (1991) Gastroenterology , vol.100 , pp. 513-519
    • Lichtman, S.N.1    Keku, J.2    Schwab, J.H.3    Sartor, R.B.4
  • 10
    • 0029008142 scopus 로고
    • Reactivation of arthritis induced by small bowel bacterial overgrowth in rats: Role of cytokines, luminal bacteria and bacterial polymers
    • Lichtman, S.N., J. Wang, R.B. Sartor, C. Zhang, D.E. Bender, F.G. Dalldorfer, and J.H. Schwab. 1995. Reactivation of arthritis induced by small bowel bacterial overgrowth in rats: role of cytokines, luminal bacteria and bacterial polymers. Infect. Immun. 63:2295-2301.
    • (1995) Infect. Immun. , vol.63 , pp. 2295-2301
    • Lichtman, S.N.1    Wang, J.2    Sartor, R.B.3    Zhang, C.4    Bender, D.E.5    Dalldorfer, F.G.6    Schwab, J.H.7
  • 12
    • 0000435409 scopus 로고
    • Absolute requirement for ubiquitous luminal bacteria in the pathogenesis of chronic intestinal inflammation
    • Abstr.
    • Sartor, R.B., D.E. Bender, T. Grenther, and L.C. Holt. 1994. Absolute requirement for ubiquitous luminal bacteria in the pathogenesis of chronic intestinal inflammation. Gastroenterology. 104:767a. (Abstr.)
    • (1994) Gastroenterology , vol.104
    • Sartor, R.B.1    Bender, D.E.2    Grenther, T.3    Holt, L.C.4
  • 13
    • 0000333423 scopus 로고
    • Normal bacterial population of the intestine and their relation to intestinal function
    • Donaldson, R.M., Jr. 1981. Normal bacterial population of the intestine and their relation to intestinal function. N. Engl. J. Med. 270:938-943.
    • (1981) N. Engl. J. Med. , vol.270 , pp. 938-943
    • Donaldson Jr., R.M.1
  • 14
    • 0019818169 scopus 로고
    • Relation between concentrations of metronidazole and Bacteroides spp in faeces of patients with Crohn's disease and healthy individuals
    • Krook, A., B. Lindstrom, J. Kjellander, G. Jarnerot, and L. Bodin. 1981. Relation between concentrations of metronidazole and Bacteroides spp in faeces of patients with Crohn's disease and healthy individuals. J. Clin. Pathol. 34:645-650.
    • (1981) J. Clin. Pathol. , vol.34 , pp. 645-650
    • Krook, A.1    Lindstrom, B.2    Kjellander, J.3    Jarnerot, G.4    Bodin, L.5
  • 15
    • 0024157187 scopus 로고
    • The obligate anaerobic faecal flora of patients with Crohn's disease and their first-degree relatives
    • van de Merwe, J.P., A.M. Schröder, F. Wensinck, and M.P. Hazenberg. 1988. The obligate anaerobic faecal flora of patients with Crohn's disease and their first-degree relatives. Scand. J. Gastroenterol. 23:1125-1131.
    • (1988) Scand. J. Gastroenterol. , vol.23 , pp. 1125-1131
    • Van De Merwe, J.P.1    Schröder, A.M.2    Wensinck, F.3    Hazenberg, M.P.4
  • 17
    • 0019468466 scopus 로고
    • Production of experimental ulcerative colitis in gnotobiotic guinea pigs with simplified microflora
    • Onderdonk, A.B., M.L. Franklin, and R.L. Cisneros. 1981. Production of experimental ulcerative colitis in gnotobiotic guinea pigs with simplified microflora. Infect. Immun. 32:225-231.
    • (1981) Infect. Immun. , vol.32 , pp. 225-231
    • Onderdonk, A.B.1    Franklin, M.L.2    Cisneros, R.L.3
  • 18
    • 0024386003 scopus 로고
    • Cell wall fragments from major residents of the human intestinal flora induce chronic arthritis in rats
    • Severijnen, A.J., R. van Kleef, M.P. Hazenberg, and J.P. van de Merwe. 1989. Cell wall fragments from major residents of the human intestinal flora induce chronic arthritis in rats. J. Rheumatol. 16:1061-1068.
    • (1989) J. Rheumatol. , vol.16 , pp. 1061-1068
    • Severijnen, A.J.1    Van Kleef, R.2    Hazenberg, M.P.3    Van De Merwe, J.P.4
  • 20
    • 0004235781 scopus 로고
    • The major histocompatibility complex
    • A.K. Abbas, A.H. Lichtman, and J.S. Pober, editors. W.B. Saunders Co., Philadelphia
    • Abbas, A.K., A.H. Lichtman, and J.S. Pober. 1994. The major histocompatibility complex. In Cellular and Molecular Immunology. A.K. Abbas, A.H. Lichtman, and J.S. Pober, editors. W.B. Saunders Co., Philadelphia. 96-114.
    • (1994) Cellular and Molecular Immunology , pp. 96-114
    • Abbas, A.K.1    Lichtman, A.H.2    Pober, J.S.3
  • 21
    • 0028306186 scopus 로고
    • Etiopathogencsis of ankylosing spondylitis and reactive arthritis
    • Inman, R.D., and R.H. Scofield. 1994. Etiopathogencsis of ankylosing spondylitis and reactive arthritis. Curr. Opin. Rheumatol. 6:360-370.
    • (1994) Curr. Opin. Rheumatol. , vol.6 , pp. 360-370
    • Inman, R.D.1    Scofield, R.H.2
  • 22
    • 0038765526 scopus 로고
    • Mechanisms of systemic inflammation associated with intestinal injury
    • S.R. Targan and F. Shanahan, editors. Williams & Wilkins, Baltimore, MD
    • Sartor, R.B., and S.N. Lichtman. 1993. Mechanisms of systemic inflammation associated with intestinal injury. In Inflammatory Bowel Disease: From Bench to Bedside. S.R. Targan and F. Shanahan, editors. Williams & Wilkins, Baltimore, MD. 210-229.
    • (1993) Inflammatory Bowel Disease: From Bench to Bedside , pp. 210-229
    • Sartor, R.B.1    Lichtman, S.N.2
  • 23
    • 0025633436 scopus 로고
    • Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: An animal model of HLA-B27-associated human disorders
    • Hammer, R.E., S.D. Maika, J.A. Richardson, J.P. Tang, and J.D. Taurog. 1990. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Cell. 63:1099-1112.
    • (1990) Cell , vol.63 , pp. 1099-1112
    • Hammer, R.E.1    Maika, S.D.2    Richardson, J.A.3    Tang, J.P.4    Taurog, J.D.5
  • 24
    • 0027300353 scopus 로고
    • Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression
    • Taurog, J.D., S.D. Maika, WA. Simmons, M. Breban, and R.E. Hammer. 1993. Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression. J. Immunol. 150:4168-4178.
    • (1993) J. Immunol. , vol.150 , pp. 4168-4178
    • Taurog, J.D.1    Maika, S.D.2    Simmons, W.A.3    Breban, M.4    Hammer, R.E.5
  • 28
    • 0002274807 scopus 로고
    • Development of an "altered Schaedler flora" for NCl gnotobiotic rodents
    • Abstr.
    • Orcutt, R.P., F.J. Gianni, and R.J. Judge. 1987. Development of an "altered Schaedler flora" for NCl gnotobiotic rodents. Microecol. Ther. 17:59a. (Abstr.)
    • (1987) Microecol. Ther. , vol.17
    • Orcutt, R.P.1    Gianni, F.J.2    Judge, R.J.3
  • 29
    • 0024999311 scopus 로고
    • Assessment of leukocyte involvement during ischemia and reperfusion of intestine
    • Grisham, M.B., J.N. Benoit, and D.N. Granger. 1990. Assessment of leukocyte involvement during ischemia and reperfusion of intestine. Methods Enzymol. 186:729-742.
    • (1990) Methods Enzymol. , vol.186 , pp. 729-742
    • Grisham, M.B.1    Benoit, J.N.2    Granger, D.N.3
  • 30
    • 0028566403 scopus 로고
    • A novel multispecific competitor fragment for quantitative PCR analysis of cytokine gene expression in rats
    • Siegling, A., M. Lehmann, C. Platzer, F. Emmrich, and H.D. Volk. 1994. A novel multispecific competitor fragment for quantitative PCR analysis of cytokine gene expression in rats. J. Immunol. Methods. 177:23-28.
    • (1994) J. Immunol. Methods , vol.177 , pp. 23-28
    • Siegling, A.1    Lehmann, M.2    Platzer, C.3    Emmrich, F.4    Volk, H.D.5
  • 33
    • 0025954704 scopus 로고
    • Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: Evolution of a cytokine control mechanism
    • Eisenberg, S.P., M.T Brewer, E. Verderber, P. Heimdal, B.J. Brandhuber, and R.C. Thompson. 1991. Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. Proc. Nail. Acad. Sci. USA. 88:5232-5236.
    • (1991) Proc. Nail. Acad. Sci. USA , vol.88 , pp. 5232-5236
    • Eisenberg, S.P.1    Brewer, M.T.2    Verderber, E.3    Heimdal, P.4    Brandhuber, B.J.5    Thompson, R.C.6
  • 34
    • 0027361081 scopus 로고
    • Cloning and sequence analysis of the rat tumor necrosis factor-encoding gene
    • Kwon, J., I. Chung, and E. Benveniste. 1993. Cloning and sequence analysis of the rat tumor necrosis factor-encoding gene. Gene. 132:227-236.
    • (1993) Gene , vol.132 , pp. 227-236
    • Kwon, J.1    Chung, I.2    Benveniste, E.3
  • 35
    • 85046166039 scopus 로고    scopus 로고
    • Interleukin-10 suppresses chronic, experimental granulomatous inflammation induced by bacterial cell wall polymers
    • In press
    • Herfarth, H.H., S.P. Mohanty, H.C. Rath, S. Tonkmogy, and R.B. Sartor. 1996. Interleukin-10 suppresses chronic, experimental granulomatous inflammation induced by bacterial cell wall polymers. Gut. In press.
    • (1996) Gut
    • Herfarth, H.H.1    Mohanty, S.P.2    Rath, H.C.3    Tonkmogy, S.4    Sartor, R.B.5
  • 38
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A.C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 75:253-261.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 39
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kühn, R., J. Löhler, D. Rennick, K. Rajewsky, and W. Müller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75:263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kühn, R.1    Löhler, J.2    Rennick, D.3    Rajewsky, K.4    Müller, W.5
  • 41
    • 0026785849 scopus 로고
    • Metronidazole reduces intestinal inflammation and blood loss in non-steroidal anti-inflammatory drug induced enteropathy
    • Bjarnason, I., J. Hayllar, P. Smethurst, A. Price, and M. J. Gumpel. 1992. Metronidazole reduces intestinal inflammation and blood loss in non-steroidal anti-inflammatory drug induced enteropathy. Gut. 33:1204-1208.
    • (1992) Gut , vol.33 , pp. 1204-1208
    • Bjarnason, I.1    Hayllar, J.2    Smethurst, P.3    Price, A.4    Gumpel, M.J.5
  • 43
    • 0029935096 scopus 로고    scopus 로고
    • Bacteroides fragilis enterotoxin modulates epithelial permeability and bacterial internalization by HT-29 enterocytes
    • Wells, C.L., M.A. van de Westerlo, R.P. Jechorek, B.A. Feltis, T.D. Wilkins, and S.L. Erlandsen. 1996. Bacteroides fragilis enterotoxin modulates epithelial permeability and bacterial internalization by HT-29 enterocytes. Gastroenterology. 110:1429-1437.
    • (1996) Gastroenterology , vol.110 , pp. 1429-1437
    • Wells, C.L.1    Van De Westerlo, M.A.2    Jechorek, R.P.3    Feltis, B.A.4    Wilkins, T.D.5    Erlandsen, S.L.6
  • 44
    • 4243962380 scopus 로고
    • Luminal bacteria and bacterial polymers potentiate indomethacin-induced intestinal injury in the rat
    • Abstr.
    • Davis, S.W., L.C. Holt, and R.B. Sartor. 1990. Luminal bacteria and bacterial polymers potentiate indomethacin-induced intestinal injury in the rat. Gastroenterology. 98:444a. (Abstr.)
    • (1990) Gastroenterology , vol.98
    • Davis, S.W.1    Holt, L.C.2    Sartor, R.B.3
  • 45
    • 0026451945 scopus 로고
    • Degradation of endogenous bacterial cell wall polymers by the muralytic enzyme mutanolysin prevents hepatobiliary injury in genetically susceptible rats with experimental intestinal bacterial overgrowth
    • Lichtman, S.N., E.E. Okoruwa, J. Keku, J.H. Schwab, and R.B. Sartor. 1992. Degradation of endogenous bacterial cell wall polymers by the muralytic enzyme mutanolysin prevents hepatobiliary injury in genetically susceptible rats with experimental intestinal bacterial overgrowth. J. Clin. Invest. 90:1313-1322.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1313-1322
    • Lichtman, S.N.1    Okoruwa, E.E.2    Keku, J.3    Schwab, J.H.4    Sartor, R.B.5
  • 48
    • 0029071036 scopus 로고
    • Spontaneous intestinal inflammation and nitric oxide metabolism in HLA B27 transgenic rats
    • Aiko, S., and M.B. Grisham. 1995. Spontaneous intestinal inflammation and nitric oxide metabolism in HLA B27 transgenic rats. Gastroenterology. 109: 142-150.
    • (1995) Gastroenterology , vol.109 , pp. 142-150
    • Aiko, S.1    Grisham, M.B.2
  • 49
    • 0028069352 scopus 로고
    • Cytokines in intestinal inflammation: Pathophysiological and clinical considerations
    • Sartor, R.B. 1994. Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology. 106:533-539.
    • (1994) Gastroenterology , vol.106 , pp. 533-539
    • Sartor, R.B.1
  • 50
    • 0028109993 scopus 로고
    • Cytokine regulation of experimental intestinal inflammation
    • Herfarth, H.H., and R.B. Sartor. 1994. Cytokine regulation of experimental intestinal inflammation. Curr. Opin. Gastroenterol. 10:625-632.
    • (1994) Curr. Opin. Gastroenterol. , vol.10 , pp. 625-632
    • Herfarth, H.H.1    Sartor, R.B.2
  • 51
    • 0022369449 scopus 로고
    • Reactivation of streptococcal cell wall-induced arthritis by homologous and heterologous cell wall polymers
    • Esser, R.E., S.A. Stimpson, W.J. Cromartie, and J.H. Schwab. 1985. Reactivation of streptococcal cell wall-induced arthritis by homologous and heterologous cell wall polymers. Arthritis Rheum. 28:1402-1411.
    • (1985) Arthritis Rheum. , vol.28 , pp. 1402-1411
    • Esser, R.E.1    Stimpson, S.A.2    Cromartie, W.J.3    Schwab, J.H.4
  • 52
    • 0023251984 scopus 로고
    • Lipopolysaccharide induces recurrence of arthritis in rat joints previously injured by peptidoglycan-polysaccharide
    • Stimpson, S.A., R.E. Esser, P.B. Carter, R.B. Sartor, W.J. Cromartie, and J.H. Schwab. 1987. Lipopolysaccharide induces recurrence of arthritis in rat joints previously injured by peptidoglycan-polysaccharide. J. Exp. Med. 165: 1688-1702.
    • (1987) J. Exp. Med. , vol.165 , pp. 1688-1702
    • Stimpson, S.A.1    Esser, R.E.2    Carter, P.B.3    Sartor, R.B.4    Cromartie, W.J.5    Schwab, J.H.6
  • 54
    • 0023706684 scopus 로고
    • Systemic uptake and intestinal inflammatory effects of luminal bacterial cell wall polymers in rats with acute colonic injury
    • Sartor, R.B., T.M. Bond, and J.H. Schwab. 1988. Systemic uptake and intestinal inflammatory effects of luminal bacterial cell wall polymers in rats with acute colonic injury. Infect. Immun. 56:2101-2108.
    • (1988) Infect. Immun. , vol.56 , pp. 2101-2108
    • Sartor, R.B.1    Bond, T.M.2    Schwab, J.H.3
  • 55
    • 0026071024 scopus 로고
    • Evidence for peptidoglycan absorption in rats with experimental small bowel bacterial overgrowth
    • Lichtman, S.N., J. Keku, J.H. Schwab, and R.B. Sartor. 1991. Evidence for peptidoglycan absorption in rats with experimental small bowel bacterial overgrowth. Infect. Immun. 59:555-562.
    • (1991) Infect. Immun. , vol.59 , pp. 555-562
    • Lichtman, S.N.1    Keku, J.2    Schwab, J.H.3    Sartor, R.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.