-
1
-
-
84868680312
-
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
-
Published Online First: 17 May 2012 doi:10.1136/gutjnl-2011-301668
-
Hueber W, Sands BE, Lewitzky S, et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 2012. Published Online First: 17 May 2012 doi:10.1136/gutjnl-2011-301668
-
(2012)
Gut
-
-
Hueber, W.1
Sands, B.E.2
Lewitzky, S.3
-
2
-
-
0842324613
-
Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
-
DOI 10.1016/j.clim.2003.09.013
-
Ogawa A, Andoh A, Araki Y, et al. Neutralization of interleukin-17 aggravates dextran sulfate sodiuminduced colitis in mice. Clin Immunol 2004;110:55-62. (Pubitemid 38177420)
-
(2004)
Clinical Immunology
, vol.110
, Issue.1
, pp. 55-62
-
-
Ogawa, A.1
Andoh, A.2
Araki, Y.3
Bamba, T.4
Fujiyama, Y.5
-
3
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 2006; 116:1310-16.
-
(2006)
J Clin Invest
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
Cheung, J.2
Scheerens, H.3
-
4
-
-
43549110961
-
Regulation of inflammatory responses by IL-17F
-
DOI 10.1084/jem.20071978
-
Yang XO, Chang SH, Park H, et al . Regulation of inflammatory responses by IL-17F. J Exp Med 2008; 205:1063-75. (Pubitemid 351679682)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.5
, pp. 1063-1075
-
-
Yang, X.O.1
Seon, H.C.2
Park, H.3
Nurieva, R.4
Shah, B.5
Acero, L.6
Wang, Y.-H.7
Schluns, K.S.8
Broaddus, R.R.9
Zhu, Z.10
Dong, C.11
-
5
-
-
80051930220
-
T helper 17 cell heterogeneity and pathogenicity in autoimmune disease
-
Ghoreschi K, Laurence A, Yang XP, et al. T helper 17 cell heterogeneity and pathogenicity in autoimmune disease. Trends Immunol 2011;32 :395-401.
-
(2011)
Trends Immunol
, vol.32
, pp. 395-401
-
-
Ghoreschi, K.1
Laurence, A.2
Yang, X.P.3
-
6
-
-
77951878587
-
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
-
Buonocore S, Ahern PP, Uhlig HH, et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 2010;464:1371-5.
-
(2010)
Nature
, vol.464
, pp. 1371-1375
-
-
Buonocore, S.1
Ahern, P.P.2
Uhlig, H.H.3
-
7
-
-
84859073115
-
Anti-interleukin- 17 monoclonal antibody ixekizumab in chronic plaque psoriasis
-
Leonardi C, Matheson R, Zachariae C, et al. Anti-interleukin- 17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med 2012;366:1190-9.
-
(2012)
N Engl J Med
, vol.366
, pp. 1190-1199
-
-
Leonardi, C.1
Matheson, R.2
Zachariae, C.3
-
8
-
-
80052325959
-
Pervasive sharing of genetic effects in autoimmune disease
-
Cotsapas C, Voight BF, Rossin E, et al. Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet 2011;7:e1002254.
-
(2011)
PLoS Genet
, vol.7
-
-
Cotsapas, C.1
Voight, B.F.2
Rossin, E.3
-
9
-
-
84255162807
-
The multitasking organ: Recent insights into skin immune function
-
Di Meglio P, Perera GK, Nestle FO. The multitasking organ: recent insights into skin immune function. Immunity 2011;35:857-69.
-
(2011)
Immunity
, vol.35
, pp. 857-869
-
-
Di Meglio, P.1
Perera, G.K.2
Nestle, F.O.3
-
10
-
-
77958072084
-
Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
-
Hueber W, Patel DD, Dryja T, et al. Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med 2010;2:52ra72.
-
(2010)
Sci Transl Med
, vol.2
-
-
Hueber, W.1
Patel, D.D.2
Dryja, T.3
-
11
-
-
74249094930
-
Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis
-
Griffiths CE, Strober BE, van de Kerkhof P, et al. Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis. N Engl J Med 2010;362 :118-28.
-
(2010)
N Engl J Med
, vol.362
, pp. 118-128
-
-
Griffiths, C.E.1
Strober, B.E.2
Van De Kerkhof, P.3
-
12
-
-
8344284998
-
Anti-interleukin-12 antibody for active Crohn's disease
-
DOI 10.1056/NEJMoa033402
-
Mannon PJ, Fuss IJ, Mayer L, et al. Anti-interleukin- 12 antibody for active Crohn's disease. N Engl J Med 2004;351:2069-79. (Pubitemid 39482500)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.20
, pp. 2069-2079
-
-
Mannon, P.J.1
Fuss, I.J.2
Mayer, L.3
Elson, C.O.4
Sandborn, W.J.5
Present, D.6
Dolin, B.7
Goodman, N.8
Groden, C.9
Hornung, R.L.10
Quezado, M.11
Neurath, M.F.12
Salfeld, J.13
Veldman, G.M.14
Schwertschlag, U.15
Strober, W.16
-
13
-
-
53049091561
-
A randomized trial of Ustekinumab, a human interleukin- 12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
-
Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of Ustekinumab, a human interleukin- 12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology 2008;135 :1130-41.
-
(2008)
Gastroenterology
, vol.135
, pp. 1130-1141
-
-
Sandborn, W.J.1
Feagan, B.G.2
Fedorak, R.N.3
-
14
-
-
84860216630
-
Microbial exposure during early life has persistent effects on natural killer T cell function
-
Olszak T, An D, Zeissig S, et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 2012; 336 :489-93.
-
(2012)
Science
, vol.336
, pp. 489-493
-
-
Olszak, T.1
An, D.2
Zeissig, S.3
|