Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics, class II major histocompatibility complex expression, and viability

Arthritis and Rheumatism

Volumn 60, Issue 9, 2009, Pages 2622-2632

  Dhaenens, Maarten ^a   Fert, Ingrid ^b   Glatigny, Simon ^b   Haerinck, Saskia ^a   Poulain, Cécile ^b   Donnadieu, Emmanuel ^b   Hacquard Bouder, Cécile ^b,c   André, Claudine ^b   Elewaut, Dirk ^d   Deforce, Dieter ^a   Breban, Maxime ^b,c  

^a GHENT UNIVERSITY   (Belgium)

^b INSTITUT COCHIN   (France)

^c LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^d GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; CD4 ANTIGEN; HLA B27 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL MATURATION; CELL MOTILITY; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOSKELETON; DENDRITIC CELL; DISEASE PREDISPOSITION; DOWN REGULATION; FLOW CYTOMETRY; IMMUNE DEFICIENCY; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; MICROSCOPY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEOMICS; RAT; SPLEEN; SPONDYLARTHRITIS; SYNAPSE; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD4; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; CYTOSKELETON; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-B27 ANTIGEN; HUMANS; INTEGRIN ALPHA CHAINS; MALE; RATS; RATS, INBRED F344; RATS, TRANSGENIC; SPONDYLARTHRITIS;

EID: 69449083847     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24780     Document Type: Article

References (45)

1. Ramos M, Lopez de Castro JA. HLA-B27 and the pathogenesis of spondyloarthritis. Tissue Antigens 2002;60:191-205.
2. Said-Nahal R, Miceli-Richard C, Gautreau C, Tamouza R, Borot N, Porcher R, et al. The role of HLA genes in familial spondyloarthropathy: a comprehensive study of 70 multiplex families. Ann Rheum Dis 2002;61:201-206 (Pubitemid 34177748)
3. Colbert RA. The immunobiology of HLA-B27: variations on a theme. Curr Mol Med 2004;4:21-30.
4. Breban M, Hacquard-Bouder C, Falgarone G. Animal models of HLA-B27-associated diseases. Curr Mol Med 2004;4:31-40.
5. 2m: an animal model of HLA-B27-associated human disorders. Cell 1990;63:1099-1112
6. Hacquard-Bouder C, Ittah M, Breban M. Animal models of HLA-B27-associated diseases: new outcomes. Joint Bone Spine 2006;73:132-138
7. Gaspar R Jr, Bagossi P, Bene L, Matko J, Szollosi J, Tozser J, et al. Clustering of class I HLA oligomers with CD8 and TCR: three-dimensional models based on fluorescence resonance energy transfer and crystallographic data. J Immunol 2001;166:5078-5086 (Pubitemid 32280721)
8. Breban M, Hammer RE, Richardson JA, Taurog JD. Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment. J Exp Med 1993;178:1607-1616 (Pubitemid 23318439)
9. Breban M, Fernandez-Sueiro JL, Richardson JA, Hadavand RR, Maika SD, Hammer RE, et al. T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats. J Immunol 1996;156:794-803. (Pubitemid 26028940)
10. Taurog JD, Maika SD, Simmons WA, Breban M, Hammer RE. Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression. J Immunol 1993;150:4168-4178 (Pubitemid 23129798)
11. Cauli A, Dessole G, Fiorillo MT, Vacca A, Mameli A, Bitti P, et al. Increased level of HLA-B27 expression in ankylosing spondylitis patients compared with healthy HLA-B27-positive subjects: a possible further susceptibility factor for the development of disease. Rheumatology (Oxford) 2002;41:1375-1379 (Pubitemid 36004313)
12. Taurog JD, Richardson JA, Croft JT, Simmons WA, Zhou M, Fernandez-Sueiro JL, et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 1994;180:2359-2364 (Pubitemid 24351619)
13. Hacquard-Bouder C, Falgarone G, Bosquet A, Smaoui F, Monnet D, Ittah M, et al. Defective costimulatory function is a striking feature of antigen-presenting cells in an HLA-B27-transgenic rat model of spondylarthropathy. Arthritis Rheum 2004;50:1624-1635 (Pubitemid 38608085)
14. Stagg AJ, Breban M, Hammer RE, Knight SC, Taurog JD. Defective dendritic cell (DC) function in a HLA-B27 transgenic rat model of spondyloarthropathy (SpA). Adv Exp Med Biol 1995;378:557-559
15. Hacquard-Bouder C, Chimenti MS, Giquel B, Donnadieu E, Fert I, Schmitt A, et al. Alteration of antigen-independent immunologic synapse formation between dendritic cells from HLA-B27-transgenic rats and CD4+ T cells: selective impairment of costimulatory molecule engagement by mature HLA-B27. Arthritis Rheum 2007;56:1478-1489 (Pubitemid 46764076)
16. 2-microglobulin-transgenic rat lines. Arthritis Rheum 2008;58:3425-3429
17. Colbert RA.HLA-B27 misfolding: a solution to the spondyloarthropathy conundrum? Mol Med Today 2000;6:224-230
18. Mear JP, Schreiber KL, Munz C, Zhu X, Stevanovic S, Rammensee HG, et al. Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies. J Immunol 1999;163:6665-6670
19. Turner MJ, Sowders DP, DeLay ML, Mohapatra R, Bai S, Smith JA, et al. HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response. J Immunol 2005;175:2438-2448 (Pubitemid 41113854)
20. Dangoria NS, DeLay ML, Kingsbury DJ, Mear JP, Uchanska-Ziegler B, Ziegler A, et al. HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum. J Biol Chem 2002;277:23459-23468 (Pubitemid 34952180)
21. Taurog JD, Maika SD, Satumtira N, Dorris ML, McLean IL, Yanagisawa H, et al. Inflammatory disease in HLA-B27 transgenic rats. Immunol Rev 1999;169:209-223 (Pubitemid 29338734)
22. Knight SC, Mertin J, Stackpoole A, Clark J. Induction of immune responses in vivo with small numbers of veiled (dendritic) cells. Proc Natl Acad Sci U S A 1983;80:6032-6035 (Pubitemid 14228238)
23. Breban M, Fernandez-Sueiro JL, Richardson JA, Hadavand RR, Maika SD, Hammer RE, et al. T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats. J Immunol 1996;156:794-803. (Pubitemid 26028940)
24. Tilleman K, Van Beneden K, Dhondt A, Hoffman I, De Keyser F, Veys E, et al. Chronically inflamed synovium from spondyloarthropathy and rheumatoid arthritis investigated by protein expression profiling followed by tandem mass spectrometry. Proteomics 2005;5:2247-2257 (Pubitemid 40770586)
25. Donnadieu E, Bismuth G, Trautmann A. Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium. Curr Biol 1994;4:584-595 (Pubitemid 2110968)
26. Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003;112:453-465
27. Hubert FX, Voisine C, Louvet C, Heslan JM, Ouabed A, Heslan M, et al. Differential pattern recognition receptor expression but stereotyped responsiveness in rat spleen dendritic cell subsets. J Immunol 2006;177:1007-1016 (Pubitemid 44036603)
28. Leverkus M, McLellan AD, Heldmann M, Eggert AO, Brocker EB, Koch N, et al. MHC class II-mediated apoptosis in dendritic cells: a role for membrane-associated and mitochondrial signaling pathways. Int Immunol 2003;15:993-1006. (Pubitemid 36987297)
29. Yrlid U, Macpherson G. Phenotype and function of rat dendritic cell subsets. APMIS 2003;111:756-765 (Pubitemid 37130022)
30. Liu L, Zhang M, Jenkins C, MacPherson GG. Dendritic cell heterogeneity in vivo: two functionally different dendritic cell populations in rat intestinal lymph can be distinguished by CD4 expression. J Immunol 1998;161:1146-1155 (Pubitemid 28380539)
31. Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 2000;101:249-258
32. 2-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats. Arthritis Rheum 2006;54:1317-1327
33. Galocha B, Lopez de Castro JA. Folding of HLA-B27 subtypes is determined by the global effect of polymorphic residues and shows incomplete correspondence to ankylosing spondylitis. Arthritis Rheum 2008;58:401-412 (Pubitemid 351294875)
34. Dustin ML. Immunology: when F-actin becomes too much of a good thing. Science 2006;313:767-768 (Pubitemid 44223330)
35. Rohrig U, Gerisch G, Morozova L, Schleicher M, Wegner A. Coactosin interferes with the capping of actin filaments. FEBS Lett 1995;374:284-286
36. Stagg AJ, Hughes RA, Keat AC, Elsley WA, Knight SC. Antigen-presenting cells but not lymphocytes in the joint may indicate the cause of reactive arthritis. Br J Rheumatol 1996;35:1082-1090 (Pubitemid 126719642)
37. Huang FP, Platt N, Wykes M, Major JR, Powell TJ, Jenkins CD, et al. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med 2000;191:435-444 (Pubitemid 30693568)
38. Villadangos JA, Schnorrer P, Wilson NS. Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces. Immunol Rev 2005;207:191-205. (Pubitemid 41415018)
39. McLellan A, Heldmann M, Terbeck G, Weih F, Linden C, Brocker EB, et al. MHC class II and CD40 play opposing roles in dendritic cell survival. Eur J Immunol 2000;30:2612-2619
40. Gourlay CW, Carpp LN, Timpson P, Winder SJ, Ayscough KR. A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol 2004;164:803-809 (Pubitemid 38366892)
41. Matsue H, Edelbaum D, Hartmann AC, Morita A, Bergstresser PR, Yagita H, et al. Dendritic cells undergo rapid apoptosis in vitro during antigen-specific interaction with CD4+ T cells. J Immunol 1999;162:5287-5298 (Pubitemid 29307135)
42. Trinite B, Voisine C, Yagita H, Josien R. A subset of cytolytic dendritic cells in rat. J Immunol 2000;165:4202-4208 (Pubitemid 30795791)
43. Voisine C, Hubert FX, Trinite B, Heslan M, Josien R. Two phenotypically distinct subsets of spleen dendritic cells in rats exhibit different cytokine production and T cell stimulatory activity. J Immunol 2002;169:2284-2291 (Pubitemid 34920968)
44. + rat dendritic cells induce rapid caspase-independent apoptosis-like cell death in various tumor and non-tumor cells and phagocytose their victims. J Immunol 2005;175:2408-2417
45. Turnbull EL, Yrlid U, Jenkins CD, Macpherson GG. Intestinal dendritic cell subsets: differential effects of systemic TLR4 stimulation on migratory fate and activation in vivo. J Immunol 2005;174:1374-1384