Spondylarthritis in HLA-B27/human β2-microglobulin- transgenic rats is not prevented by lack of CD8

Arthritis and Rheumatism

Volumn 60, Issue 7, 2009, Pages 1977-1984

  Taurog, Joel D ^a,b   Dorris, Martha L ^a   Satumtira, Nimman ^a   Tran, Tri M ^a   Sharma, Rohit ^a   Dressel, Ralf ^c   Van Den Brandt, Jens ^c   Reichardt, Holger M ^c  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CD8 ANTIGEN; ETHYLNITROSOUREA; HLA B27 ANTIGEN; MESSENGER RNA;

ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ARTICLE; CD8+ T LYMPHOCYTE; CD8A GENE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE; HISTOPATHOLOGY; IMMUNOPATHOGENESIS; MALE; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPONDYLITIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD8; BETA 2-MICROGLOBULIN; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; HLA-B27 ANTIGEN; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PHENOTYPE; PREVALENCE; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SPONDYLARTHRITIS;

EID: 67650074528     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24599     Document Type: Article

References (50)

1. Benjamin R, Parham P. Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol Today 1990;11:137-42.
2. Alvarez I, Sesma L, Marcilla M, Ramos M, Marti M, Camafeita E, et al. Identification of novel HLA-B27 ligands derived from polymorphic regions of its own or other class I molecules based on direct generation by 20 S proteasome. J Biol Chem 2001;276:32729-37.
3. Ramos M, Alvarez I, Sesma L, Logean A, Rognan D, Lopez de Castro JA. Molecular mimicry of an HLA-B27-derived ligand of arthritis-linked subtypes with chlamydial proteins. J Biol Chem 2002;277:37573-81.
4. Cragnolini JJ, Lopez de Castro JA. Identification of endogenously presented peptides from Chlamydia trachomatis with high homology to human proteins and to a natural self-ligand of HLA-B27. Mol Cell Proteomics 2008;7:170-80.
5. + T-cell autoreactivity to an HLA-B27-restricted self-epitope correlates with ankylosing spondylitis. J Clin Invest 2000;106:47-53.
6. Holler PD, Kranz DM. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity 2003;18:255-64.
7. Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, et al. Crystal structure of the complex between human CD8αα and HLA-A2. Nature 1997;387:630-4.
8. b. Immunity 1998;9:519-30.
9. 2m: an animal model of HLA-B27-associated human disorders. Cell 1990;63:1099-112.
10. Taurog JD, Maika SD, Satumtira N, Dorris ML, McLean IL, Yanagisawa H, et al. Inflammatory disease in HLA-B27 transgenic rats. Immunol Rev 1999;169:209-23.
11. 2-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats. Arthritis Rheum 2006;54:1317-27.
12. May E, Dorris ML, Satumtira N, Iqbal I, Rehman MI, Lightfoot E, et al. CD8αβ T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. J Immunol 2003;170:1099-105.
13. Huber M, Timms E, Mak TW, Rollinghoff M, Lohoff M. Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice. Infect Immun 1998;66:3968-70.
14. Zhang GX, Xiao BG, Bakhiet M, van der Meide P, Wigzell H, Link H, et al. Both CD4+ and CD8+ T cells are essential to induce experimental autoimmune myasthenia gravis. J Exp Med 1996;184:349-56.
15. Bosselut R, Feigenbaum L, Sharrow SO, Singer A. Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes. Immunity 2001;14:483-94.
16. Leishman AJ, Naidenko OV, Attinger A, Koning F, Lena CJ, Xiong Y, et al. T cell responses modulated through interaction between CD8αα and the nonclassical MHC class I molecule, TL. Science 2001;294:1936-9.
17. 2-microglobulin- deficient mice without expression of HLA-B27: association with deficiency of endogenous major histocompatibility complex class I expression. Arthritis Rheum 2000;43:2290-6.
18. Zan Y, Haag JD, Chen KS, Shepel LA, Wigington D, Wang YR, et al. Production of knockout rats using ENU mutagenesis and a yeast-based screening assay. Nat Biotechnol 2003;21:645-51.
19. Classon BJ, Brown MH, Garnett D, Somoza C, Barclay AN, Willis AC, et al. The hinge region of the CD8 α chain: structure, antigenicity, and utility in expression of immunoglobulin superfamily domains. Int Immunol 1992;4:215-25.
20. Torres-Nagel N, Kraus E, Brown MH, Tiefenthaler G, Mitnacht R, Williams AF, et al. Differential thymus dependence of rat CD8 isoform expression. Eur J Immunol 1992;22:2841-8.
21. Tran TM, Satumtira N, Dorris ML, May E, Wang A, Furuta E, et al. HLA-B27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone BiP. J Immunol 2004;172:5110-9.
22. Dressel R, Elsner L, Quentin T, Walter L, Gunther E. Heat shock protein 70 is able to prevent heat shock-induced resistance of target cells to CTL. J Immunol 2000;164:2362-71.
23. Leahy DJ, Axel R, Hendrickson WA. Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6A resolution. Cell 1992;68:1145-62.
24. Sanders SK, Fox RO, Kavathas P. Mutations in CD8 that affect interactions with HLA class I and monoclonal anti-CD8 antibodies. J Exp Med 1991;174:371-9.
25. De la Calle-Martin O, Hernandez M, Ordi J, Casamitjana N, Arostegui JI, Caragol I, et al. Familial CD8 deficiency due to a mutation in the CD8α gene. J Clin Invest 2001;108:117-23.
26. Goldrath AW, Hogquist KA, Bevan MJ. CD8 lineage commitment in the absence of CD8. Immunity 1997;6:633-42.
27. Fung-Leung WP, Schilham MW, Rahemtulla A, Kundig TM, Vollenweider M, Potter J, et al. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 1991;65:443-9.
28. Baba T, Ishizu A, Iwasaki S, Suzuki A, Tomaru U, Ikeda H, et al. CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype. Blood 2006;107:2004-12.
29. Hacquard-Bouder C, Chimenti MS, Giquel B, Donnadieu E, Fert I, Schmitt A, et al. Alteration of antigen-independent immunologic synapse formation between dendritic cells from HLA-B27-transgenic rats and CD4+ T cells: selective impairment of costimulatory molecule engagement by mature HLA-B27. Arthritis Rheum 2007;56:1478-89.
30. Hacquard-Bouder C, Falgarone G, Bosquet A, Smaoui F, Monnet D, Ittah M, et al. Defective costimulatory function is a striking feature of antigen-presenting cells in an HLA-B27-transgenic rat model of spondylarthropathy. Arthritis Rheum 2004;50:1624-35.
31. Stagg AJ, Breban M, Hammer RE, Knight SC, Taurog JD. Defective dendritic cell (DC) function in a HLA-B27 transgenic rat model of spondyloarthropathy (SpA). Adv Exp Med Biol 1995;378:557-9.
32. 2-microglobulin-transgenic rat lines. Arthritis Rheum 2008;58:3425-9.
33. Falgarone G, Blanchard HS, Riot B, Simonet M, Breban M. Cytotoxic T-cell-mediated response against Yersinia pseudotuberculosis in HLA-B27 transgenic rat. Infect Immun 1999;67:3773-9.
34. Dangoria NS, DeLay ML, Kingsbury DJ, Mear JP, Uchanska-Ziegler B, Ziegler A, et al. HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum. J Biol Chem 2002;277:23459-68.
35. Kollnberger S, Bird L, Sun MY, Retiere C, Braud VM, McMichael A, et al. Cell-surface expression and immune receptor recognition of HLA-B27 homodimers. Arthritis Rheum 2002;46:2972-82.
36. Antoniou AN, Ford S, Taurog JD, Butcher GW, Powis SJ. Formation of HLA-B27 homodimers and their relationship to assembly kinetics. J Biol Chem 2004;279:8895-902.
37. Smith JA, Turner MJ, Delay ML, Klenk EI, Sowders DP, Colbert RA. Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-β induction via X-box binding protein 1. Eur J Immunol 2008;38:1194-203.
38. Qian BF, Tonkonogy SL, Sartor RB. Aberrant innate immune responses in TLR-ligand activated HLA-B27 transgenic rat cells. Inflamm Bowel Dis 2008;14:1358-65.
39. Boyle LH, Goodall JC, Gaston JS. The recognition of abnormal forms of HLA-B27 by CD4+ T cells. Curr Mol Med 2004;4:51-8.
40. Roddis M, Carter RW, Sun MY, Weissensteiner T, McMichael AJ, Bowness P, et al. Fully functional HLA B27-restricted CD4+ as well as CD8+ T cell responses in TCR transgenic mice. J Immunol 2004;172:155-61.
41. Najafian N, Chitnis T, Salama AD, Zhu B, Benou C, Yuan X, et al. Regulatory functions of CD8+CD28+ T cells in an autoimmune disease model. J Clin Invest 2003;112:1037-48.
42. Sun D, Whitaker JN, Huang Z, Liu D, Coleclough C, Wekerle H, et al. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J Immunol 2001;166:7579-87.
43. Jiang H, Zhang SI, Pernis B. Role of CD8+ T cells in murine experimental allergic encephalomyelitis. Science 1992;256:1213-5.
44. -/- mice. Science 1992;256:1210-3.
45. Cohen ES, Bodmer HC. Cytotoxic T lymphocytes recognize and lyse chondrocytes under inflammatory, but not non-inflammatory conditions. Immunology 2003;109:8-14.
46. Kuhne M, Erben U, Schulze-Tanzil G, Kohler D, Wu P, Richter JF, et al. HLA-B27-restricted antigen presentation by human chondrocytes to CD8+ T cells: potential contribution to local immunopathologic processes in ankylosing spondylitis. Arthritis Rheum 2009;60:1635-46.
47. Lin TJ, Hirji N, Stenton GR, Gilchrist M, Grill BJ, Schreiber AD, et al. Activation of macrophage CD8: pharmacological studies of TNF and IL-1β production. J Immunol 2000;164:1783-92.
48. Taurog JD. The mystery of HLA-B27: if it isn't one thing, it's another [editorial]. Arthritis Rheum 2007;56:2478-81.
49. Marcilla M, Lopez de Castro JA. Peptides: the cornerstone of HLA-B27 biology and pathogenetic role in spondyloarthritis. Tissue Antigens 2008;71:495-506.
50. Wellcome Trust Case Control Consortium and The Australo-Anglo-American Spondylitis Consortium (TASC). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007;39:1329-337.