Process for protein PEGylation

Journal of Controlled Release

Volumn 180, Issue 1, 2014, Pages 134-149

  Pfister, David ^a   Morbidelli, Massimo ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Bioengineering; Drug delivery; PEGylation; Reaction engineering; Separation

Indexed keywords

COSTS; DRUG DELIVERY; SEPARATION; SYSTEMS SCIENCE;

CONJUGATED PROTEINS; CONJUGATION CHEMISTRY; DELIVERY TECHNIQUES; MARKET REQUIREMENTS; PEGYLATION; PURIFICATION PROCESS; REACTION ENGINEERING; THERAPEUTIC PROTEIN;

PROTEINS;

ALDEHYDE; ARX 201; ASPARAGINASE MACROGOL; BAX 855; CERTOLIZUMAB PEGOL; CONTINUOUS ERYTHROPOIESIS RECEPTOR ACTIVATOR; ENZ 2208; ETIRINOTECAN PEGOL; MACROGOL; NALOXEGOL; NKTR 181; NKTR 192; PEGADEMASE; PEGAPTANIB; PEGINESATIDE; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PEGLOTICASE; PEGVISOMANT; POLYHISTIDINE TAG; PROTEIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; THIOL; UNCLASSIFIED DRUG; MACROGOL DERIVATIVE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; BATCH PROCESS; BATCH REACTOR; BINDING AFFINITY; CAPILLARY ELECTROPHORESIS; CHEMICAL MODIFICATION; CHEMICAL REACTION KINETICS; CONTINUOUS PROCESS; DNA MODIFICATION; DRUG BINDING; DRUG CONJUGATION; DRUG COST; DRUG DELIVERY SYSTEM; DRUG QUALITY; DRUG SOLUBILITY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; HYDROPHOBICITY; ION EXCHANGE CHROMATOGRAPHY; LARGE SCALE PRODUCTION; PEGYLATION; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN PURIFICATION; REVERSED PHASE LIQUID CHROMATOGRAPHY; REVIEW; SCALE UP; STATIC ELECTRICITY; ULTRAFILTRATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; PHARMACEUTICS; PROCEDURES; PROTEIN CONFORMATION;

ANIMALS; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HUMANS; MODELS, MOLECULAR; POLYETHYLENE GLYCOLS; PROTEIN CONFORMATION; PROTEINS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84896112309     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.02.002     Document Type: Review

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