Site-specific PEGylation of native disulfide bonds in therapeutic proteins

Nature Chemical Biology

Volumn 2, Issue 6, 2006, Pages 312-313

  Shaunak, Sunil ^a   Godwin, Antony ^b   Choi, Ji Won ^a   Balan, Sibu ^b   Pedone, Elisa ^b   Vijayarangam, Damotharan ^a   Heidelberger, Sibylle ^b   Teo, Ian ^a   Zloh, Mire ^b   Brocchini, Steve ^b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2B INTERFERON; ANTIBODY; CD4 ANTIGEN; CYSTEINE; PEGINTERFERON ALPHA2B; PROTEIN; SULFUR;

ADDITION REACTION; ALKYLATION; ARTICLE; CONJUGATION; DISULFIDE BOND; ELIMINATION REACTION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE;

EID: 33646863688     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio786     Document Type: Article

References (12)

1. Wedemeyer, W.J., Welker, E., Narayan, M. & Scheraga, H.A. Biochemistry 39, 4207-4216 (2000).
2. Guo, Z.Y., Jia, X.Y. & Feng, Y.M. Biol. Chem. 385, 1171-1175 (2004).
3. Harris, J.M. & Chess, R.B. Nat. Rev. Drug Discov. 2, 214-221 (2003).
4. Grace, M.J. et al. J. Biol. Chem. 280, 6327-6336 (2005).
5. Brocchini, S.J., Eberle, M. & Lawton, R.G. J. Am. Chem. Soc. 110, 5211-5212 (1988).
6. Liberatore, F., Eberle, M. & Lawton, R.G. Bioconjug. Chem. 1, 36-50 (1990).
7. Godwin, A. et al. Theoretical Chem. Acc. (in the press).
8. Bailon, P. et al. Bioconjug. Chem. 2, 195-202 (2001).
9. Grace, M. et al. J. Interferon Cytokine Res. 1, 1103-1115 (2001).
10. Rajender Reddy, K., Modi, M.W. & Pedder, S. Adv. Drug Deliv. Rev. 54, 571-586 (2002).
11. Healey, D. et al. J. Exp. Med. 172, 1233-1242 (1990).
12. Balan, S. et al. in Proceedings of 33rd Controlled Release Society Meeting (ed. Davies, M.) (in press).