Carboxyalkylated histidine is a pH-dependent product of pegylation with SC-PEG

Pharmaceutical Research

Volumn 18, Issue 9, 2001, Pages 1354-1360

  Wylie, David C ^a   Voloch, Marcio ^a   Lee, Seoju ^a   Liu, Yan Hui ^a   Cannon Carlson, Susan ^a   Cutler, Collette ^a   Pramanik, Birenda ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Chemical modification; Interferon; Polyethylene glycol

Indexed keywords

HISTIDINE; HYDROXYLAMINE; LYSINE; MACROGOL DERIVATIVE; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT INTERLEUKIN 10; SUCCINIMIDYLCARBONYLPOLYETHYLENE GLYCOL; UNCLASSIFIED DRUG; URETHAN;

ALKYLATION; ARTICLE; CARBOXYLATION; CHEMICAL REACTION; CYTOPATHOGENIC EFFECT; DRUG ACTIVITY; PEPTIDE MAPPING; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEIN PURIFICATION; PROTEIN STABILITY; QUANTITATIVE ASSAY;

ALKYLATION; AMINO ACID SEQUENCE; BIOLOGICAL ASSAY; CARDIOVIRUS INFECTIONS; ENCEPHALOMYOCARDITIS VIRUS; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; HYDROXYLAMINE; INTERFERON-BETA; INTERLEUKIN-10; ISOMERISM; MOLECULAR SEQUENCE DATA; PEPTIDES; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; SUCCINIMIDES;

EID: 0034848092     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013006515587     Document Type: Article

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