Model simulation and experimental verification of a cation-exchange IgG capture step in batch and continuous chromatography

Journal of Chromatography A

Volumn 1218, Issue 31, 2011, Pages 5195-5204

  Muller Spath T ^a,b   Strohlein G ^a,b   Aumann, L ^a,b   Kornmann, H ^c   Valax, P ^c   Delegrange, L ^c   Charbaut, E ^c   Baer, G ^c   Lamproye, A ^c   Johnck M ^d   Schulte, M ^d   Morbidelli, M ^a  

^a ETH ZURICH   (Switzerland)

^b CHROMACON AG   (Switzerland)

^c MERCK SERONO S A   (Switzerland)

^d MERCK KGAA   (Germany)

Author keywords

Continuous chromatography; Lumped kinetic model; MCSGP; Monoclonal antibody

Indexed keywords

CATION EXCHANGES; CONTINUOUS CHROMATOGRAPHY; CULTURE SUPERNATANT; CYCLIC STEADY STATE; EXPERIMENTAL VERIFICATION; GRADIENT ELUTION; IN-PROCESS; KINETIC MODELS; LANGMUIR-TYPE ADSORPTION; LUMPED KINETIC MODEL; MASS TRANSFER PARAMETERS; MCSGP; MODEL PARAMETERS; MODEL SIMULATION; MONOCLONAL ANTIBODIES (MAB); MULTI-COLUMN CONTINUOUS CHROMATOGRAPHIES; PEAK FITTING; PERFORMANCE PARAMETERS; PRODUCT CONCENTRATION; PRODUCT PURITY; PURIFICATION PROCESS; QUANTITATIVE INFORMATION; RETENTION FACTORS; SATURATION CAPACITIES; START-UPS;

ADSORPTION; CELL CULTURE; COLUMN CHROMATOGRAPHY; KINETIC THEORY; MONOCLONAL ANTIBODIES; POSITIVE IONS; PURIFICATION; SURFACE PLASMON RESONANCE;

COMPUTER SIMULATION;

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

ADSORPTION; ANALYTIC METHOD; ARTICLE; CATION EXCHANGE; CHROMATOGRAPHY; ISOTHERM; KINETICS; MULTICOLUMN CONTINUOUS CHROMATOGRAPHY; POROSITY; PREDICTION; PRIORITY JOURNAL; PURIFICATION; SIMULATION; SINGLE COLUMN CHROMATOGRAPHY; STEADY STATE;

ADSORPTION; ANTIBODIES, MONOCLONAL; CATION EXCHANGE RESINS; CHROMATOGRAPHY, ION EXCHANGE; IMMUNOGLOBULIN G; MODELS, CHEMICAL;

EID: 79960146499     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.05.103     Document Type: Article

References (38)

1. Beck A., Wurch T., Bailly C., Corvaia N. Nat. Rev. Immunol. 2010, 10:345.
2. Aggarwal S. Nat. Biotechnol. 2010, 28:1165.
3. Shukla A.A., Thommes J. Trends Biotechnol. 2010, 28:253.
4. Kelley B. Biotechnol. Prog. 2007, 23:995.
5. Ferreira G.M., Dembecki J., Patel K., Arunakumari A. Biopharm. Int. 2007, 20:32.
6. Urmann M., Graalfs H., Joehnck M., Jacob L.R., Frech C. Mabs 2010, 2:395.
7. Muller-Spath T., Aumann L., Morbidelli M. Sep. Sci. Technol. 2009, 44:1.
8. Stein A., Kiesewetter A. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2007, 848:151.
9. Mehta A., Tse M.L., Fogle J., Len A., Shrestha R., Fontes N., Lebreton B., Wolk B., van Reis R. Chem. Eng. Prog. 2008, 104:S14.
10. Muller-Spath T., Aumann L., Strohlein G., Kornmann H., Valax P., Delegrange L., Charbaut E., Baer G., Lamproye A., Johnck M., Schulte M., Morbidelli M. Biotechnol. Bioeng. 2010, 107:974.
11. Wang J., Diehl T., Aguiar D., Dai X.P., Arunakumari A. Biopharm. Int. 2009, 4.
12. Peram T., McDonald P., Carter-Franklin J., Fahrner R. Biotechnol. Prog. 2010, 26:1322.
13. Yang T., Sundling M.C., Freed A.S., Breneman C.M., Cramer S.M. Anal. Chem. (Washington, DC, US) 2007, 79:8927.
14. Ladiwala A., Rege K., Breneman C.M., Cramer S.M. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:11710.
15. Guelat B., Strohlein G., Lattuada M., Morbidelli M. J. Chromatogr. A 2010, 1217:5610.
16. Lenhoff A.M. Langmuir 2008, 24:5991.
17. Stone M.C., Carta G. J. Chromatogr. A 2007, 1160:206.
18. Zydney A.L., Harinarayan C., van Reis R. Biotechnol. Bioeng. 2009, 102:1131.
19. Dziennik S.R., Belcher E.B., Barker G.A., DeBergalis M.J., Fernandez S.E., Lenhoff A.M. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:420.
20. Forrer N., Butte A., Morbidelli M. J. Chromatogr. A 2008, 1214:71.
21. Orellana C.A., Shene C., Asenjo J.A. Biotechnol. Bioeng. 2009, 104:572.
22. Brooks C.A., Cramer S.M. AIChE J. 1992, 38:1969.
23. Gallant S.R., Vunnum S., Cramer S.M. AIChE J. 1996, 42:2511.
24. Ruthven D. Principles of Adsorption and Adsorption Processes 1984, John Wiley & Sons, Inc., New York.
25. Voitl A., Butte A., Morbidelli M. J. Chromatogr. A 2010, 1217:5492.
26. Degerman M., Jakobsson N., Nilsson B. J. Chromatogr. A 2006, 1113:92.
27. Guiochon G., Golshan-Shirazi S., Katti AM. Fundamentals of Preparative and Nonlinear Chromatography 1994, Academic Press, Boston.
28. Miyabe K., Guiochon G. J. Chromatogr. A 2000, 890:211.
29. Seidel-Morgenstern A. J. Chromatogr. A 2004, 1037:255.
30. Carta G., Ubiera A.R., Pabst T.M. Chem. Eng. Technol. 2005, 28:1252.
31. Aumann L., Morbidelli M. Biotechnol. Bioeng. 2008, 99:728.
32. Aumann L., Morbidelli M. Biotechnol. Bioeng. 2007, 98:1043.
33. Aumann L., Stroehlein G., Morbidelli M. Biotechnol. Bioeng. 2007, 98:1029.
34. Muller-Spath T., Aumann L., Melter L., Strohlein G., Morbidelli M. Biotechnol. Bioeng. 2008, 100:1166.
35. Muller-Spath T., Krattli M., Aumann L., Strohlein G., Morbidelli M. Biotechnol. Bioeng. 2010, 107:652.
36. Barker P. Preparative and Production Scale Chromatography 1993, Marcel Dekker, New York, Basel, Hong Kong.
37. van Deemter J.J., Zuiderweg F.J., Klinkenberg A. Chem. Eng. Sci. 1956, 5.
38. Forrer N., Kartachova O., Butte A., Morbidelli M. Ind. Eng. Chem. Res. 2008, 47:9133.