-
1
-
-
0000342286
-
Pharmacokinetics of peptide and protein drugs
-
Lee, V.H.L., Ed., Marcel Dekker:New York, NY
-
Kompella, U.B. and Lee, V.H.L., Pharmacokinetics of peptide and protein drugs, in Peptide and Protein Drug Delivery, Lee, V.H.L., Ed., Marcel Dekker:New York, NY, 1991, 391-404.
-
(1991)
Peptide and Protein Drug Delivery
, pp. 391-404
-
-
Kompella, U.B.1
Lee, V.H.L.2
-
2
-
-
85056042269
-
Emerging protein delivery systems
-
Cleland, J.L., Daugherty, A., and Mrsny. R., Emerging protein delivery systems, Current opinion in Biotechnology, 12, 21, 2001.
-
(2001)
Current opinion in Biotechnology
, vol.12
, pp. 21
-
-
Cleland, J.L.1
Daugherty, A.2
Mrsny, R.3
-
3
-
-
0026124772
-
The therapeutic value of poly (ethylene glycol)-modified proteins
-
Nucci, M. L., Shorr, R., and Aubuchowski, A. The therapeutic value of poly (ethylene glycol)-modified proteins, Adv. Drug Delivery Rev., 6, 133, 1991.
-
(1991)
Adv. Drug Delivery Rev.
, vol.6
, pp. 133
-
-
Nucci, M.L.1
Shorr, R.2
Aubuchowski, A.3
-
4
-
-
0029256724
-
Biological and Biotechnological applications of PEG and PM-modified proteins
-
Inada Y, Furukawa, M., Sasaki H., Kodera, Y., Hiroto, M., Nishimura, H., Matsusshima, A., Biological and Biotechnological applications of PEG and PM-modified proteins. Tibtech. 1995;13:86-90.
-
(1995)
Tibtech.
, vol.13
, pp. 86-90
-
-
Inada, Y.1
Furukawa, M.2
Sasaki, H.3
Kodera, Y.4
Hiroto, M.5
Nishimura, H.6
Matsusshima, A.7
-
5
-
-
0037362655
-
Effect of PEGylation on pharmaceuticals
-
Harris, J.M. and Chess, R.B., Effect of PEGylation on pharmaceuticals, Nat. Rev.Drug Discov., 2, 214, 2003.
-
(2003)
Nat. Rev.Drug Discov.
, vol.2
, pp. 214
-
-
Harris, J.M.1
Chess, R.B.2
-
6
-
-
3042722268
-
Protein, peptide and non-peptide drug PEGylation for therapeutic application
-
Pasut, G., Guiotto, A., and Veronese, F. M., Protein, peptide and non-peptide drug PEGylation for therapeutic application, Expert Opinion on Therapeutic Patents, 14, 6, 859, 2004.
-
(2004)
Expert Opinion on Therapeutic Patents
, vol.14
, Issue.6
, pp. 859
-
-
Pasut, G.1
Guiotto, A.2
Veronese, F.M.3
-
7
-
-
0036398983
-
Structure, biology and therapeutic implications of PEGylated interferon Alpha-2b
-
Youngster, S., Wang, Yu-Sen, Grace, M., Bausch, J., Bordens, R., Wyss, D. F. Structure, biology and therapeutic implications of PEGylated interferon Alpha-2b. Current Pharmaceutical Design 2002; 8:2139-2157.
-
(2002)
Current Pharmaceutical Design
, vol.8
, pp. 2139-2157
-
-
Youngster, S.1
Wang, Y.-S.2
Grace, M.3
Bausch, J.4
Bordens, R.5
Wyss, D.F.6
-
8
-
-
0035086519
-
Rational design of a potent, long lasting form of interferon: A 40 Kda branched polyethylene glycol conjugated interferon α-2a for the treatment of Hepatitis C
-
Bailon, P., Palleroni, A., and Scxhaffer, C.A., Rational design of a potent, long lasting form of interferon: a 40 Kda branched polyethylene glycol conjugated interferon α-2a for the treatment of Hepatitis C, Bioconjugate Chem., 12, 195, 2001.
-
(2001)
Bioconjugate Chem.
, vol.12
, pp. 195
-
-
Bailon, P.1
Palleroni, A.2
Scxhaffer, C.A.3
-
9
-
-
0036668565
-
Pegvisomant: Structure and function
-
Pradghanaga, S., Wilkinson, I., and Ross, R.J.M., Pegvisomant: structure and function, Journal of Molecular Endocrinology, 29, 11, 2002.
-
(2002)
Journal of Molecular Endocrinology
, vol.29
, pp. 11
-
-
Pradghanaga, S.1
Wilkinson, I.2
Ross, R.J.M.3
-
10
-
-
0032868653
-
Therapeutic antibody fragments with prolonged half-lives
-
Chapman, A., Antoniw, P., Spitali, M., West, S., Stephens, S., King. Therapeutic antibody fragments with prolonged half-lives, Nature Biotechnology, 1999;17:780-783.
-
(1999)
Nature Biotechnology
, vol.17
, pp. 780-783
-
-
Chapman, A.1
Antoniw, P.2
Spitali, M.3
West, S.4
Stephens, S.5
King6
-
11
-
-
0032745325
-
A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize pBPC in both mice and humans
-
27
-
Molineux G., Kinstler O., Briddell, B., Hartley, C., McElroy, P., Kerzic, P., Sutherland, w., Stoney, G., Kern, B., Fletcher, F., Cohen, A., Korach, E., Ulich, T., McNiece, I., Lockbaum, P., Miller-Messana, M. A., Gardner, S., Hunt, T., Schwab, G. A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize pBPC in both mice and humans, Experimental Hematology, 27. 1999; 27:1724-1734.
-
(1999)
Experimental Hematology
, vol.27
, pp. 1724-1734
-
-
Molineux, G.1
Kinstler, O.2
Briddell, B.3
Hartley, C.4
McElroy, P.5
Kerzic, P.6
Sutherland, W.7
Stoney, G.8
Kern, B.9
Fletcher, F.10
Cohen, A.11
Korach, E.12
Ulich, T.13
McNiece, I.14
Lockbaum, P.15
Miller-Messana, M.A.16
Gardner, S.17
Hunt, T.18
Schwab, G.19
-
12
-
-
0035187822
-
A Single Dose of PEGylated Leridistim Significantly Improves Neutrophil Recovery in Sublethally Irradiated Rhesus Macaques
-
Farese, A. M., D.B. Casey, R.M. Vigneulle, N.R. Siegel, R. F. Finn, J. A. Klover, D.Villani-Price, W.G. Smith, J. P. McKearn and T. J. MacVittie. 2001. A Single Dose of PEGylated Leridistim Significantly Improves Neutrophil Recovery in Sublethally Irradiated Rhesus Macaques, Stem Cells, 19: 514-521.
-
(2001)
Stem Cells
, vol.19
, pp. 514-521
-
-
Farese, A.M.1
Casey, D.B.2
Vigneulle, R.M.3
Siegel, N.R.4
Finn, R.F.5
Klover, J.A.6
Villani-Price, D.7
Smith, W.G.8
McKearn, J.P.9
MacVittie, T.J.10
-
13
-
-
4644323709
-
PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methionase in primates
-
Yang, Z., Wang, J., Lu, J., Kobayashi, y., Takakura, T., Takimoto, A., Yoshioka, T., Lian, C., Chen, C., Zhang, d., Zhang, Y., Li, s., sun, x., Tan, Y., Yagi, S., Frenkel, E., Hoffman, R. M. PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methionase in primates, Cancer Research, 2004; 64:6673-6678.
-
(2004)
Cancer Research
, vol.64
, pp. 6673-6678
-
-
Yang, Z.1
Wang, J.2
Lu, J.3
Kobayashi, Y.4
Takakura, T.5
Takimoto, A.6
Yoshioka, T.7
Lian, C.8
Chen, C.9
Zhang, D.10
Zhang, Y.11
Li, S.12
Sun, X.13
Tan, Y.14
Yagi, S.15
Frenkel, E.16
Hoffman, R.M.17
-
14
-
-
0017701219
-
Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
-
Aubuchowski, A., van Es, T., Palczuk, N.C., and Davis, F. F. Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol, J. Biol. Chem., 1977; 252:3578-3581.
-
(1977)
J. Biol. Chem.
, vol.252
, pp. 3578-3581
-
-
Aubuchowski, A.1
van Es, T.2
Palczuk, N.C.3
Davis, F.F.4
-
15
-
-
0001365675
-
Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine meth A sarcoma model
-
Katre N.V., Knauf, M.J., and Laird, W.J., Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine meth A sarcoma model, Proc. Natl. Acad. Sci. USA, 84, 1487, 1987.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 1487
-
-
Katre, N.V.1
Knauf, M.J.2
Laird, W.J.3
-
16
-
-
0033618471
-
Immunogenic and tolerogenic properties of monomethoxypoly (ethylene glycol) conjugated proteins
-
Caliceti, P., Veronese, F.M., and Jonak, Z., Immunogenic and tolerogenic properties of monomethoxypoly (ethylene glycol) conjugated proteins, Il Farmaco, 54, 430, 1999.
-
(1999)
Il Farmaco
, vol.54
, pp. 430
-
-
Caliceti, P.1
Veronese, F.M.2
Jonak, Z.3
-
17
-
-
0023683508
-
Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers
-
Knauf, M.J., Bell, D.P., Hirtzer, P., Luo, ZP., Young, J.D., Katres N.V. Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers, J. Biol Chem., 1988;263; 29:15064-15070.
-
(1988)
J. Biol Chem.
, vol.263
, Issue.29
, pp. 15064-15070
-
-
Knauf, M.J.1
Bell, D.P.2
Hirtzer, P.3
Luo, Z.P.4
Young, J.D.5
Katres, N.V.6
-
18
-
-
9544220647
-
Long-acting growth hormones produced by conjugation with polyethylene glycol
-
Clark, R., Olson, K., Fuh, G., Marian, M., Mortensen, D., Teshima, G., Chang, S., Chu, H., Mukku, V., Canova-Davis, E., Somers T., Cronin, M., Winkler, M., Wells J. A. Long-acting growth hormones produced by conjugation with polyethylene glycol, J. Biol. Chem., 1996; 271:21969-21977.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 21969-21977
-
-
Clark, R.1
Olson, K.2
Fuh, G.3
Marian, M.4
Mortensen, D.5
Teshima, G.6
Chang, S.7
Chu, H.8
Mukku, V.9
Canova-Davis, E.10
Somers, T.11
Cronin, M.12
Winkler, M.13
Wells, J.A.14
-
19
-
-
0025128987
-
Immunogenicity of recombinant IL-2 modified by covalent attachment of polyethylene glycol
-
Katre N.V., Immunogenicity of recombinant IL-2 modified by covalent attachment of polyethylene glycol, Journal of Immunology, 144, 209, 1990.
-
(1990)
Journal of Immunology
, vol.144
, pp. 209
-
-
Katre, N.V.1
-
20
-
-
0037124501
-
Effects of PEG conjugation on insulin properties
-
Hinds K.D. and Kim, S.W., Effects of PEG conjugation on insulin properties, Advanced Drug Delivery review, 54, 505, 2002.
-
(2002)
Advanced Drug Delivery review
, vol.54
, pp. 505
-
-
Hinds, K.D.1
Kim, S.W.2
-
21
-
-
0032409905
-
PEGylation prevents N-terminal degradation of megakaryocyte growth and development factor
-
Guerra, P.I., Acklin, C., Kosky, A.A., Davis, J. M., Treuheit, M.J., Brems, D.N. PEGylation prevents N-terminal degradation of megakaryocyte growth and development factor, Pharmaceutical Research, 1998;15;12: 1822-1827.
-
(1998)
Pharmaceutical Research
, vol.15
, Issue.12
, pp. 1822-1827
-
-
Guerra, P.I.1
Acklin, C.2
Kosky, A.A.3
Davis, J.M.4
Treuheit, M.J.5
Brems, D.N.6
-
22
-
-
0032904275
-
Conformational stability of lyophilized PEGylated proteins in a phase-separating system
-
Heller, M.C., Carpenter, J.F., and Randolph, T.W., Conformational stability of lyophilized PEGylated proteins in a phase-separating system, Journal of Pharmaceutical Sciences, 88, 58, 1999.
-
(1999)
Journal of Pharmaceutical Sciences
, vol.88
, pp. 58
-
-
Heller, M.C.1
Carpenter, J.F.2
Randolph, T.W.3
-
23
-
-
12344281758
-
Commercial challenges of protein drug delivery
-
Brown, Larry R., Commercial challenges of protein drug delivery, Expert Opinion on Drug Delivery, 2, 29, 2005.
-
(2005)
Expert Opinion on Drug Delivery
, vol.2
, pp. 29
-
-
Brown, L.R.1
-
24
-
-
0026812687
-
Evaluation of a new reagent for covalent attachment of polyethylene glycol to proteins
-
Zalipsky, S., Seltzer, R. and Menon-Rudolph, S., Evaluation of a new reagent for covalent attachment of polyethylene glycol to proteins, Biotechnology and Applied Biochemistry, 15(1), 100, 1992.
-
(1992)
Biotechnology and Applied Biochemistry
, vol.15
, Issue.1
, pp. 100
-
-
Zalipsky, S.1
Seltzer, R.2
Menon-Rudolph, S.3
-
25
-
-
4644301510
-
Conjugates of peptides and proteins to polyethylene glycols
-
Totowa, NJ, United States, Bioconjugation Protocols, Humana Press Inc
-
Morpurgo, M. and Veronese, F.M., Conjugates of peptides and proteins to polyethylene glycols, in Methods in Molecular Biology, Totowa, NJ, United States, Bioconjugation Protocols, 283, 45, 2004, Humana Press Inc.
-
(2004)
Methods in Molecular Biology
, vol.283
, pp. 45
-
-
Morpurgo, M.1
Veronese, F.M.2
-
26
-
-
0035284411
-
Peptide and protein PEGylation. A review of problems and solutions
-
Veronese, F.M., Peptide and protein PEGylation. A review of problems and solutions, Biomaterials, 22, 405, 2001.
-
(2001)
Biomaterials
, vol.22
, pp. 405
-
-
Veronese, F.M.1
-
27
-
-
0037124473
-
Introduction and overview of peptide and protein PEGylation
-
Veronese, F.M. and Harris, J.M., Introduction and overview of peptide and protein PEGylation, Advanced Drug Delivery Reviews, 54, 453, 2002.
-
(2002)
Advanced Drug Delivery Reviews
, vol.54
, pp. 453
-
-
Veronese, F.M.1
Harris, J.M.2
-
28
-
-
0037124506
-
Chemistry for peptide and protein PEGylation
-
Roberts, M.J., Bentley, MD., and Harris, J.M., Chemistry for peptide and protein PEGylation, Advanced Drug Delivery Reviews, 54, 459, 2002.
-
(2002)
Advanced Drug Delivery Reviews
, vol.54
, pp. 459
-
-
Roberts, M.J.1
Bentley, M.D.2
Harris, J.M.3
-
29
-
-
0032126845
-
PEGylation of cytokines and other therapeutic proteins and peptides: The importance of biological optimization of coupling techniques
-
Francis G E; Fisher D; Delgado C; Malik F; Gardiner A; Neale D. PEGylation of cytokines and other therapeutic proteins and peptides: the importance of biological optimization of coupling techniques. International journal of hematology (1998), 68(1), 1-18.
-
(1998)
International journal of hematology
, vol.68
, Issue.1
, pp. 1-18
-
-
Francis, G.E.1
Fisher, D.2
Delgado, C.3
Malik, F.4
Gardiner, A.5
Neale, D.6
-
30
-
-
0033105254
-
Tresyl-mediated synthesis: Kinetics of competing coupling and hydrolysis reactions as a function of pH, temperature, and steric factors
-
Sperinde, J.J., Martens, B.D. and Griffith, L.G., Tresyl-mediated synthesis: Kinetics of competing coupling and hydrolysis reactions as a function of pH, temperature, and steric factors, Bioconjugate Chemistry, 10, 213, 1999.
-
(1999)
Bioconjugate Chemistry
, vol.10
, pp. 213
-
-
Sperinde, J.J.1
Martens, B.D.2
Griffith, L.G.3
-
31
-
-
0034609586
-
Identification of the major positional isomer of pegylated interferon alpha-2b
-
Wang, Yu-Sen; Youngster, Stephen; Bausch, James; Zhang, Rumin; McNemar, Charles; Wyss, Daniel F. Identification of the major positional isomer of pegylated interferon alpha-2b. Biochemistry (2000), 39(35), 10634-10640.
-
(2000)
Biochemistry
, vol.39
, Issue.35
, pp. 10634-10640
-
-
Wang, Y.-S.1
Youngster, S.2
James, B.3
Zhang, R.4
Charles, M.5
Wyss Daniel, F.6
-
32
-
-
0031125001
-
Improved conjugation of cytokines using high molecular weight poly(ethylene glycol): PEG-GM-CSF as a prototype
-
Saifer, Mark G. P.; Williams, L. David; Sherman, Merry R.; French, John A.; Kwak, Larry W.; Oppenheim, Joost J. Improved conjugation of cytokines using high molecular weight poly(ethylene glycol): PEG-GM-CSF as a prototype. Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) (1997), 38(1), 576-577.
-
(1997)
Polymer Preprints (American Chemical Society, Division of Polymer Chemistry)
, vol.38
, Issue.1
, pp. 576-577
-
-
Saifer, M.G.P.1
Williams, L.D.2
Sherman, M.R.3
French, J.A.4
Kwak, L.W.5
Oppenheim, J.J.6
-
33
-
-
0026438972
-
The uses and properties of PEG-linked proteins
-
Delgado, C., Francis, G.E. and Fisher, D., The uses and properties of PEG-linked proteins, Critical Reviews in Therapeutic Drug Carrier Systems, 9, 249, 1992.
-
(1992)
Critical Reviews in Therapeutic Drug Carrier Systems
, vol.9
, pp. 249
-
-
Delgado, C.1
Francis, G.E.2
Fisher, D.3
-
34
-
-
67649121312
-
-
(Surface Engineering Technologies, Division of Innerdyne, Inc., USA). US patent 55650234
-
Dolence, Eric K.; Hu, Chen-Ze; Tsang, Ray; Sanders, Clifton G.; Osaki, Shigemasa. Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and polymer surfaces. (Surface Engineering Technologies, Division of Innerdyne, Inc., USA). US patent 55650234 1997.
-
(1997)
Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and polymer surfaces
-
-
Dolence, E.K.1
Hu, C.-Z.2
Tsang, R.3
Sanders, C.G.4
Osaki, S.5
-
35
-
-
0041701404
-
Novel Biodegradable Ternary Copolymers hy-PEI-g-PCL-b-PEG: Synthesis, Characterization, and Potential as Efficient Nonviral Gene Delivery Vectors
-
Shuai, Xintao; Merdan, Thomas; Unger, Florian; Wittmar, Matthias; Kissel, Thomas. Novel Biodegradable Ternary Copolymers hy-PEI-g-PCL-b-PEG: Synthesis, Characterization, and Potential as Efficient Nonviral Gene Delivery Vectors, Macromolecules, (2003), 36(15), 5751-5759.
-
(2003)
Macromolecules
, vol.36
, Issue.15
, pp. 5751-5759
-
-
Shuai, X.1
Merdan, T.2
Florian, U.3
Wittmar, M.4
Thomas, K.5
-
36
-
-
0017388651
-
Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase
-
Abuchowsk, i A.; McCoy, J.R.; Palczuk, N.C.; van Es, T.; Davis, F.F., Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase, Journal of Biological Chemistry, (1977), 252(11), 3582-6.
-
(1977)
Journal of Biological Chemistry
, vol.252
, Issue.11
, pp. 3582-3586
-
-
Abuchowsk, I.A.1
McCoy, J.R.2
Palczuk, N.C.3
van Es, T.4
Davis, F.F.5
-
37
-
-
0021891903
-
Surface modification of proteins. Activation of monomethoxy-polyethylene glycols by phenylchloroformates and modification of ribonuclease and superoxide dismutase
-
Veronese, F.M.; Largajolli, R.; Boccu, E.; Benassi, C.A.; Schiavon, O., Surface modification of proteins. Activation of monomethoxy-polyethylene glycols by phenylchloroformates and modification of ribonuclease and superoxide dismutase, Applied Biochemistry and Biotechnology, (1985), 11(2), 141-52.
-
(1985)
Applied Biochemistry and Biotechnology
, vol.11
, Issue.2
, pp. 141-152
-
-
Veronese, F.M.1
Largajolli, R.2
Boccu, E.3
Benassi, C.A.4
Schiavon, O.5
-
38
-
-
0020607315
-
A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha 2-macroglobulin
-
Journal code: 0370535. ISSN:0003-2697
-
Beauchamp, C.O.; Gonias, S.L.; Menapace, D.P.; Pizzo, S.V., A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha 2-macroglobulin. Analytical biochemistry (1983), 131(1), 25-33. Journal code: 0370535. ISSN:0003-2697.
-
(1983)
Analytical biochemistry
, vol.131
, Issue.1
, pp. 25-33
-
-
Beauchamp, C.O.1
Gonias, S.L.2
Menapace, D.P.3
Pizzo, S.V.4
-
39
-
-
0025360498
-
Facile synthesis of α-hydroxy ω-carboxymethyl poly(ethylene oxide)
-
Zalipsky, S. and Barany, G., Facile synthesis of α-hydroxy ω-carboxymethyl poly(ethylene oxide), Journal of Bioactive and Compatible Polymers, 5(2), 227, 1990.
-
(1990)
Journal of Bioactive and Compatible Polymers
, vol.5
, Issue.2
, pp. 227
-
-
Zalipsky, S.1
Barany, G.2
-
40
-
-
3042671790
-
Pegvisomant Pfizer/Sensus
-
London, England
-
Vincent, G. and Philippe, T., Pegvisomant Pfizer/Sensus, Current Opinion in Investigational Drugs, (London, England:2000), 5(4), 463, 2004.
-
(2000)
Current Opinion in Investigational Drugs
, vol.5
, Issue.4
, pp. 463
-
-
Vincent, G.1
Philippe, T.2
-
41
-
-
18844427853
-
Structural and Biophysical Characterization of the 40 kDa PEG-Interferon-α2a and Its Individual Positional Isomers
-
Dhalluin, Christophe; Ross, Alfred; Leuthold, Luc-Alexis; Foser, Stefan; Gsell, Bernard; Mueller, Francis; Senn, Hans. Structural and Biophysical Characterization of the 40 kDa PEG-Interferon-α2a and Its Individual Positional Isomers, Bioconjugate Chemistry (2005), 16(3), 504-517.
-
(2005)
Bioconjugate Chemistry
, vol.16
, Issue.3
, pp. 504-517
-
-
Dhalluin, C.1
Ross, A.2
Luc-Alexis, L.3
Foser, S.4
Bernard, G.5
Mueller, F.6
Hans, S.7
-
42
-
-
0242584999
-
N-terminal site-specific mono-PEGylation of epidermal growth factor
-
Lee, Haeshin; Jang, Il Ho; Ryu, Sung Ho; Park, Tae Gwan. N-terminal site-specific mono-PEGylation of epidermal growth factor, Pharmaceutical Research (2003), 20(5), 818-825.
-
(2003)
Pharmaceutical Research
, vol.20
, Issue.5
, pp. 818-825
-
-
Lee, H.1
Jang Ryu, I.H.2
Ho, S.3
Gwan, P.T.4
-
43
-
-
0037124498
-
Mono-N-terminal poly(ethylene glycol)-protein conjugates
-
Kinstler Olaf; Molineux Graham; Treuheit Michael; Ladd David; Gegg Colin, Mono-N-terminal poly(ethylene glycol)-protein conjugates, Advanced Drug Delivery Reviews (2002), 54(4), 477-85.
-
(2002)
Advanced Drug Delivery Reviews
, vol.54
, Issue.4
, pp. 477-485
-
-
Olaf, K.1
Graham, M.2
Michael, T.3
David, L.4
Colin, G.5
-
44
-
-
12344336363
-
Characterization of site-specific ScFv PEGylation for tumor-targeting pharmaceuticals
-
Arutselvan, N.; Xiong Cheng-Yi; Albrecht Huguette; DeNardo Gerald L; DeNardo Sally J Characterization of site-specific ScFv PEGylation for tumor-targeting pharmaceuticals, Bioconjugate Chemistry (2005), 16(1), 113-21.
-
(2005)
Bioconjugate Chemistry
, vol.16
, Issue.1
, pp. 113-121
-
-
Arutselvan, N.1
Xiong, C.-Y.2
Huguette, A.3
DeNardo, G.L.4
DeNardo, S.J.5
-
45
-
-
0030135376
-
Preparation and Characterization of Poly(ethylene glycol) Vinyl Sulfone
-
Morpurgo, Margherita; Veronese, Francesco M.; Kachensky, David; Harris, J. Milton. Preparation and Characterization of Poly(ethylene glycol) Vinyl Sulfone, Bioconjugate Chemistry (1996), 7(3), 363-368.
-
(1996)
Bioconjugate Chemistry
, vol.7
, Issue.3
, pp. 363-368
-
-
Morpurgo, M.1
Veronese, F.M.2
Kachensky, D.3
Milton, H.J.4
-
46
-
-
0026644853
-
Synthesis of substituted methoxypolyethylene glycol derivatives suitable for selective protein modification
-
Kogan, T.P., Synthesis of substituted methoxypolyethylene glycol derivatives suitable for selective protein modification, Synthetic Communications, 22(16), 2417, 1992.
-
(1992)
Synthetic Communications
, vol.22
, Issue.16
, pp. 2417
-
-
Kogan, T.P.1
-
47
-
-
34547776752
-
Sitespecific protein PEGylation: Application to cysteine analogs of recombinant human granulocyte colony-stimulating factor
-
Rosendahl, Mary S.; Doherty, Daniel H.; Smith, Darin J.; Bendele, Alison M.; Cox, George N. Sitespecific protein PEGylation: Application to cysteine analogs of recombinant human granulocyte colony-stimulating factor, BioProcess International (2005), 3(4), 52-56, 58-60, 62.
-
(2005)
BioProcess International
, vol.3
, Issue.4
-
-
Rosendahl Mary, S.1
Doherty Daniel, H.2
Smith Darin, J.3
Bendele Alison, M.4
Cox George, N.5
-
48
-
-
85056360280
-
Protein conjugation, cross-linking, and PEGylation
-
Mahato, R.I., Ed. CRC Press LLC, Boca Raton, Fla
-
Hinds, K.D., Protein conjugation, cross-linking, and PEGylation, in Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids, Mahato, R.I., Ed. CRC Press LLC, Boca Raton, Fla, 2005, 119-185.
-
(2005)
Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids
, pp. 119-185
-
-
Hinds, K.D.1
-
49
-
-
0009503301
-
Preparation of polyethylene glycol derivatives with two different functional groups at the termini
-
Zalipsky, S. and Barany, G., Preparation of polyethylene glycol derivatives with two different functional groups at the termini, Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 1986, 27(1), 1-2.
-
(1986)
Polymer Preprints (American Chemical Society, Division of Polymer Chemistry)
, vol.27
, Issue.1
, pp. 1-2
-
-
Zalipsky, S.1
Barany, G.2
-
50
-
-
1542406597
-
Synthesis of symmetrically and asymmetrically branched PEGylating reagents
-
Felix, A.M. and Bandaranayake, R.M., Synthesis of symmetrically and asymmetrically branched PEGylating reagents, Theoretical and Applied Science, Journal of Peptide Research, 63(2), 85, 2004
-
(2004)
Theoretical and Applied Science, Journal of Peptide Research
, vol.63
, Issue.2
, pp. 85
-
-
Felix, A.M.1
Bandaranayake, R.M.2
-
51
-
-
0035997341
-
Long-circulating poly(ethylene glycol)-modified gelatin nanoparticles for intracellular delivery
-
Kaul, G. and Amiji, M., Long-circulating poly(ethylene glycol)-modified gelatin nanoparticles for intracellular delivery, Pharmaceutical Research, 19(7), 1061, 2002.
-
(2002)
Pharmaceutical Research
, vol.19
, Issue.7
, pp. 1061
-
-
Kaul, G.1
Amiji, M.2
-
52
-
-
0031901771
-
Combined use of carboxyl-directed protein PEGylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration
-
Pardridge, W.M., Wu, D. and Sakane, T., Combined use of carboxyl-directed protein PEGylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration, Pharmaceutical Research, 15(4), 576, 1998.
-
(1998)
Pharmaceutical Research
, vol.15
, Issue.4
, pp. 576
-
-
Pardridge, W.M.1
Wu, D.2
Sakane, T.3
-
53
-
-
85056068108
-
Preparation and characterization of mixed monolayers of PEG and peptides on gold nanoparticles
-
229th ACS National Meeting, San Diego, CA, United States, March 13-17, 2005
-
Liu, Y., Franzen, S. and Feldheim, D.L., Preparation and characterization of mixed monolayers of PEG and peptides on gold nanoparticles, in Abstracts of Papers, 229th ACS National Meeting, San Diego, CA, United States, March 13-17, 2005, 2005.
-
(2005)
Abstracts of Papers
-
-
Liu, Y.1
Franzen, S.2
Feldheim, D.L.3
-
54
-
-
13444303906
-
PEGylated peptide-based dendritic nanoparticulate systems for delivery of artemether
-
Bhadra, D., Bhadra, S. and Jain, N.K., PEGylated peptide-based dendritic nanoparticulate systems for delivery of artemether, Journal of Drug Delivery Science and Technology, 15(1), 65-2005.
-
(2005)
Journal of Drug Delivery Science and Technology
, vol.15
, Issue.1
, pp. 65
-
-
Bhadra, D.1
Bhadra, S.2
Jain, N.K.3
-
55
-
-
0028806691
-
Highly water soluble taxol derivatives: 7-polyethylene glycol carbamates and carbonates
-
Greenwald, R.B., Pendri, A. and Bolikal, D., Highly water soluble taxol derivatives: 7-polyethylene glycol carbamates and carbonates, Journal of Organic Chemistry, 60(2), 331, 1995.
-
(1995)
Journal of Organic Chemistry
, vol.60
, Issue.2
, pp. 331
-
-
Greenwald, R.B.1
Pendri, A.2
Bolikal, D.3
-
56
-
-
0036398983
-
Structure, biology and therapeutic implications of PEGylated interferon alpha-2b
-
Youngster, S., Wang, Yu-Sen, Grace, M., Bausch, J., Bordens, R., Wyss, D. F., Structure, biology and therapeutic implications of PEGylated interferon alpha-2b, Current Pharmaceutical Design, 8, 2139, 2002.
-
(2002)
Current Pharmaceutical Design
, vol.8
, pp. 2139
-
-
Youngster, S.1
Wang, Y.-S.2
Grace, M.3
Bausch, J.4
Bordens, R.5
Wyss, D.F.6
-
57
-
-
27844515221
-
PEG-proteins: Reaction Engineering and separation issues
-
Fee, C.J. and Van Alstine, J.M., PEG-proteins: Reaction Engineering and separation issues, Chemical Engineering Science, 61, 924, 2006.
-
(2006)
Chemical Engineering Science
, vol.61
, pp. 924
-
-
Fee, C.J.1
Van Alstine, J.M.2
-
58
-
-
0343527961
-
Synthesis and Characterization of Poly(ethylene glycol)-Insulin Conjugates
-
Ken Hinds, Ken; Koh, Jae Joon; Joss, Lisa; Liu, Feng; Baudys, Miroslav and Kim, Sung Wan. Synthesis and Characterization of Poly(ethylene glycol)-Insulin Conjugates, Bioconjugate Chem., 11, 195-201 (2000)
-
(2000)
Bioconjugate Chem.
, vol.11
, pp. 195-201
-
-
Ken Hinds, K.1
Koh, J.J.2
Joss, L.3
Liu, F.4
Miroslav, B.5
Wan, K.S.6
-
59
-
-
0030744221
-
Electrospray Mass Spectrometric Analysis of Poly(ethylene Glycol)-Protein Conjugates
-
Gioacchini, Anna Maria; Carrea, Giacomo; Secundo, Francesco; Baraldini, Mario and Roda1, Aldo. Electrospray Mass Spectrometric Analysis of Poly(ethylene Glycol)-Protein Conjugates. Rapid Communication in Mass Spectrometry, 11, 1219-1222 (1997)
-
(1997)
Rapid Communication in Mass Spectrometry
, vol.11
, pp. 1219-1222
-
-
Gioacchini, A.M.1
Carrea, G.2
Secundo, F.3
Mario, B.4
Aldo, R.5
-
60
-
-
0036288833
-
Preparation and characterization of mono-pegylated epidermal growth factor: Evaluation of in vitro biologic activity
-
Lee H. and Parg, T. G., Preparation and characterization of mono-pegylated epidermal growth factor:evaluation of in vitro biologic activity, Pharmaceutical Research, 19, 845, 2002.
-
(2002)
Pharmaceutical Research
, vol.19
, pp. 845
-
-
Lee, H.1
Parg, T.G.2
-
61
-
-
0037124398
-
Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications
-
Wang, Yu-Sen; Youngster, Stephen; Grace, Michael, et. al. Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications, Advanced Drug Delivery Reviews, 54 (2002) 547-570.
-
(2002)
Advanced Drug Delivery Reviews
, vol.54
, pp. 547-570
-
-
Wang, Y.-S.1
Youngster, S.2
Michael, G.3
-
62
-
-
85056027807
-
-
presented at International Association for Biologicals: State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparability, NIH, Bethesda, Maryland, June
-
Bass, L., Strategy for Evaluation of Analytical Comparability of PEGylated Biomolecules, presented at International Association for Biologicals: State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparability, NIH, Bethesda, Maryland, June 2006.
-
(2006)
Strategy for Evaluation of Analytical Comparability of PEGylated Biomolecules
-
-
Bass, L.1
-
63
-
-
0037343959
-
Site-specific PEGylation of Hemoglobin at Cys -93 (Β): Correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain
-
Manjula, B,. Tsai, A., Upadhya, K., Perumalsamy, P. K., Malavalli, A., Vandegriff, K., Winslow, R. M., Intaglietta, M.J., Prabhakaran, M., Friedman, J.M., Acharya, A.S. Site-specific PEGylation of Hemoglobin at Cys -93 (Β): Correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain, Bioconjugate Chem., 14 464-472, 2003.
-
(2003)
Bioconjugate Chem.
, vol.14
, pp. 464-472
-
-
Manjula, B.1
Tsai, A.2
Upadhya, K.3
Perumalsamy, P.K.4
Malavalli, A.5
Vandegriff, K.6
Winslow, R.M.7
Intaglietta, M.J.8
Prabhakaran, M.9
Friedman, J.M.10
Acharya, A.S.11
-
64
-
-
0037124498
-
Mono-N-terminal poly(ethylene glycol)- protein conjugates
-
Kinstler O., Molineux G., Treuheit M., Ladd D., Gegg C. Mono-N-terminal poly(ethylene glycol)- protein conjugates, Advanced drug delivery reviews (2002), 54(4), 477-85.
-
(2002)
Advanced drug delivery reviews
, vol.54
, Issue.4
, pp. 477-485
-
-
Kinstler, O.1
Molineux, G.2
Treuheit, M.3
Ladd, D.4
Gegg, C.5
-
65
-
-
0030862261
-
Thermal/oxidative degradation and stabilization of polyethylene glycol
-
Han, S., Thermal/oxidative degradation and stabilization of polyethylene glycol, Polymer, 38(2), 317, 1997.
-
(1997)
Polymer
, vol.38
, Issue.2
, pp. 317
-
-
Han, S.1
-
66
-
-
0025265384
-
Site directed PEGylation of recombinant interleukin-2 at its glycosylation site
-
Goodson, R.J. and Katre, N.V., Site directed PEGylation of recombinant interleukin-2 at its glycosylation site, Biotechnology, 8(4), 343, 1990.
-
(1990)
Biotechnology
, vol.8
, Issue.4
, pp. 343
-
-
Goodson, R.J.1
Katre, N.V.2
-
67
-
-
0034682480
-
Site -specific chemical modification with polyethylene glycol of recombinant immunotoxins anti-Tac(Fv) -PE38 (LMB-2)_improves antitumor and reduces animal toxicity and immunogenicity
-
Tsutsumi, Y., Onda, M., Nagata, S., Lee, B., Kreitman R.J., Pastan, I. Site -specific chemical modification with polyethylene glycol of recombinant immunotoxins anti-Tac(Fv) -PE38 (LMB-2)_improves antitumor and reduces animal toxicity and immunogenicity. Proc. Natl. Acad. Sci., 2000; 18,97,15: 8548-8553.
-
(2000)
Proc. Natl. Acad. Sci.
, vol.18-97
, Issue.15
, pp. 8548-8553
-
-
Tsutsumi, Y.1
Onda, M.2
Nagata, S.3
Lee, B.4
Kreitman, R.J.5
Pastan, I.6
-
68
-
-
12344336363
-
Characterization of Site-Specific ScFc PEGylation for Tumor targeting Pharmaceuticals
-
Natarajan, A., Xiong, C-Y, Albrecht, H. DeNardo, G. L., DeNardo, S. J., Characterization of Site-Specific ScFc PEGylation for Tumor targeting Pharmaceuticals, Bioconjugate Chem., 2005; 16:113-121.
-
(2005)
Bioconjugate Chem.
, vol.16
, pp. 113-121
-
-
Natarajan, A.1
Xiong, C.-Y.2
Albrecht, H.3
DeNardo, G.L.4
DeNardo, S.J.5
-
69
-
-
4644256655
-
Chaik of, E.L. C terminal Site Specific PEGylation of a truncated thrombomodulin mutant with retention of full bioactivity
-
Cazalis, C. S., Haller, C. A., Sease-Cargo, L., Chaik of, E.L. C terminal Site Specific PEGylation of a truncated thrombomodulin mutant with retention of full bioactivity, Bioconjugate Chem., 2004; 15:1005-1009.
-
(2004)
Bioconjugate Chem.
, vol.15
, pp. 1005-1009
-
-
Cazalis, C.S.1
Haller, C.A.2
Sease-Cargo, L.3
-
70
-
-
0037124507
-
Enzymatic procedure for site specific PEGylation of proteins
-
Sato, H., Enzymatic procedure for site specific PEGylation of proteins, Adv. Drug Deliv. Rev., 54, 487, 2002.
-
(2002)
Adv. Drug Deliv. Rev.
, vol.54
, pp. 487
-
-
Sato, H.1
-
71
-
-
0037422608
-
Addition of the keto functional group to the genetic code of Escherichia coli
-
Wang, L., Zhang, Z., Ansger, B., Schultz, P.G. Addition of the keto functional group to the genetic code of Escherichia coli, PNAS, 2003, 100; 1:56-61.
-
(2003)
PNAS
, vol.100
, Issue.1
, pp. 56-61
-
-
Wang, L.1
Zhang, Z.2
Ansger, B.3
Schultz, P.G.4
-
72
-
-
0028472660
-
Stabilization of L-Aspariginase modified with comb shaped poly(ethylene glycol) derivatives, in Vivo and in Vitro
-
Kodera, Y., Sekine, T., Yasokochi, T., Kiriu, Yoshihiro, Hiroto, Misao, Matsushima, A., Inada, Y., Stabilization of L-Aspariginase modified with comb shaped poly(ethylene glycol) derivatives, in Vivo and in Vitro, Bioconjugate Chem., 1994;5:283-286.
-
(1994)
Bioconjugate Chem.
, vol.5
, pp. 283-286
-
-
Kodera, Y.1
Sekine, T.2
Yasokochi, T.3
Kiriu, Y.4
Hiroto, M.5
Matsushima, A.6
Inada, Y.7
-
73
-
-
85056037979
-
-
presented at Int. Symp. on the Separation of Proteins, Peptides and Polynucleotides, Aachen, Federal Republic of Germany, Oct 19-22
-
Lee, E.K. and Lee, J.D., Solid-phase, N-terminus-specific, mono-PEGylation of recombinant interferon- alpha-2a: Purification, characterization, and bioactivity, presented at Int. Symp. on the Separation of Proteins, Peptides and Polynucleotides, Aachen, Federal Republic of Germany, Oct 19-22, 2004.
-
(2004)
Solid-phase, N-terminus-specific, mono-PEGylation of recombinant interferon- alpha-2a: Purification, characterization, and bioactivity
-
-
Lee, E.K.1
Lee, J.D.2
-
74
-
-
0037457502
-
Size-exclusion reaction chromatography (SERC): A new technique for protein PEGylation
-
Fee, C.J., Size-exclusion reaction chromatography (SERC): A new technique for protein PEGylation, Biotechnology & Bioengineering, 82(2), 200, 2003.
-
(2003)
Biotechnology & Bioengineering
, vol.82
, Issue.2
, pp. 200
-
-
Fee, C.J.1
-
75
-
-
0042830593
-
Solid-phase enzyme modification via affinity chromatography
-
Baran, E.T., Ozer, N. and Hasirci, V., Solid-phase enzyme modification via affinity chromatography, Journal of Chromatography B, 794(2), 311, 2003.
-
(2003)
Journal of Chromatography B
, vol.794
, Issue.2
, pp. 311
-
-
Baran, E.T.1
Ozer, N.2
Hasirci, V.3
-
76
-
-
0006228843
-
Site-specific poly(ethylene glycol)ylation of peptides
-
Harris, J.M. and Zalipsky, S., Eds., American Chemical Society, Washington, D.C
-
Felix, A.M., Site-specific poly(ethylene glycol)ylation of peptides, in Poly(ethylene glycol) ACS Symposium series 680, Harris, J.M. and Zalipsky, S., Eds., American Chemical Society, Washington, D.C., 1997, 218-238.
-
(1997)
Poly(ethylene glycol) ACS Symposium series 680
, pp. 218-238
-
-
Felix, A.M.1
-
77
-
-
0345909511
-
Isolation of positional isomers of mono-poly(ethylene glycol)ylated interferon/α-2a and the determination of their biochemical and biological characteristics
-
Harris, J.M. and Zalipsky, S., (Eds.), American Chemical Society, Washington, D.C
-
Monkarsh, S.P., Spence, C., Porter, J.E., Palleroni, A., Nalin, C., Rosen, P. and Bailon, P. (1997). Isolation of positional isomers of mono-poly(ethylene glycol)ylated interferon/α-2a and the determination of their biochemical and biological characteristics, in: Harris, J.M. and Zalipsky, S., (Eds.), Poly(ethylene glycol) ACS Symposium series 680, American Chemical Society, Washington, D.C. 207-216.
-
(1997)
Poly(ethylene glycol) ACS Symposium series 680
, pp. 207-216
-
-
Monkarsh, S.P.1
Spence, C.2
Porter, J.E.3
Palleroni, A.4
Nalin, C.5
Rosen, P.6
Bailon, P.7
-
78
-
-
0031001543
-
Analytical partitioning of poly(ethylene glycol)- modified proteins
-
Delgado, C., Malmsten, M. and Van Alstine, J.M., Analytical partitioning of poly(ethylene glycol)- modified proteins, Journal of Chromatography B, 692(2), 263, 1997.
-
(1997)
Journal of Chromatography B
, vol.692
, Issue.2
, pp. 263
-
-
Delgado, C.1
Malmsten, M.2
Van Alstine, J.M.3
-
79
-
-
85056074123
-
-
Gepasi 3.30, (Bio)chemical Kinetics Simulation Software written by Pedro Mendes, University of Wales Aberystwyth., downloadable at
-
Gepasi 3.30, (Bio)chemical Kinetics Simulation Software written by Pedro Mendes, University of Wales Aberystwyth., downloadable at http:/www.gepasi.org.
-
-
-
|