PEGylation of octreotide: I. Separation of positional isomers and stability against acylation by poly(D,L-lactide-co-glycolide)

Pharmaceutical Research

Volumn 22, Issue 5, 2005, Pages 736-742

  Na, Dong Hee ^a   DeLuca, Patrick P ^b  

^a Kyungsung University   (South Korea)

^b University of Kentucky   (United States)

Author keywords

Acylation; Microsphere; Octreotide; PEGylation; Poly(D,L lactide co glycolide)

Indexed keywords

ARGININE CARBOXYPEPTIDASE; MACROGOL; OCTREOTIDE; POLYGLACTIN; PROTEINASE;

ACIDITY; ACYLATION; ADSORPTION; AMINO TERMINAL SEQUENCE; ARTICLE; CHEMICAL MODIFICATION; DRUG ACETYLATION; DRUG DETERMINATION; DRUG STABILITY; HYDROPHILICITY; HYDROPHOBICITY; ISOMER; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PH MEASUREMENT; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ACYLATION; ADSORPTION; AMINO ACID SEQUENCE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG INTERACTIONS; DRUG STABILITY; ISOMERISM; LACTIC ACID; OCTREOTIDE; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; POLYMERS; TECHNOLOGY, PHARMACEUTICAL;

EID: 20044385277     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-2589-4     Document Type: Article

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