Reprogramming homing endonuclease specificity through computational design and directed evolution

Nucleic Acids Research

Volumn 42, Issue 4, 2014, Pages 2564-2576

  Thyme, Summer B ^a,b,f   Boissel, Sandrine J S ^b   Arshiya Quadri, S ^a   Nolan, Tony ^c   Baker, Dean A ^d   Park, Rachel U ^a   Kusak, Lara ^a   Ashworth, Justin ^e   Baker, David ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^f HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; HOMING ENDONUCLEASE; UNCLASSIFIED DRUG;

ANOPHELES GAMBIAE; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; DNA CLEAVAGE; ENZYME SPECIFICITY; GENETIC VARIABILITY; MATHEMATICAL MODEL; MOLECULAR EVOLUTION; NONHUMAN; NUCLEAR REPROGRAMMING; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS;

ANIMALS; ANOPHELES GAMBIAE; BACTERIA; COMPUTATIONAL BIOLOGY; DIRECTED MOLECULAR EVOLUTION; DNA CLEAVAGE; ENDODEOXYRIBONUCLEASES; GENES, INSECT; MODELS, MOLECULAR; PROTEIN ENGINEERING; SUBSTRATE SPECIFICITY;

EID: 84895834027     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt1212     Document Type: Article

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