-
1
-
-
78951479577
-
Targeting DNA double-strand breaks with TAL effector nucleases
-
Christian M., et al. (2010) Targeting DNA double-strand breaks with TAL effector nucleases. Genetics 186:757-761.
-
(2010)
Genetics
, vol.186
, pp. 757-761
-
-
Christian, M.1
-
2
-
-
78651270582
-
TAL nucleases (TALNs): Hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain
-
Li T., et al. (2010) TAL nucleases (TALNs): Hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain. Nucleic Acids Res 39:359-372.
-
(2010)
Nucleic Acids Res
, vol.39
, pp. 359-372
-
-
Li, T.1
-
3
-
-
77949885922
-
Homing endonucleases: From basics to therapeutic applications
-
Marcaida M.J., Munoz I.G., Blanco F.J., Prieto J., Montoya G. (2010) Homing endonucleases: From basics to therapeutic applications. Cell Mol Life Sci 67:727-748.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 727-748
-
-
Marcaida, M.J.1
Munoz, I.G.2
Blanco, F.J.3
Prieto, J.4
Montoya, G.5
-
4
-
-
78651240053
-
Homing endonucleases: From microbial genetic invaders to reagents for targeted DNA modification
-
Stoddard B.L. (2011) Homing endonucleases: From microbial genetic invaders to reagents for targeted DNA modification. Structure 19:7-15.
-
(2011)
Structure
, vol.19
, pp. 7-15
-
-
Stoddard, B.L.1
-
5
-
-
77955867185
-
Genome editing with engineered zinc finger nucleases
-
Urnov F.D., Rebar E.J., Holmes M.C., Zhang H.S., Gregory P.D. (2010) Genome editing with engineered zinc finger nucleases. Nat Rev Genet 11:636-646.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 636-646
-
-
Urnov, F.D.1
Rebar, E.J.2
Holmes, M.C.3
Zhang, H.S.4
Gregory, P.D.5
-
6
-
-
33644756595
-
Homing endonuclease structure and function
-
Stoddard B.L. (2005) Homing endonuclease structure and function. Q Rev Biophys 38:49-95.
-
(2005)
Q Rev Biophys
, vol.38
, pp. 49-95
-
-
Stoddard, B.L.1
-
7
-
-
78650432023
-
The I-CreI meganuclease and its engineered derivatives: Applications from cell modification to gene therapy
-
Arnould S., et al. (2010) The I-CreI meganuclease and its engineered derivatives: Applications from cell modification to gene therapy. Protein Eng Des Sel 24:27-31.
-
(2010)
Protein Eng des Sel
, vol.24
, pp. 27-31
-
-
Arnould, S.1
-
8
-
-
33847246298
-
Meganucleases and DNA double-strand break-induced recombination: Perspectives for gene therapy
-
DOI 10.2174/156652307779940216
-
Paques F., Duchateau P. (2007) Meganucleases and DNA double-strand break-induced recombination: Perspectives for gene therapy. Curr Gene Ther 7:49-66. (Pubitemid 46322288)
-
(2007)
Current Gene Therapy
, vol.7
, Issue.1
, pp. 49-66
-
-
Paques, F.1
Duchateau, P.2
-
10
-
-
77951234910
-
Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds
-
Grizot S., et al. (2010) Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds. Nucleic Acids Res 38:2006-2018.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 2006-2018
-
-
Grizot, S.1
-
11
-
-
72749124013
-
Heritable targeted mutagenesis in maize using a designed endonuclease
-
Gao H., et al. (2010) Heritable targeted mutagenesis in maize using a designed endonuclease. Plant J 61:176-187.
-
(2010)
Plant J
, vol.61
, pp. 176-187
-
-
Gao, H.1
-
12
-
-
70349407359
-
Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease
-
Grizot S., et al. (2009) Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease. Nucleic Acids Res 37:5405-5419.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 5405-5419
-
-
Grizot, S.1
-
13
-
-
70349902619
-
Genes within genes: Multiple LAGLIDADG homing endonucleases target the ribosomal protein S3 gene encoded within an rnl group I intron of Ophiostoma and related taxa
-
Sethuraman J., Majer A., Friedrich N.C., Edgell D.R., Hausner G. (2009) Genes within genes: Multiple LAGLIDADG homing endonucleases target the ribosomal protein S3 gene encoded within an rnl group I intron of Ophiostoma and related taxa. Mol Biol Evol 26:2299-2315.
-
(2009)
Mol Biol Evol
, vol.26
, pp. 2299-2315
-
-
Sethuraman, J.1
Majer, A.2
Friedrich, N.C.3
Edgell, D.R.4
Hausner, G.5
-
14
-
-
77950806408
-
New algorithms and methods to estimate maximum-likelihood phylogenies: Assessing the performance of PhyML 3
-
Guindon S., et al. (2010) New algorithms and methods to estimate maximum-likelihood phylogenies: Assessing the performance of PhyML 3. Syst Biol 59:307-321.
-
(2010)
Syst Biol
, vol.59
, pp. 307-321
-
-
Guindon, S.1
-
15
-
-
77956046534
-
A group II intron encodes a functional LAGLIDADG homing endonuclease and self-splices under moderate temperature and ionic conditions
-
Mullineux S.T., Costa M., Bassi G.S., Michel F., Hausner G. (2010) A group II intron encodes a functional LAGLIDADG homing endonuclease and self-splices under moderate temperature and ionic conditions. RNA 16:1818-1831.
-
(2010)
RNA
, vol.16
, pp. 1818-1831
-
-
Mullineux, S.T.1
Costa, M.2
Bassi, G.S.3
Michel, F.4
Hausner, G.5
-
16
-
-
0346030573
-
Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor
-
DOI 10.1101/gad.1109003
-
Bolduc J.M., et al. (2003) Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor. Genes Dev 17:2875-2888. (Pubitemid 37523153)
-
(2003)
Genes and Development
, vol.17
, Issue.23
, pp. 2875-2888
-
-
Bolduc, J.M.1
Spiegel, P.C.2
Chatterjee, P.3
Brady, K.L.4
Downing, M.E.5
Caprara, M.G.6
Waring, R.B.7
Stoddard, B.L.8
-
17
-
-
0242636378
-
The crystal structure of the gene targeting homing endonuclease I-SceI reveals the origins of its target site specificity
-
DOI 10.1016/j.jmb.2003.09.068
-
Moure C.M., Gimble F.S., Quiocho F.A. (2003) The crystal structure of the gene targeting homing endonuclease I-SceI reveals the origins of its target site specificity. J Mol Biol 334:685-695. (Pubitemid 37433885)
-
(2003)
Journal of Molecular Biology
, vol.334
, Issue.4
, pp. 685-695
-
-
Moure, C.M.1
Gimble, F.S.2
Quiocho, F.A.3
-
18
-
-
34548505001
-
Coevolution of a Homing Endonuclease and Its Host Target Sequence
-
DOI 10.1016/j.jmb.2007.07.052, PII S0022283607010054
-
Scalley-Kim M., McConnell-Smith A., Stoddard B.L. (2007) Coevolution of a homing endonuclease and its host target sequence. J Mol Biol 372:1305-1319. (Pubitemid 47374723)
-
(2007)
Journal of Molecular Biology
, vol.372
, Issue.5
, pp. 1305-1319
-
-
Scalley-Kim, M.1
McConnell-Smith, A.2
Stoddard, B.L.3
-
19
-
-
73349127524
-
High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display
-
Jarjour J., et al. (2009) High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display. Nucleic Acids Res 37:6871-6880.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 6871-6880
-
-
Jarjour, J.1
-
20
-
-
70350635776
-
Exploitation of binding energy for catalysis and design
-
Thyme S.B., et al. (2009) Exploitation of binding energy for catalysis and design. Nature 461:1300-1304.
-
(2009)
Nature
, vol.461
, pp. 1300-1304
-
-
Thyme, S.B.1
-
21
-
-
0032540751
-
I-Ppol and I-CreI homing site sequence degeneracy determined by random mutagenesis and sequential in vitro enrichment
-
DOI 10.1006/jmbi.1998.1886
-
Argast G.M., Stephens K.M., Emond M.J., Monnat R.J., Jr (1998) I-PpoI and I-CreI homing site sequence degeneracy determined by random mutagenesis and sequential in vitro enrichment. J Mol Biol 280:345-353. (Pubitemid 28327275)
-
(1998)
Journal of Molecular Biology
, vol.280
, Issue.3
, pp. 345-353
-
-
Argast, G.M.1
Stephens, K.M.2
Emond, M.J.3
Monnat Jr., R.J.4
-
22
-
-
0038061526
-
Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI
-
DOI 10.1016/S0022-2836(03)00447-9
-
Chevalier B., Turmel M., Lemieux C., Monnat R.J., Jr, Stoddard B.L. (2003) Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI. J Mol Biol 329:253-269. (Pubitemid 36561582)
-
(2003)
Journal of Molecular Biology
, vol.329
, Issue.2
, pp. 253-269
-
-
Chevalier, B.1
Turmel, M.2
Lemieux, C.3
Monnat Jr., R.J.4
Stoddard, B.L.5
-
23
-
-
2342471959
-
Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector
-
DOI 10.1038/nbt957
-
Szymczak A.L., et al. (2004) Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector. Nat Biotechnol 22:589-594. (Pubitemid 38585911)
-
(2004)
Nature Biotechnology
, vol.22
, Issue.5
, pp. 589-594
-
-
Szymczak, A.L.1
Workman, C.J.2
Wang, Y.3
Vignali, K.M.4
Dilioglou, S.5
Vanin, E.F.6
Vignali, D.A.A.7
-
24
-
-
0033569684
-
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
-
DOI 10.1101/gad.13.20.2633
-
Pierce A.J., Johnson R.D., Thompson L.H., Jasin M. (1999) XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev 13:2633-2638. (Pubitemid 29508550)
-
(1999)
Genes and Development
, vol.13
, Issue.20
, pp. 2633-2638
-
-
Pierce, A.J.1
Johnson, R.D.2
Thompson, L.H.3
Jasin, M.4
-
25
-
-
8644255915
-
Homing endonuclease genes: The rise and fall and rise again of a selfish element
-
DOI 10.1016/j.gde.2004.09.010, PII S0959437X04001571
-
Burt A., Koufopanou V. (2004) Homing endonuclease genes: The rise and fall and rise again of a selfish element. Curr Opin Genet Dev 14:609-615. (Pubitemid 39505364)
-
(2004)
Current Opinion in Genetics and Development
, vol.14
, Issue.6
, pp. 609-615
-
-
Burt, A.1
Koufopanou, V.2
-
26
-
-
28544437131
-
A highly sensitive selection method for directed evolution of homing endonucleases
-
Chen Z., Zhao H. (2005) A highly sensitive selection method for directed evolution of homing endonucleases. Nucleic Acids Res 33:e154.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Chen, Z.1
Zhao, H.2
-
27
-
-
8344256614
-
Metal-dependent DNA cleavage mechanism of the I-CreI LAGLIDADG homing endonuclease
-
DOI 10.1021/bi048970c
-
Chevalier B., et al. (2004) Metal-dependent DNA cleavage mechanism of the I-CreI LAGLIDADG homing endonuclease. Biochemistry 43:14015-14026. (Pubitemid 39482751)
-
(2004)
Biochemistry
, vol.43
, Issue.44
, pp. 14015-14026
-
-
Chevalier, B.1
Sussman, D.2
Otis, C.3
Noel, A.-J.4
Turmel, M.5
Lemieux, C.6
Stephens, K.7
Monnat Jr., R.J.8
Stoddard, B.L.9
-
28
-
-
65249139484
-
Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease
-
McConnell Smith A., et al. (2009) Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease. Proc Natl Acad Sci USA 106:5099-5104.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 5099-5104
-
-
McConnell Smith, A.1
-
29
-
-
77956532389
-
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs
-
Ashworth J., et al. (2010) Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs. Nucleic Acids Res 38:5601-5608.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 5601-5608
-
-
Ashworth, J.1
-
30
-
-
55549138062
-
Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases
-
Redondo P., et al. (2008) Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases. Nature 456:107-111.
-
(2008)
Nature
, vol.456
, pp. 107-111
-
-
Redondo, P.1
-
31
-
-
33645307953
-
The therapeutic potential of monoamine oxidase inhibitors
-
Youdim M.B., Edmondson D., Tipton K.F. (2006) The therapeutic potential of monoamine oxidase inhibitors. Nat Rev Neurosci 7:295-309.
-
(2006)
Nat Rev Neurosci
, vol.7
, pp. 295-309
-
-
Youdim, M.B.1
Edmondson, D.2
Tipton, K.F.3
-
32
-
-
77954858931
-
Discordant effects of rasagiline doses in Parkinson disease
-
10.1038/nrneurol.2010.2-c1
-
Deftereos S.N., Andronis C.A. (2010) Discordant effects of rasagiline doses in Parkinson disease. Nat Rev Neurol 6, 10.1038/nrneurol.2010.2-c1.
-
(2010)
Nat Rev Neurol
, vol.6
-
-
Deftereos, S.N.1
Andronis, C.A.2
-
33
-
-
77953383270
-
Early pharmacologic treatment in Parkinson's disease
-
Hauser R.A. (2010) Early pharmacologic treatment in Parkinson's disease. Am J Manag Care 16:S100-S107.
-
(2010)
Am J Manag Care
, vol.16
-
-
Hauser, R.A.1
-
34
-
-
70349456475
-
A double-blind, delayed-start trial of rasagiline in Parkinson's disease
-
Olanow C.W., et al. (2009) A double-blind, delayed-start trial of rasagiline in Parkinson's disease. N Engl J Med 361:1268-1278.
-
(2009)
N Engl J Med
, vol.361
, pp. 1268-1278
-
-
Olanow, C.W.1
-
35
-
-
77949378919
-
Parkinson disease: ADAGIO trial hints that rasagiline slows disease progression
-
Sampaio C., Ferreira J.J. (2010) Parkinson disease: ADAGIO trial hints that rasagiline slows disease progression. Nat Rev Neurol 6:126-128.
-
(2010)
Nat Rev Neurol
, vol.6
, pp. 126-128
-
-
Sampaio, C.1
Ferreira, J.J.2
-
36
-
-
77149157862
-
Rasagiline in Parkinson's disease
-
Youdim M.B. (2010) Rasagiline in Parkinson's disease. N Engl J Med 362:657-658.
-
(2010)
N Engl J Med
, vol.362
, pp. 657-658
-
-
Youdim, M.B.1
-
37
-
-
77953229115
-
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
-
Lieber M.R. (2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79:181-211.
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 181-211
-
-
Lieber, M.R.1
-
38
-
-
79951565665
-
Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template
-
Metzger M.J., McConnell-Smith A., Stoddard B.L., Miller A.D. (2011) Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template. Nucleic Acids Res 39:926-935.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 926-935
-
-
Metzger, M.J.1
McConnell-Smith, A.2
Stoddard, B.L.3
Miller, A.D.4
-
39
-
-
77952296680
-
Zinc finger nuclease technology heralds a new era in mammalian transgenesis
-
Le Provost F., et al. (2010) Zinc finger nuclease technology heralds a new era in mammalian transgenesis. Trends Biotechnol 28:134-141.
-
(2010)
Trends Biotechnol
, vol.28
, pp. 134-141
-
-
Le Provost, F.1
-
40
-
-
49349086561
-
Engineering variants of the I-SceI homing endonuclease with strand-specific and site-specific DNA-nicking activity
-
Niu Y., Tenney K., Li H., Gimble F.S. (2008) Engineering variants of the I-SceI homing endonuclease with strand-specific and site-specific DNA-nicking activity. J Mol Biol 382:188-202.
-
(2008)
J Mol Biol
, vol.382
, pp. 188-202
-
-
Niu, Y.1
Tenney, K.2
Li, H.3
Gimble, F.S.4
-
41
-
-
63349094041
-
Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation
-
Takeuchi R., Certo M., Caprara M.G., Scharenberg A.M., Stoddard B.L. (2009) Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation. Nucleic Acids Res 37:877-890.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 877-890
-
-
Takeuchi, R.1
Certo, M.2
Caprara, M.G.3
Scharenberg, A.M.4
Stoddard, B.L.5
-
42
-
-
80051999439
-
Native homing endonucleases can target conserved genes in humans and in animal models
-
10.1093/nar/gkr242
-
Barzel A., et al. (2011) Native homing endonucleases can target conserved genes in humans and in animal models. Nucleic Acids Res, 10.1093/nar/gkr242.
-
(2011)
Nucleic Acids Res
-
-
Barzel, A.1
|