Exploitation of binding energy for catalysis and design

Nature

Volumn 461, Issue 7268, 2009, Pages 1300-1304

  Thyme, Summer B ^a,b   Jarjour, Jordan ^b,c   Takeuchi, Ryo ^d   Havranek, James J ^e   Ashworth, Justin ^a,b   Scharenberg, Andrew M ^b,c   Stoddard, Barry L ^b,d   Baker, David ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE I; ENDONUCLEASE;

CATALYSIS; DNA; ENZYME ACTIVITY; GENETIC ENGINEERING; GENOMICS; MUTATION; PROTEIN; SUBSTRATE; YEAST;

ARTICLE; BASE PAIRING; CATALYSIS; CHEMICAL REACTION; DISSOCIATION CONSTANT; ENERGY; ENZYME SUBSTRATE COMPLEX; GENE MUTATION; GENE TARGETING; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; TURNOVER TIME;

BINDING SITES; BIOCATALYSIS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DNA; ENDONUCLEASES; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RNA-DIRECTED DNA POLYMERASE; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 70350635776     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08508     Document Type: Article

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