Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences

Nucleic Acids Research

Volumn 36, Issue 7, 2008, Pages 2163-2173

  Fajardo Sanchez, Emmanuel ^a,b   Stricher, François ^a,b   Pâques, Frédéric ^c   Isalan, Mark ^a,b   Serrano, Luis ^a,b  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^c Arvid Wallgrens Backe 20   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; HETERODIMER; MEGANUCLEASE; MONOMER; PALINDROMIC DNA; PROTEIN I CREI; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; DNA; ENDODEOXYRIBONUCLEASE CREI; RESTRICTION ENDONUCLEASE;

ALGORITHM; ARTICLE; COMPUTER AIDED DESIGN; CONTROLLED STUDY; DIMERIZATION; GENE IDENTIFICATION; GENE LIBRARY; GENETIC ENGINEERING; HETERODIMERIZATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TARGETING; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; METABOLISM; METHODOLOGY; NUCLEOTIDE SEQUENCE; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS;

ALGORITHMS; BASE SEQUENCE; DIMERIZATION; DNA; DNA RESTRICTION ENZYMES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN ENGINEERING; SUBSTRATE SPECIFICITY;

EID: 42449124824     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkn059     Document Type: Article

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