Modeling Backbone Flexibility to Achieve Sequence Diversity: The Design of Novel α-Helical Ligands for Bcl-xL

Journal of Molecular Biology

Volumn 371, Issue 4, 2007, Pages 1099-1117

  Fu, Xiaoran ^a   Apgar, James R ^a   Keating, Amy E ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

backbone flexibility; Bcl 2 binding peptides; BH3 peptides; computational design; protein protein interaction specificity

Indexed keywords

BH3 PROTEIN; LIGAND; PROTEIN BCL XL;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 34547121250     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.04.069     Document Type: Article

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