Overcoming the cutaneous barrier with microemulsions

Pharmaceutics

Volumn 6, Issue 1, 2014, Pages 52-77

  Lopes, Luciana B ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

Author keywords

Composition; Cutaneous delivery; Internal structure; Microemulsion; Skin; Transdermal delivery

Indexed keywords

ASCORBIC ACID; CITALOPRAM; COSMETIC; CREMOPHOR; CYCLOSPORIN A; PENCICLOVIR; SURFACTANT;

ADVERSE OUTCOME; DISPERSION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; ELECTRIC CONDUCTIVITY; HUMAN; HYDROPHILICITY; MICROEMULSION; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PHASE SEPARATION; REVIEW; SKIN IRRITATION; SKIN PENETRATION; SURFACE PROPERTY; THERMODYNAMICS; TOPICAL DRUG ADMINISTRATION; TRANSDERMAL DRUG ADMINISTRATION; VISCOSITY; WATER CONTENT;

EID: 84895435428     PISSN: None     EISSN: 19994923     Source Type: Journal    
DOI: 10.3390/pharmaceutics6010052     Document Type: Review

References (133)

1. Menon, G.K. New insights into skin structure: Scratching the surface. Adv. Drug Deliv. Rev. 2002, 54, S3-S17.
2. Madison, K.C. Barrier function of the skin: "La raison d'etre" of the epidermis. J. Investig. Dermatol. 2003, 121, 231-241.
3. Jepps, O.G.; Dancik, Y.; Anissimov, Y.G.; Roberts, M.S. Modeling the human skin barrier-Towards a better understanding of dermal absorption. Adv. Drug Deliv. Rev. 2013, 65, 152-168.
4. Bouwstra, J.A.; Honeywell-Nguyen, P.L.; Gooris, G.S.; Ponec, M. Structure of the skin barrier and its modulation by vesicular formulations. Prog. Lipid Res. 2003, 42, 1-36.
5. Van Smeden, J.; Janssens, M.; Gooris, G.S.; Bouwstra, J.A. The important role of stratum corneum lipids for the cutaneous barrier function. Biochim. Biophys. Acta 2013, 1841, 295-313.
6. Otto, A.; du Plessis, J.; Wiechers, J.W. Formulation effects of topical emulsions on transdermal and dermal delivery. Int. J. Cosmet. Sci. 2009, 31, 1-19.
7. Peppin, J.F.; Pappagallo, M. Capsaicinoids in the treatment of neuropathic pain: A review. Ther. Adv. Neurol. Disord. 2014, 7, 22-32.
8. Lawrence, M.J.; Rees, G.D. Microemulsion-based media as novel drug delivery systems. Adv. Drug Deliv. Rev. 2000, 45, 89-121.
9. Kogan, A.; Garti, N. Microemulsions as transdermal drug delivery vehicles. Adv. Colloid Interface Sci. 2006, 123-126, 369-385.
10. Hathout, R.M.; Woodman, T.J.; Mansour, S.; Mortada, N.D.; Geneidi, A.S.; Guy, R.H. Microemulsion formulations for the transdermal delivery of testosterone. Eur. J. Pharm. Sci. 2010, 40, 188-196.
11. Santos, P.; Watkinson, A.C.; Hadgraft, J.; Lane, M.E. Application of microemulsions in dermal and transdermal drug delivery. Skin Pharmacol. Physiol. 2008, 21, 246-259.
12. Lawrence, M.; Warisnoicharoen, E. Recent Advances in Microemulsions as Drug Delivery Vehicles. In Nanoparticulates as Drug Carriers; Torchilin, V.P., Ed.; Imperial College Press: London, UK, 2006; pp. 125-172.
13. Kumar, K.; Mittal, K.L. Handbook of Microemulsion Science and Technology; Marcel Dekker Inc.: New York, NY, USA, 1999.
14. Russell-Jones, G.; Himes, R. Water-in-oil microemulsions for effective transdermal delivery of proteins. Expert Opin. Drug Deliv. 2011, 8, 537-546.
15. Kreilgaard, M. Influence of microemulsions on cutaneous drug delivery. Adv. Drug Deliv. Rev. 2002, 54, S77-S98.
16. Lindman, B.; Shinoda, K.; Olsson, U.; Andersson, D.; Karlstrom, G.; Wenner-Strom, H. On the demonstration of bicontinuous structures in microemulsions. Colloids Surf. 1989, 38, 205-224.
17. Hoar, T.P.; Schulman, J.H. Transparent water-in-oil dispersions: The oleophatic hydro-micelle. Nature 1943, 152, 102-103.
18. Heuschkel, S.; Goebel, A.; Neubert, R.H. Microemulsions-Modern colloidal carrier for dermal and transdermal drug delivery. J. Pharm. Sci. 2008, 97, 603-631.
19. McClements, D.J. Nanoemulsions versus microemulsions: Terminology, differences, and similarities. Soft Matter 2012, 8, 1719-1729.
20. Balogh, J.; Olsson, U.; Jan, S.P.; Kaper, H.; Wennerstrom, H.; Schillén, K.; Miguel, M. Non-Ionic Microemulsions: Dependence of Oil Chain Lenght and Active Component. In Self-Organized Surfactant Structure; Tadros, T.F., Ed.; Wiley-VCH: Weinheim, Germany, 2010.
21. Tadros, T.F. Applied Surfactants; Wiley-VHC: Weinheim, Germany, 2005.
22. Sjoblom, J.; Lindbergh, R.; Friberg, S. Microemulsions-Phase equilibria characterization, structures, applications and chemical reactions. Adv. Colloid Interface Sci. 1986, 95, 125-287.
23. Kogan, A.; Aserin, A.; Garti, N. Improved solubilization of carbamazepine and structural transitions in nonionic microemulsions upon aqueous phase dilution. J. Colloid Interface Sci. 2007, 315, 637-647.
24. Malheiro, A.R.; Varanda, L.C.; Perez, J.; Villullas, H.M. The Aerosol OT + n-butanol + n-heptane + water system: Phase behavior, structure characterization, and application to Pt70Fe30 nanoparticle synthesis. Langmuir 2007, 23, 11015-11020.
25. Cabaleiro-Lago, C.; Garcia-Rio, L.; Hervella, P. The effect of changing the microstructure of a microemulsion on chemical reactivity. Langmuir 2007, 23, 9586-9595.
26. Pepe, D.; Phelps, J.; Lewis, K.; Dujack, J.; Scarlett, K.; Jahan, S.; Bonnier, E.; Milic-Pasetto, T.; Hass, M.A.; Lopes, L.B. Decylglucoside-based microemulsions for cutaneous localization of lycopene and ascorbic acid. Int. J. Pharm. 2012, 434, 420-428.
27. El Maghraby, G.M. Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: Effects of cosurfactants. Int. J. Pharm. 2008, 355, 285-292.
28. Schwarz, J.; Weisspapir, M.; Friedman, D. Enhanced transdermal delivery of diazepam by submicron emulsion (sme) creams. Pharm. Res. 1995, 12, 687-692.
29. Friedman, D.; Schwarz, J.S.; Weisspapir, M. Submicron emulsion vehicle for enhanced transdermal delivery of steroidal and nonsteroidal antiinflammatory drugs. J. Pharm. Sci. 1995, 84, 324-329.
30. Shim, J.; Kim, M.J.; Kim, H.K.; Kim, D.H.; Oh, S.G.; Ko, S.Y.; Jang, H.G.; Kim, J.W. Morphological effect of lipid carriers on permeation of lidocaine hydrochloride through lipid membranes. Int. J. Pharm. 2010, 388, 251-256.
31. Baroli, B.; Lopez-Quintela, M.A.; Delgado-Charro, M.B.; Fadda, A.M.; Blanco-Mendez, J. Microemulsions for topical delivery of 8-methoxsalen. J. Control. Release 2000, 69, 209-218.
32. Chen, H.; Chang, X.; Weng, T.; Zhao, X.; Gao, Z.; Yang, Y.; Xu, H.; Yang, X. A study of microemulsion systems for transdermal delivery of triptolide. J. Control. Release 2004, 98, 427-436.
33. Biruss, B.; Kahlig, H.; Valenta, C. Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones. Int. J. Pharm. 2007, 328, 142-151.
34. Lopes, L.B.; VanDeWall, H.; Li, H.T.; Venugopal, V.; Li, H.K.; Naydin, S.; Hosmer, J.; Levendusky, M.; Zheng, H.; Bentley, M.V.; et al. Topical delivery of lycopene using microemulsions: Enhanced skin penetration and tissue antioxidant activity. J. Pharm. Sci. 2010, 99, 1346-1357.
35. Hathout, R.M.; Mansour, S.; Mortada, N.D.; Geneidi, A.S.; Guy, R.H. Uptake of microemulsion components into the stratum corneum and their molecular effects on skin barrier function. Mol. Pharm. 2010, 7, 1266-1273.
36. Williams, A.C.; Barry, B.W. Penetration enhancers. Adv. Drug Deliv. Rev. 2004, 56, 603-618.
37. Gupta, R.R.; Jain, S.K.; Varshney, M. Aot water-in-oil microemulsions as a penetration enhancer in transdermal drug delivery of 5-fluorouracil. Colloids Surf. 2005, 41, 25-32.
38. Patzelt, A.; Lademann, J.; Richter, H.; Darvin, M.E.; Schanzer, S.; Thiede, G.; Sterry, W.; Vergou, T.; Hauser, M. In vivo investigations on the penetration of various oils and their influence on the skin barrier. Skin Res. Technol. 2012, 18, 364-369.
39. Dederen, J.C.; Chavan, B.; Rawlings, A.V. Emollients are more than sensory ingredients: The case of isostearyl isostearate. Int. J. Cosmet. Sci. 2012, 34, 502-510.
40. Fluhr, J.; Holleran, W.M.; Beradesca, E. Clinical Effects of Emollients on Skin. In Skin Moisturization; Leyden, J.J., Rwalings, A.V., Eds.; Marcel Dekker, Inc.: New York, NY, USA, 2005; pp. 220-242.
41. Malcolmson, C.; Satra, C.; Kantaria, S.; Sidhu, A.; Lawrence, M.J. Effect of oil on the level of solubilization of testosterone propionate into nonionic oil-in-water microemulsions. J. Pharm. Sci. 1998, 87, 109-116.
42. Bolko, K.; Zvonar, A.; Gasperlin, M. Mixed lipid phase smedds as an innovative approach to enhance resveratrol solubility. Drug Dev. Ind. Pharm. 2014, 40, 102-109.
43. Land, L.M.; Li, P.; Bummer, P.M. Mass transport properties of progesterone and estradiol in model microemulsion formulations. Pharm. Res. 2006, 23, 2482-2490.
44. Rhee, Y.S.; Choi, J.G.; Park, E.S.; Chi, S.C. Transdermal delivery of ketoprofen using microemulsions. Int. J. Pharm. 2001, 228, 161-170.
45. Zhang, J.; Michniak-Kohn, B. Investigation of microemulsion microstructures and their relationship to transdermal permeation of model drugs: Ketoprofen, lidocaine, and caffeine. Int. J. Pharm. 2011, 421, 34-44.
46. Junyaprasert, V.B.; Boonme, P.; Songkro, S.; Krauel, K.; Rades, T. Transdermal delivery of hydrophobic and hydrophilic local anesthetics from O/W and W/O BRIJ 97-based microemulsions. J. Pharm. Pharm. Sci. 2007, 10, 288-298.
47. Zhu, W.; Yu, A.; Wang, W.; Dong, R.; Wu, J.; Zhai, G. Formulation design of microemulsion for dermal delivery of penciclovir. Int. J. Pharm. 2008, 360, 184-190.
48. Kantarci, G.; Ozguney, I.; Karasulu, H.Y.; Arzik, S.; Guneri, T. Comparison of different water/oil microemulsions containing diclofenac sodium: Preparation, characterization, release rate, and skin irritation studies. AAPS PharmSciTech 2007, 8, E91.
49. Liu, C.H.; Chang, F.Y.; Hung, D.K. Terpene microemulsions for transdermal curcumin delivery: Effects of terpenes and cosurfactants. Colloids Surf. 2011, 82, 63-70.
50. Junyaprasert, V.B.; Boonme, P.; Wurster, D.E.; Rades, T. Aerosol OT microemulsions as carriers for transdermal delivery of hydrophobic and hydrophilic local anesthetics. Drug Deliv. 2008, 15, 323-330.
51. Liu, C.; Wu, J.; Shi, B.; Zhang, Y.; Gao, T.; Pei, Y. Enhancing the bioavailability of cyclosporine a using solid dispersion containing polyoxyethylene (40) stearate. Drug Dev. Ind. Pharm. 2006, 32, 115-123.
52. Shevachman, M.; Garti, N.; Shani, A.; Sintov, A.C. Enhanced percutaneous permeability of diclofenac using a new U-type dilutable microemulsion. Drug Dev. Ind. Pharm. 2008, 34, 403-412.
53. Biruss, B.; Valenta, C. The advantage of polymer addition to a non-ionic oil in water microemulsion for the dermal delivery of progesterone. Int. J. Pharm. 2008, 349, 269-273.
54. Pepe, D.; McCall, M.; Zheng, H.; Lopes, L.B. Protein transduction domain-containing microemulsions as cutaneous delivery systems for an anticancer agent. J. Pharm. Sci. 2013, 102, 1476-1487.
55. Huang, Y.B.; Lin, Y.H.; Lu, T.M.; Wang, R.J.; Tsai, Y.H.; Wu, P.C. Transdermal delivery of capsaicin derivative-sodium nonivamide acetate using microemulsions as vehicles. Int. J. Pharm. 2008, 349, 206-211.
56. Kamal, M.A.; Iimura, N.; Nabekura, T.; Kitagawa, S. Enhanced skin permeation of diclofenac by ion-pair formation and further enhancement by microemulsion. Chem. Pharm. Bull. 2007, 55, 368-371.
57. Peltola, S.; Saarinen-Savolainen, P.; Kiesvaara, J.; Suhonen, T.M.; Urtti, A. Microemulsions for topical delivery of estradiol. Int. J. Pharm. 2003, 254, 99-107.
58. Subramanian, N.; Ghosal, S.K.; Acharya, A.; Moulik, S.P. Formulation and physicochemical characterization of microemulsion system using isopropyl myristate, medium-chain glyceride, polysorbate 80 and water. Chem. Pharm. Bull. 2005, 53, 1530-1535.
59. Hua, L.; Weisan, P.; Jiayu, L.; Ying, Z. Preparation, evaluation, and NMR characterization of vinpocetine microemulsion for transdermal delivery. Drug Dev. Ind. Pharm. 2004, 30, 657-666.
60. Djordjevic, L.; Primorac, M.; Stupar, M.; Krajisnik, D. Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug. Int. J. Pharm. 2004, 271, 11-19.
61. Jurkovic, P.; Sentjurc, M.; Gasperlin, M.; Kristl, J.; Pecar, S. Skin protection against ultraviolet induced free radicals with ascorbyl palmitate in microemulsions. Eur. J. Pharm. Biopharm. 2003, 56, 59-66.
62. Baboota, S.; Al-Azaki, A.; Kohli, K.; Ali, J.; Dixit, N.; Shakeel, F. Development and evaluation of a microemulsion formulation for transdermal delivery of terbinafine. PDA J. Pharm. Sci. Technol. 2007, 61, 276-285.
63. Lee, J.; Lee, Y.; Kim, J.; Yoon, M.; Choi, Y.W. Formulation of microemulsion systems for transdermal delivery of aceclofenac. Arch. Pharm. Res. 2005, 28, 1097-1102.
64. Yuan, J.S.; Ansari, M.; Samaan, M.; Acosta, E.J. Linker-based lecithin microemulsions for transdermal delivery of lidocaine. Int. J. Pharm. 2008, 349, 130-143.
65. Changez, M.; Varshney, M.; Chander, J.; Dinda, A.K. Effect of the composition of lecithin/ n-propanol/isopropyl myristate/water microemulsions on barrier properties of mice skin for transdermal permeation of tetracaine hydrochloride: In vitro Colloids Surf. 2006, 50, 18-25.
66. Hoeller, S.; Klang, V.; Valenta, C. Skin-compatible lecithin drug delivery systems for fluconazole: Effect of phosphatidylethanolamine and oleic acid on skin permeation. J. Pharm. Pharmacol. 2008, 60, 587-591.
67. Sintov, A.C.; Shapiro, L. New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo J. Control. Release 2004, 95, 173-183.
68. Suppasansatorn, P.; Nimmannit, U.; Conway, B.R.; Du, L.; Wang, Y. Microemulsions as topical delivery vehicles for the anti-melanoma prodrug, temozolomide hexyl ester (TMZA-HE). J. Pharm. Pharmacol. 2007, 59, 787-794.
69. Cichewicz, A.; Pacleb, C.; Connors, A.; Hass, M.A.; Lopes, L.B. Cutaneous delivery of α-tocopherol and lipoic acid using microemulsions: Influence of composition and charge. J. Pharm. Pharmacol. 2013, 65, 817-826.
70. Peira, E.; Carlotti, M.E.; Trotta, C.; Cavalli, R.; Trotta, M. Positively charged microemulsions for topical application. Int. J. Pharm. 2008, 346, 119-123.
71. El Meshad, A.N.; Tadros, M.I. Transdermal delivery of an anti-cancer drug via W/O emulsions based on alkyl polyglycosides and lecithin: Design, characterization, and in vivo evaluation of the possible irritation potential in rats. AAPS PharmSciTech 2011, 12, 1-9.
72. Djekic, L.; Primorac, M. The influence of cosurfactants and oils on the formation of pharmaceutical microemulsions based on PEG-8 caprylic/capric glycerides. Int. J. Pharm. 2008, 352, 231-239.
73. Hashem, F.M.; Shaker, D.S.; Ghorab, M.K.; Nasr, M.; Ismail, A. Formulation, characterization, and clinical evaluation of microemulsion containing clotrimazole for topical delivery. AAPS PharmSciTech 2011, 12, 879-886.
74. Hosmer, J.; Reed, R.; Bentley, M.V.; Nornoo, A.; Lopes, L.B. Microemulsions containing medium-chain glycerides as transdermal delivery systems for hydrophilic and hydrophobic drugs. AAPS PharmSciTech 2009, 10, 589-596.
75. Patel, N.; Schmid, U.; Lawrence, M.J. Phospholipid-based microemulsions suitable for use in foods. J. Agric. Food Chem. 2006, 54, 7817-7824.
76. Montenegro, L.; Carbone, C.; Puglisi, G. Vehicle effects on in vitro release and skin permeation of octylmethoxycinnamate from microemulsions. Int. J. Pharm. 2011, 405, 162-168.
77. Yuan, J.S.; Yip, A.; Nguyen, N.; Chu, J.; Wen, X.Y.; Acosta, E.J. Effect of surfactant concentration on transdermal lidocaine delivery with linker microemulsions. Int. J. Pharm. 2010, 392, 274-284.
78. McCarley, K.D.; Bunge, A.L. Pharmacokinetic models of dermal absorption. J. Pharm. Sci. 2001, 90, 1699-1719.
79. Reddy, M.B.; McCarley, K.D.; Bunge, A.L. Physiologically relevant one-compartment pharmacokinetic models for skin. 2. Comparison of models when combined with a systemic pharmacokinetic model. J. Pharm. Sci. 1998, 87, 482-490.
80. Mitragotri, S.; Anissimov, Y.G.; Bunge, A.L.; Frasch, H.F.; Guy, R.H.; Hadgraft, J.; Kasting, G.B.; Lane, M.E.; Roberts, M.S. Mathematical models of skin permeability: An overview. Int. J. Pharm. 2011, 418, 115-129.
81. Anissimov, Y.G.; Jepps, O.G.; Dancik, Y.; Roberts, M.S. Mathematical and pharmacokinetic modelling of epidermal and dermal transport processes. Adv. Drug Deliv. Rev. 2013, 65, 169-190.
82. Singh, P.; Roberts, M.S. Effects of vasoconstriction on dermal pharmacokinetics and local tissue distribution of compounds. J. Pharm. Sci. 1994, 83, 783-791.
83. Al Abood, R.M.; Talegaonkar, S.; Tariq, M.; Ahmad, F.J. Microemulsion as a tool for the transdermal delivery of ondansetron for the treatment of chemotherapy induced nausea and vomiting. Colloids Surf. 2013, 101, 143-151.
84. Kogan, A.; Rozner, S.; Mehta, S.; Somasundaran, P.; Aserin, A.; Garti, N.; Ottaviani, M.F. Characterization of the nonionic microemulsions by EPR. I. Effect of solubilized drug on nanostructure. J. Phys. Chem. 2009, 113, 691-699.
85. Garti, N.; Avrahami, M.; Aserin, A. Improved solubilization of celecoxib in U-type nonionic microemulsions and their structural transitions with progressive aqueous dilution. J. Colloid Interface Sci. 2006, 299, 352-365.
86. Alvarez-Lorenzo, C.; Gomez-Amoza, J.L.; Martinez-Pacheco, R.; Souto, C.; Concheiro, A. Microviscosity of hydroxypropylcellulose gels as a basis for prediction of drug diffusion rates. Int. J. Pharm. 1999, 180, 91-103.
87. Rojanasakul, Y.; Wang, L.Y.; Bhat, M.; Glover, D.D.; Malanga, C.J.; Ma, J.K. The transport barrier of epithelia: A comparative study on membrane permeability and charge selectivity in the rabbit. Pharm. Res. 1992, 9, 1029-1034.
88. Yilmaz, E.; Borchert, H.H. Design of a phytosphingosine-containing, positively-charged nanoemulsion as a colloidal carrier system for dermal application of ceramides. Eur. J. Pharm. Biopharm. 2005, 60, 91-98.
89. Hoeller, S.; Sperger, A.; Valenta, C. Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation. Int. J. Pharm. 2009, 370, 181-186.
90. Baspinar, Y.; Borchert, H.H. Penetration and release studies of positively and negatively charged nanoemulsions-Is there a benefit of the positive charge? Int. J. Pharm. 2012, 430, 247-252.
91. Zhou, H.; Yue, Y.; Liu, G.; Li, Y.; Zhang, J.; Gong, Q.; Yan, Z.; Duan, M. Preparation and characterization of a lecithin nanoemulsion as a topical delivery system. Nanoscale Res. Lett. 2009, 5, 224-230.
92. Sahle, F.F.; Wohlrab, J.; Neubert, R.H.H. Controlled penetration of ceramides into and across the stratum corneum using various types of microemulsions and formulation associated toxicity studies. Eur. J. Pharm. Biopharm. 2013, doi:10.1016/j.ejpb.2013.07.011.
93. Izquierdo, P.; Wiechers, J.W.; Escribano, E.; Garcia-Celma, M.J.; Tadros, T.F.; Esquena, J.; Dederen, J.C.; Solans, C. A study on the influence of emulsion droplet size on the skin penetration of tetracaine. Skin Pharmacol. Physiol. 2007, 20, 263-270.
94. Valenta, C.; Schultz, K. Influence of carrageenan on the rheology and skin permeation of microemulsion formulations. J. Control. Release 2004, 95, 257-265.
95. Rozman, B.; Zvonar, A.; Falson, F.; Gasperlin, M. Temperature-sensitive microemulsion gel: An effective topical delivery system for simultaneous delivery of vitamins C and E. AAPS PharmSciTech 2009, 10, 54-61.
96. Araujo, L.M.; Thomazine, J.A.; Lopez, R.F. Development of microemulsions to topically deliver 5-aminolevulinic acid in photodynamic therapy. Eur. J. Pharm. Biopharm. 2010, 75, 48-55.
97. Delgado-Charro, M.B.; Iglesias-Vilas, G.; Blanco-Mendez, J.; Lopez-Quintela, M.A.; Marty, J.P.; Guy, R.H. Delivery of a hydrophobic solute through the skin from novel microemulsion systems. Eur. J. Pharm. Biopharm. 1997, 43, 37-42.
98. Naoui, W.; Bolzinger, M.A.; Fenet, B.; Pelletier, J.; Valour, J.P.; Kalfat, R.; Chevalier, Y. Microemulsion microstructure influences the skin delivery of an hydrophilic drug. Pharm. Res. 2011, 28, 1683-1695.
99. Lopes, L.B.; Lopes, J.L.; Oliveira, D.C.; Thomazini, J.A.; Garcia, M.T.; Fantini, M.C.; Collett, J.H.; Bentley, M.V. Liquid crystalline phases of monoolein and water for topical delivery of cyclosporin a: Characterization and study of in vitro and in vivo delivery. Eur. J. Pharm. Biopharm. 2006, 63, 146-155.
100. Lee, C.M.; Maibach, H.I. Deep percutaneous penetration into muscles and joints. J. Pharm. Sci. 2006, 95, 1405-1413.
101. Huang, C.T.; Tsai, M.J.; Lin, Y.H.; Fu, Y.S.; Huang, Y.B.; Tsai, Y.H.; Wu, P.C. Effect of microemulsions on transdermal delivery of citalopram: Optimization studies using mixture design and response surface methodology. Int. J. Nanomed. 2013, 8, 2295-2304.
102. Tashtoush, B.M.; Bennamani, A.N.; Al-Taani, B.M. Preparation and characterization of microemulsion formulations of nicotinic acid and its prodrugs for transdermal delivery. Pharm. Dev. Technol. 2013, 18, 834-843.
103. Zhao, J.H.; Ji, L.; Wang, H.; Chen, Z.Q.; Zhang, Y.T.; Liu, Y.; Feng, N.P. Microemulsion-based novel transdermal delivery system of tetramethylpyrazine: Preparation and evaluation in vitro and in vivo Int. J. Nanomed. 2011, 6, 1611-1619.
104. Tsai, Y.H.; Chang, J.T.; Chang, J.S.; Huang, C.T.; Huang, Y.B.; Wu, P.C. The effect of component of microemulsions on transdermal delivery of buspirone hydrochloride. J. Pharm. Sci. 2011, 100, 2358-2365.
105. Elshafeey, A.H.; Kamel, A.O.; Fathallah, M.M. Utility of nanosized microemulsion for transdermal delivery of tolterodine tartrate: Ex vivo permeation and in vivo pharmacokinetic studies. Pharm. Res. 2009, 26, 2446-2453.
106. Patel, P.A.; Patil, S.C.; Kalaria, D.R.; Kalia, Y.N.; Patravale, V.B. Comparative in vitro and in vivo evaluation of lipid based nanocarriers of huperzine A. Int. J. Pharm. 2013, 446, 16-23.
107. Yuan, Y.; Li, S.M.; Mo, F.K.; Zhong, D.F. Investigation of microemulsion system for transdermal delivery of meloxicam. Int. J. Pharm. 2006, 321, 117-123.
108. Fouad, S.A.; Basalious, E.B.; El-Nabarawi, M.A.; Tayel, S.A. Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: In vitro/in vivo evaluation. Int. J. Pharm. 2013, 453, 569-578.
109. Hathout, R.M.; Elshafeey, A.H. Development and characterization of colloidal soft nano-carriers for transdermal delivery and bioavailability enhancement of an angiotensin II receptor blocker. Eur. J. Pharm. Biopharm. 2012, 82, 230-240.
110. Bhatia, G.; Zhou, Y.; Banga, A.K. Adapalene microemulsion for transfollicular drug delivery. J. Pharm. Sci. 2013, 102, 2622-2631.
111. Hathout, R.M.; Nasr, M. Transdermal delivery of betahistine hydrochloride using microemulsions: Physical characterization, biophysical assessment, confocal imaging and permeation studies. Colloids Surf. 2013, 110, 254-260.
112. Pakpayat, N.; Nielloud, F.; Fortune, R.; Tourne-Peteilh, C.; Villareal, A.; Grillo, I.; Bataille, B. Formulation of ascorbic acid microemulsions with alkyl polyglycosides. Eur. J. Pharm. Biopharm. 2009, 72, 444-452.
113. Carlotti, M.E.; Gallarate, M.; Rossatto, V. O/W microemulsion as a vehicle for sunscreens. J. Cosmet. Sci. 2003, 54, 451-462.
114. Arevalo, M.I.; Escribano, E.; Calpena, A.; Domenech, J.; Queralt, J. Rapid skin anesthesia using a new topical amethocaine formulation: A preclinical study. Anesth. Analg. 2004, 98, 1407-1412.
115. Escribano, E.; Obach, M.; Arevalo, M.I.; Calpena, A.C.; Domenech, J.; Queralt, J. Rapid human skin permeation and topical anaesthetic activity of a new amethocaine microemulsion. Skin Pharmacol. Physiol. 2005, 18, 294-300.
116. Liu, H.; Wang, Y.; Lang, Y.; Yao, H.; Dong, Y.; Li, S. Bicontinuous cyclosporin a loaded water-AOT/Tween 85-isopropylmyristate microemulsion: Structural characterization and dermal pharmacokinetics in vivo J. Pharm. Sci. 2009, 98, 1167-1176.
117. Rangarajan, M.; Zatz, J.L. Effect of formulation on the topical delivery of alpha-tocopherol. J. Cosmet. Sci. 2003, 54, 161-174.
118. Rozman, B.; Gasperlin, M.; Tinois-Tessoneaud, E.; Pirot, F.; Falson, F. Simultaneous absorption of vitamins C and E from topical microemulsions using reconstructed human epidermis as a skin model. Eur. J. Pharm. Biopharm. 2009, 72, 69-75.
119. Getie, M.; Wohlrab, J.; Neubert, R.H. Dermal delivery of desmopressin acetate using colloidal carrier systems. J. Pharm. Pharmacol. 2005, 57, 423-427.
120. Rossetti, F.C.; Lopes, L.B.; Carollo, A.R.; Thomazini, J.A.; Tedesco, A.C.; Bentley, M.V. A delivery system to avoid self-aggregation and to improve in vitro and in vivo skin delivery of a phthalocyanine derivative used in the photodynamic therapy. J. Control. Release 2011, 155, 400-408.
121. Goebel, A.S.; Knie, U.; Abels, C.; Wohlrab, J.; Neubert, R.H. Dermal targeting using colloidal carrier systems with linoleic acid. Eur. J. Pharm. Biopharm. 2010, 75, 162-172.
122. Draelos, Z.D.; DiNardo, J.C. A re-evaluation of the comedogenicity concept. J. Am. Acad. Dermatol. 2006, 54, 507-512.
123. Fulton, J.E. Comedogenicity and irritancy of commonly used ingredients in skin care products. J. Soc. Cosmet. Chem. 1989, 40, 321-333.
124. Nguyen, S.H.; Dang, T.P.; Maibach, H.I. Comedogenicity in rabbit: Some cosmetic ingredients/ vehicles. Cutan. Ocul. Toxicol 2007, 26, 287-292.
125. Savic, S.; Savic, M.; Tamburic, S.; Vuleta, G.; Vesic, S.; Muller-Goymann, C.C. An alkyl polyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation. Eur. J. Pharm. Sci. 2007, 30, 441-450.
126. Karande, P.; Jain, A.; Mitragotri, S. Insights into synergistic interactions in binary mixtures of chemical permeation enhancers for transdermal drug delivery. J. Control. Release 2006, 115, 85-93.
127. Newby, C.S.; Barr, R.M.; Greaves, M.W.; Mallet, A.I. Cytokine release and cytotoxicity in human keratinocytes and fibroblasts induced by phenols and sodium dodecyl sulfate. J. Invest. Dermatol. 2000, 115, 292-298.
128. Kandárová, H.; Hayden, P.; Klausner, M.; Kubilus, J.; Sheasgreen, J. An in vitro skin irritation test (SIT) using the epiderm reconstructed human epidermal (RHE) model. J. Vis. Exp. 2009, doi:10.3791/1366.
129. Mehling, A.; Kleber, M.; Hensen, H. Comparative studies on the ocular and dermal irritation potential of surfactants. Food Chem. Toxicol. 2007, 45, 747-758.
130. Basketter, D.A.; Chamberlain, M.; Griffiths, H.A.; Rowson, M.; Whittle, E.; York, M. The classification of skin irritants by human patch test. Food Chem. Toxicol. 1997, 35, 845-852.
131. Savic, S.; Weber, C.; Savic, M.M.; Muller-Goymann, C. Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance. Int. J. Pharm. 2009, 381, 220-230.
132. Moniruzzaman, M.; Tamura, M.; Tahara, Y.; Kamiya, N.; Goto, M. Ionic liquid-in-oil microemulsion as a potential carrier of sparingly soluble drug: Characterization and cytotoxicity evaluation. Int. J. Pharm. 2010, 400, 243-250.
133. Ayehunie, S.; Cannon, C.; Lamore, S.; Kubilus, J.; Anderson, D.J.; Pudney, J.; Klausner, M. Organotypic human vaginal-ectocervical tissue model for irritation studies of spermicides, microbicides, and feminine-care products. Toxicol. In Vitro 2006, 20, 689-698.