Transdermal delivery of ketoprofen using microemulsions

International Journal of Pharmaceutics

Volumn 228, Issue 1-2, 2001, Pages 161-170

  Rhee, Yun Seok ^a   Choi, Jung Gyo ^a   Park, Eun Seok ^a   Chi, Sang Cheol ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

Enhancer; Ketoprofen; Microemulsion; Transdermal delivery

Indexed keywords

CAMPHOR; CINEOLE; CORN OIL; COSURFACTANT; COTTON SEED OIL; CREMOPHOR; KETOPROFEN; LABRASOL; LIMONENE; MENTHOL; MINERAL OIL; MYRISTIC ACID ISOPROPYL ESTER; OIL; OLEIC ACID; OLIVE OIL; SESAME SEED OIL; SQUALENE; SURFACTANT; TERPENE; TRIACETIN; UNCLASSIFIED DRUG; WATER;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG SCREENING; MALE; MICROEMULSION; MYVACET; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN PERMEABILITY; SOLUBILIZATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EMULSIONS; KETOPROFEN; MALE; OILS; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SKIN ABSORPTION; SOLUBILITY;

EID: 0035834177     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00827-4     Document Type: Article

References (30)

1. Enhancing effect of terpenes on the in vitro percutaneous absorption of diclofenac sodium
2. Chemical means of transdermal drug permeation enhancement
3. Anti-inflammatory activity of ketoprofen gel on carrageenan-induced paw edema in rats
4. A comparative study of the transdermal penetration of a series of nonsteroidal antiinflammatory drugs
5. Modes of action of terpene penetration enhancers in human skin; differential scanning calorimetry, small-angle X-ray diffraction and enhancer uptake studies
6. Delivery of a hydrophilic solute through the skin from novel microemulsion systems
7. Percutaneous absorption of ketoprofen. I. In vitro release and percutaneous absorption of ketoprofen from different ointment bases
8. Application of an oily gel formed by hydrogenated soybean phospholipids as a percutaneous absorption-type ointment base
9. Clinical pharmacokinetics of ketoprofen and its enantiomers
10. Structure-activity relationship of chemical penetration enhancers in transdermal drug delivery
11. Ketoprofen: A review of its pharmacologic and clinical properties
12. Effect of fatty acids and urea on the penetration of ketoprofen through rat skin
13. Percutaneous absorption of indomethacin from mixtures of fatty alcohol and propylene glycol (FAPG bases) through rat skin: Effect of oleic acid added to FAPG base
14. Effect of synthesized cyclohexanol derivatives using l-menthol as a lead compound on the percutaneous absorption of ketoprofen
15. Transdermal iontophoretic delivery of ketoprofen through human cadaver skin and in humans
16. Topical oleo-hydrogel preparation of ketoprofen with enhanced skin permeability
17. High-performance liquid chromatographic determination of ketoprofen and naproxen in rat plasma
18. Skin penetration enhancers: Scientific perspectives
19. Effect of additives on the diffusion of ketoprofen through human skin
20. In vitro transport of sodium diclofenac across rat abdominal skin: Effect of selection of oleaginous component and the addition of alcohols to the vehicle
21. Iontophoretic transdermal delivery of ketoprofen: Novel method for the evaluation of plasma drug concentration in cutaneous vein
22. In vitro diffusion studies of ketoprofen transdermal therapeutic systems
23. Evaluation of novel soya-lecithin formulation for dermal use containing ketoprofen as a model drug
24. In vitro topical delivery of non-steroidal anti-inflammatory drugs through human skin
25. The enhancement index concept applied to terpene penetration enhancers for human skin and model lipophilic (oestradiol) and hydrophilic (5-fluorouracil) drugs
26. Pharmacokinetic and skin irritation of transdermal ketoprofen