Simultaneous absorption of vitamins C and E from topical microemulsions using reconstructed human epidermis as a skin model

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 72, Issue 1, 2009, Pages 69-75

  Rozman, Branka ^a,b   Gasperlin, Mirjana ^b   Tinois Tessoneaud, Estelle ^c   Pirot, Fabrice ^a   Falson, Francoise ^a  

^a UNIVERSITÉ LYON 1   (France)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

^c Episkin SNC   (France)

Author keywords

Antioxidant; Microemulsion; Percutaneous absorption; Reconstructed human epidermis; Vitamin C; Vitamin E

Indexed keywords

AEROSIL; ALPHA TOCOPHEROL; ASCORBIC ACID; IMWITOR 308; MYRISTIC ACID ISOPROPYL ESTER; OCTANOIN; POLYSORBATE 40; UNCLASSIFIED DRUG; WATER OIL CREAM;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG FORMULATION; DRUG PENETRATION; EPIDERMIS; EXPERIMENTAL MODEL; GEL; HUMAN; HUMAN TISSUE; MICROEMULSION; SKIN ABSORPTION; SKIN PERMEABILITY; SKIN WATER LOSS;

ABSORPTION; ADMINISTRATION, CUTANEOUS; ANTIOXIDANTS; ASCORBIC ACID; COLLOIDS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EMULSIONS; EPIDERMIS; FREE RADICALS; HUMANS; RHEOLOGY; SKIN; THERMODYNAMICS; VITAMIN E;

EID: 62949196902     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.10.004     Document Type: Article

References (30)

1. Kohen R., and Gati I. Skin low molecular weight antioxidants and their role in aging and in oxidative stress. Toxicology 148 (2000) 149-157
2. Steenvorden D.P., and van Henegouwen G.M. The use of endogenous antioxydants to improve photoprotection. J. Photochem. Photobiol. B Biol. 41 (1997) 1-10
3. Packer L., and Fuchs J. Vitamin E in Health and Disease (1993), Marcel Dekker Inc., New York pp. 269-283
4. Lupo M.P. Antioxidants and vitamins in cosmetics. Clin. Dermatol. 19 (2001) 467-473
5. Lin J.Y., Selim M.A., Shea C.R., Grichnik J.M., Omar M.M., Monteiro-Riviere N.A., and Pinnell S.R. UV photoprotection by combination topical antioxidants vitamin C and vitamin E. J. Am. Acad. Dermatol. 48 (2003) 866-874
6. Burke K.E. Interaction of vitamins C and E as better cosmeceuticals. Dermatol. Ther. 20 (2007) 314-321
7. Lawrence M.J., and Rees G.D. Microemulsion-based media as novel drug delivery systems. Adv. Drug Deliv. Rev. 45 (2000) 89-121
8. Kogan A., and Garti N. Microemulsions as transdermal drug delivery vehicles. Adv. Colloid. Interface Sci. 123-126 (2006) 369-385
9. Schreiber S., Mahmoud A., Vuia A., Rubbelke M.K., Schmidt E., Schaller M., Kandarova H., Haberland A., Schafer U.F., Bock U., Korting H.C., Liebsch M., and Schafer-Korting M. Reconstructed epidermis versus human and animal skin in skin absorption studies. Toxicol. In Vitro 19 (2005) 813-822
10. Netzlaff F., Kaca M., Bock U., Haltner-Ukomadu E., Meiers P., Lehr C.-M., and Schaefer U.F. Permeability of the reconstructed human epidermis model Episkin(R) in comparison to various human skin preparations. Eur. J. Pharm. Biopharm. 66 (2007) 127-134
11. Netzlaff F., Lehr C.-M., Wertz P.W., and Schaefer U.F. The human epidermis models EpiSkin(R) SkinEthic(R) and EpiDerm(R) An evaluation of morphology and their suitability for testing phototoxicity irritancy corrosivity and substance transport. Eur. J. Pharm. Biopharm. 60 (2005) 167-178
12. Dreher F., Fouchard F., Patouillet C., Andrian M., Simmonet J., and Benech-Kiefer F. Comparison of cutaneous bioavailability of cosmetic preparations containing caffeine or alpha-tocopherol applied on human skin models or human skin ex vivo at finite doses. Skin Pharmacol. Physiol. 15 Suppl.1 (2002) 40-58
13. Shigeta Y., Imanaka H., Yonezawa S., Oku N., Baba N., and Makino T. Suppressed permeation of linoleic acid in a liposomal formulation through reconstructed skin tissue. Biol. Pharm. Bull. 27 (2004) 879-882
14. Lombardi Borgia S., Schlupp P., Mehnert W., and Schafer-Korting M. In vitro skin absorption and drug release - a comparison of six commercial prednicarbate preparations for topical use. Eur. J. Pharm. Biopharm. 68 (2008) 380-389
15. Rozman B., and Gasperlin M. Stability of vitamins E and C in topical microemulsions for combined antioxidant therapy. Drug Deliv. 14 (2007) 235-245
16. Netzlaff F., Kostka K.-H., Lehr C.-M., and Schaefer U.F. TEWL measurements as a routine method for evaluating the integrity of epidermis sheets in static Franz type diffusion cells in vitro. Limitations shown by transport data testing. Eur. J. Pharm. Biopharm. 63 (2006) 44-50
17. Podlogar F., Bester Rogac M., and Gasperlin M. The effect of internal structure of selected water-Tween 40(R)-Imwitor 308(R)-IPM microemulsions on ketoprofene release. Int. J. Pharm. 302 (2005) 68-77
18. Podlogar F., Gasperlin M., Tomsic M., Jamnik A., and Rogac M.B. Structural characterisation of water-Tween 40(R)/Imwitor 308(R)-isopropyl myristate microemulsions using different experimental methods. Int. J. Pharm. 276 (2004) 115-128
19. Tomsic M., Podlogar F., Gasperlin M., Bester-Rogac M., and Jamnik A. Water-Tween 40(R)/Imwitor 308(R)-isopropyl myristate microemulsions as delivery systems for ketoprofen: small-angle X-ray scattering study. Int. J. Pharm. 327 (2006) 170-177
20. Osmann-Garbadou H., Pelletier J., Sfar-Gandoura S., and Martini M.C. Thickening of hydrophilic/lipophilic and lipophilic/hydrophilic microemulsions I Comparative study of the gelling agent influence on the physical characteristcs of the H/L and L/H microemulsions. STP Pharmacol. Sci. 10 (2000) 220-223
21. Spiclin P., Homar M., Zupancic-Valant A., and Gasperlin M. Sodium ascorbyl phosphate in topical microemulsions. Int. J. Pharm. 256 (2003) 65-73
22. Mavon A., Raufast V., and Redoules D. Skin absorption and metabolism of a new vitamin E prodrug, [delta]-tocopherol-glucoside: in vitro evaluation in human skin models. J. Control. Release 100 (2004) 221-231
23. Schreiber S., Mahmoud A., Vuia A., Rubbelke M.K., Schmidt E., Schaller M., Kandarova H., Haberland A., Schafer U.F., Bock U., Korting H.C., Liebsch M., and Schafer-Korting M. Reconstructed epidermis versus human and animal skin in skin absorption studies. Toxicol. In Vitro 19 (2005) 813-822
24. Pirot F., Millet J., Kalia J., and Humbert P. In vitro study of percutaneous absorption, cutaneous bioavailability, bioequivalence of zinc and copper from five topical formulations. Skin Pharmacol. 9 (1996)
25. Casagrande R., Georgetti S.R., Verri J., Waldiceu A., Borin M.F., Lopez R.F.V., and Fonseca M.J.V. In vitro evaluation of quercetin cutaneous absorption from topical formulations and its functional stability by antioxidant activity. Int. J. Pharm. 328 (2007) 183-190
26. Marti-Mestres G., Mestres J.P., Bres J., Martin S., Ramos J., and Vian L. The "in vitro" percutaneous penetration of three antioxidant compounds. Int. J. Pharm. 331 (2007) 139-144
27. Peira E., Scolari P., and Gasco M.R. Transdermal permeation of apomorphine through hairless mouse skin from microemulsions. Int. J. Pharm. 226 (2001) 47-51
28. Schmook F.P., Meingassner J.G., and Billich A. Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption. Int. J. Pharm. 215 (2001) 51-56
29. Ostacolo C., Marra F., Laneri S., Sacchi A., Nicoli S., Padula C., and Santi P. [alpha]-Tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin. J. Control. Release 99 (2004) 403-413
30. Guo H., Liu Z., Li J., Nie S., and Pan W. Effects of isopropyl palmitate on the skin permeation of drugs. Biol. Pharm. Bull. 29 (2006) 2324-2326