Transdermal delivery of an anti-cancer drug via W/O emulsions based on alkyl polyglycosides and lecithin: Design, characterization, and in vivo evaluation of the possible irritation potential in rats

AAPS PharmSciTech

Volumn 12, Issue 1, 2011, Pages 1-9

  Elmeshad, Aliaa Nabil ^a   Tadros, Mina Ibrahim ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

5 fluorouracil w o emulsions; alkyl polyglycosides; irritation potential; lecithin; transdermal delivery

Indexed keywords

ALCOHOL; ANTINEOPLASTIC AGENT; COSURFACTANT; DIACYLGLYCEROL DERIVATIVE; FLUOROURACIL; GLUCOSIDE; GLYCOSIDE; MACROGOL; PHOSPHATIDYLCHOLINE; SURFACTANT; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRIFUGATION; COOLING; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG PENETRATION; EMULSION; FLOW KINETICS; FREEZE DRYING; HEATING; HISTOPATHOLOGY; IN VIVO STUDY; NEWBORN; NONHUMAN; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SKIN; SKIN IRRITATION; STEADY STATE; THAWING; THERMODYNAMICS; TRANSMISSION ELECTRON MICROSCOPY;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; FLUOROURACIL; GLYCOSIDES; IRRITANTS; LECITHINS; MALE; MICE; PARTICLE SIZE; PERMEABILITY; POLYETHYLENE GLYCOLS; POLYMERS; RATS; SKIN; SKIN IRRITANCY TESTS; SURFACE-ACTIVE AGENTS; WATER;

EID: 79954420829     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9557-y     Document Type: Article

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