Effect of oil on the level of solubilization of testosterone propionate into nonionic oil-in-water microemulsions

Journal of Pharmaceutical Sciences

Volumn 87, Issue 1, 1998, Pages 109-116

  Malcolmson, Carole ^a   Satra, Chetna ^b   Kantaria, Shilpa ^b   Sidhu, Amalock ^c   Lawrence, M Jayne ^b  

^a Marion Merrell Ltd UK   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OIL; POLYOXYETHYLENE OLEYL ETHER; TESTOSTERONE PROPIONATE;

ARTICLE; DRUG CONFORMATION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; DRUG STABILITY; MICROEMULSION; THERMODYNAMICS;

EID: 0031888408     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js9700863     Document Type: Article

References (23)

1. Friberg, S. E. Microemulsions. Prog. Colloid Polym. Sci. 1983, 68, 41-47.
2. Siano, D. B. The swollen micelle-microemulsion transition. J. Colloid Interface Sci. 1983, 3, 1-7.
3. Attwood, D. Microemulsions. In Colloidal Drug Delivery Systems; Kreuter, J., Ed.; Marcel Dekker: Inc.: New York, 1994; pp 31-71.
4. Lawrence, M. J. Microemulsions as drug delivery vehicles. Curr. Opin. Colloid Interface Sci. 1996, 1, 826-832.
5. Malcolmson, C. A The physicochemical properties of nonionic oil-in-water microemulsions. Ph.D. Thesis, University of London, 1992.
6. Malcolmson, C.; Lawrence, M. J. A comparison of the incorporation of steroids into nonionic micellar and microemulsion systems. J. Pharm. Pharmacol. 1993, 45, 141-143.
7. Craig, P. N. Drug Compendium. In Comprehensive Medicinal Chemistry. Vol. 6: Cumulative Subject Index and Drug Compendium; Hansch, C.; Sammes, P. G.; Taylor, J. B., Eds.; Pergamon Press: New York, 1990; pp 237-991.
8. Elworthy, P. H.; Patel, M. S. Demonstration of maximum solubilization in a polyoxyethylene alkyl ether series of nonionic surfactants. J. Pharm. Pharmacol. 1982, 34, 543-546.
9. Chevalier, Y.; Zemb, T. The structure of micelles and microemulsions. Rep. Prog. Phys. 1990, 53, 270-371.
10. 2O-oil-surfactant. J. Phys. Chem. 1983, 87, 5032-5040.
11. Gulari, E.; Chu, B.; Lui, T. Y. Characertization of meningococcal polysaccharides by light-scattering spectroscopy. IV Molecular weight distribution of group B meningococcal polysaccharide in buffer solution. Biopolymers 1979, 18, 2943-2962.
12. Koppel, D. E. Analysis of macromolecular polydispersity in intensity correlation spectroscopy. Methods of cumulants. J. Phys. Chem. 1972, 57, 4814-4820.
13. Malcolmson, C.; Lawrence, M. J. Three-component nonionic oil-in-water microemulsions using polyoxyethylene ether surfactants. Colloids Surf. B: Biointerfaces 1995, 4, 97-109.
14. Aboofazeli, R,; Patel, N.; Thomas, M.; Lawrence, M. J. Investigations into the formation and characterization of phospholipid microemulsions. IV. Pseudo-ternary phase diagrams of systems containing water-lecithin-alcohol and oil; the influence of oil. Int. J. Pharm. 1995, 125, 107-116.
15. Maclay, W. N. Factors affecting the solubility of nonionic emulsifiers J. Colloid Sci. 1956, 11, 272-285.
16. Saito, H.; Shinoda, K. The solubilization of hydrocarbons in aqueous solutions of nonionic surfactants. J. Colloid Interface Sci. 1967, 24, 10-15.
17. Shinoda, K.; Arai, H. Cloud points, solubilisation and interfacial tensions in systems containing nonionic surfactants. J. Phys. Chem. 1964, 68, 3485-3490.
18. Aveyard, B.; Binks, B. P.; Clark, S.; Flectcher, P. D. I. Cloud points, solubilisation and interfacial tensions in systems containing nonionic surfactants. J. Chem. Technol. Biotech. 1990, 48, 161-171.
19. Aveyard, R.; Binks, B. P.; Flectcher, P. D. I.; MacNab, J. R.. Interaction of alkanes with monolayers of nonionic surfactants Langmuir 1995, 11, 2515-2524.
20. Lu, J. R.; Thomas, R. K.; Binks, B. P.; Flectcher, P. D. I.; Penfold, J. Structure and composition of dodecane layers spread on aqueous solutions of dodceyl-and hexadecyltrimethylammonium bromides studies by neutron reflection. J. Phys. Chem. 1995, 99, 4113-4123.
21. McFann, G. J.; Johnson, K. P. Phase behavior of nonionic surfactant/oil/water systems containing light alkanes. Langmuir 1993, 9, 2942-2948.
22. Hoffmann, H.; Ulbright, W. Transition of rodlike to globular micelle by the solubilization of additives. J. Colloid Interface Sci. 1989, 129, 388-405.
23. Gonzalez-Sanchez, M. T. Surfactant/polymers mixes as drug delivery vehicles. MSc Thesis, University of London, 1994.