메뉴 건너뛰기




Volumn 86, Issue 2, 2014, Pages 244-250

Controlled penetration of ceramides into and across the stratum corneum using various types of microemulsions and formulation associated toxicity studies

Author keywords

Ceramide; HET CAM; Microemulsion; Permeation; Stratum corneum; Toxicity

Indexed keywords

CERAMIDE; PHOSPHATIDYLCHOLINE;

EID: 84896392279     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.07.011     Document Type: Article
Times cited : (37)

References (57)
  • 3
    • 33845308573 scopus 로고    scopus 로고
    • The skin barrier in healthy and diseased state
    • DOI 10.1016/j.bbamem.2006.06.021, PII S0005273606002410, Sphingolipids, Apoptosis and Disease
    • J.A. Bouwstra, and M. Ponec The skin barrier in healthy and diseased state Biochim. Biophys. Acta 1758 2006 2080 2095 (Pubitemid 44879362)
    • (2006) Biochimica et Biophysica Acta - Biomembranes , vol.1758 , Issue.12 , pp. 2080-2095
    • Bouwstra, J.A.1    Ponec, M.2
  • 4
    • 0028967778 scopus 로고
    • Analysis of all stratum corneum lipids by automated multiple development high-performance thin-layer chromatography
    • F. Bonte, P. Pinguet, J.M. Chevalier, and A. Meybeck Analysis of all stratum corneum lipids by automated multiple development high-performance thin-layer chromatography J. Chromatogr. B Biomed. Appl. 664 1995 311 316
    • (1995) J. Chromatogr. B Biomed. Appl. , vol.664 , pp. 311-316
    • Bonte, F.1    Pinguet, P.2    Chevalier, J.M.3    Meybeck, A.4
  • 5
    • 0028816731 scopus 로고
    • Molecular properties of a stratum corneum model lipid system: Large unilamellar vesicles
    • R.M. Hatfield, and L.W. Fung Molecular properties of a stratum corneum model lipid system: large unilamellar vesicles Biophys. J. 68 1995 196 207
    • (1995) Biophys. J. , vol.68 , pp. 196-207
    • Hatfield, R.M.1    Fung, L.W.2
  • 6
    • 4344696019 scopus 로고    scopus 로고
    • Modelling the stratum corneum lipid organisation with synthetic lipid mixtures: The importance of synthetic ceramide composition
    • DOI 10.1016/j.bbamem.2004.05.001, PII S0005273604001233
    • M.W. de Jager, G.S. Gooris, I.P. Dolbnya, M. Ponec, and J.A. Bouwstra Modelling the stratum corneum lipid organisation with synthetic lipid mixtures: the importance of synthetic ceramide composition Biochim. Biophys. Acta 1664 2004 132 140 (Pubitemid 39140986)
    • (2004) Biochimica et Biophysica Acta - Biomembranes , vol.1664 , Issue.2 , pp. 132-140
    • De Jager, M.W.1    Gooris, G.S.2    Dolbnya, I.P.3    Ponec, M.4    Bouwstra, J.A.5
  • 7
    • 52049116882 scopus 로고    scopus 로고
    • Two new methods for preparing a unique stratum corneum substitute
    • D. Groen, G.S. Gooris, M. Ponec, and J.A. Bouwstra Two new methods for preparing a unique stratum corneum substitute Biochim. Biophys. Acta 1778 2008 2421 2429
    • (2008) Biochim. Biophys. Acta , vol.1778 , pp. 2421-2429
    • Groen, D.1    Gooris, G.S.2    Ponec, M.3    Bouwstra, J.A.4
  • 8
    • 33644895175 scopus 로고    scopus 로고
    • Interactions between a skin penetration enhancer and the main components of human stratum corneum lipids: Isothermal titration calorimetry study
    • DOI 10.1007/s10973-005-7050-8
    • L. Kang, P.C. Ho, and S.Y. Chan Interactions between a skin penetration enhancer and the main components of human stratum corneum lipids isothermal titration calorimetry study J. Therm. Anal. Calorim. 83 2006 27 30 (Pubitemid 43383206)
    • (2006) Journal of Thermal Analysis and Calorimetry , vol.83 , Issue.1 , pp. 27-30
    • Kang, L.1    Ho, P.C.2    Chan, S.Y.3
  • 9
    • 34248579896 scopus 로고    scopus 로고
    • Human stratum corneum lipid organization as observed by atomic force microscopy on Langmuir-Blodgett films
    • DOI 10.1016/j.jsb.2006.12.006, PII S1047847706003935
    • L. Norlen, I.P. Gil, A. Simonsen, and P. Descouts Human stratum corneum lipid organization as observed by atomic force microscopy on Langmuir-Blodgett films J. Struct. Biol. 158 2007 386 400 (Pubitemid 46764566)
    • (2007) Journal of Structural Biology , vol.158 , Issue.3 , pp. 386-400
    • Norlen, L.1    Gil, I.P.2    Simonsen, A.3    Descouts, P.4
  • 10
    • 33749049791 scopus 로고    scopus 로고
    • Epidermal sphingolipids: Metabolism, function, and roles in skin disorders
    • DOI 10.1016/j.febslet.2006.08.039, PII S0014579306010155
    • W.M. Holleran, Y. Takagi, and Y. Uchida Epidermal sphingolipids: metabolism, function, and roles in skin disorders FEBS Lett. 580 2006 5456 5466 (Pubitemid 44465907)
    • (2006) FEBS Letters , vol.580 , Issue.23 , pp. 5456-5466
    • Holleran, W.M.1    Takagi, Y.2    Uchida, Y.3
  • 11
    • 0037357809 scopus 로고    scopus 로고
    • The skin barrier and use of moisturizers in atopic dermatitis
    • DOI 10.1016/S0738-081X(02)00373-5
    • M. Loden The skin barrier and use of moisturizers in atopic dermatitis Clin. Dermatol. 21 2003 145 157 (Pubitemid 36428985)
    • (2003) Clinics in Dermatology , vol.21 , Issue.2 , pp. 145-157
    • Loden, M.1
  • 13
    • 18044396524 scopus 로고    scopus 로고
    • Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin
    • DOI 10.1007/s00403-005-0551-2
    • H. Farwanah, K. Raith, R.H. Neubert, and J. Wohlrab Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin Arch. Dermatol. Res. 296 2005 514 521 (Pubitemid 40603269)
    • (2005) Archives of Dermatological Research , vol.296 , Issue.11 , pp. 514-521
    • Farwanah, H.1    Raith, K.2    Neubert, R.H.H.3    Wohlrab, J.4
  • 14
    • 67349094025 scopus 로고    scopus 로고
    • Ceramide biosynthesis in keratinocyte and its role in skin function
    • Y. Mizutani, S. Mitsutake, K. Tsuji, A. Kihara, and Y. Igarashi Ceramide biosynthesis in keratinocyte and its role in skin function Biochimie 91 2009 784 790
    • (2009) Biochimie , vol.91 , pp. 784-790
    • Mizutani, Y.1    Mitsutake, S.2    Tsuji, K.3    Kihara, A.4    Igarashi, Y.5
  • 16
    • 33646038558 scopus 로고    scopus 로고
    • Enzymatic production of ceramide from sphingomyelin
    • L. Zhang, L.I. Hellgren, and X. Xu Enzymatic production of ceramide from sphingomyelin J. Biotechnol. 123 2006 93 105
    • (2006) J. Biotechnol. , vol.123 , pp. 93-105
    • Zhang, L.1    Hellgren, L.I.2    Xu, X.3
  • 18
    • 18344419439 scopus 로고    scopus 로고
    • Ceramide analogue 14S24 ((S)-2-tetracosanoylamino-3-hydroxypropionic acid tetradecyl ester) is effective in skin barrier repair in vitro
    • DOI 10.1016/j.ejps.2003.12.009, PII S0928098704000156
    • K. Vavrova, J. Zbytovska, K. Palat, T. Holas, J. Klimentova, A. Hrabalek, and P. Dolezal Ceramide analogue 14S24 ((S)-2-tetracosanoylamino-3- hydroxypropionic acid tetradecyl ester) is effective in skin barrier repair in vitro Eur. J. Pharm. Sci. 21 2004 581 587 (Pubitemid 38447139)
    • (2004) European Journal of Pharmaceutical Sciences , vol.21 , Issue.5 , pp. 581-587
    • Vavrova, K.1    Zbytovska, J.2    Palat, K.3    Holas, T.4    Klimentova, J.5    Hrabalek, A.6    Dolezal, P.7
  • 19
    • 12144255373 scopus 로고    scopus 로고
    • An inverse relationship between ceramide synthesis and clinical severity in patients with psoriasis
    • Y. Cho, B.L. Lew, K. Seong, and N.I. Kim An inverse relationship between ceramide synthesis and clinical severity in patients with psoriasis J. Korean Med. Sci. 19 2004 859 863 (Pubitemid 40104880)
    • (2004) Journal of Korean Medical Science , vol.19 , Issue.6 , pp. 859-863
    • Cho, Y.1    Lew, B.-L.2    Seong, K.3    Kim, N.-I.4
  • 20
    • 0034759574 scopus 로고    scopus 로고
    • Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: A multicenter study
    • DOI 10.1034/j.1600-0536.2001.450505.x
    • E. Berardesca, M. Barbareschi, S. Veraldi, and N. Pimpinelli Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study Contact Dermatitis 45 2001 280 285 (Pubitemid 33032967)
    • (2001) Contact Dermatitis , vol.45 , Issue.5 , pp. 280-285
    • Berardesca, E.1    Barbareschi, M.2    Veraldi, S.3    Pimpinelli, N.4
  • 21
    • 0037357652 scopus 로고    scopus 로고
    • Skin lipids and epidermal differentiation in atopic dermatitis
    • DOI 10.1016/S0738-081X(02)00370-X
    • E. Proksch, J.M. Jensen, and P.M. Elias Skin lipids and epidermal differentiation in atopic dermatitis Clin. Dermatol. 21 2003 134 144 (Pubitemid 36428984)
    • (2003) Clinics in Dermatology , vol.21 , Issue.2 , pp. 134-144
    • Proksch, E.1    Jensen, J.-M.2    Elias, P.M.3
  • 22
    • 0035038540 scopus 로고    scopus 로고
    • Determination of stratum corneum lipid profile by tape stripping in combination with high-performance thin-layer chromatography
    • DOI 10.1007/s004030100212
    • A. Weerheim, and M. Ponec Determination of stratum corneum lipid profile by tape stripping in combination with high-performance thin-layer chromatography Arch. Dermatol. Res. 293 2001 191 199 (Pubitemid 32391425)
    • (2001) Archives of Dermatological Research , vol.293 , Issue.4 , pp. 191-199
    • Weerheim, A.1    Ponec, M.2
  • 23
    • 0030912995 scopus 로고    scopus 로고
    • Thermotropic phase behavior of in vivo extracted human stratum corneum lipids
    • DOI 10.1007/s11745-997-0083-3
    • F. Bonte, P. Pinguet, A. Saunois, A. Meybeck, S. Beugin, M. Ollivon, and S. Lesieur Thermotropic phase behavior of in vivo extracted human stratum corneum lipids Lipids 32 1997 653 660 (Pubitemid 27278577)
    • (1997) Lipids , vol.32 , Issue.6 , pp. 653-660
    • Bonte, F.1    Pinguet, P.2    Saunois, A.3    Meybeck, A.4    Beugin, S.5    Ollivon, M.6    Lesieur, S.7
  • 24
    • 77957685290 scopus 로고    scopus 로고
    • Terpene microemulsions for transdermal curcumin delivery: Effects of terpenes and cosurfactants
    • C.H. Liu, F.Y. Chang, and D.K. Hung Terpene microemulsions for transdermal curcumin delivery: effects of terpenes and cosurfactants Colloids Surf. B Biointerfaces 82 2011 63 70
    • (2011) Colloids Surf. B Biointerfaces , vol.82 , pp. 63-70
    • Liu, C.H.1    Chang, F.Y.2    Hung, D.K.3
  • 25
    • 77952741003 scopus 로고    scopus 로고
    • Effect of surfactant concentration on transdermal lidocaine delivery with linker microemulsions
    • J.S. Yuan, A. Yip, N. Nguyen, J. Chu, X.Y. Wen, and E.J. Acosta Effect of surfactant concentration on transdermal lidocaine delivery with linker microemulsions Int. J. Pharm. 392 2010 274 284
    • (2010) Int. J. Pharm. , vol.392 , pp. 274-284
    • Yuan, J.S.1    Yip, A.2    Nguyen, N.3    Chu, J.4    Wen, X.Y.5    Acosta, E.J.6
  • 26
    • 77951652824 scopus 로고    scopus 로고
    • Development of microemulsions to topically deliver 5-aminolevulinic acid in photodynamic therapy
    • L.M. Araujo, J.A. Thomazine, and R.F. Lopez Development of microemulsions to topically deliver 5-aminolevulinic acid in photodynamic therapy Eur. J. Pharm. Biopharm. 75 2010 48 55
    • (2010) Eur. J. Pharm. Biopharm. , vol.75 , pp. 48-55
    • Araujo, L.M.1    Thomazine, J.A.2    Lopez, R.F.3
  • 27
    • 67449143225 scopus 로고    scopus 로고
    • Dermal and transdermal targeting of dihydroavenanthramide D using enhancer molecules and novel microemulsions
    • S. Heuschkel, J. Wohlrab, and R.H. Neubert Dermal and transdermal targeting of dihydroavenanthramide D using enhancer molecules and novel microemulsions Eur. J. Pharm. Biopharm. 72 2009 552 560
    • (2009) Eur. J. Pharm. Biopharm. , vol.72 , pp. 552-560
    • Heuschkel, S.1    Wohlrab, J.2    Neubert, R.H.3
  • 28
    • 67650602089 scopus 로고    scopus 로고
    • Microemulsion-based hydrogel formulation of penciclovir for topical delivery
    • W. Zhu, C. Guo, A. Yu, Y. Gao, F. Cao, and G. Zhai Microemulsion-based hydrogel formulation of penciclovir for topical delivery Int. J. Pharm. 378 2009 152 158
    • (2009) Int. J. Pharm. , vol.378 , pp. 152-158
    • Zhu, W.1    Guo, C.2    Yu, A.3    Gao, Y.4    Cao, F.5    Zhai, G.6
  • 29
    • 84866047834 scopus 로고    scopus 로고
    • Polyglycerol fatty acid ester surfactant-based microemulsions for targeted delivery of ceramide AP into the stratum corneum: Formulation, characterisation, in vitro release and penetration investigation
    • F.F. Sahle, H. Metz, J. Wohlrab, and R.H. Neubert Polyglycerol fatty acid ester surfactant-based microemulsions for targeted delivery of ceramide AP into the stratum corneum: formulation, characterisation, in vitro release and penetration investigation Eur. J. Pharm. Biopharm. 82 2012 139 150
    • (2012) Eur. J. Pharm. Biopharm. , vol.82 , pp. 139-150
    • Sahle, F.F.1    Metz, H.2    Wohlrab, J.3    Neubert, R.H.4
  • 30
    • 84873416227 scopus 로고    scopus 로고
    • Lecithin-based microemulsions for targeted delivery of ceramide AP into the stratum corneum: Formulation, characterizations, and in vitro release and penetration studies
    • F.F. Sahle, H. Metz, J. Wohlrab, and R.H. Neubert Lecithin-based microemulsions for targeted delivery of ceramide AP into the stratum corneum: formulation, characterizations, and in vitro release and penetration studies Pharm. Res. 30 2013 538 551
    • (2013) Pharm. Res. , vol.30 , pp. 538-551
    • Sahle, F.F.1    Metz, H.2    Wohlrab, J.3    Neubert, R.H.4
  • 31
    • 61949343299 scopus 로고    scopus 로고
    • Characterization of the nonionic microemulsions by EPR. I. Effect of solubilized drug on nanostructure
    • A. Kogan, S. Rozner, S. Mehta, P. Somasundaran, A. Aserin, N. Garti, and M.F. Ottaviani Characterization of the nonionic microemulsions by EPR. I. Effect of solubilized drug on nanostructure J. Phys. Chem. B 113 2009 691 699
    • (2009) J. Phys. Chem. B , vol.113 , pp. 691-699
    • Kogan, A.1    Rozner, S.2    Mehta, S.3    Somasundaran, P.4    Aserin, A.5    Garti, N.6    Ottaviani, M.F.7
  • 33
    • 61349193119 scopus 로고    scopus 로고
    • Formation and characterisation of mint oil/S and CS/water microemulsions
    • F. Zhong, M. Yu, C.R. Luo, C. Shoemaker, Y. Li, S.Q. Xia, and J.G. Ma Formation and characterisation of mint oil/S and CS/water microemulsions Food Chem. 115 2009 539 544
    • (2009) Food Chem. , vol.115 , pp. 539-544
    • Zhong, F.1    Yu, M.2    Luo, C.R.3    Shoemaker, C.4    Li, Y.5    Xia, S.Q.6    Ma, J.G.7
  • 34
    • 34447627691 scopus 로고    scopus 로고
    • Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration
    • DOI 10.1016/j.ijpharm.2007.03.052, PII S0378517307002979
    • H. Chen, D. Mou, D. Du, X. Chang, D. Zhu, J. Liu, H. Xu, and X. Yang Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration Int. J. Pharm. 341 2007 78 84 (Pubitemid 47088114)
    • (2007) International Journal of Pharmaceutics , vol.341 , Issue.1-2 , pp. 78-84
    • Chen, H.1    Mou, D.2    Du, D.3    Chang, X.4    Zhu, D.5    Liu, J.6    Xu, H.7    Yang, X.8
  • 35
    • 76549134681 scopus 로고    scopus 로고
    • Enhanced bioavailability of lacidipine via microemulsion based transdermal gels: Formulation optimization, ex vivo and in vivo characterization
    • R. Gannu, C.R. Palem, V.V. Yamsani, S.K. Yamsani, and M.R. Yamsani Enhanced bioavailability of lacidipine via microemulsion based transdermal gels: formulation optimization, ex vivo and in vivo characterization Int. J. Pharm. 388 2010 231 241
    • (2010) Int. J. Pharm. , vol.388 , pp. 231-241
    • Gannu, R.1    Palem, C.R.2    Yamsani, V.V.3    Yamsani, S.K.4    Yamsani, M.R.5
  • 36
    • 77957683026 scopus 로고    scopus 로고
    • Ionic liquid-in-oil microemulsion as a potential carrier of sparingly soluble drug: Characterization and cytotoxicity evaluation
    • M. Moniruzzaman, M. Tamura, Y. Tahara, N. Kamiya, and M. Goto Ionic liquid-in-oil microemulsion as a potential carrier of sparingly soluble drug: characterization and cytotoxicity evaluation Int. J. Pharm. 400 2010 243 250
    • (2010) Int. J. Pharm. , vol.400 , pp. 243-250
    • Moniruzzaman, M.1    Tamura, M.2    Tahara, Y.3    Kamiya, N.4    Goto, M.5
  • 38
    • 83955161128 scopus 로고    scopus 로고
    • Development and validation of LC/ESI-MS method for the detection and quantification of exogenous ceramide NP in stratum corneum and other layers of the skin
    • F.F. Sahle, S. Lange, B. Dobner, J. Wohlrab, and R.H. Neubert Development and validation of LC/ESI-MS method for the detection and quantification of exogenous ceramide NP in stratum corneum and other layers of the skin J. Pharm. Biomed. Anal. 60 2012 7 13
    • (2012) J. Pharm. Biomed. Anal. , vol.60 , pp. 7-13
    • Sahle, F.F.1    Lange, S.2    Dobner, B.3    Wohlrab, J.4    Neubert, R.H.5
  • 41
    • 84855388289 scopus 로고    scopus 로고
    • Transdermal delivery of paeonol using cubic gel and microemulsion gel
    • M. Luo, Q. Shen, and J. Chen Transdermal delivery of paeonol using cubic gel and microemulsion gel Int. J. Nanomed. 6 2011 1603 1610
    • (2011) Int. J. Nanomed. , vol.6 , pp. 1603-1610
    • Luo, M.1    Shen, Q.2    Chen, J.3
  • 43
    • 78649318567 scopus 로고    scopus 로고
    • Systemic delivery of insulin via the nasal route using a new microemulsion system: In vitro and in vivo studies
    • A.C. Sintov, H.V. Levy, and S. Botner Systemic delivery of insulin via the nasal route using a new microemulsion system: in vitro and in vivo studies J. Control. Release 148 2010 168 176
    • (2010) J. Control. Release , vol.148 , pp. 168-176
    • Sintov, A.C.1    Levy, H.V.2    Botner, S.3
  • 44
    • 77956881931 scopus 로고    scopus 로고
    • Properties of microemulsions with mixed nonionic surfactants and citrus oil
    • M. Fanun Properties of microemulsions with mixed nonionic surfactants and citrus oil Colloids Surf. A - Physicochem. Eng. Aspects 369 2010 246 252
    • (2010) Colloids Surf. A - Physicochem. Eng. Aspects , vol.369 , pp. 246-252
    • Fanun, M.1
  • 45
    • 31744439136 scopus 로고    scopus 로고
    • Diffusion behavior of pharmaceutical O/W microemulsions studied by dynamic light scattering
    • DOI 10.1007/s00396-005-1416-0
    • A. Shukla, and R.H.H. Neubert Diffusion behavior of pharmaceutical O/W microemulsions studied by dynamic light scattering Colloid Polym. Sci. 284 2006 568 573 (Pubitemid 43174311)
    • (2006) Colloid and Polymer Science , vol.284 , Issue.5 , pp. 568-573
    • Shukla, A.1    Neubert, R.H.H.2
  • 46
    • 5444246325 scopus 로고    scopus 로고
    • Observation of two diffusive relaxation modes in microemulsions by dynamic light scattering
    • A. Shukla, H. Graener, and R.H.H. Neubert Observation of two diffusive relaxation modes in microemulsions by dynamic light scattering Langmuir 20 2004 8526 8530
    • (2004) Langmuir , vol.20 , pp. 8526-8530
    • Shukla, A.1    Graener, H.2    Neubert, R.H.H.3
  • 47
    • 47749134500 scopus 로고    scopus 로고
    • Structure of biodiesel based bicontinuous microemulsions for environmentally compatible decontamination: A small angle neutron scattering and freeze fracture electron microscopy study
    • S. Wellert, M. Karg, H. Imhof, A. Steppin, H.J. Altmann, M. Dolle, A. Richardt, B. Tiersch, J. Koetz, A. Lapp, and T. Hellweg Structure of biodiesel based bicontinuous microemulsions for environmentally compatible decontamination: a small angle neutron scattering and freeze fracture electron microscopy study J. Colloid Interface Sci. 325 2008 250 258
    • (2008) J. Colloid Interface Sci. , vol.325 , pp. 250-258
    • Wellert, S.1    Karg, M.2    Imhof, H.3    Steppin, A.4    Altmann, H.J.5    Dolle, M.6    Richardt, A.7    Tiersch, B.8    Koetz, J.9    Lapp, A.10    Hellweg, T.11
  • 48
    • 67349099417 scopus 로고    scopus 로고
    • Stability and characterisation of phospholipid-based curcumin- encapsulated microemulsions
    • C.C. Lin, H.Y. Lin, H.C. Chen, M.W. Yu, and M.H. Lee Stability and characterisation of phospholipid-based curcumin-encapsulated microemulsions Food Chem. 116 2009 923 928
    • (2009) Food Chem. , vol.116 , pp. 923-928
    • Lin, C.C.1    Lin, H.Y.2    Chen, H.C.3    Yu, M.W.4    Lee, M.H.5
  • 50
    • 0036288134 scopus 로고    scopus 로고
    • Investigation of pharmaceutical oil/water microemulsions by small-angle scattering
    • DOI 10.1023/A:1016173303738
    • A. Shukla, M. Janich, K. Jahn, A. Krause, M.A. Kiselev, and R.H.H. Neubert Investigation of pharmaceutical oil/water microemulsions by small-angle scattering Pharmaceut. Res. 19 2002 881 886 (Pubitemid 34686749)
    • (2002) Pharmaceutical Research , vol.19 , Issue.6 , pp. 881-886
    • Shukla, A.1    Janich, M.2    Jahn, K.3    Krause, A.4    Kiselev, M.A.5    Neubert, R.H.H.6
  • 51
    • 0037381371 scopus 로고    scopus 로고
    • Microemulsions for dermal drug delivery studied by dynamic light scattering: Effect of interparticle interactions in oil-in-water microemulsions
    • DOI 10.1002/jps.10333
    • A. Shukla, M. Janich, K. Jahn, and R.H.H. Neubert Microemulsions for dermal drug delivery studied by dynamic light scattering: effect of interparticle interactions in oil-in-water microemulsions J. Pharm. Sci. 92 2003 730 738 (Pubitemid 36396991)
    • (2003) Journal of Pharmaceutical Sciences , vol.92 , Issue.4 , pp. 730-738
    • Shukla, A.1    Janich, M.2    Jahn, K.3    Neubert, R.H.H.4
  • 52
    • 0035827018 scopus 로고    scopus 로고
    • Water-soluble complexes formed by poly(2-vinylpyridinium)-block- poly(ethylene oxide) and poly(sodium methacrylate)-block-poly(ethylene oxide) copolymers
    • DOI 10.1021/ma0020483
    • J.F. Gohy, S.K. Varshney, and R. Jerome Water-soluble complexes formed by poly(2-vinylpyridinium)-block-poly(ethylene oxide) and poly(sodium methacrylate)-block-poly(ethylene oxide) copolymers Macromolecules 34 2001 3361 3366 (Pubitemid 34216958)
    • (2001) Macromolecules , vol.34 , Issue.10 , pp. 3361-3366
    • Gohy, J.-F.1    Varshney, S.K.2    Jerome, R.3
  • 54
    • 77957233989 scopus 로고    scopus 로고
    • Skin irritation and the inhibition effect on HSV-1 in vivo of penciclovir-loaded microemulsion
    • A.H. Yu, C.Y. Guo, Y.B. Zhou, F.L. Cao, W.W. Zhu, M. Sun, and G.X. Zhai Skin irritation and the inhibition effect on HSV-1 in vivo of penciclovir-loaded microemulsion Int. Immunopharmacol. 10 2010 1305 1309
    • (2010) Int. Immunopharmacol. , vol.10 , pp. 1305-1309
    • Yu, A.H.1    Guo, C.Y.2    Zhou, Y.B.3    Cao, F.L.4    Zhu, W.W.5    Sun, M.6    Zhai, G.X.7
  • 55
    • 77957285711 scopus 로고    scopus 로고
    • Microemulsions for oral delivery of insulin: Design, development and evaluation in streptozotocin induced diabetic rats
    • G. Sharma, K. Wilson, C.F. van der Walle, N. Sattar, J.R. Petrie, and M.N. Ravi Kumar Microemulsions for oral delivery of insulin: design, development and evaluation in streptozotocin induced diabetic rats Eur. J. Pharm. Biopharm. 76 2010 159 169
    • (2010) Eur. J. Pharm. Biopharm. , vol.76 , pp. 159-169
    • Sharma, G.1    Wilson, K.2    Van Der Walle, C.F.3    Sattar, N.4    Petrie, J.R.5    Ravi Kumar, M.N.6
  • 56
    • 57149147742 scopus 로고    scopus 로고
    • Development and evaluation of lorazepam microemulsions for parenteral delivery
    • A.A. Kale, and V.B. Patravale Development and evaluation of lorazepam microemulsions for parenteral delivery AAPS PharmSciTech 9 2008 966 971
    • (2008) AAPS PharmSciTech , vol.9 , pp. 966-971
    • Kale, A.A.1    Patravale, V.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.