Physiologically relevant one-compartment pharmacokinetic models for skin. 2. Comparison of models when combined with a systemic pharmacokinetic model

Journal of Pharmaceutical Sciences

Volumn 87, Issue 4, 1998, Pages 482-490

  Reddy, Micaela B ^a   Mccarley, Kelly D ^a   Bunge, Annette L ^a  

^a Department of Geology and Geological Engineering   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG;

ARTICLE; COMPARTMENT MODEL; DRUG DIFFUSION; DRUG PENETRATION; MEMBRANE MODEL; PARTITION COEFFICIENT; PREDICTION; SKIN; SKIN BLOOD FLOW; SKIN PERMEABILITY;

EID: 0031923355     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js9702877     Document Type: Article

References (12)

1. Kligman, A. M. In The Epidermis; Montagna, W., Lobitz, W. C., Eds.; Academic: New York, 1964; pp 387-433.
2. Bunge, A. L.; Cleek, R. L.; Vecchia, B. E. A New Method for Estimating Dermal Absorption from Chemical Exposure. 3. Compared with Steady-State Methods for Prediction and Data Analysis. Pharm. Res. 1995, 12, 972-982.
3. U.S. EPA Dermal Exposure Assessment: Principles and Applications, EPA/600/8-91/011B, Exposure Assessment Group, Office of Health and Environmental Assessment, Washington, 1992.
4. Silcox, G. D.; Parry, G. E.; Bunge, A. L.; Pershing, L. K.; Pershing, D. W. Percutaneous absorption of benzoic acid across human skin. II. Prediction of an in vivo, skin-flap system using in vitro parameters. Pharm. Res. 1990, 7, 352-358.
5. Scheuplein, R. J.; Blank, I. H. Permeability of the Skin. Physiol. Rev. 1971, 51, 702-747.
6. McKone, T. E. Linking a PBPK Model for Chloroform with Measured Breath Concentrations in Showers: Implications for Dermal Exposure Models. J. Expos. Anal. Environ. Epidem. 1993, 3, 339-365.
7. Rao, H. V.; Brown, D. R. A Physiologically Based Pharmacokinetic Assessment of Tetrachloroethylene in Groundwater for a Bathing and Showering Determination. Risk Anal. 1993, 13, 37-49.
8. Brown, H. S.; Hattis, D. The Role of Skin Absorption as a Route of Exposure to Volatile Organic Compounds in Household Tap Water: A Simulated Kinetic Approach. J. Am. Coll. Toxicol. 1989, 8, 839-851.
9. Shatkin, J.; Brown, H. S. Pharmacokinetics of the Dermal Route of Exposure to Volatile Organic Chemicals in Water: A Computer Simulation Model. Environ. Res. 1991, 56, 90-108.
10. Chinery, R. L.; Gleason, K. A. A Compartment Model for the Prediction of Breath Concentration and Absorbed Dose of Chloroform After Exposure While Showering. Risk Anal. 1993, 13, 51-62.
11. Klaassen, C. D.; Amdur, M. O.; Doull, J., Eds. Casarett & Doull's Toxicology The Basic Science of Poisons; McGraw-Hill: New York, 1996.
12. McCarley, K. D.; Bunge, A. L. Physiologically Relevant One-Compartment Pharmacokinetic Models for Skin. 1. Development of Models. J. Pharm. Sci. 1998, 87, 470-481 (preceding paper in this issue).