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Volumn 41, Issue 2, 2014, Pages 371-386

Triggers and cues that activate antibiotic production by actinomycetes

Author keywords

Elicitor; Genome mining; Natural product; Silent antibiotic; Soil ecology; Streptomyces

Indexed keywords

ACTINOBACTERIA; ANTI-BACTERIAL AGENTS; BIOLOGICAL PRODUCTS; BIOSYNTHETIC PATHWAYS; GENE EXPRESSION REGULATION, BACTERIAL; SIGNAL TRANSDUCTION;

EID: 84895072830     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-013-1309-z     Document Type: Review
Times cited : (156)

References (169)
  • 1
    • 0019299176 scopus 로고
    • Nitrogen metabolite regulation of antibiotic biosynthesis
    • 1:STN:280:DyaL3M%2FmtV2rsQ%3D%3D 6108090
    • Aharonowitz Y (1980) Nitrogen metabolite regulation of antibiotic biosynthesis. Annu Rev Microbiol 34:209-233
    • (1980) Annu Rev Microbiol , vol.34 , pp. 209-233
    • Aharonowitz, Y.1
  • 2
    • 77956489067 scopus 로고    scopus 로고
    • Development of a genetic system for combinatorial biosynthesis of lipopeptides in Streptomyces fradiae and heterologous expression of the A54145 biosynthesis gene cluster
    • 1:CAS:528:DC%2BC3cXhsVKks73I 2953024 20802082
    • Alexander DC, Rock J, He X, Brian P, Miao V, Baltz RH (2010) Development of a genetic system for combinatorial biosynthesis of lipopeptides in Streptomyces fradiae and heterologous expression of the A54145 biosynthesis gene cluster. Appl Environ Microbiol 76:6877-6887
    • (2010) Appl Environ Microbiol , vol.76 , pp. 6877-6887
    • Alexander, D.C.1    Rock, J.2    He, X.3    Brian, P.4    Miao, V.5    Baltz, R.H.6
  • 3
    • 84868160004 scopus 로고    scopus 로고
    • Diverse control of metabolism and other cellular processes in Streptomyces coelicolor by the PhoP transcription factor: Genome-wide identification of in vivo targets
    • 1:CAS:528:DC%2BC38XhsFygurbO 3479208 22904076
    • Allenby NE, Laing E, Bucca G, Kierzek AM, Smith CP (2012) Diverse control of metabolism and other cellular processes in Streptomyces coelicolor by the PhoP transcription factor: genome-wide identification of in vivo targets. Nucleic acids Res 40:9543-9556
    • (2012) Nucleic Acids Res , vol.40 , pp. 9543-9556
    • Allenby, N.E.1    Laing, E.2    Bucca, G.3    Kierzek, A.M.4    Smith, C.P.5
  • 4
    • 25444482839 scopus 로고    scopus 로고
    • PathwayVoyager: Pathway mapping using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database
    • 1112592 15869710
    • Altermann E, Klaenhammer TR (2005) PathwayVoyager: pathway mapping using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. BMC genomics 6:60
    • (2005) BMC Genomics , vol.6 , pp. 60
    • Altermann, E.1    Klaenhammer, T.R.2
  • 5
    • 0028069031 scopus 로고
    • Glucose repression in Streptomyces coelicolor A3(2): A likely regulatory role for glucose kinase
    • 1:CAS:528:DyaK2MXjtFylsro%3D 8052232
    • Angell S, Lewis CG, Buttner MJ, Bibb MJ (1994) Glucose repression in Streptomyces coelicolor A3(2): a likely regulatory role for glucose kinase. Mol Gen Genet 244:135-143
    • (1994) Mol Gen Genet , vol.244 , pp. 135-143
    • Angell, S.1    Lewis, C.G.2    Buttner, M.J.3    Bibb, M.J.4
  • 6
    • 0026673733 scopus 로고
    • The glucose kinase gene of Streptomyces coelicolor A3(2): Its nucleotide sequence, transcriptional analysis and role in glucose repression
    • 1:CAS:528:DyaK3sXks1Cgtbg%3D 1435260
    • Angell S, Schwarz E, Bibb MJ (1992) The glucose kinase gene of Streptomyces coelicolor A3(2): its nucleotide sequence, transcriptional analysis and role in glucose repression. Mol Microbiol 6:2833-2844
    • (1992) Mol Microbiol , vol.6 , pp. 2833-2844
    • Angell, S.1    Schwarz, E.2    Bibb, M.J.3
  • 7
    • 0033537959 scopus 로고    scopus 로고
    • The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes
    • 1:CAS:528:DyaK1MXis1Gjt7o%3D 10187796
    • Aparicio JF, Colina AJ, Ceballos E, Martin JF (1999) The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes. J Biol Chem 274:10133-10139
    • (1999) J Biol Chem , vol.274 , pp. 10133-10139
    • Aparicio, J.F.1    Colina, A.J.2    Ceballos, E.3    Martin, J.F.4
  • 8
    • 59449088862 scopus 로고    scopus 로고
    • Antibiotic-resistant bugs in the 21st century - A clinical super-challenge
    • 1:CAS:528:DC%2BD1MXht1Ciu7Y%3D 19179312
    • Arias CA, Murray BE (2009) Antibiotic-resistant bugs in the 21st century - a clinical super-challenge. N Engl J Med 360:439-443
    • (2009) N Engl J Med , vol.360 , pp. 439-443
    • Arias, C.A.1    Murray, B.E.2
  • 9
    • 64249084052 scopus 로고    scopus 로고
    • Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data
    • 1:CAS:528:DC%2BD1MXpsFejs7c%3D 19374984
    • Bachmann BO, Ravel J (2009) Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data. Methods Enzymol 458:181-217
    • (2009) Methods Enzymol , vol.458 , pp. 181-217
    • Bachmann, B.O.1    Ravel, J.2
  • 10
    • 35448957251 scopus 로고    scopus 로고
    • Antimicrobials from actinomycetes: Back to the future
    • Baltz RH (2007) Antimicrobials from actinomycetes: back to the future. Microbe 2:125-131
    • (2007) Microbe , vol.2 , pp. 125-131
    • Baltz, R.H.1
  • 11
    • 80855147553 scopus 로고    scopus 로고
    • Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery
    • 1:CAS:528:DC%2BC3MXhtlGhtrnO 21826462
    • Baltz RH (2011) Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery. J Ind Microbiol Biotechnol 38:1747-1760
    • (2011) J Ind Microbiol Biotechnol , vol.38 , pp. 1747-1760
    • Baltz, R.H.1
  • 12
    • 54849405130 scopus 로고    scopus 로고
    • Renaissance in antibacterial discovery from actinomycetes
    • 1:CAS:528:DC%2BD1cXhtlaqsLvO
    • Baltz RH (2008) Renaissance in antibacterial discovery from actinomycetes. Current Opin Pharmacol 8:557-563
    • (2008) Current Opin Pharmacol , vol.8 , pp. 557-563
    • Baltz, R.H.1
  • 13
    • 33644765065 scopus 로고    scopus 로고
    • Antibiotic production improvement in the rare actinomycete Planobispora rosea by selection of mutants resistant to the aminoglycosides streptomycin and gentamycin and to rifamycin
    • 1:CAS:528:DC%2BD28XitV2qt7Y%3D 16331474
    • Beltrametti F, Rossi R, Selva E, Marinelli F (2006) Antibiotic production improvement in the rare actinomycete Planobispora rosea by selection of mutants resistant to the aminoglycosides streptomycin and gentamycin and to rifamycin. J Ind Microbiol Biotechnol 33:283-288
    • (2006) J Ind Microbiol Biotechnol , vol.33 , pp. 283-288
    • Beltrametti, F.1    Rossi, R.2    Selva, E.3    Marinelli, F.4
  • 15
    • 14544294545 scopus 로고    scopus 로고
    • Bioactive microbial metabolites
    • Bérdy J (2005) Bioactive microbial metabolites. J Antibiot (Tokyo) 58:1-26
    • (2005) J Antibiot (Tokyo) , vol.58 , pp. 1-26
    • Bérdy, J.1
  • 16
    • 15744383448 scopus 로고    scopus 로고
    • Regulation of secondary metabolism in streptomycetes
    • 1:CAS:528:DC%2BD2MXivFSltrc%3D 15802254
    • Bibb MJ (2005) Regulation of secondary metabolism in streptomycetes. Curr Opin Microbiol 8:208-215
    • (2005) Curr Opin Microbiol , vol.8 , pp. 208-215
    • Bibb, M.J.1
  • 17
    • 64249095577 scopus 로고    scopus 로고
    • Chapter 4. Analyzing the regulation of antibiotic production in streptomycetes
    • 1:CAS:528:DC%2BD1MXpsFejs7s%3D 19374980
    • Bibb MJ, Hesketh A (2009) Chapter 4. Analyzing the regulation of antibiotic production in streptomycetes. Methods Enzymol 458:93-116
    • (2009) Methods Enzymol , vol.458 , pp. 93-116
    • Bibb, M.J.1    Hesketh, A.2
  • 19
    • 0018838709 scopus 로고
    • A substance effecting differentiation in Streptomyces griseus. Purification and properties
    • 1:CAS:528:DyaL3cXhtVKisrw%3D 6767606
    • Biro S, Bekesi I, Vitalis S, Szabo G (1980) A substance effecting differentiation in Streptomyces griseus. Purification and properties. Eur J Biochem 103:359-363
    • (1980) Eur J Biochem , vol.103 , pp. 359-363
    • Biro, S.1    Bekesi, I.2    Vitalis, S.3    Szabo, G.4
  • 20
    • 0034450184 scopus 로고    scopus 로고
    • Transcriptional and functional analysis of the gene for factor C, an extracellular signal protein involved in cytodifferentiation of Streptomyces griseus
    • 1:CAS:528:DC%2BD3MXktVOhurc%3D 11386350
    • Biro S, Birko Z, van Wezel GP (2000) Transcriptional and functional analysis of the gene for factor C, an extracellular signal protein involved in cytodifferentiation of Streptomyces griseus. Antonie Van Leeuwenhoek 78:277-285
    • (2000) Antonie Van Leeuwenhoek , vol.78 , pp. 277-285
    • Biro, S.1    Birko, Z.2    Van Wezel, G.P.3
  • 22
    • 0037046271 scopus 로고    scopus 로고
    • Carbon catabolite repression in bacteria: Choice of the carbon source and autoregulatory limitation of sugar utilization
    • 12007797
    • Brückner R, Titgemeyer F (2002) Carbon catabolite repression in bacteria: choice of the carbon source and autoregulatory limitation of sugar utilization. FEMS Microbiol Lett 209:141-148
    • (2002) FEMS Microbiol Lett , vol.209 , pp. 141-148
    • Brückner, R.1    Titgemeyer, F.2
  • 24
    • 0036015632 scopus 로고    scopus 로고
    • The vbs genes that direct synthesis of the siderophore vicibactin in Rhizobium leguminosarum: Their expression in other genera requires ECF sigma factor RpoI
    • 1:CAS:528:DC%2BD38XksFGqtbg%3D 12028377
    • Carter RA, Worsley PS, Sawers G, Challis GL, Dilworth MJ, Carson KC, Lawrence JA, Wexler M, Johnston AW, Yeoman KH (2002) The vbs genes that direct synthesis of the siderophore vicibactin in Rhizobium leguminosarum: their expression in other genera requires ECF sigma factor RpoI. Mol Microbiol 44:1153-1166
    • (2002) Mol Microbiol , vol.44 , pp. 1153-1166
    • Carter, R.A.1    Worsley, P.S.2    Sawers, G.3    Challis, G.L.4    Dilworth, M.J.5    Carson, K.C.6    Lawrence, J.A.7    Wexler, M.8    Johnston, A.W.9    Yeoman, K.H.10
  • 25
    • 0345492332 scopus 로고    scopus 로고
    • Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species
    • 1:CAS:528:DC%2BD3sXpsFaku78%3D 12970466
    • Challis GL, Hopwood DA (2003) Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species. Proc Natl Acad Sci USA 100:14555-14561
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14555-14561
    • Challis, G.L.1    Hopwood, D.A.2
  • 26
    • 84863359225 scopus 로고    scopus 로고
    • Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction
    • 1:CAS:528:DC%2BC38XltVyms7g%3D 3312335 22470465
    • Charusanti P, Fong NL, Nagarajan H, Pereira AR, Li HJ, Abate EA, Su Y, Gerwick WH, Palsson BO (2012) Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction. PLoS One 7:e33727
    • (2012) PLoS One , vol.7 , pp. 33727
    • Charusanti, P.1    Fong, N.L.2    Nagarajan, H.3    Pereira, A.R.4    Li, H.J.5    Abate, E.A.6    Su, Y.7    Gerwick, W.H.8    Palsson, B.O.9
  • 27
    • 33746865723 scopus 로고    scopus 로고
    • Streptomyces inside-out: A new perspective on the bacteria that provide us with antibiotics. Philosophical Transactions of the Royal Society of London
    • 1:CAS:528:DC%2BD28XpsFGkur4%3D
    • Chater KF (2006) Streptomyces inside-out: a new perspective on the bacteria that provide us with antibiotics. Philosophical Transactions of the Royal Society of London. Ser B Biol Sci 361:761-768
    • (2006) Ser B Biol Sci , vol.361 , pp. 761-768
    • Chater, K.F.1
  • 28
    • 84864282751 scopus 로고    scopus 로고
    • Global transcriptional responses to triclosan exposure in Pseudomonas aeruginosa
    • 1:CAS:528:DC%2BC38XoslGmtbY%3D 22704809
    • Chuanchuen R, Schweizer HP (2012) Global transcriptional responses to triclosan exposure in Pseudomonas aeruginosa. Int J Antimicrob Agents 40:114-122
    • (2012) Int J Antimicrob Agents , vol.40 , pp. 114-122
    • Chuanchuen, R.1    Schweizer, H.P.2
  • 29
    • 33845749062 scopus 로고    scopus 로고
    • Conserved cis-acting elements upstream of genes composing the chitinolytic system of streptomycetes are DasR-responsive elements
    • 1:CAS:528:DC%2BD2sXjsFSnsQ%3D%3D 17183212
    • Colson S, Stephan J, Hertrich T, Saito A, van Wezel GP, Titgemeyer F, Rigali S (2007) Conserved cis-acting elements upstream of genes composing the chitinolytic system of streptomycetes are DasR-responsive elements. J Mol Microbiol Biotechnol 12:60-66
    • (2007) J Mol Microbiol Biotechnol , vol.12 , pp. 60-66
    • Colson, S.1    Stephan, J.2    Hertrich, T.3    Saito, A.4    Van Wezel, G.P.5    Titgemeyer, F.6    Rigali, S.7
  • 30
    • 39749177789 scopus 로고    scopus 로고
    • The chitobiose-binding protein, DasA, acts as a link between chitin utilization and morphogenesis in Streptomyces coelicolor
    • 1:CAS:528:DC%2BD1cXjtFCrsLw%3D 18227241
    • Colson S, van Wezel GP, Craig M, Noens EE, Nothaft H, Mommaas AM, Titgemeyer F, Joris B, Rigali S (2008) The chitobiose-binding protein, DasA, acts as a link between chitin utilization and morphogenesis in Streptomyces coelicolor. Microbiology 154:373-382
    • (2008) Microbiology , vol.154 , pp. 373-382
    • Colson, S.1    Van Wezel, G.P.2    Craig, M.3    Noens, E.E.4    Nothaft, H.5    Mommaas, A.M.6    Titgemeyer, F.7    Joris, B.8    Rigali, S.9
  • 31
    • 56249143138 scopus 로고    scopus 로고
    • 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining
    • 1:CAS:528:DC%2BD1cXhsVWnt7%2FP 18988741
    • Corre C, Song L, O'Rourke S, Chater KF, Challis GL (2008) 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proc Natl Acad Sci USA 105:17510-17515
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 17510-17515
    • Corre, C.1    Song, L.2    O'Rourke, S.3    Chater, K.F.4    Challis, G.L.5
  • 33
    • 84865477861 scopus 로고    scopus 로고
    • Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism
    • 1:CAS:528:DC%2BC38Xht1Kku7bO 22921069
    • Craney A, Ozimok C, Pimentel-Elardo SM, Capretta A, Nodwell JR (2012) Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism. Chem Biol 19:1020-1027
    • (2012) Chem Biol , vol.19 , pp. 1020-1027
    • Craney, A.1    Ozimok, C.2    Pimentel-Elardo, S.M.3    Capretta, A.4    Nodwell, J.R.5
  • 34
    • 79951818856 scopus 로고    scopus 로고
    • Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2)
    • 21342469
    • D'Alia D, Eggle D, Nieselt K, Hu WS, Breitling R, Takano E (2011) Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2). Microb Biotechnol 4:239-251
    • (2011) Microb Biotechnol , vol.4 , pp. 239-251
    • D'Alia, D.1    Eggle, D.2    Nieselt, K.3    Hu, W.S.4    Breitling, R.5    Takano, E.6
  • 37
    • 0032745552 scopus 로고    scopus 로고
    • Pharmaceutically active secondary metabolites of microorganisms
    • 1:CAS:528:DyaK1MXnt1Kisb0%3D 10570792
    • Demain AL (1999) Pharmaceutically active secondary metabolites of microorganisms. Appl Microbiol Biotechnol 52:455-463
    • (1999) Appl Microbiol Biotechnol , vol.52 , pp. 455-463
    • Demain, A.L.1
  • 38
    • 34247125300 scopus 로고    scopus 로고
    • The effect of quorum-sensing blockers on the formation of marine microbial communities and larval attachment
    • 1:CAS:528:DC%2BD2sXkvFSlt7c%3D 17371321
    • Dobretsov S, Dahms HU, Yili H, Wahl M, Qian PY (2007) The effect of quorum-sensing blockers on the formation of marine microbial communities and larval attachment. FEMS Microbiol Ecol 60:177-188
    • (2007) FEMS Microbiol Ecol , vol.60 , pp. 177-188
    • Dobretsov, S.1    Dahms, H.U.2    Yili, H.3    Wahl, M.4    Qian, P.Y.5
  • 39
    • 0037715808 scopus 로고
    • Observations on Streptomyces griseus: II. Nitrogen sources for growth and streptomycin production
    • 1:CAS:528:DyaH1MXptVU%3D 518583
    • Dulaney EL (1948) Observations on Streptomyces griseus: II. Nitrogen sources for growth and streptomycin production. J Bacteriol 56:305-313
    • (1948) J Bacteriol , vol.56 , pp. 305-313
    • Dulaney, E.L.1
  • 40
    • 84934442432 scopus 로고    scopus 로고
    • Bioinformatics approaches and software for detection of secondary metabolic gene clusters
    • N. Keller G. Turner (eds) Humana Press New York
    • Fedorova D, Moktali V, Medema H (2012) Bioinformatics approaches and software for detection of secondary metabolic gene clusters. In: Keller NP, Turner G (eds) Fungal secondary metabolism, vol. 944. Humana Press, New York, pp 23-45
    • (2012) Fungal Secondary Metabolism, Vol. 944 , pp. 23-45
    • Fedorova, D.1    Moktali, V.2    Medema, H.3
  • 41
    • 55549086417 scopus 로고    scopus 로고
    • Streptomyces morphogenetics: Dissecting differentiation in a filamentous bacterium
    • 19079351
    • Flärdh K, Buttner MJ (2009) Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium. Nat Rev Microbiol 7:36-49
    • (2009) Nat Rev Microbiol , vol.7 , pp. 36-49
    • Flärdh, K.1    Buttner, M.J.2
  • 42
    • 0000378637 scopus 로고
    • The antibacterial action of a Penicillium, with special reference to their use for the isolation of B. Influenzae
    • 1:CAS:528:DyaB1MXkt12htw%3D%3D
    • Fleming A (1929) The antibacterial action of a Penicillium, with special reference to their use for the isolation of B. influenzae. Brit J Exp Pathol 10:226-236
    • (1929) Brit J Exp Pathol , vol.10 , pp. 226-236
    • Fleming, A.1
  • 43
    • 0029762312 scopus 로고    scopus 로고
    • AfsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2)
    • 1:CAS:528:DyaK28XkvVansrY%3D 8858592
    • Floriano B, Bibb M (1996) afsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2). Mol Microbiol 21:385-396
    • (1996) Mol Microbiol , vol.21 , pp. 385-396
    • Floriano, B.1    Bibb, M.2
  • 44
    • 0028922082 scopus 로고
    • The regulation of transcription initiation by integration host factor
    • 1:CAS:528:DyaK2MXlt1agsb8%3D 7651128
    • Goosen N, van de Putte P (1995) The regulation of transcription initiation by integration host factor. Mol Microbiol 16:1-7
    • (1995) Mol Microbiol , vol.16 , pp. 1-7
    • Goosen, N.1    Van De Putte, P.2
  • 45
    • 47549110972 scopus 로고    scopus 로고
    • Carbon catabolite repression in bacteria: Many ways to make the most out of nutrients
    • 18628769
    • Görke B, Stülke J (2008) Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Nat Rev Microbiol 6:613-624
    • (2008) Nat Rev Microbiol , vol.6 , pp. 613-624
    • Görke, B.1    Stülke, J.2
  • 46
    • 62149089979 scopus 로고    scopus 로고
    • Genomic mining - A concept for the discovery of new bioactive natural products
    • 1:CAS:528:DC%2BD1MXnt12lurg%3D
    • Gross H (2009) Genomic mining - a concept for the discovery of new bioactive natural products. Curr Opin Drug Discov Dev 12:207-219
    • (2009) Curr Opin Drug Discov Dev , vol.12 , pp. 207-219
    • Gross, H.1
  • 47
    • 84871002014 scopus 로고    scopus 로고
    • Identification of glucose kinase dependent and independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics
    • 1:CAS:528:DC%2BC38XhvVeltLfK 23078239
    • Gubbens J, Janus M, Florea BI, Overkleeft HS, van Wezel GP (2012) Identification of glucose kinase dependent and independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics. Mol Microbiol 86:1490-1507
    • (2012) Mol Microbiol , vol.86 , pp. 1490-1507
    • Gubbens, J.1    Janus, M.2    Florea, B.I.3    Overkleeft, H.S.4    Van Wezel, G.P.5
  • 48
    • 69949123857 scopus 로고    scopus 로고
    • DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus
    • 1:CAS:528:DC%2BD1MXovFemsr8%3D 19389771
    • Hara H, Ohnishi Y, Horinouchi S (2009) DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus. Microbiology 155:2197-2210
    • (2009) Microbiology , vol.155 , pp. 2197-2210
    • Hara, H.1    Ohnishi, Y.2    Horinouchi, S.3
  • 50
    • 42949119908 scopus 로고    scopus 로고
    • Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus
    • 1:CAS:528:DC%2BD1cXjvFersLc%3D 18310036
    • Hirano S, Tanaka K, Ohnishi Y, Horinouchi S (2008) Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus. Microbiology 154:905-914
    • (2008) Microbiology , vol.154 , pp. 905-914
    • Hirano, S.1    Tanaka, K.2    Ohnishi, Y.3    Horinouchi, S.4
  • 51
    • 0032879027 scopus 로고    scopus 로고
    • Forty years of genetics with Streptomyces: From in vivo through in vitro to in silico
    • 1:CAS:528:DyaK1MXmsVyhsbk%3D 10517572
    • Hopwood DA (1999) Forty years of genetics with Streptomyces: from in vivo through in vitro to in silico. Microbiology 145:2183-2202
    • (1999) Microbiology , vol.145 , pp. 2183-2202
    • Hopwood, D.A.1
  • 52
    • 33845653671 scopus 로고    scopus 로고
    • Soil to genomics: The Streptomyces chromosome
    • 1:CAS:528:DC%2BD2sXnslGq 16761950
    • Hopwood DA (2006) Soil to genomics: the Streptomyces chromosome. Annu Rev Genet 40:1-23
    • (2006) Annu Rev Genet , vol.40 , pp. 1-23
    • Hopwood, D.A.1
  • 54
    • 0026709964 scopus 로고
    • Autoregulatory factors and communication in actinomycetes
    • 1:CAS:528:DyaK3sXjsFGiug%3D%3D 1444261
    • Horinouchi S, Beppu T (1992) Autoregulatory factors and communication in actinomycetes. Annu Rev Microbiol 46:377-398
    • (1992) Annu Rev Microbiol , vol.46 , pp. 377-398
    • Horinouchi, S.1    Beppu, T.2
  • 55
    • 0028245937 scopus 로고
    • A-factor as a microbial hormone that controls cellular differentiation and secondary metabolism in Streptomyces griseus
    • 1:CAS:528:DyaK2cXkslOruro%3D 7934895
    • Horinouchi S, Beppu T (1994) A-factor as a microbial hormone that controls cellular differentiation and secondary metabolism in Streptomyces griseus. Mol Microbiol 12:859-864
    • (1994) Mol Microbiol , vol.12 , pp. 859-864
    • Horinouchi, S.1    Beppu, T.2
  • 57
    • 64249108113 scopus 로고    scopus 로고
    • Chapter 6. Regulation of antibiotic production by bacterial hormones
    • 1:CAS:528:DC%2BD1MXpsFejs7k%3D 19374982
    • Hsiao NH, Gottelt M, Takano E (2009) Chapter 6. Regulation of antibiotic production by bacterial hormones. Methods Enzymol 458:143-157
    • (2009) Methods Enzymol , vol.458 , pp. 143-157
    • Hsiao, N.H.1    Gottelt, M.2    Takano, E.3
  • 60
    • 83055188789 scopus 로고    scopus 로고
    • Scandium stimulates the production of amylase and bacilysin in Bacillus subtilis
    • 1:CAS:528:DC%2BC3MXhs1Gqt77L 3209005 21948839
    • Inaoka T, Ochi K (2011) Scandium stimulates the production of amylase and bacilysin in Bacillus subtilis. Appl Environ Microbiol 77:8181-8183
    • (2011) Appl Environ Microbiol , vol.77 , pp. 8181-8183
    • Inaoka, T.1    Ochi, K.2
  • 61
    • 0942265514 scopus 로고    scopus 로고
    • RNA polymerase mutation activates the production of a dormant antibiotic 3,3′-neotrehalosadiamine via an autoinduction mechanism in Bacillus subtilis
    • 1:CAS:528:DC%2BD2cXmtlGjsw%3D%3D 14612444
    • Inaoka T, Takahashi K, Yada H, Yoshida M, Ochi K (2004) RNA polymerase mutation activates the production of a dormant antibiotic 3,3′- neotrehalosadiamine via an autoinduction mechanism in Bacillus subtilis. J Biol Chem 279:3885-3892
    • (2004) J Biol Chem , vol.279 , pp. 3885-3892
    • Inaoka, T.1    Takahashi, K.2    Yada, H.3    Yoshida, M.4    Ochi, K.5
  • 62
    • 84863201496 scopus 로고    scopus 로고
    • Extracting regulator activity profiles by integration of de novo motifs and expression data: Characterizing key regulators of nutrient depletion responses in Streptomyces coelicolor
    • 1:CAS:528:DC%2BC38XpsFKnurw%3D 3384326 22406834
    • Iqbal M, Mast Y, Amin R, Hodgson DA, Wohlleben W, Burroughs NJ (2012) Extracting regulator activity profiles by integration of de novo motifs and expression data: characterizing key regulators of nutrient depletion responses in Streptomyces coelicolor. Nucleic Acids Res 40:5227-5239
    • (2012) Nucleic Acids Res , vol.40 , pp. 5227-5239
    • Iqbal, M.1    Mast, Y.2    Amin, R.3    Hodgson, D.A.4    Wohlleben, W.5    Burroughs, N.J.6
  • 63
    • 33746106088 scopus 로고    scopus 로고
    • Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2′-O-methylations in 16S and 23S rRNAs
    • 1:CAS:528:DC%2BD28XotVCjuro%3D 16857584
    • Johansen SK, Maus CE, Plikaytis BB, Douthwaite S (2006) Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2′-O- methylations in 16S and 23S rRNAs. Mol Cell 23:173-182
    • (2006) Mol Cell , vol.23 , pp. 173-182
    • Johansen, S.K.1    Maus, C.E.2    Plikaytis, B.B.3    Douthwaite, S.4
  • 64
    • 77952309568 scopus 로고    scopus 로고
    • Superfamilies SDR and MDR: From early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities
    • 20494124
    • Jornvall H, Hedlund J, Bergman T, Oppermann U, Persson B (2010) Superfamilies SDR and MDR: from early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities. Biochem Biophys Res Commun 396:125-130
    • (2010) Biochem Biophys Res Commun , vol.396 , pp. 125-130
    • Jornvall, H.1    Hedlund, J.2    Bergman, T.3    Oppermann, U.4    Persson, B.5
  • 65
    • 33847407962 scopus 로고    scopus 로고
    • Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces
    • 1:CAS:528:DC%2BD2sXisVWrt7s%3D 17277085
    • Kato JY, Funa N, Watanabe H, Ohnishi Y, Horinouchi S (2007) Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces. Proc Natl Acad Sci USA 104:2378-2383
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2378-2383
    • Kato, J.Y.1    Funa, N.2    Watanabe, H.3    Ohnishi, Y.4    Horinouchi, S.5
  • 66
    • 0034011484 scopus 로고    scopus 로고
    • Identification of an AfsA homologue (BarX) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis, virginiamycin biosynthesis and virginiamycin M1 resistance
    • 1:CAS:528:DC%2BD3cXjtlKisb8%3D 10792718
    • Kawachi R, Akashi T, Kamitani Y, Sy A, Wangchaisoonthorn U, Nihira T, Yamada Y (2000) Identification of an AfsA homologue (BarX) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis, virginiamycin biosynthesis and virginiamycin M1 resistance. Mol Microbiol 36:302-313
    • (2000) Mol Microbiol , vol.36 , pp. 302-313
    • Kawachi, R.1    Akashi, T.2    Kamitani, Y.3    Sy, A.4    Wangchaisoonthorn, U.5    Nihira, T.6    Yamada, Y.7
  • 67
    • 34547885750 scopus 로고    scopus 로고
    • The rare earth, scandium, causes antibiotic overproduction in Streptomyces spp
    • 1:CAS:528:DC%2BD2sXhtVaisLfL 17645525
    • Kawai K, Wang G, Okamoto S, Ochi K (2007) The rare earth, scandium, causes antibiotic overproduction in Streptomyces spp. FEMS Microbiol Lett 274:311-315
    • (2007) FEMS Microbiol Lett , vol.274 , pp. 311-315
    • Kawai, K.1    Wang, G.2    Okamoto, S.3    Ochi, K.4
  • 69
    • 0034972542 scopus 로고    scopus 로고
    • Gene replacement analysis of the butyrolactone autoregulator receptor (FarA) reveals that FarA acts as a novel regulator in secondary metabolism of Streptomyces lavendulae FRI-5
    • 1:CAS:528:DC%2BD3MXkvVaks7w%3D 95326 11418577
    • Kitani S, Yamada Y, Nihira T (2001) Gene replacement analysis of the butyrolactone autoregulator receptor (FarA) reveals that FarA acts as a novel regulator in secondary metabolism of Streptomyces lavendulae FRI-5. J Bacteriol 183:4357-4363
    • (2001) J Bacteriol , vol.183 , pp. 4357-4363
    • Kitani, S.1    Yamada, Y.2    Nihira, T.3
  • 71
    • 0032872173 scopus 로고    scopus 로고
    • How many leads from HTS?
    • 10481138
    • Lahana R (1999) How many leads from HTS? Drug Discov Today 4:447-448
    • (1999) Drug Discov Today , vol.4 , pp. 447-448
    • Lahana, R.1
  • 72
    • 79954997859 scopus 로고    scopus 로고
    • Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
    • 1:CAS:528:DC%2BC3MXltVOqu7o%3D 21444795
    • Laureti L, Song L, Huang S, Corre C, Leblond P, Challis GL, Aigle B (2011) Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proc Natl Acad Sci USA 108:6258-6263
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 6258-6263
    • Laureti, L.1    Song, L.2    Huang, S.3    Corre, C.4    Leblond, P.5    Challis, G.L.6    Aigle, B.7
  • 73
    • 3142672123 scopus 로고    scopus 로고
    • Substrate recognition by nonribosomal peptide synthetase multi-enzymes
    • 1:CAS:528:DC%2BD2cXlslWntrc%3D 15184549
    • Lautru S, Challis GL (2004) Substrate recognition by nonribosomal peptide synthetase multi-enzymes. Microbiology 150:1629-1636
    • (2004) Microbiology , vol.150 , pp. 1629-1636
    • Lautru, S.1    Challis, G.L.2
  • 74
    • 0034210940 scopus 로고    scopus 로고
    • Effect of a global regulatory gene, afsR2, from Streptomyces lividans on avermectin production in Streptomyces avermitilis
    • 1:CAS:528:DC%2BD3cXmtFGjtbY%3D 16232806
    • Lee J, Hwang Y, Kim S, Kim E, Choi C (2000) Effect of a global regulatory gene, afsR2, from Streptomyces lividans on avermectin production in Streptomyces avermitilis. J Biosci Bioeng 89:606-608
    • (2000) J Biosci Bioeng , vol.89 , pp. 606-608
    • Lee, J.1    Hwang, Y.2    Kim, S.3    Kim, E.4    Choi, C.5
  • 75
    • 0036268103 scopus 로고    scopus 로고
    • AfsS is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in Streptomyces coelicolor A3(2)
    • 1:CAS:528:DC%2BD38XivFylsr4%3D 11952895
    • Lee PC, Umeyama T, Horinouchi S (2002) afsS is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in Streptomyces coelicolor A3(2). Mol Microbiol 43:1413-1430
    • (2002) Mol Microbiol , vol.43 , pp. 1413-1430
    • Lee, P.C.1    Umeyama, T.2    Horinouchi, S.3
  • 76
    • 0030812917 scopus 로고    scopus 로고
    • Histone deacetylases, acetoin utilization proteins and acetylpolyamine amidohydrolases are members of an ancient protein superfamily
    • 1:CAS:528:DyaK2sXmsVahsbw%3D 146955 9278492
    • Leipe DD, Landsman D (1997) Histone deacetylases, acetoin utilization proteins and acetylpolyamine amidohydrolases are members of an ancient protein superfamily. Nucleic Acids Res 25:3693-3697
    • (1997) Nucleic Acids Res , vol.25 , pp. 3693-3697
    • Leipe, D.D.1    Landsman, D.2
  • 77
    • 33845884076 scopus 로고    scopus 로고
    • Antibiotics as intermicrobial signaling agents instead of weapons
    • 1:CAS:528:DC%2BD2sXhs1yrtQ%3D%3D 17148599
    • Linares JF, Gustafsson I, Baquero F, Martinez JL (2006) Antibiotics as intermicrobial signaling agents instead of weapons. Proc Natl Acad Sci USA 103:19484-19489
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 19484-19489
    • Linares, J.F.1    Gustafsson, I.2    Baquero, F.3    Martinez, J.L.4
  • 78
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • 1:CAS:528:DC%2BD3MXitVOhs7o%3D 11259830
    • Lipinski CA, Lombardo F, Dominy BW, Feeney PJ (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46:3-26
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 79
    • 84874850153 scopus 로고    scopus 로고
    • Molecular regulation of antibiotic biosynthesis in Streptomyces
    • 1:CAS:528:DC%2BC3sXlsFSisr0%3D 23471619
    • Liu G, Chater KF, Chandra G, Niu G, Tan H (2013) Molecular regulation of antibiotic biosynthesis in Streptomyces. Microbiol Mol Biol Rev 77:112-143
    • (2013) Microbiol Mol Biol Rev , vol.77 , pp. 112-143
    • Liu, G.1    Chater, K.F.2    Chandra, G.3    Niu, G.4    Tan, H.5
  • 80
    • 0033857994 scopus 로고    scopus 로고
    • The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA
    • 1:CAS:528:DC%2BD3cXmsVejtbk%3D 10972803
    • Liu M, Kirpekar F, Van Wezel GP, Douthwaite S (2000) The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA. Mol Microbiol 37:811-820
    • (2000) Mol Microbiol , vol.37 , pp. 811-820
    • Liu, M.1    Kirpekar, F.2    Van Wezel, G.P.3    Douthwaite, S.4
  • 81
    • 64549133456 scopus 로고    scopus 로고
    • Identification and functional characterization of an afsR homolog regulatory gene from Streptomyces venezuelae ATCC 15439
    • 1:CAS:528:DC%2BD1MXktlGnu7w%3D 19307759
    • Maharjan S, Oh TJ, Lee HC, Sohng JK (2009) Identification and functional characterization of an afsR homolog regulatory gene from Streptomyces venezuelae ATCC 15439. J Microbiol Biotechnol 19:121-127
    • (2009) J Microbiol Biotechnol , vol.19 , pp. 121-127
    • Maharjan, S.1    Oh, T.J.2    Lee, H.C.3    Sohng, J.K.4
  • 82
    • 0023001541 scopus 로고
    • Physical and genetic characterisation of the gene cluster for the antibiotic actinorhodin in Streptomyces coelicolor A3(2)
    • 1:CAS:528:DyaL2sXhtFGh 3025560
    • Malpartida F, Hopwood DA (1986) Physical and genetic characterisation of the gene cluster for the antibiotic actinorhodin in Streptomyces coelicolor A3(2). Mol Gen Genet 205:66-73
    • (1986) Mol Gen Genet , vol.205 , pp. 66-73
    • Malpartida, F.1    Hopwood, D.A.2
  • 83
    • 27744439433 scopus 로고    scopus 로고
    • A death round affecting a young compartmentalized mycelium precedes aerial mycelium dismantling in confluent surface cultures of Streptomyces antibioticus
    • 1:CAS:528:DC%2BD2MXht1Cms7nL 16272390
    • Manteca A, Fernandez M, Sanchez J (2005) A death round affecting a young compartmentalized mycelium precedes aerial mycelium dismantling in confluent surface cultures of Streptomyces antibioticus. Microbiology 151:3689-3697
    • (2005) Microbiology , vol.151 , pp. 3689-3697
    • Manteca, A.1    Fernandez, M.2    Sanchez, J.3
  • 84
    • 27544472676 scopus 로고    scopus 로고
    • Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary
    • 1:CAS:528:DC%2BD2MXhtFWlsbbJ 15817693
    • Mao X, Cai T, Olyarchuk JG, Wei L (2005) Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary. Bioinformatics 21:3787-3793
    • (2005) Bioinformatics , vol.21 , pp. 3787-3793
    • Mao, X.1    Cai, T.2    Olyarchuk, J.G.3    Wei, L.4
  • 85
    • 3843050181 scopus 로고    scopus 로고
    • Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: An unfinished story
    • 490900 15292120
    • Martín JF (2004) Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story. J Bacteriol 186:5197-5201
    • (2004) J Bacteriol , vol.186 , pp. 5197-5201
    • Martín, J.F.1
  • 86
    • 0019292120 scopus 로고
    • Control of antibiotic biosynthesis
    • 373178 6991900
    • Martín JF, Demain A (1980) Control of antibiotic biosynthesis. Microbiol Rev 44:230-251
    • (1980) Microbiol Rev , vol.44 , pp. 230-251
    • Martín, J.F.1    Demain, A.2
  • 87
    • 64049085732 scopus 로고    scopus 로고
    • Enzymology of the polyenes pimaricin and candicidin biosynthesis
    • 1:CAS:528:DC%2BD1MXpsFaqtbc%3D 19362642
    • Martin JF, Aparicio JF (2009) Enzymology of the polyenes pimaricin and candicidin biosynthesis. Methods Enzymol 459:215-242
    • (2009) Methods Enzymol , vol.459 , pp. 215-242
    • Martin, J.F.1    Aparicio, J.F.2
  • 88
    • 77952909070 scopus 로고    scopus 로고
    • Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces
    • 1:CAS:528:DC%2BC3cXntVSlur0%3D 20303823
    • Martin JF, Liras P (2010) Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces. Curr Opin Microbiol 13:263-273
    • (2010) Curr Opin Microbiol , vol.13 , pp. 263-273
    • Martin, J.F.1    Liras, P.2
  • 90
    • 15444380824 scopus 로고    scopus 로고
    • Environmental DNA fragment conferring early and increased sporulation and antibiotic production in Streptomyces species
    • 1:CAS:528:DC%2BD2MXisVOitrk%3D 1065173 15746369
    • Martinez A, Kolvek SJ, Hopke J, Yip CL, Osburne MS (2005) Environmental DNA fragment conferring early and increased sporulation and antibiotic production in Streptomyces species. Appl Environ Microbiol 71:1638-1641
    • (2005) Appl Environ Microbiol , vol.71 , pp. 1638-1641
    • Martinez, A.1    Kolvek, S.J.2    Hopke, J.3    Yip, C.L.4    Osburne, M.S.5
  • 91
    • 0001420957 scopus 로고
    • Involvement of a small ORF downstream of the afsR gene in the regulation of secondary metabolism in Streptomyces coelicolor A3(2)
    • Matsumoto A, Ishizuka H, Beppu T, Horinouchi S (1995) Involvement of a small ORF downstream of the afsR gene in the regulation of secondary metabolism in Streptomyces coelicolor A3(2). Actinomycetologica 9:37-43
    • (1995) Actinomycetologica , vol.9 , pp. 37-43
    • Matsumoto, A.1    Ishizuka, H.2    Beppu, T.3    Horinouchi, S.4
  • 92
    • 0032914702 scopus 로고    scopus 로고
    • Phosphate control of oxytetracycline production by Streptomyces rimosus is at the level of transcription from promoters overlapped by tandem repeats similar to those of the DNA-binding sites of the OmpR family
    • 1:CAS:528:DyaK1MXjt1yrsrY%3D 93756 10322002
    • McDowall KJ, Thamchaipenet A, Hunter IS (1999) Phosphate control of oxytetracycline production by Streptomyces rimosus is at the level of transcription from promoters overlapped by tandem repeats similar to those of the DNA-binding sites of the OmpR family. J Bacteriol 181:3025-3032
    • (1999) J Bacteriol , vol.181 , pp. 3025-3032
    • McDowall, K.J.1    Thamchaipenet, A.2    Hunter, I.S.3
  • 93
    • 79959920872 scopus 로고    scopus 로고
    • AntiSMASH: Rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
    • 1:CAS:528:DC%2BC3MXosVOms7o%3D 3125804 21672958
    • Medema M, Blin K, Cimermancic P, de Jager V, Zakrzewski P, Fischbach MA, Weber T, Takano E, Breitling R (2011) antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res 39:W339-W346
    • (2011) Nucleic Acids Res , vol.39
    • Medema, M.1    Blin, K.2    Cimermancic, P.3    De Jager, V.4    Zakrzewski, P.5    Fischbach, M.A.6    Weber, T.7    Takano, E.8    Breitling, R.9
  • 94
    • 78651517511 scopus 로고    scopus 로고
    • Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms
    • 1:CAS:528:DC%2BC3cXhs1agu7fN 21189477
    • Medema MH, Breitling R, Bovenberg R, Takano E (2011) Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms. Nat Rev Microbiol 9:131-137
    • (2011) Nat Rev Microbiol , vol.9 , pp. 131-137
    • Medema, M.H.1    Breitling, R.2    Bovenberg, R.3    Takano, E.4
  • 95
    • 33847661977 scopus 로고    scopus 로고
    • The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis
    • 1:CAS:528:DC%2BD2sXhvVyktbY%3D 17142079
    • Mendes MV, Tunca S, Anton N, Recio E, Sola-Landa A, Aparicio JF, Martin JF (2007) The two-component phoR-phoP system of Streptomyces natalensis: inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis. Metab Eng 9:217-227
    • (2007) Metab Eng , vol.9 , pp. 217-227
    • Mendes, M.V.1    Tunca, S.2    Anton, N.3    Recio, E.4    Sola-Landa, A.5    Aparicio, J.F.6    Martin, J.F.7
  • 96
    • 84867642336 scopus 로고    scopus 로고
    • Use and discovery of chemical elicitors that stimulate biosynthetic gene clusters in Streptomyces bacteria
    • 1:CAS:528:DC%2BC3sXlvVehuw%3D%3D 23084948
    • Moore JM, Bradshaw E, Seipke RF, Hutchings MI, McArthur M (2012) Use and discovery of chemical elicitors that stimulate biosynthetic gene clusters in Streptomyces bacteria. Methods Enzymol 517:367-385
    • (2012) Methods Enzymol , vol.517 , pp. 367-385
    • Moore, J.M.1    Bradshaw, E.2    Seipke, R.F.3    Hutchings, M.I.4    McArthur, M.5
  • 97
    • 0030667760 scopus 로고    scopus 로고
    • Will combinatorial chemistry deliver real medicines?
    • 1:CAS:528:DyaK2sXotVOhtLc%3D 9425660
    • Myers PL (1997) Will combinatorial chemistry deliver real medicines? Curr Opin Biotechnol 8:701-707
    • (1997) Curr Opin Biotechnol , vol.8 , pp. 701-707
    • Myers, P.L.1
  • 98
    • 84871890218 scopus 로고    scopus 로고
    • Chitin-induced gene expression involved in secondary metabolic pathways in Streptomyces coelicolor A3(2) grown in soil
    • 23124229
    • Nazari B, Kobayashi M, Saito A, Hassaninasab A, Miyashita K, Fujii T (2012) Chitin-induced gene expression involved in secondary metabolic pathways in Streptomyces coelicolor A3(2) grown in soil. Appl Environ Microbiol 79:707-713
    • (2012) Appl Environ Microbiol , vol.79 , pp. 707-713
    • Nazari, B.1    Kobayashi, M.2    Saito, A.3    Hassaninasab, A.4    Miyashita, K.5    Fujii, T.6
  • 99
    • 70350722394 scopus 로고    scopus 로고
    • Genomic basis for natural product biosynthetic diversity in the actinomycetes
    • 1:CAS:528:DC%2BD1MXht12ht7vF 3063060 19844637
    • Nett M, Ikeda H, Moore BS (2009) Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat Prod Rep 26:1362-1384
    • (2009) Nat Prod Rep , vol.26 , pp. 1362-1384
    • Nett, M.1    Ikeda, H.2    Moore, B.S.3
  • 100
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • 1:CAS:528:DC%2BD2sXhvFKrsro%3D 17309302
    • Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461-477
    • (2007) J Nat Prod , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 101
    • 0031885643 scopus 로고    scopus 로고
    • Purification of an extracellular signaling molecule involved in production of the aerial mycelium by Streptomyces coelicolor
    • 1:CAS:528:DyaK1cXhsFyntbw%3D 107025 9495776
    • Nodwell JR, Losick R (1998) Purification of an extracellular signaling molecule involved in production of the aerial mycelium by Streptomyces coelicolor. J Bacteriol 180:1334-1337
    • (1998) J Bacteriol , vol.180 , pp. 1334-1337
    • Nodwell, J.R.1    Losick, R.2
  • 102
    • 0345687895 scopus 로고    scopus 로고
    • The phosphotransferase system of Streptomyces coelicolor is biased for N-acetylglucosamine metabolism
    • 1:CAS:528:DC%2BD3sXpt1yms7g%3D 262694 14617669
    • Nothaft H, Dresel D, Willimek A, Mahr K, Niederweis M, Titgemeyer F (2003) The phosphotransferase system of Streptomyces coelicolor is biased for N-acetylglucosamine metabolism. J Bacteriol 185:7019-7023
    • (2003) J Bacteriol , vol.185 , pp. 7019-7023
    • Nothaft, H.1    Dresel, D.2    Willimek, A.3    Mahr, K.4    Niederweis, M.5    Titgemeyer, F.6
  • 103
    • 77349108857 scopus 로고    scopus 로고
    • The permease gene nagE2 is the key to N-acetylglucosamine sensing and utilization in Streptomyces coelicolor and is subject to multi-level control
    • 1:CAS:528:DC%2BC3cXjsFartL4%3D 20487300
    • Nothaft H, Rigali S, Boomsma B, Swiatek M, McDowall KJ, van Wezel GP, Titgemeyer F (2010) The permease gene nagE2 is the key to N-acetylglucosamine sensing and utilization in Streptomyces coelicolor and is subject to multi-level control. Mol Microbiol 75:1133-1144
    • (2010) Mol Microbiol , vol.75 , pp. 1133-1144
    • Nothaft, H.1    Rigali, S.2    Boomsma, B.3    Swiatek, M.4    McDowall, K.J.5    Van Wezel, G.P.6    Titgemeyer, F.7
  • 104
    • 79958171833 scopus 로고    scopus 로고
    • The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239
    • 1:CAS:528:DC%2BC3MXosVSlsb8%3D 21393365
    • Novakova R, Rehakova A, Kutas P, Feckova L, Kormanec J (2011) The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239. Microbiology 157:1629-1639
    • (2011) Microbiology , vol.157 , pp. 1629-1639
    • Novakova, R.1    Rehakova, A.2    Kutas, P.3    Feckova, L.4    Kormanec, J.5
  • 105
    • 58449090159 scopus 로고    scopus 로고
    • Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor
    • 19054329
    • O'Rourke S, Wietzorrek A, Fowler K, Corre C, Challis GL, Chater KF (2009) Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor. Mol Microbiol 71:763-778
    • (2009) Mol Microbiol , vol.71 , pp. 763-778
    • O'Rourke, S.1    Wietzorrek, A.2    Fowler, K.3    Corre, C.4    Challis, G.L.5    Chater, K.F.6
  • 106
    • 84872353481 scopus 로고    scopus 로고
    • New strategies for drug discovery: Activation of silent or weakly expressed microbial gene clusters
    • 1:CAS:528:DC%2BC3sXjtlGhtQ%3D%3D 3536979 23143535
    • Ochi K, Hosaka T (2013) New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters. Appl Microbiol Biotechnol 97:87-98
    • (2013) Appl Microbiol Biotechnol , vol.97 , pp. 87-98
    • Ochi, K.1    Hosaka, T.2
  • 107
    • 84865448283 scopus 로고    scopus 로고
    • A magic bullet for antibiotic discovery
    • 1:CAS:528:DC%2BC38Xht1Kktb7L 22921060
    • Ochi K, Okamoto S (2012) A magic bullet for antibiotic discovery. Chem Biol 19:932-934
    • (2012) Chem Biol , vol.19 , pp. 932-934
    • Ochi, K.1    Okamoto, S.2
  • 108
    • 84895076025 scopus 로고    scopus 로고
    • Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements
    • Ochi K, Tanaka Y, Tojo S (2013) Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements. J Ind Microbiol Biotechnol (submitted)
    • (2013) J Ind Microbiol Biotechnol (Submitted)
    • Ochi, K.1    Tanaka, Y.2    Tojo, S.3
  • 110
    • 0032847109 scopus 로고    scopus 로고
    • The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: Identification of a target gene of the A-factor receptor
    • 1:CAS:528:DyaK1MXmslGqsbY%3D 10540289
    • Ohnishi Y, Kameyama S, Onaka H, Horinouchi S (1999) The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor. Mol Microbiol 34:102-111
    • (1999) Mol Microbiol , vol.34 , pp. 102-111
    • Ohnishi, Y.1    Kameyama, S.2    Onaka, H.3    Horinouchi, S.4
  • 113
    • 79551488636 scopus 로고    scopus 로고
    • Mycolic acid-containing bacteria induce natural-product biosynthesis in Streptomyces species
    • 1:CAS:528:DC%2BC3MXisVOqs7Y%3D 3020563 21097597
    • Onaka H, Mori Y, Igarashi Y (2011) Mycolic acid-containing bacteria induce natural-product biosynthesis in Streptomyces species. Appl Environ Microbiol 77:400-406
    • (2011) Appl Environ Microbiol , vol.77 , pp. 400-406
    • Onaka, H.1    Mori, Y.2    Igarashi, Y.3
  • 114
    • 84880996010 scopus 로고    scopus 로고
    • Clavulanic acid production by Streptomyces clavuligerus: Biogenesis, regulation and strain improvement
    • doi: 10.1038/ja.2013.26
    • Paradkar A (2013) Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement. J Antibiot. doi: 10.1038/ja.2013.26
    • (2013) J Antibiot
    • Paradkar, A.1
  • 115
    • 20444390097 scopus 로고    scopus 로고
    • Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952
    • 1:CAS:528:DC%2BD2MXltFehtr4%3D 15921897
    • Parajuli N, Viet HT, Ishida K, Tong HT, Lee HC, Liou K, Sohng JK (2005) Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952. Res Microbiol 156:707-712
    • (2005) Res Microbiol , vol.156 , pp. 707-712
    • Parajuli, N.1    Viet, H.T.2    Ishida, K.3    Tong, H.T.4    Lee, H.C.5    Liou, K.6    Sohng, J.K.7
  • 116
    • 33846678395 scopus 로고    scopus 로고
    • A cryptic type i polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2)
    • 1:CAS:528:DC%2BD2sXhtFWju7o%3D 17009021
    • Pawlik K, Kotowska M, Chater KF, Kuczek K, Takano E (2007) A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2). Arch Microbiol 187:87-99
    • (2007) Arch Microbiol , vol.187 , pp. 87-99
    • Pawlik, K.1    Kotowska, M.2    Chater, K.F.3    Kuczek, K.4    Takano, E.5
  • 117
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: Confronting the challenges of antibacterial discovery
    • 1:CAS:528:DC%2BD28XhtlGktbfM 17159923
    • Payne DJ, Gwynn MN, Holmes DJ, Pompliano DL (2007) Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 6:29-40
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3    Pompliano, D.L.4
  • 118
    • 84978696453 scopus 로고    scopus 로고
    • Aminoglycosides and sugar components in other secondary metabolites
    • H.J. Rehm G. Reed (eds) 2 VCH-Verlagsgesellschaft Weinheim
    • Piepersberg W, Distler J (1997) Aminoglycosides and sugar components in other secondary metabolites. In: Rehm HJ, Reed G (eds) Products of secondary metabolism, vol. 7, 2nd edn. VCH-Verlagsgesellschaft, Weinheim, pp 397-488
    • (1997) Products of Secondary Metabolism, Vol. 7 , pp. 397-488
    • Piepersberg, W.1    Distler, J.2
  • 120
    • 84865077879 scopus 로고    scopus 로고
    • Genetic and proteomic characterization of rpoB mutations and their effect on nematicidal activity in Photorhabdus luminescens LN2
    • 1:CAS:528:DC%2BC38Xht1CnsbbK 3422287 22912803
    • Qiu X, Yan X, Liu M, Han R (2012) Genetic and proteomic characterization of rpoB mutations and their effect on nematicidal activity in Photorhabdus luminescens LN2. PLoS One 7:e43114
    • (2012) PLoS One , vol.7 , pp. 43114
    • Qiu, X.1    Yan, X.2    Liu, M.3    Han, R.4
  • 121
    • 79955532348 scopus 로고    scopus 로고
    • Microbiology. Alternative actions for antibiotics
    • 1:CAS:528:DC%2BC3MXmsFSnsrw%3D 21527704
    • Ratcliff WC, Denison RF (2011) Microbiology. Alternative actions for antibiotics. Science 332:547-548
    • (2011) Science , vol.332 , pp. 547-548
    • Ratcliff, W.C.1    Denison, R.F.2
  • 122
    • 0017727925 scopus 로고
    • Clavulanic acid: A beta-lactamase-inhibiting beta-lactam from Streptomyces clavuligerus
    • 1:CAS:528:DyaE2sXks1GjtLw%3D 352086 879738
    • Reading C, Cole M (1977) Clavulanic acid: a beta-lactamase-inhibiting beta-lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother 11:852-857
    • (1977) Antimicrob Agents Chemother , vol.11 , pp. 852-857
    • Reading, C.1    Cole, M.2
  • 123
    • 4744343551 scopus 로고    scopus 로고
    • PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis
    • 1:CAS:528:DC%2BD2cXnvFWgs7s%3D 15231842
    • Recio E, Colinas A, Rumbero A, Aparicio JF, Martín JF (2004) PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis. J Biol Chem 279:41586-41593
    • (2004) J Biol Chem , vol.279 , pp. 41586-41593
    • Recio, E.1    Colinas, A.2    Rumbero, A.3    Aparicio, J.F.4    Martín, J.F.5
  • 124
    • 33747043508 scopus 로고    scopus 로고
    • The sugar phosphotransferase system of Streptomyces coelicolor is regulated by the GntR-family regulator DasR and links N-acetylglucosamine metabolism to the control of development
    • 1:CAS:528:DC%2BD28XhtlWqtr7J 16925557
    • Rigali S, Nothaft H, Noens EE, Schlicht M, Colson S, Muller M, Joris B, Koerten HK, Hopwood DA, Titgemeyer F, van Wezel GP (2006) The sugar phosphotransferase system of Streptomyces coelicolor is regulated by the GntR-family regulator DasR and links N-acetylglucosamine metabolism to the control of development. Mol Microbiol 61:1237-1251
    • (2006) Mol Microbiol , vol.61 , pp. 1237-1251
    • Rigali, S.1    Nothaft, H.2    Noens, E.E.3    Schlicht, M.4    Colson, S.5    Muller, M.6    Joris, B.7    Koerten, H.K.8    Hopwood, D.A.9    Titgemeyer, F.10    Van Wezel, G.P.11
  • 125
    • 46449120734 scopus 로고    scopus 로고
    • Feast or famine: The global regulator DasR links nutrient stress to antibiotic production by Streptomyces
    • 1:CAS:528:DC%2BD1cXnvV2rs7Y%3D 2475330 18511939
    • Rigali S, Titgemeyer F, Barends S, Mulder S, Thomae AW, Hopwood DA, van Wezel GP (2008) Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces. EMBO Rep 9:670-675
    • (2008) EMBO Rep , vol.9 , pp. 670-675
    • Rigali, S.1    Titgemeyer, F.2    Barends, S.3    Mulder, S.4    Thomae, A.W.5    Hopwood, D.A.6    Van Wezel, G.P.7
  • 126
    • 67249083329 scopus 로고    scopus 로고
    • Phosphate control over nitrogen metabolism in Streptomyces coelicolor: Direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP
    • 1:CAS:528:DC%2BD1MXntVSqsrY%3D 2691820 19321498
    • Rodriguez-Garcia A, Sola-Landa A, Apel K, Santos-Beneit F, Martin JF (2009) Phosphate control over nitrogen metabolism in Streptomyces coelicolor: direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP. Nucleic Acids Res 37:3230-3242
    • (2009) Nucleic Acids Res , vol.37 , pp. 3230-3242
    • Rodriguez-Garcia, A.1    Sola-Landa, A.2    Apel, K.3    Santos-Beneit, F.4    Martin, J.F.5
  • 127
    • 80052792018 scopus 로고    scopus 로고
    • Antibiotics as signal molecules
    • 1:CAS:528:DC%2BC3MXptlSnurY%3D 3173521 21786783
    • Romero D, Traxler MF, Lopez D, Kolter R (2011) Antibiotics as signal molecules. Chem Rev 111:5492-5505
    • (2011) Chem Rev , vol.111 , pp. 5492-5505
    • Romero, D.1    Traxler, M.F.2    Lopez, D.3    Kolter, R.4
  • 129
    • 83155178456 scopus 로고    scopus 로고
    • The RNA polymerase omega factor RpoZ is regulated by PhoP and has an important role in antibiotic biosynthesis and morphological differentiation in Streptomyces coelicolor
    • 1:CAS:528:DC%2BC3MXhs1Ors7vN 3209170 21908625
    • Santos-Beneit F, Barriuso-Iglesias M, Fernandez-Martinez LT, Martinez-Castro M, Sola-Landa A, Rodriguez-Garcia A, Martin JF (2011) The RNA polymerase omega factor RpoZ is regulated by PhoP and has an important role in antibiotic biosynthesis and morphological differentiation in Streptomyces coelicolor. Appl Environ Microbiol 77:7586-7594
    • (2011) Appl Environ Microbiol , vol.77 , pp. 7586-7594
    • Santos-Beneit, F.1    Barriuso-Iglesias, M.2    Fernandez-Martinez, L.T.3    Martinez-Castro, M.4    Sola-Landa, A.5    Rodriguez-Garcia, A.6    Martin, J.F.7
  • 130
    • 62949243440 scopus 로고    scopus 로고
    • Cross-talk between two global regulators in Streptomyces: PhoP and AfsR interact in the control of afsS, pstS and phoRP transcription
    • 1:CAS:528:DC%2BD1MXkslCktr8%3D 19220751
    • Santos-Beneit F, Rodriguez-Garcia A, Sola-Landa A, Martin JF (2009) Cross-talk between two global regulators in Streptomyces: PhoP and AfsR interact in the control of afsS, pstS and phoRP transcription. Mol Microbiol 72:53-68
    • (2009) Mol Microbiol , vol.72 , pp. 53-68
    • Santos-Beneit, F.1    Rodriguez-Garcia, A.2    Sola-Landa, A.3    Martin, J.F.4
  • 131
    • 0032807332 scopus 로고    scopus 로고
    • Molecular cloning and analysis of a pleiotropic regulatory gene locus from the nystatin producer Streptomyces noursei ATCC11455
    • 1:CAS:528:DyaK1MXkvVCjsrw%3D 10474196
    • Sekurova O, Sletta H, Ellingsen TE, Valla S, Zotchev S (1999) Molecular cloning and analysis of a pleiotropic regulatory gene locus from the nystatin producer Streptomyces noursei ATCC11455. FEMS Microbiol Lett 177:297-304
    • (1999) FEMS Microbiol Lett , vol.177 , pp. 297-304
    • Sekurova, O.1    Sletta, H.2    Ellingsen, T.E.3    Valla, S.4    Zotchev, S.5
  • 132
    • 0001831548 scopus 로고
    • Nitrogen assimilation in actinomycetes and the influence of nitrogen nutrition on actinomycete secondary metabolism
    • S. Shapiro (eds) CRC Press Boca Raton
    • Shapiro S (1989) Nitrogen assimilation in actinomycetes and the influence of nitrogen nutrition on actinomycete secondary metabolism. In: Shapiro S (ed) Regulation of secondary metabolism in actinomycetes. CRC Press, Boca Raton, pp 135-211
    • (1989) Regulation of Secondary Metabolism in Actinomycetes , pp. 135-211
    • Shapiro, S.1
  • 133
    • 84867654069 scopus 로고    scopus 로고
    • Gamma-butyrolactone and furan signaling systems in Streptomyces
    • 1:CAS:528:DC%2BC3sXlvVeitA%3D%3D 23084934
    • Sidda JD, Corre C (2012) Gamma-butyrolactone and furan signaling systems in Streptomyces. Methods Enzymol 517:71-87
    • (2012) Methods Enzymol , vol.517 , pp. 71-87
    • Sidda, J.D.1    Corre, C.2
  • 134
    • 0021064473 scopus 로고
    • Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics
    • 1:CAS:528:DyaL2cXis1Gk 6195156
    • Skinner R, Cundliffe E, Schmidt FJ (1983) Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics. J Biol Chem 258:12702-12706
    • (1983) J Biol Chem , vol.258 , pp. 12702-12706
    • Skinner, R.1    Cundliffe, E.2    Schmidt, F.J.3
  • 135
    • 0038284769 scopus 로고    scopus 로고
    • The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans
    • 1:CAS:528:DC%2BD3sXjvFOltbY%3D 12730372
    • Sola-Landa A, Moura RS, Martin JF (2003) The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc Natl Acad Sci USA 100:6133-6138
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6133-6138
    • Sola-Landa, A.1    Moura, R.S.2    Martin, J.F.3
  • 136
    • 0038284769 scopus 로고    scopus 로고
    • The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans
    • Sola-Landa A, Moura RS, Martín JF (2002) The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc Natl Acad Sci USA 100:6133-6138
    • (2002) Proc Natl Acad Sci USA , vol.100 , pp. 6133-6138
    • Sola-Landa, A.1    Moura, R.S.2    Martín, J.F.3
  • 137
    • 0034051227 scopus 로고    scopus 로고
    • Acetylation of histones and transcription-related factors
    • 1:CAS:528:DC%2BD3cXksVGis7o%3D 98999 10839822
    • Sterner DE, Berger SL (2000) Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev 64:435-459
    • (2000) Microbiol Mol Biol Rev , vol.64 , pp. 435-459
    • Sterner, D.E.1    Berger, S.L.2
  • 138
    • 78650200243 scopus 로고    scopus 로고
    • Regulation of secondary metabolism by chromatin structure and epigenetic codes
    • 1:CAS:528:DC%2BC3cXhsVGnur%2FO 20659575
    • Strauss J, Reyes-Dominguez Y (2011) Regulation of secondary metabolism by chromatin structure and epigenetic codes. Fungal Genet Biol 48:62-69
    • (2011) Fungal Genet Biol , vol.48 , pp. 62-69
    • Strauss, J.1    Reyes-Dominguez, Y.2
  • 139
    • 84874681854 scopus 로고    scopus 로고
    • The ROK family regulator Rok7B7 pleiotropically affects xylose utilization, carbon catabolite repression, and antibiotic production in Streptomyces coelicolor
    • 1:CAS:528:DC%2BC3sXlsFWgsr0%3D 3591991 23292782
    • Swiatek MA, Gubbens J, Bucca G, Song E, Yang YH, Laing E, Kim BG, Smith CP, van Wezel GP (2013) The ROK family regulator Rok7B7 pleiotropically affects xylose utilization, carbon catabolite repression, and antibiotic production in Streptomyces coelicolor. J Bacteriol 195:1236-1248
    • (2013) J Bacteriol , vol.195 , pp. 1236-1248
    • Swiatek, M.A.1    Gubbens, J.2    Bucca, G.3    Song, E.4    Yang, Y.H.5    Laing, E.6    Kim, B.G.7    Smith, C.P.8    Van Wezel, G.P.9
  • 140
    • 84857848545 scopus 로고    scopus 로고
    • Functional analysis of the N-acetylglucosamine metabolic genes of Streptomyces coelicolor and role in the control of development and antibiotic production
    • 1:CAS:528:DC%2BC38XjtV2isLY%3D 3294797 22194457
    • Swiatek MA, Tenconi E, Rigali S, van Wezel GP (2012) Functional analysis of the N-acetylglucosamine metabolic genes of Streptomyces coelicolor and role in the control of development and antibiotic production. J Bacteriol 194:1136-1144
    • (2012) J Bacteriol , vol.194 , pp. 1136-1144
    • Swiatek, M.A.1    Tenconi, E.2    Rigali, S.3    Van Wezel, G.P.4
  • 141
    • 84877715451 scopus 로고    scopus 로고
    • Engineering of N-acetylglucosamine metabolism for improved antibiotic production in Streptomyces coelicolor A3(2) and an unsuspected role of NagA in glucosamine metabolism
    • 3477696 22892576
    • Swiatek MA, Urem M, Tenconi E, Rigali S, van Wezel GP (2012) Engineering of N-acetylglucosamine metabolism for improved antibiotic production in Streptomyces coelicolor A3(2) and an unsuspected role of NagA in glucosamine metabolism. Bioengineered 3:280-285
    • (2012) Bioengineered , vol.3 , pp. 280-285
    • Swiatek, M.A.1    Urem, M.2    Tenconi, E.3    Rigali, S.4    Van Wezel, G.P.5
  • 142
    • 0242405881 scopus 로고    scopus 로고
    • Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus
    • 1:CAS:528:DC%2BD3sXptVyksLo%3D 262278 14602594
    • Tamehiro N, Hosaka T, Xu J, Hu H, Otake N, Ochi K (2003) Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus. Appl Environ Microbiol 69:6412-6417
    • (2003) Appl Environ Microbiol , vol.69 , pp. 6412-6417
    • Tamehiro, N.1    Hosaka, T.2    Xu, J.3    Hu, H.4    Otake, N.5    Ochi, K.6
  • 143
    • 77956254493 scopus 로고    scopus 로고
    • Rare earth elements activate the secondary metabolite-biosynthetic gene clusters in Streptomyces coelicolor A3(2)
    • 1:CAS:528:DC%2BC3cXhtVOnsb%2FK 20551989
    • Tanaka Y, Hosaka T, Ochi K (2010) Rare earth elements activate the secondary metabolite-biosynthetic gene clusters in Streptomyces coelicolor A3(2). J Antibiot 63:477-481
    • (2010) J Antibiot , vol.63 , pp. 477-481
    • Tanaka, Y.1    Hosaka, T.2    Ochi, K.3
  • 144
  • 145
    • 33845811423 scopus 로고    scopus 로고
    • Carbon and nitrogen regulation in Gram-positive bacteria: A tribute to Milton H. Saier, Jr
    • 1:CAS:528:DC%2BD2sXjsFSgtQ%3D%3D 17183206
    • Titgemeyer F (2007) Carbon and nitrogen regulation in Gram-positive bacteria: a tribute to Milton H. Saier, Jr. J Mol Microbiol Biotechnol 12:5-8
    • (2007) J Mol Microbiol Biotechnol , vol.12 , pp. 5-8
    • Titgemeyer, F.1
  • 146
    • 0028000790 scopus 로고
    • Evolutionary relationships between sugar kinases and transcriptional repressors in bacteria
    • 1:CAS:528:DyaK2cXmsleku74%3D 7952186
    • Titgemeyer F, Reizer J, Reizer A, Saier MH Jr (1994) Evolutionary relationships between sugar kinases and transcriptional repressors in bacteria. Microbiology 140:2349-2354
    • (1994) Microbiology , vol.140 , pp. 2349-2354
    • Titgemeyer, F.1    Reizer, J.2    Reizer, A.3    Saier, Jr.M.H.4
  • 148
    • 26244432061 scopus 로고    scopus 로고
    • Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor
    • 1:CAS:528:DC%2BD2MXhtFWit73P 16164554
    • Uguru GC, Stephens KE, Stead JA, Towle JE, Baumberg S, McDowall KJ (2005) Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor. Mol Microbiol 58:131-150
    • (2005) Mol Microbiol , vol.58 , pp. 131-150
    • Uguru, G.C.1    Stephens, K.E.2    Stead, J.A.3    Towle, J.E.4    Baumberg, S.5    McDowall, K.J.6
  • 149
    • 33845751000 scopus 로고    scopus 로고
    • A new piece of an old jigsaw: Glucose kinase is activated posttranslationally in a glucose transport-dependent manner in Streptomyces coelicolor A3(2)
    • 17183213
    • van Wezel GP, Konig M, Mahr K, Nothaft H, Thomae AW, Bibb M, Titgemeyer F (2007) A new piece of an old jigsaw: glucose kinase is activated posttranslationally in a glucose transport-dependent manner in Streptomyces coelicolor A3(2). J Mol Microbiol Biotechnol 12:67-74
    • (2007) J Mol Microbiol Biotechnol , vol.12 , pp. 67-74
    • Van Wezel, G.P.1    Konig, M.2    Mahr, K.3    Nothaft, H.4    Thomae, A.W.5    Bibb, M.6    Titgemeyer, F.7
  • 151
    • 80052077061 scopus 로고    scopus 로고
    • The regulation of the secondary metabolism of Streptomyces: New links and experimental advances
    • 21611665
    • van Wezel GP, McDowall KJ (2011) The regulation of the secondary metabolism of Streptomyces: new links and experimental advances. Nat Prod Rep 28:1311-1333
    • (2011) Nat Prod Rep , vol.28 , pp. 1311-1333
    • Van Wezel, G.P.1    McDowall, K.J.2
  • 152
    • 64249163186 scopus 로고    scopus 로고
    • Chapter 5. Applying the genetics of secondary metabolism in model actinomycetes to the discovery of new antibiotics
    • 19374981
    • van Wezel GP, McKenzie NL, Nodwell JR (2009) Chapter 5. Applying the genetics of secondary metabolism in model actinomycetes to the discovery of new antibiotics. Methods Enzymol 458:117-141
    • (2009) Methods Enzymol , vol.458 , pp. 117-141
    • Van Wezel, G.P.1    McKenzie, N.L.2    Nodwell, J.R.3
  • 154
    • 0033763852 scopus 로고    scopus 로고
    • Application of redD, the transcriptional activator gene of the undecylprodigiosin biosynthetic pathway, as a reporter for transcriptional activity in Streptomyces coelicolor A3(2) and Streptomyces lividans
    • 11075931
    • van Wezel GP, White J, Hoogvliet G, Bibb MJ (2000) Application of redD, the transcriptional activator gene of the undecylprodigiosin biosynthetic pathway, as a reporter for transcriptional activity in Streptomyces coelicolor A3(2) and Streptomyces lividans. J Mol Microbiol Biotechnol 2:551-556
    • (2000) J Mol Microbiol Biotechnol , vol.2 , pp. 551-556
    • Van Wezel, G.P.1    White, J.2    Hoogvliet, G.3    Bibb, M.J.4
  • 156
    • 0026656738 scopus 로고
    • Secondary metabolism, inventive evolution and biochemical diversity: A review
    • 1:CAS:528:DyaK38Xks1Kisbw%3D 1612428
    • Vining LC (1992) Secondary metabolism, inventive evolution and biochemical diversity: a review. Gene 115:135-140
    • (1992) Gene , vol.115 , pp. 135-140
    • Vining, L.C.1
  • 157
    • 0028171561 scopus 로고
    • AfsR2: A previously undetected gene encoding a 63-amino-acid protein that stimulates antibiotic production in Streptomyces lividans
    • 1:CAS:528:DyaK2MXivFansrc%3D 7891553
    • Vogtli M, Chang PC, Cohen SN (1994) afsR2: a previously undetected gene encoding a 63-amino-acid protein that stimulates antibiotic production in Streptomyces lividans. Mol Microbiol 14:643-653
    • (1994) Mol Microbiol , vol.14 , pp. 643-653
    • Vogtli, M.1    Chang, P.C.2    Cohen, S.N.3
  • 159
    • 84895073940 scopus 로고    scopus 로고
    • WHO-Media-centre Antimicrobial resistance WHO
    • WHO-Media-centre (2012) Antimicrobial resistance WHO. http://www.who.int/mediacentre/factsheets/fs194/en/
    • (2012)
  • 160
    • 0030929313 scopus 로고    scopus 로고
    • A novel family of proteins that regulates antibiotic production in Streptomyces appears to contain an OmpR-like DNA-binding fold
    • 1:CAS:528:DyaK2sXmslWmurY%3D 9350875
    • Wietzorrek AM, Bibb (1997) A novel family of proteins that regulates antibiotic production in Streptomyces appears to contain an OmpR-like DNA-binding fold. Mol Microbiol 25:1181-1184
    • (1997) Mol Microbiol , vol.25 , pp. 1181-1184
    • Wietzorrek, A.M.1    Bibb2
  • 161
    • 78651404410 scopus 로고    scopus 로고
    • Morphogenetic signaling molecules of the streptomycetes
    • 1:CAS:528:DC%2BC3cXhsVGktrnM 21090718
    • Willey JM, Gaskell AA (2011) Morphogenetic signaling molecules of the streptomycetes. Chem Rev 111:174-187
    • (2011) Chem Rev , vol.111 , pp. 174-187
    • Willey, J.M.1    Gaskell, A.A.2
  • 162
    • 84895074348 scopus 로고
    • Studies on the physiology of a streptomycin-producing strain of Streptomyces griseus on proline medium
    • 1:CAS:528:DyaH1MXptVY%3D 518584
    • Woodruff HB, Ruger M (1948) Studies on the physiology of a streptomycin-producing strain of Streptomyces griseus on proline medium. J Bacteriol 56:315-321
    • (1948) J Bacteriol , vol.56 , pp. 315-321
    • Woodruff, H.B.1    Ruger, M.2
  • 164
    • 0000224884 scopus 로고    scopus 로고
    • Microbial hormones and microbial chemical ecology
    • K. Mori (eds) Elsevier Scientific Publishers Dordrecht
    • Yamada Y, Nihira T (1999) Microbial hormones and microbial chemical ecology. In: Mori K (ed) Comprehensive natural products chemistry, vol. 8. Elsevier Scientific Publishers, Dordrecht, pp 377-413
    • (1999) Comprehensive Natural Products Chemistry, Vol. 8 , pp. 377-413
    • Yamada, Y.1    Nihira, T.2
  • 165
    • 38949186517 scopus 로고    scopus 로고
    • γ-Butyrolactone-dependent expression of the streptomyces antibiotic regulatory protein gene srrY plays a central role in the regulatory cascade leading to Lankacidin and lankamycin production in Streptomyces rochei
    • 1:CAS:528:DC%2BD1cXhvVOls74%3D 2238197 18083808
    • Yamamoto S, He Y, Arakawa K, Kinashi H (2008) γ-Butyrolactone- dependent expression of the streptomyces antibiotic regulatory protein gene srrY plays a central role in the regulatory cascade leading to Lankacidin and lankamycin production in Streptomyces rochei. J Bacteriol 190:1308-1316
    • (2008) J Bacteriol , vol.190 , pp. 1308-1316
    • Yamamoto, S.1    He, Y.2    Arakawa, K.3    Kinashi, H.4
  • 166
    • 84857912851 scopus 로고    scopus 로고
    • A novel function of Streptomyces integration host factor (sIHF) in the control of antibiotic production and sporulation in Streptomyces coelicolor
    • 1:CAS:528:DC%2BC38XisFWisrs%3D 22038127
    • Yang YH, Song E, Willemse J, Park SH, Kim WS, Kim EJ, Lee BR, Kim JN, van Wezel GP, Kim BG (2012) A novel function of Streptomyces integration host factor (sIHF) in the control of antibiotic production and sporulation in Streptomyces coelicolor. Antonie Van Leeuwenhoek 101:479-492
    • (2012) Antonie Van Leeuwenhoek , vol.101 , pp. 479-492
    • Yang, Y.H.1    Song, E.2    Willemse, J.3    Park, S.H.4    Kim, W.S.5    Kim, E.J.6    Lee, B.R.7    Kim, J.N.8    Van Wezel, G.P.9    Kim, B.G.10
  • 167
    • 73549086351 scopus 로고    scopus 로고
    • Translating metabolic exchange with imaging mass spectrometry
    • 1:CAS:528:DC%2BD1MXhsVWlsbrM 2778862 19915536
    • Yang YL, Xu Y, Straight P, Dorrestein PC (2009) Translating metabolic exchange with imaging mass spectrometry. Nat Chem Biol 5:885-887
    • (2009) Nat Chem Biol , vol.5 , pp. 885-887
    • Yang, Y.L.1    Xu, Y.2    Straight, P.3    Dorrestein, P.C.4
  • 168
    • 84864103526 scopus 로고    scopus 로고
    • Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor
    • 1:CAS:528:DC%2BC38XhtFCku7zE 22676800
    • Yu Z, Zhu H, Dang F, Zhang W, Qin Z, Yang S, Tan H, Lu Y, Jiang W (2012) Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor. Mol Microbiol 85:535-556
    • (2012) Mol Microbiol , vol.85 , pp. 535-556
    • Yu, Z.1    Zhu, H.2    Dang, F.3    Zhang, W.4    Qin, Z.5    Yang, S.6    Tan, H.7    Lu, Y.8    Jiang, W.9
  • 169
    • 65549083361 scopus 로고    scopus 로고
    • Strategies for the discovery of new natural products by genome mining
    • 1:CAS:528:DC%2BD1MXjsVaisr8%3D
    • Zerikly M, Challis GL (2009) Strategies for the discovery of new natural products by genome mining. Chembiochem: Eur J Chem Biol 10:625-633
    • (2009) Chembiochem: Eur J Chem Biol , vol.10 , pp. 625-633
    • Zerikly, M.1    Challis, G.L.2


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