afsS is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in Streptomyces coelicolor A3(2)

Molecular Microbiology

Volumn 43, Issue 6, 2002, Pages 1413-1430

  Lee, Ping Chin ^a   Umeyama, Takashi ^a,b   Horinouchi, Sueharu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINORHODINE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEIN; DEOXYRIBONUCLEASE; GUANOSINE TRIPHOSPHATASE; PRODIGIOSIN; PROTEIN AFSR; PROTEIN AFSS; PROTEIN SERINE KINASE; REGULATOR PROTEIN; RNA POLYMERASE; SERINE; THREONINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL METABOLISM; BINDING SITE; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; GENE ACTIVATION; GENETIC TRANSCRIPTION; HYDROLYSIS; ISOMERISM; METABOLIC REGULATION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; STREPTOMYCES COELICOLOR;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; ANTHRAQUINONES; BACTERIAL PROTEINS; BASE SEQUENCE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; STREPTOMYCES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); PROKARYOTA; STREPTOMYCES; STREPTOMYCES COELICOLOR; UNCULTURED ACTINOMYCETE;

EID: 0036268103     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02840.x     Document Type: Article

References (60)

1. Allosteric underwinding of DNA is a critical step in positive control of transcription by Hg-MerR
2. DNA-bend modulation in a repressor-to-activator switching mechanism
3. Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein
4. The prokaryotic enhancer binding protein NTRC has an ATPase activity which is phosphorylation and DNA dependent
5. Nucleotide sequence and exact localisation of the neomycin phosphotransferase gene from transposon Tn5
6. Genetic studies of the fertility plasmid SCP1 and its SCP1* variants in Streptomyces coelicolor A3(2)
7. 1 ATPase family of proteins
8. The act cluster contains regulatory and antibiotic export genes, direct targets for transcriptional control by the bldA tRNA gene of Streptomyces
9. A common switch in activation of the response regulators NtrC and PhoB: Phosphorylation induces dimerization of the receiver modules
10. afsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2)
11. Modular structure of transcription factors: Implications for gene regulation
12. PcaR-mediated activation and repression of pca genes from Pseudomonas putida are propagated by its binding to both the -35 and the -10 promoter elements
13. An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein
14. Spacing of promoter elements regulates the basal expression of the soxS gene and converts SoxR from a transcriptional activator into a repressor
15. Phosphorylation of the afsR product, a global regulatory protein for secondary-metabolite formation in Streptomyces coelicolor A3(2)
16. Production in large quantities of actinorhodin and undecylprodigiosin induced by afsB. Streptomyces lividans
17. Cloning of a pleiotropic gene that positively controls biosynthesis of A-factor, actinorhodin, and prodigiosin in Streptomyces coelicolor A3(2) and Streptomyces lividans
18. afsB stimulates transcription of the actinorhodin biosynthetic pathway in Streptomyces coelicolor A3(2) and Streptomyces lividans
19. Primary structure of AfsR, a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2)
20. Regulation by A-factor and afsR of secondary metabolism and morphogenesis in Streptomyces
21. Cloning of large DNA fragments, which hybridize with actinorhodin biosynthesis genes, from kalafungin and nanaomycin A methyl ester producers and identification of genes for kalafungin biosynthesis of the kalafungin producer
22. Acid and base hydrolysis of phosphoproteins bound to immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins
23. Cloning and expression of the tyrosinase gene from Streptomyces antibioticus in Streptomyces lividans
24. The position of the sigma-factor genes, whiG and sigF, in the hierarchy controlling the development of spores chains in the aerial hyphae of Streptomyces coelicolor A3(2)
25. Modulation of actinorhodin biosynthesis in Streptomyces lividans by glucose repression of afsR2 gene transcription
26. Phosphorylation-induced signal propagation in the response regulator NtrC
27. Phosphorylation of the AfsR protein involved in secondary metabolism in Streptomyces species by a eukaryotic-type protein kinase
28. Involvement of a small ORF downstream of the afsR gene in the regulation of secondary metabolism in Streptomyces coelicolor A3(2)
29. Sequencing end-labeled DNA with base-specific chemical cleavages
30. Nucleotide sequence and transcriptional analysis of the redD locus of Streptomyces coelicolor A3(2)
31. Prokaryotic enhancer-binding proteins reflect eukaryote-like modularity: The puzzle of nitrogen regulatory protein C
32. Genetic mapping and characterization of novel mutations which suppress the effect of a relC mutation on antibiotic production in Streptomyces coelicolor A3(2)
33. Denaturation of circular or linear DNA facilitates targeted integrative transformation of Streptomyces coelicolor A3(2): Possible relevance to other organisms
34. A mutation at proline-115 in the A-factor receptor protein of Streptomyces griseus abolishes DNA-binding ability but not ligand-binding ability
35. A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligenus: Amplification results in overproduction of both beta-lactam compounds
36. Oligomerization of NTRC at the glnA enhancer is required for transcriptional activation
37. Construction and analysis of in vivo activity of E. coli promoter hybrids and promoter mutants that alter the -35 to -10 spacing
38. Molecular cloning and analysis of a pleiotropic regulatory gene locus from the nystatin producer Streptomyces noursei ATCC11455
39. The nucleotide sequence of the initiation and termination sites for ribosomal RNA transcription in X. leavis
40. A cloned regulatory gene of Streptomyces lividans can suppress the pigment deficiency phenotype of different developmental mutants
41. Compilation and analysis of DNA sequences associated with apparent streptomycete promoters
42. Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius
43. Purification and characterization of the DNA-binding protein DnrI, a transcriptional factor of daunorubicin biosynthesis in Streptomyces peucetius
44. Autophosphorylation of a bacterial serine/threonine kinase, AfsK, is inhibited by KbpA, an AfsK-binding protein
45. An AfsK/AfsR system involved in the response of aerial mycelium formation to glucose in Streptomyces griseus
46. afsR2: A previously undetected gene encoding a 63-amino-acid protein that stimulates antibiotic production in Streptomyces lividans
47. Detection of an A-factor-responsive protein that binds to the upstream activation sequence of strR, a regulatory gene for streptomycin biosynthesis in Streptomyces griseus
48. Construction and characterization of a series of multi-copy plasmid vectors for Streptomyces using the aminoglycoside phosphotransferase gene from Tn5 as indicator
49. The bacterial enhancer-binding protein NTRC is a molecular machine: ATP hydrolysis is coupled to transcriptional activation
50. The phosphorylated form of the enhancer-binding protein NTRC has an ATPase activity that is essential for activation of transcription
51. Phosphorylation of nitrogen regulator I of Escherichia coli induces strong cooperative binding to DNA essential for activation of transcription
52. A novel family of proteins that regulate antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold
53. Unusual oligomerization required for activity of NtrC, a bacterial enhancer-binding protein
54. AdsA) that is essential for morphological development in Streptomyces griseus
55. Improved M13 phage cloning vectors and host strains: Nucleotide sequences of M13mp18 and pUC19 vectors
56. Involvement of amfC in physiological and morphological development in Streptomyces coelicolor A3(2)
57. A common topology of proteins catalyzing ATP-triggered reactions