Identification and functional characterization of an afsR homolog regulatory gene from Streptomyces venezuelae ATCC 15439

Journal of Microbiology and Biotechnology

Volumn 19, Issue 2, 2009, Pages 121-127

  Maharjan, Sushila ^a   Oh, Tae Jin ^a   Lee, Hei Chan ^a   Sohng, Jae Kyung ^a  

^a SunMoon University   (South Korea)

Author keywords

afsR sv; Regulatory gene; Reverse transcriptase PCR; SARP family; Streptomyces venezuelae

Indexed keywords

AFSR PROTEIN; DNA FRAGMENT; PIKROMYCIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL GENETICS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG SYNTHESIS; ESCHERICHIA COLI; GENE ACTIVATION; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HETEROLOGOUS EXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PROTEIN DOMAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRAIN DIFFERENCE; STREPTOMYCES LIVIDANS; STREPTOMYCES VENEZUELAE; TETRATRICOPEPTIDE REPEAT;

BACTERIAL PROTEINS; DNA, BACTERIAL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, REGULATOR; MACROLIDES; OPEN READING FRAMES; SEQUENCE ANALYSIS, DNA; STREPTOMYCES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS); STREPTOMYCES; STREPTOMYCES VENEZUELAE;

EID: 64549133456     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.0803.223     Document Type: Article

References (32)

1. Arias, P., M. A. Fernández-Moreno, and F. Malpartida. 1999. Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein. J. Bacteriol. 181: 6958-6968.
2. Bibb, M. 1996. 1995 Colworth Prize Lecture. The regulation of antibiotic production in Streptomyces coelicolor A3(2). Microbiology 142: 1335-1344.
3. Bystrykh, L. V., M. A. FernáNdez-Moreno, J. K. Herrema, F. Malpartida, D. A. Hopwood, and L. Dijkhuizen. 1996. Production of actinorhodin-related "blue pigments" by Streptomyces coelicolor A3(2). J. Bacteriol. 178: 2238-2244.
4. Demain, A. L. 1999. Pharmaceutically active secondary metabolites of microorganisms. Appl. Microbiol. Biotechnol. 52: 455-463.
5. Floriano, B. and M. Bibb. 1996. afsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2). Mol. Microbiol. 21: 385-396.
6. Hopwood, D. A., K. F. Chater, and M. J. Bibb. 1995. Genetics of antibiotic production in Streptomyces coelicolor A3(2), a model streptomycete. Biotechnology 28: 65-102.
7. Horinouchi, S. 2003. AfsR as an integrator of signals that are sensed by multiple serine/threonine kinases in Streptomyces coelicolor A3(2). J. Ind. Microbiol. Biotechnol. 30: 462-467.
8. Im, J. H., M. G. Kim, and E. S. Kim. 2007. Comparative transcriptome analysis for avermectin overproduction via Streptomyces avermitilis microarray system. J. Microbiol. Biotechnol. 17: 534-538.
9. Kieser, T., J. B. Mervyn, B. J. Mark, C. F. Keith, and D. A. Hopwood. 2000. Practical Streptomyces Genetics. John Innes Foundation Norwich, U.K.
10. Kim, C. Y., H. J. Park, and E. S. Kim. 2006. Functional dissection of sigma-like domain in antibiotic regulatory gene, afsR2 in Streptomyces lividans. J. Microbiol. Biotechnol. 16: 1477-1480.
11. Kim, E. S., H. J. Hong, C. Y. Choi, and S. N. Cohen. 2001. Modulation of actinorhodin biosynthesis in Streptomyces lividans by glucose repression of afsR2 gene transcription. J. Bacteriol. 183: 2198-2203.
12. Kim, Y. J., J. Y. Song, M. H. Moon, C. P. Smith, S. K. Hong, and Y. K. Chang. 2007. pH shock induces overexpression of regulatory and biosynthetic genes for actinorhodin production in Streptomyces coelicolor A3(2). Appl. Microbiol. Biotechnol. 76: 1119-1130.
13. Lee, P. C., T. Umeyama, and S. Horinouchi. 2002. afsS is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in Streptomyces coelicolor A3(2). Mol. Microbiol. 43: 1413-1430.
14. Lee, S. K., J. W. Park, J. W. Kim, W. S. Jung, S. R. Park, C. Y. Choi, et al. 2006. Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae. J. Nat. Prod. 69: 847-849.
15. Maezawa, I., A. Kinumaki, and M. Suzuki. 1978. Biological glycosidation of macrolide aglycones. II. Isolation and characterization of desosaminyl-platenolide I. J. Antibiot. (Tokyo) 31: 309-318.
16. Pageni, B. B., T. J. Oh, K. Liou, Y. J. Yoon, and J. K. Sohng. 2008. Genetically engineered biosynthesis of macrolide derivatives including 4-amino-4,6-dideoxy-L-glucose from Streptomyces Venezuelae YJ003-OTBP3. J. Microbiol. Biotechnol. 18: 88-94.
17. Parajuli, N., H. T. Viet, K. Ishida, H. T. Tong, H. C. Lee, K. Liou, and J. K. Sohng. 2005. Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952. Res. Microbiol. 156: 707-712.
18. Perlman, D. 1953. Colorimetric method for determination of aureomycin, carbomycin, erythromycin, and terramycin in aqueous solution. Science 118: 628-629.
19. Rajkarnikar, A., H. J. Kwon, Y. W. Ryu, and J. W. Suh. 2007. Two threonine residues required for role of AfsKav in controlling morphogenesis and avermectin production in Streptomyces avermitilis. J. Microbiol. Biotechnol. 17: 1563-1567.
20. Richet, E. and O. Raibaud. 1989. MalT, the regulatory protein of the Escherichia coli maltose system, is an ATP-dependent transcriptional activator. EMBO J. 8: 981-987.
21. Sambrook, J. and D. W. Russel. 2001. Molecular Cloning: A Laboratory Manual, 3 Ed. Cold Spring Harbor Laboratory Press, New York, U.S.A.
22. Schreiber, V. and E. Richet. 1999. Self-association of the Escherichia coli transcription activator MalT in the presence of maltotriose and ATP. J. Biol. Chem. 19: 33220-33226.
23. Sheldon, P. J., S. B. Busarow, and C. R. Hutchinson. 2002. Mapping the DNA-binding domain and target sequences of the Streptomyces peucetius daunorubicin biosynthesis regulatory protein, DnrI. Mol. Microbiol. 44: 449-460.
24. Sthapit, B., T. J. Oh, R. Lamichhane, K. Liou, H. C. Lee, C. G. Kim, and J. K. Sohng. 2004. Neocarzinostatin naphthoate synthase: An unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus. FEBS Lett. 566: 201-206.
25. Tanaka, A., Y. Takano, Y. Ohnishi, and S. Horinouchi. 2007. AfsR recruits RNA polymerase to the afsS promoter: A model for transcriptional activation by SARPs. J. Mol. Biol. 369: 322-333.
26. Thompson, J. D., T. J. Gibson, F. Plewniak, F. Jeanmougin, and D. G. Higgins. 1997. The ClustalX Windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 24: 4876-4882.
27. Tomono, A., M. Mashiko, T. Shimazu, H. Inoue, H. Nagasawa, M. Yoshida, Y. Ohnishi, and S. Horinouchi. 2006. Self-activation of serine/threonine kinase AfsK on autophosphorylation at threonine-168. J. Antibiot. (Tokyo) 59: 117-123.
28. Umeyama, T. and S. Horinouchi. 2001. Autophosphorylation of a bacterial serine/threonine kinase, AfsK, is inhibited by KbpA, an AfsK-binding protein. J. Bacteriol. 183: 5506-5512.
29. Umeyama, T., P. C. Lee, and S. Horinouchi. 2002. Protein serine/ threonine kinases in signal transduction for secondary metabolism and morphogenesis in Streptomyces. Appl. Microbiol. Biotechnol. 59: 419-425.
30. Umeyama, T., P. C. Lee, K. Ueda, and S. Horinouchi. 1999. An AfsK/AfsR system involved in the response of aerial mycelium formation to glucose in Streptomyces griseus. Microbiology 145: 2281-2292.
31. Wilson, D. J., Y. Xue, K. A. Reynolds, and D. H. Sherman. 2001. Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. J. Bacteriol. 183: 3468-3475.
32. Xue, Y., L. Zhao, H. W. Liu, and D. H. Sherman. 1998. A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: Architecture of metabolic diversity. Proc. Natl. Acad. Sci. USA 95: 12111-12116.