Identification of an AfsA homologue (BarX) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis, virginiamycin biosynthesis and virginiamycin M1 resistance

Molecular Microbiology

Volumn 36, Issue 2, 2000, Pages 302-313

  Kawachi, Ryu ^a   Akashi, Takahiro ^a   Kamitani, Yuka ^a   Sy, Arleen ^a   Wangchaisoonthorn, Usamas ^a   Nihira, Takuya ^a   Yamada, Yasuhiro ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

REGULATOR PROTEIN; VIRGINIAMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BIOSYNTHESIS; DELETION MUTANT; DNA BINDING; DNA SEQUENCE; NONHUMAN; OPEN READING FRAME; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; STREPTOMYCES;

BACTERIAL PROTEINS; BASE SEQUENCE; DNA, BACTERIAL; DRUG RESISTANCE, MICROBIAL; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PHENOTYPE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; STREPTOMYCES; TRANSCRIPTION, GENETIC; VIRGINIAMYCIN;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); PROKARYOTA; STREPTOMYCES COELICOLOR; STREPTOMYCES GRISEUS; STREPTOMYCES VIRGINIAE; UNCULTURED ACTINOMYCETE; VIRGINIAE;

EID: 0034011484     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2000.01819.x     Document Type: Article

References (47)

1. Ando, N., Matsumori, N., Sakuda, S., Beppu, T., and Horinouchi, S. (1997) Involvement of AfsA in A-factor biosynthesis as a key enzyme. J Antibiot 50: 847-852.
2. Bibb, M.J., Findlay, P.R., and Johnson, M.W. (1984) The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein-coding sequences. Gene 30: 157-166.
3. Fernandez-Moreno, M.A., Caballero, J.L., Hopwood, D.A., and Malpartida, F. (1991) The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces. Cell 66: 769-780.
4. Hallam, S.E., Malpartida, F., and Hopwood, D.A. (1988) Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor. Gene 74: 305-320.
5. Hanahan, D. (1983) Studies on transformation of Escherichia coli with plasmids. J Mol Biol 166: 557-580.
6. Hanahan, D., Jessee, J., and Bloom, F.R. (1991) Plasmid transformation of Escherichia coli and other bacteria. Methods Enzymol 204: 63-113.
7. Hashimoto, K., Nihira, T., Sakuda, S., and Yamada, Y. (1992) IM-2, a butyrolactone autoregulator, induces production of several nucleoside antibiotics in Streptomyces sp. FRI-5. J Ferment Bioeng 73: 449-455.
8. Hopwood, D.A., Bibb, M.J., Chater, K.F., Kieser, T., Bruton, C.J., Kieser, H.M., et al. (1985) Genetic Manipulation of Streptomyces: a Laboratory Manual. Norwich: The John Innes Foundation.
9. Horinouchi, S., Suzuki, H., Nishiyama, M., and Beppu, T. (1989) Nucleotide sequence and transcriptional analysis of the Streptomyces griseus gene (afsA) responsible for A-factor biosynthesis. J Bacteriol 171: 1206-1210.
10. Hyde, S.C., Elmsley, P., Hartshorn, M., Mimmack, M.M., Gileadi, U., Pearce, S.R., et al. (1990) Structural model of ATP-binding proteins associated with cyctic fibrosis, muitidrug resistance and bacterial transport. Nature 346: 362-365.
11. Kawachi, R., Nihira, T., and Yamada, Y. (1997) Development of a transformation system in Streptomyces virginiae. Actinomycetologica 11: 46-53.
12. Kim, H.S., Nihira, T., Tada, H., Yanagimoto, M., and Yamada, Y. (1989) Identification of binding protein of virginiae butanolide C, an autoregulator in virginiamycin production, from Streptomyces virginiae. J Antibiot 42: 769-778.
13. Kim, H.S., Tada, H., Nihira, T., and Yamada, Y. (1990) Purification and characterization of virginiae butanolide C-binding protein, a possible pleiotropic signal-transducer in Streptomyces virginiae. J Antibiot 43: 692-706.
14. Kinoshita, H., Ipposhi, H., Okamoto, S., Nakano, H., Nihira, T., and Yamada, Y. (1997) Butyrolactone autoregulator receptor protein (BarA) as a transcriptional regulator in Streptomyces virginiae. J Bacteriol 179: 6986-6993.
15. Kinoshita, H., Tsuji, T., Ipposhi, H., Nihira, T., and Yamada, Y. (1999) Characterization of binding sequences for butyrolactone autoregulator receptors in Streptomycetes. J Bacteriol 181: 5075-5080.
16. Kleiner, E.M., Pliner, S.A., Soifer, V.S., Onoprienko, V.V., Blashova, T.A., Rosynov, B.V., et al. (1976) The structure of A-factor, a bioregulator from Streptomyces griseus. Bioorg Khim 2: 1142-1147.
17. Kondo, K., Higuchi, Y., Sakuda, S., Nihira, T., and Yamada, Y. (1989) New virginiae butanolides from Streptomyces virginiae. J Antibiot 42: 1873-1876.
18. Lee, C.K., Kamitani, Y., Nihira, T., and Yamada, Y. (1999) Identification and in vivo functional analysis of a virginiamycin S resistance gene (varS) from Streptomyces virginiae. J Bacteriol 181: 3293-3297.
19. 1 as the virginiamycin resistance pathway in Streptomyces virginiae. Antimicrob Agents Chemother 40: 595-601.
20. Merson-Davies, L.A., and Cundliffe, E. (1994) Analysis of five tylosin biosynthetic genes from the tyIIBA region of the Streptomyces fradiae genome. Mol Microbiol 13: 349-355.
21. Mizuno, K., Sakuda, S., Nihira, T., and Yamada, Y. (1994) Enzymatic resolution of 2-acyl-3-hydroxymethyl-4-butanolide and preparation of optically active IM-2, the autoregulator from Streptomyces sp. FRI-5. Tetrahedron 50: 10849-10858.
22. Mori, K. (1983) Revision of the absolute configuration of A-factor. Tetrahedron 39: 3107-3109.
23. Nakano, H., Takehara, E., Nihira, T., and Yamada, Y. (1998) Gene replacement analysis of the Streptomyces virginiae barA gene encoding the butyrolactone autoregulator receptor reveals that BarA acts as a repressor in virginiamycin biosynthesis. J Bacteriol 180: 3317-3322.
24. Narva, K.E., and Feitelson, J.S. (1990) Nucleotide sequence and transcriptional analysis of the redD locus of Streptomyces coelicolor A3(2). J Bacteriol 172: 326-333.
25. Nihira, T., Shimizu, Y., Kim, H.S., and Yamada, Y. (1988) Structure-activity relationships of virginiae butanolide C, an inducer of virginiamycin production in Streptomyces virginiae. J Antibiot 41: 1828-1837.
26. Okamoto, S., Nakamura, N., Nihira, T., and Yamada, Y. (1995) Virginiae butanolide binding protein from Streptomyces virginiae. J Biol Chem 270: 12319-12326.
27. Olano, C., Rodriguez, A.M., Mendez, C., and Salas, J.A. (1995) A second ABC-transporter is involved in oleandomycin resistance and its secretion by Streptomyces antibiotics. Mol Microbionl 16: 333-343.
28. Onaka, H., Ando, N., Nihira, T., Yamada, Y., Beppu, T., and Horinouchi, S. (1995) Cloning and characterization of the A-factor receptor gene from Streptomyces griseus. J Bacteriol 177: 6083-6092.
29. Onaka, H., Nakagawa, T., and Horinouchi, S. (1998) Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3(2): in the regulation of secondary metabolism and morphogenesis. Mol Microbiol 28 (4): 743-753.
30. Persson, B., Krook, M., and Jörnvall, H. (1991) Charactaristics of short-chain alcohol dehydrogenases and related enzymes. Eur J Biochem 200: 537-543.
31. Peschke, U., Schmidt, H., Zhang, H., and Piepersberg, W. (1995) Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11. Mol Microbiol 16: 1137-1156.
32. Rosteck, P.R. Jr, Reynolds, P.A., and Hershberger, C.L. (1991) Homology between proteins controling Streptomyces fradiae tylosin resistance and ATP-binding transport. Gene 102: 27-32.
33. Sakuda, S., and Yamada, Y. (1991) Stereochemistry of butyrolactone autoregulators from Streptomyces. Tetrahedron Lett 32: 1817-1820.
34. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning, A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
35. Sanger, F., Nicklen, S., and Coulson, A.R. (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74: 5463-5467.
36. Sato, K., Nihira, T., Kondo, K., Yanagimoto, M., and Yamada, Y. (1989) Isolation and structure of a new butyrolactone autoregurator from Streptomyces sp. FRI-5. J Ferment Bioeng 68: 170-173.
37. Scrutton, N.S., Berry, A., and Perham, R.N. (1990) Redesign of the coenzyme specificity of a dehydrogenase by protein engineering. Nature 343: 38-43.
38. Shikura, N., Nihira, T., and Yamada, Y. (1999) Identification and characterization of 6-dehydro VB-A reductase from Streptomyces antibiotics. FEMS Microbiol Lett 171: 183-189.
39. Stutzman-Engwell, K.J., Otten, S.L., and Hutchinson, C.R. (1992) Regulation of secondary metabolism in Streptomyces spp. & overproduction of daunorubicin in Streptomyces peucetius. J Bacteriol 174: 144-154.
40. Sugiyama, M., Onaka, H., Nakagawa, T., and Horinouchi, S. (1998) Site-directed mutagenesis of the A-factor receptor protein: Val-41 important for DNA-binding and Trp-119 important for ligamd-binding. Gene 222: 133-144.
41. Waki, M., Nihira, T., and Yamada, Y. (1997) Cloning and characterization of the gene (farA) encoding the receptor for an extracellular regulatory factor (IM-2) from Streptomyces sp. strain FRI-5. J Bacteriol 179: 5131-5137.
42. Walker, J.A., Saraste, M., Runswick, M.J., and Gay, N.J. (1982) Distantly related sequences in the α-and β-subunits of ATP synthase, myosin, kinase and other ATP-requiring enzymes and a common nucleotide binding told. EMBO J 1: 945-951.
43. Wehmeier, U.F. (1995) New multifunctional Escherichia coli-Streptomyces shuttle vectors allowing blue-white screening on XGal plates. Gene 165: 149-150.
44. Yamada, Y., and Nihira, T. (1998) Microbial hormones and microbial chemical ecology. In Comprehensive Natural Products Chemistry, Vol. 8. Barton, D.H.R., Nakanishi, K., and Meth-Cohn, O. (eds). Oxford: Elsevier Science Ltd, pp. 377-413.
45. Yamada, Y., Sugamura, K., Kondo, K., Yanagimoto, M., and Okada, H. (1987) The structure of inducing factors for virginiamycin production in Streptomyces virginiae. J Antibiot 40: 496-504.
46. Yanagimoto, M. (1983) Novel actions of inducer in staphylomycin production by Streptomyces virginiae. J Ferment Technol 61: 443-448.
47. Yanisch-Perron, C., Viera, J., and Messing, J. (1985) Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33: 103-119.