Clavulanic acid production by Streptomyces clavuligerus: Biogenesis, regulation and strain improvement

Journal of Antibiotics

Volumn 66, Issue 7, 2013, Pages 411-420

  Paradkar, Ashish ^a  

^a DUPONT COMPANY   (United States)

Author keywords

lactams; Actinomycetes; clavulanic acid; secondary metabolism; Streptomyces

Indexed keywords

CEPHAMYCIN C; CLAVULANIC ACID; SIGMA FACTOR;

ANTIBIOTIC BIOSYNTHESIS; BINDING AFFINITY; BIOGENESIS; CHROMOSOME; DEAMINATION; DNA FOOTPRINTING; DNA SEQUENCE; ELECTRON TRANSPORT; ENZYMATIC DEGRADATION; FATTY ACID DESATURATION; GENE CLUSTER; GENE DOSAGE; GENE EXPRESSION; GENOME; GLUCONEOGENESIS; HYDROLYSIS; MOLECULAR CLONING; MORPHOGENESIS; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; REGULATOR GENE; REGULATORY MECHANISM; REVIEW; STEREOCHEMISTRY; STRAIN IMPROVEMENT; STREPTOMYCES CLAVULIGERUS;

ANTI-BACTERIAL AGENTS; BIOSYNTHETIC PATHWAYS; CLAVULANIC ACID; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; INDUSTRIAL MICROBIOLOGY; METABOLIC ENGINEERING; STREPTOMYCES; TECHNOLOGY, PHARMACEUTICAL;

EID: 84880996010     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2013.26     Document Type: Review

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