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1
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77349116867
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The dynamic architecture of the metabolic switch in Streptomyces coelicolor
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This is a systems biology study of the metabolic switch (transition phase) from primary to secondary metabolism.
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Nieselt K., Battke F., Herbig A., Bruheim P., Wentzel A., Jakobsen O.M., Sletta H., Alam M.T., Merlo M.E., Moore J., et al. The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genom 11 (2010) 10. This is a systems biology study of the metabolic switch (transition phase) from primary to secondary metabolism.
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(2010)
BMC Genom
, vol.11
, pp. 10
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Nieselt, K.1
Battke, F.2
Herbig, A.3
Bruheim, P.4
Wentzel, A.5
Jakobsen, O.M.6
Sletta, H.7
Alam, M.T.8
Merlo, M.E.9
Moore, J.10
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2
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3843050181
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Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story
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A comprehensive review of the mechanisms of phosphate control of secondary metabolite biosynthesis.
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Martín J.F. Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story. J Bacteriol 186 (2004) 5197-5201. A comprehensive review of the mechanisms of phosphate control of secondary metabolite biosynthesis.
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(2004)
J Bacteriol
, vol.186
, pp. 5197-5201
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Martín, J.F.1
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3
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46449120734
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Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces
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An excellent article on the control of metabolism by the global regulator DasR.
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Rigali S., Titgemeyer F., Barends S., Mulder S., Thomae A.W., Hopwood D.A., and van Wezel G.P. Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces. EMBO Rep 9 (2008) 670-675. An excellent article on the control of metabolism by the global regulator DasR.
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(2008)
EMBO Rep
, vol.9
, pp. 670-675
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Rigali, S.1
Titgemeyer, F.2
Barends, S.3
Mulder, S.4
Thomae, A.W.5
Hopwood, D.A.6
van Wezel, G.P.7
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4
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15744383448
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Regulation of secondary metabolism in streptomycetes
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A good general overview of the control of secondary metabolism.
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Bibb M. Regulation of secondary metabolism in streptomycetes. Curr Opin Microbiol 8 (2005) 208-215. A good general overview of the control of secondary metabolism.
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(2005)
Curr Opin Microbiol
, vol.8
, pp. 208-215
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Bibb, M.1
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5
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33744552662
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Gamma-butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation
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A good review describing the role of butyrolactones in regulation in Streptomyces.
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Takano E. Gamma-butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation. Curr Opin Microbiol 9 (2006) 287-294. A good review describing the role of butyrolactones in regulation in Streptomyces.
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(2006)
Curr Opin Microbiol
, vol.9
, pp. 287-294
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Takano, E.1
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6
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67249083329
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Phosphate control over nitrogen metabolism in Streptomyces coelicolor: direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP
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Pioneer article describing the control exerted by PhoP over the nitrogen metabolism.
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Rodríguez-García A., Sola-Landa A., Apel K., Santos-Beneit F., and Martín J.F. Phosphate control over nitrogen metabolism in Streptomyces coelicolor: direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP. Nucleic Acids Res 37 (2009) 3230-3242. Pioneer article describing the control exerted by PhoP over the nitrogen metabolism.
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(2009)
Nucleic Acids Res
, vol.37
, pp. 3230-3242
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Rodríguez-García, A.1
Sola-Landa, A.2
Apel, K.3
Santos-Beneit, F.4
Martín, J.F.5
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7
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62949243440
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Cross-talk between two global regulators in Streptomyces: PhoP and AfsR interact in the control of afsS, pstS and phoRP transcription
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Excellent research article describing the cross-talk between PhoP and AfsR.
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Santos-Beneit F., Rodríguez-García A., Sola-Landa A., and Martín J.F. Cross-talk between two global regulators in Streptomyces: PhoP and AfsR interact in the control of afsS, pstS and phoRP transcription. Mol Microbiol 72 (2009) 53-68. Excellent research article describing the cross-talk between PhoP and AfsR.
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(2009)
Mol Microbiol
, vol.72
, pp. 53-68
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Santos-Beneit, F.1
Rodríguez-García, A.2
Sola-Landa, A.3
Martín, J.F.4
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8
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34748813819
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Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production
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An interesting study on a regulator (IcIR-like) that connects primary and secondary metabolism.
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Santamarta I., Lopez-Garcia M.T., Perez-Redondo R., Koekman B., Martin J.F., and Liras P. Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production. Mol Microbiol 66 (2007) 511-524. An interesting study on a regulator (IcIR-like) that connects primary and secondary metabolism.
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(2007)
Mol Microbiol
, vol.66
, pp. 511-524
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Santamarta, I.1
Lopez-Garcia, M.T.2
Perez-Redondo, R.3
Koekman, B.4
Martin, J.F.5
Liras, P.6
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9
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77952894734
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Martín JF, Sola-Landa A, Santos-Beneit, F, Rodríguez-García A: Network mechanisms of phosphate control of primary and secondary metabolism. In Streptomyces: Molecular Biology and Biotechnology. Edited by Dyson P. Horizon Press; 2010 (in press). An up-to-date review of the networks of phosphate control of both primary and secondary metabolism.
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Martín JF, Sola-Landa A, Santos-Beneit, F, Rodríguez-García A: Network mechanisms of phosphate control of primary and secondary metabolism. In Streptomyces: Molecular Biology and Biotechnology. Edited by Dyson P. Horizon Press; 2010 (in press). An up-to-date review of the networks of phosphate control of both primary and secondary metabolism.
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10
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28244432190
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Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor
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Huang J., Shi J., Molle V., Sohlberg B., Weaver D., Bibb M.J., Karoonuthaisiri N., Lih C.J., Kao C.M., Buttner M.J., and Cohen S.N. Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor. Mol Microbiol 58 (2005) 1276-1287
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(2005)
Mol Microbiol
, vol.58
, pp. 1276-1287
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Huang, J.1
Shi, J.2
Molle, V.3
Sohlberg, B.4
Weaver, D.5
Bibb, M.J.6
Karoonuthaisiri, N.7
Lih, C.J.8
Kao, C.M.9
Buttner, M.J.10
Cohen, S.N.11
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11
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0030929313
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A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold
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Wietzorrek A., and Bibb M. A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold. Mol Microbiol 25 (1997) 1181-1184
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(1997)
Mol Microbiol
, vol.25
, pp. 1181-1184
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Wietzorrek, A.1
Bibb, M.2
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12
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0344146592
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Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein
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Arias P., Fernández-Moreno M.A., and Malpartida F. Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein. J Bacteriol 181 (1999) 6958-6968
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(1999)
J Bacteriol
, vol.181
, pp. 6958-6968
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Arias, P.1
Fernández-Moreno, M.A.2
Malpartida, F.3
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13
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0036097237
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CcaR is an autoregulatory protein that binds to the ccaR and the cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus
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A good article describing the mode of action of the β-lactam autoregulatory protein CcaR.
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Santamarta I., Rodríguez-Garcia A., Pérez-Redondo R., Martín J.F., and Liras P. CcaR is an autoregulatory protein that binds to the ccaR and the cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus. J Bacteriol 184 (2002) 3106-3113. A good article describing the mode of action of the β-lactam autoregulatory protein CcaR.
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(2002)
J Bacteriol
, vol.184
, pp. 3106-3113
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Santamarta, I.1
Rodríguez-Garcia, A.2
Pérez-Redondo, R.3
Martín, J.F.4
Liras, P.5
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14
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0036229192
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Mapping the DNA-binding domain and target sequences of the Streptomyces peucetius daunorubicin biosynthesis regulatory protein, DnrI
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Sheldon P.J., Busarow S.B., and Hutchinson C.R. Mapping the DNA-binding domain and target sequences of the Streptomyces peucetius daunorubicin biosynthesis regulatory protein, DnrI. Mol Microbiol 44 (2002) 449-460
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(2002)
Mol Microbiol
, vol.44
, pp. 449-460
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Sheldon, P.J.1
Busarow, S.B.2
Hutchinson, C.R.3
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15
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34247604950
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AfsR recruits RNA polymerase to the afsS promoter: a model for transcriptional activation by SARPs
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Tanaka A., Takano Y., Ohnishi Y., and Horinouchi S. AfsR recruits RNA polymerase to the afsS promoter: a model for transcriptional activation by SARPs. J Mol Biol 369 (2007) 322-333
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(2007)
J Mol Biol
, vol.369
, pp. 322-333
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Tanaka, A.1
Takano, Y.2
Ohnishi, Y.3
Horinouchi, S.4
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16
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67650741686
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Phosphate and carbon source regulation of two PhoP-dependent glycerophosphodiester phosphodiesterase genes of Streptomyces coelicolor
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Santos-Beneit F., Rodríguez-García A., Apel A.K., and Martín J.F. Phosphate and carbon source regulation of two PhoP-dependent glycerophosphodiester phosphodiesterase genes of Streptomyces coelicolor. Microbiology 155 (2009) 1800-1811
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(2009)
Microbiology
, vol.155
, pp. 1800-1811
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Santos-Beneit, F.1
Rodríguez-García, A.2
Apel, A.K.3
Martín, J.F.4
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17
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0032510817
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The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene
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Description of a novel regulatory gene (claR) controlling clavulanic acid biosynthesis.
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Pérez-Redondo R., Rodríguez-García A., Martín J.F., and Liras P. The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene. Gene 211 (1998) 311-321. Description of a novel regulatory gene (claR) controlling clavulanic acid biosynthesis.
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(1998)
Gene
, vol.211
, pp. 311-321
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Pérez-Redondo, R.1
Rodríguez-García, A.2
Martín, J.F.3
Liras, P.4
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18
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33847161732
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5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus
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Tahlan K., Anders C., Wong A., Mosher R.H., Beatty P.H., Brumlik M.J., Griffin A., Hughes C., Griffin J., Barton B., and Jensen S.E. 5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus. Chem Biol 14 (2007) 131-142
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(2007)
Chem Biol
, vol.14
, pp. 131-142
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Tahlan, K.1
Anders, C.2
Wong, A.3
Mosher, R.H.4
Beatty, P.H.5
Brumlik, M.J.6
Griffin, A.7
Hughes, C.8
Griffin, J.9
Barton, B.10
Jensen, S.E.11
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19
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1942539982
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Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis
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Antón N., Mendes M.V., Martín J.F., and Aparicio J.F. Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis. J Bacteriol 186 (2004) 2567-2575
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(2004)
J Bacteriol
, vol.186
, pp. 2567-2575
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Antón, N.1
Mendes, M.V.2
Martín, J.F.3
Aparicio, J.F.4
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20
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33847407962
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Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces
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This article describes the biosynthetic pathway of A-factor in S. coelicolor.
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Kato J.Y., Funa N., Watanabe H., Ohnishi Y., and Horinouchi S. Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces. Proc Natl Acad Sci USA 104 (2007) 2378-2383. This article describes the biosynthetic pathway of A-factor in S. coelicolor.
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(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 2378-2383
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Kato, J.Y.1
Funa, N.2
Watanabe, H.3
Ohnishi, Y.4
Horinouchi, S.5
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21
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4744343551
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PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis
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This article describes an entirely novel inducer molecule that governs pimaricin biosynthesis in S. natalensis.
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Recio E., Colinas A., Rumbero A., Aparicio J.F., and Martín J.F. PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis. J Biol Chem 279 (2004) 41586-41593. This article describes an entirely novel inducer molecule that governs pimaricin biosynthesis in S. natalensis.
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(2004)
J Biol Chem
, vol.279
, pp. 41586-41593
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Recio, E.1
Colinas, A.2
Rumbero, A.3
Aparicio, J.F.4
Martín, J.F.5
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22
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67749142402
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PimT an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis
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Vicente C.M., Santos-Aberturas J., Guerra S.M., Payero T.D., Martín J.F., and Aparicio JF: PimT. an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis. Microb Cell Fact 8 (2009) 8-33
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(2009)
Microb Cell Fact
, vol.8
, pp. 8-33
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Vicente, C.M.1
Santos-Aberturas, J.2
Guerra, S.M.3
Payero, T.D.4
Martín, J.F.5
Aparicio, J.F.6
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23
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23744448206
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Different proteins bind to the butyrolactone-receptor protein ARE sequence located upstream of the regulatory ccaR gene of S. clavuligerus
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A brilliant demonstration of the protein rescue technique to identify proteins that bind to the ARE sequence.
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Santamarta I., Pérez-Redondo R., Lorenzana L.M., Martín J.F., and Liras P. Different proteins bind to the butyrolactone-receptor protein ARE sequence located upstream of the regulatory ccaR gene of S. clavuligerus. Mol Microbiol 57 (2005) 1175-1176. A brilliant demonstration of the protein rescue technique to identify proteins that bind to the ARE sequence.
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(2005)
Mol Microbiol
, vol.57
, pp. 1175-1176
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Santamarta, I.1
Pérez-Redondo, R.2
Lorenzana, L.M.3
Martín, J.F.4
Liras, P.5
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24
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0036365252
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Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced gamma-butyrolactone receptor
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Stratigopoulos G., Gandecha A.R., and Cundliffe E. Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced gamma-butyrolactone receptor. Mol Microbiol 45 (2002) 735-744
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(2002)
Mol Microbiol
, vol.45
, pp. 735-744
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Stratigopoulos, G.1
Gandecha, A.R.2
Cundliffe, E.3
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25
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0032847109
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The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor
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A pioneer study describing the A-factor cascade in S. griseus.
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Ohnishi Y., Kameyama S., Onaka H., and Horinouchi S. The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor. Mol Microbiol 34 (1999) 102-111. A pioneer study describing the A-factor cascade in S. griseus.
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(1999)
Mol Microbiol
, vol.34
, pp. 102-111
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Ohnishi, Y.1
Kameyama, S.2
Onaka, H.3
Horinouchi, S.4
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26
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56649114287
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Control of tylosin biosynthesis in Streptomyces fradiae
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An excellent review on the networks of regulation of tylosin biosynthesis.
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Cundliffe E. Control of tylosin biosynthesis in Streptomyces fradiae. J Microbiol Biotechnol 18 (2008) 1485-1491. An excellent review on the networks of regulation of tylosin biosynthesis.
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(2008)
J Microbiol Biotechnol
, vol.18
, pp. 1485-1491
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Cundliffe, E.1
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27
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9644257510
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Positive control of tylosin biosynthesis: pivotal role of TylR
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Stratigopoulos G., Bate N., and Cundliffe E. Positive control of tylosin biosynthesis: pivotal role of TylR. Mol Microbiol 54 (2004) 1326-1334
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(2004)
Mol Microbiol
, vol.54
, pp. 1326-1334
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Stratigopoulos, G.1
Bate, N.2
Cundliffe, E.3
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28
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33846255342
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Regulation of tylosin production: role of a TylP-interactive ligand
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Bignell D.R., Bate N., and Cundliffe E. Regulation of tylosin production: role of a TylP-interactive ligand. Mol Microbiol 63 (2007) 838-847
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(2007)
Mol Microbiol
, vol.63
, pp. 838-847
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Bignell, D.R.1
Bate, N.2
Cundliffe, E.3
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29
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33748644917
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Regulation of tylosin biosynthesis involving 'SARP-helper' activity
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Bate N., Bignell D.R., and Cundliffe E. Regulation of tylosin biosynthesis involving 'SARP-helper' activity. Mol Microbiol 62 (2006) 148-156
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(2006)
Mol Microbiol
, vol.62
, pp. 148-156
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Bate, N.1
Bignell, D.R.2
Cundliffe, E.3
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30
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46949098460
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Identification of transcriptional activators of thienamycin and cephamycin C biosynthetic genes within thienamycin gene cluster from Streptomyces catleya
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Rodríguez M., Núñez L.E., Braña A.F., Méndez C., Salas J.A., and Blanco G. Identification of transcriptional activators of thienamycin and cephamycin C biosynthetic genes within thienamycin gene cluster from Streptomyces catleya. Mol Microbiol 69 (2008) 633-645
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(2008)
Mol Microbiol
, vol.69
, pp. 633-645
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Rodríguez, M.1
Núñez, L.E.2
Braña, A.F.3
Méndez, C.4
Salas, J.A.5
Blanco, G.6
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31
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4844230017
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Sensing and responding to diverse extracellular signals? Analysis of the sensor kinases and response regulators of Streptomyces coelicolor A3(2)
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An overview of two-component systems in Streptomyces coelicolor.
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Hutchings M.I., Hoskisson P.A., Chandra G., and Buttner M.J. Sensing and responding to diverse extracellular signals? Analysis of the sensor kinases and response regulators of Streptomyces coelicolor A3(2). Microbiology 150 (2004) 2795-2806. An overview of two-component systems in Streptomyces coelicolor.
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(2004)
Microbiology
, vol.150
, pp. 2795-2806
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Hutchings, M.I.1
Hoskisson, P.A.2
Chandra, G.3
Buttner, M.J.4
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32
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0038284769
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The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans
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Excellent article on the initial characterization of the PhoR-PhoP TCS.
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Sola-Landa A., Moura R.S., and Martín J.F. The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc Natl Acad Sci USA 100 (2003) 6133-6318. Excellent article on the initial characterization of the PhoR-PhoP TCS.
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(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 6133-6318
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Sola-Landa, A.1
Moura, R.S.2
Martín, J.F.3
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33
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35448940010
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Phosphate control of phoA, phoC and phoD gene expression in Streptomyces coelicolor reveals significant differences in binding of PhoP to their promoter regions
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Describes important differences in the phosphate control of three phosphatase genes.
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Apel A.K., Sola-Landa A., Rodríguez-García A., and Martín J.F. Phosphate control of phoA, phoC and phoD gene expression in Streptomyces coelicolor reveals significant differences in binding of PhoP to their promoter regions. Microbiology 153 (2007) 3527-3537. Describes important differences in the phosphate control of three phosphatase genes.
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(2007)
Microbiology
, vol.153
, pp. 3527-3537
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Apel, A.K.1
Sola-Landa, A.2
Rodríguez-García, A.3
Martín, J.F.4
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34
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19944370498
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Binding of PhoP to promoters of phosphate-regulated genes in Streptomyces coelicolor: identification of PHO boxes
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An article describing the binding sequences of PhoP in several phosphate-regulated promoters.
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Sola-Landa A., Rodríguez-García A., Franco-Domínguez E., and Martín J.F. Binding of PhoP to promoters of phosphate-regulated genes in Streptomyces coelicolor: identification of PHO boxes. Mol Microbiol 56 (2005) 1373-1385. An article describing the binding sequences of PhoP in several phosphate-regulated promoters.
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(2005)
Mol Microbiol
, vol.56
, pp. 1373-1385
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Sola-Landa, A.1
Rodríguez-García, A.2
Franco-Domínguez, E.3
Martín, J.F.4
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35
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0034745163
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Genetic evidence that the alpha5 helix of the receiver domain of PhoB is involved in interdomain interactions
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Allen M.P., Zumbrennen K.B., and McCleary W.R. Genetic evidence that the alpha5 helix of the receiver domain of PhoB is involved in interdomain interactions. J Bacteriol 183 (2001) 2204-2211
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(2001)
J Bacteriol
, vol.183
, pp. 2204-2211
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Allen, M.P.1
Zumbrennen, K.B.2
McCleary, W.R.3
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36
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11844296791
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Biochemical activities of the absA two-component system of Streptomyces coelicolor
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Sheeler N.L., MacMillan S.V., and Nodwell J.R. Biochemical activities of the absA two-component system of Streptomyces coelicolor. J Bacteriol 187 (2005) 687-696
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(2005)
J Bacteriol
, vol.187
, pp. 687-696
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Sheeler, N.L.1
MacMillan, S.V.2
Nodwell, J.R.3
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37
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0036176756
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Regulation of the Streptomyces coelicolor calcium-dependent antibiotic by absA, encoding a cluster-linked two-component system
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Ryding N.J., Anderson T.B., and Champness W.C. Regulation of the Streptomyces coelicolor calcium-dependent antibiotic by absA, encoding a cluster-linked two-component system. J Bacteriol 184 (2002) 794-805
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(2002)
J Bacteriol
, vol.184
, pp. 794-805
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Ryding, N.J.1
Anderson, T.B.2
Champness, W.C.3
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38
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34447560037
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Phosphorylated AbsA2 negatively regulates antibiotic production in Streptomyces coelicolor through interactions with pathway-specific regulatory gene promoters
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A description of how the AbsA1-AbsA2 TCS controls expression of secondary metabolite biosynthesis.
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McKenzie N.L., and Nodwell J.R. Phosphorylated AbsA2 negatively regulates antibiotic production in Streptomyces coelicolor through interactions with pathway-specific regulatory gene promoters. J Bacteriol 189 (2007) 5284-5292. A description of how the AbsA1-AbsA2 TCS controls expression of secondary metabolite biosynthesis.
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(2007)
J Bacteriol
, vol.189
, pp. 5284-5292
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McKenzie, N.L.1
Nodwell, J.R.2
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39
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0029762312
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afsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2)
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Floriano B., and Bibb M. afsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2). Mol Microbiol 21 (1996) 385-396
-
(1996)
Mol Microbiol
, vol.21
, pp. 385-396
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Floriano, B.1
Bibb, M.2
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40
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0028171561
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afsR2: a previously undetected gene encoding a 63-amino-acid protein that stimulates antibiotic production in Streptomyces lividans
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Vögtli M., Chang P.C., and Cohen S.N. afsR2: a previously undetected gene encoding a 63-amino-acid protein that stimulates antibiotic production in Streptomyces lividans. Mol Microbiol 14 (1994) 643-653
-
(1994)
Mol Microbiol
, vol.14
, pp. 643-653
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Vögtli, M.1
Chang, P.C.2
Cohen, S.N.3
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41
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0036268103
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afsS is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in Streptomyces coelicolor A3(2)
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Lee P.C., Umeyama T., and Horinouchi S. afsS is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in Streptomyces coelicolor A3(2). Mol Microbiol 43 (2002) 1413-1430
-
(2002)
Mol Microbiol
, vol.43
, pp. 1413-1430
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Lee, P.C.1
Umeyama, T.2
Horinouchi, S.3
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42
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33845740146
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Nitrogen metabolism in Streptomyces coelicolor: transcriptional and post-translational regulation
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A good article on the different levels of regulation of nitrogen metabolism.
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Reuther J., and Wohlleben W. Nitrogen metabolism in Streptomyces coelicolor: transcriptional and post-translational regulation. J Mol Microbiol Biotechnol 12 (2007) 139-146. A good article on the different levels of regulation of nitrogen metabolism.
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(2007)
J Mol Microbiol Biotechnol
, vol.12
, pp. 139-146
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Reuther, J.1
Wohlleben, W.2
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43
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34547144162
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Genome-wide transcriptomic and proteomic analysis of the primary response to phosphate limitation in Streptomyces coelicolor M145 and in a DeltaphoP mutant
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Outstanding article on the transcriptomics and proteomics of phosphate control in Streptomyces.
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Rodríguez-García A., Barreiro C., Santos-Beneit F., Sola-Landa A., and Martín J.F. Genome-wide transcriptomic and proteomic analysis of the primary response to phosphate limitation in Streptomyces coelicolor M145 and in a DeltaphoP mutant. Proteomics 7 (2007) 2410-2429. Outstanding article on the transcriptomics and proteomics of phosphate control in Streptomyces.
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(2007)
Proteomics
, vol.7
, pp. 2410-2429
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Rodríguez-García, A.1
Barreiro, C.2
Santos-Beneit, F.3
Sola-Landa, A.4
Martín, J.F.5
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44
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23844490045
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The high-affinity phosphate-binding protein PstS is accumulated under high fructose concentrations and mutation of the corresponding gene affects differentiation in Streptomyces lividans
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Díaz M., Esteban A., Fernández-Abalos J.M., and Santamaría R.I. The high-affinity phosphate-binding protein PstS is accumulated under high fructose concentrations and mutation of the corresponding gene affects differentiation in Streptomyces lividans. Microbiology 151 (2005) 2583-2592
-
(2005)
Microbiology
, vol.151
, pp. 2583-2592
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Díaz, M.1
Esteban, A.2
Fernández-Abalos, J.M.3
Santamaría, R.I.4
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45
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58149094952
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Expression of the pstS gene of Streptomyces lividans is regulated by the carbon source and is partially independent of the PhoP regulator
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An article describing interesting observations on the interaction of phosphate and carbon sources.
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Esteban A., Díaz M., Yepes A., and Santamaría R.I. Expression of the pstS gene of Streptomyces lividans is regulated by the carbon source and is partially independent of the PhoP regulator. BMC Microbiol 8 (2008) 201-212. An article describing interesting observations on the interaction of phosphate and carbon sources.
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(2008)
BMC Microbiol
, vol.8
, pp. 201-212
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Esteban, A.1
Díaz, M.2
Yepes, A.3
Santamaría, R.I.4
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46
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0027169727
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The Streptomyces coelicolor glnR gene encodes a protein similar to other bacterial response regulators
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Wray Jr. L.V., and Fisher S.H. The Streptomyces coelicolor glnR gene encodes a protein similar to other bacterial response regulators. Gene 130 (1993) 145-150
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(1993)
Gene
, vol.130
, pp. 145-150
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Wray Jr., L.V.1
Fisher, S.H.2
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47
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2942707687
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Iron-regulatory proteins DmdR1 and DmdR2 of Streptomyces coelicolor form two different DNA-protein complexes with iron boxes
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Flores F.J., and Martín J.F. Iron-regulatory proteins DmdR1 and DmdR2 of Streptomyces coelicolor form two different DNA-protein complexes with iron boxes. Biochem J 380 (2004) 497-503
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(2004)
Biochem J
, vol.380
, pp. 497-503
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Flores, F.J.1
Martín, J.F.2
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48
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33847661977
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The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis
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A good study of the metabolic engineering of phosphate control of pimaricin biosynthesis.
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Mendes M.V., Tunca S., Antón N., Recio E., Sola-Landa A., Aparicio J.F., and Martín J.F. The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis. Metabol Eng 9 (2007) 217-227. A good study of the metabolic engineering of phosphate control of pimaricin biosynthesis.
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(2007)
Metabol Eng
, vol.9
, pp. 217-227
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Mendes, M.V.1
Tunca, S.2
Antón, N.3
Recio, E.4
Sola-Landa, A.5
Aparicio, J.F.6
Martín, J.F.7
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49
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0030954966
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A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds
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This was the first report on the characterization of ccaR and the metabolic engineering of cephamycin C and clavulanic acid production by amplification of ccaR.
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Pérez-Llarena F.J., Liras P., Rodríguez-García A., and Martín J.F. A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds. J Bacteriol 179 (1997) 2053-2059. This was the first report on the characterization of ccaR and the metabolic engineering of cephamycin C and clavulanic acid production by amplification of ccaR.
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(1997)
J Bacteriol
, vol.179
, pp. 2053-2059
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Pérez-Llarena, F.J.1
Liras, P.2
Rodríguez-García, A.3
Martín, J.F.4
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50
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35348922983
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Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585
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Viet H.T., Malla S., Park B.C., Liou K., Lee H.C., and Sohng J.K. Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585. J Microbiol Biotechnol 17 (2007) 1538-1545
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(2007)
J Microbiol Biotechnol
, vol.17
, pp. 1538-1545
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Viet, H.T.1
Malla, S.2
Park, B.C.3
Liou, K.4
Lee, H.C.5
Sohng, J.K.6
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51
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77949913523
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Improvement in doxorubicin productivity by overexpression of regulatory genes in Streptomyces peucetius
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10.1016/j.resmic.2009.12.003
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Malla S., Niraula N.P., Liou K., and Kyung J. Improvement in doxorubicin productivity by overexpression of regulatory genes in Streptomyces peucetius. Res Microbiol (2010) 10.1016/j.resmic.2009.12.003
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(2010)
Res Microbiol
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Malla, S.1
Niraula, N.P.2
Liou, K.3
Kyung, J.4
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52
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77249153701
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Genome-minimized Streptomyces host of the heterologous expression of secondary metabolism
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A very recent article on the possibility of minimizing Streptomyces genomes.
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Komatsu M., Uchiyama T., Omura S., Cane D.E., and Ikeda H. Genome-minimized Streptomyces host of the heterologous expression of secondary metabolism. Proc Natl Acad Sci USA 107 (2010) 2646-2651. A very recent article on the possibility of minimizing Streptomyces genomes.
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(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 2646-2651
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Komatsu, M.1
Uchiyama, T.2
Omura, S.3
Cane, D.E.4
Ikeda, H.5
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