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Volumn 1-2, Issue , 2014, Pages 986-999

Pathology of Asthma

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EID: 84894457912     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-323-08593-9.00061-9     Document Type: Chapter
Times cited : (7)

References (202)
  • 1
    • 70349110838 scopus 로고    scopus 로고
    • Localization of pathology in asthma
    • James AL Localization of pathology in asthma. Clin Exp Allergy 2009, 39:1450-1452.
    • (2009) Clin Exp Allergy , vol.39 , pp. 1450-1452
    • James, A.L.1
  • 4
    • 0036095111 scopus 로고    scopus 로고
    • Allergic vs nonallergic asthma: what makes the difference?
    • Romanet-Manent S, Charpin D, Magnan A, et al. Allergic vs nonallergic asthma: what makes the difference?. Allergy 2002, 57:607-613.
    • (2002) Allergy , vol.57 , pp. 607-613
    • Romanet-Manent, S.1    Charpin, D.2    Magnan, A.3
  • 5
    • 22144452574 scopus 로고    scopus 로고
    • Severe asthma in adults
    • Wenzel S Severe asthma in adults. Am J Respir Crit Care Med 2005, 172:149-160.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 149-160
    • Wenzel, S.1
  • 6
    • 33747756534 scopus 로고    scopus 로고
    • Asthma: defining of the persistent adult phenotypes
    • Wenzel SE Asthma: defining of the persistent adult phenotypes. Lancet 2006, 368:804-813.
    • (2006) Lancet , vol.368 , pp. 804-813
    • Wenzel, S.E.1
  • 8
    • 52049087356 scopus 로고    scopus 로고
    • Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
    • Anderson GP Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 2008, 372:1107-1119.
    • (2008) Lancet , vol.372 , pp. 1107-1119
    • Anderson, G.P.1
  • 9
    • 79551505136 scopus 로고    scopus 로고
    • Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome
    • Lotvall J, Akdis CA, Bacharier LB, et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011, 127:355-360.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 355-360
    • Lotvall, J.1    Akdis, C.A.2    Bacharier, L.B.3
  • 10
    • 0002969775 scopus 로고    scopus 로고
    • The pathology of asthma: an inflammatory disorder
    • Marcel Dekker, New York, S.J. Szefler, D.Y.M. Leung (Eds.)
    • Hegele RG, Hogg C The pathology of asthma: an inflammatory disorder. Severe asthma: pathogenesis and clinical management 1996, 61-76. Marcel Dekker, New York. S.J. Szefler, D.Y.M. Leung (Eds.).
    • (1996) Severe asthma: pathogenesis and clinical management , pp. 61-76
    • Hegele, R.G.1    Hogg, C.2
  • 11
    • 0029782335 scopus 로고    scopus 로고
    • Pathology of mild, severe and fatal asthma
    • Kay AB Pathology of mild, severe and fatal asthma. Am J Respir Crit Care Med 1996, 154:S66-S69.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. S66-S69
    • Kay, A.B.1
  • 14
    • 0141840847 scopus 로고    scopus 로고
    • Methods for the assessment of endobronchial biopsies in clinical research: application to studies of pathogenesis and the effects of treatment
    • Jeffery PK, Holgate ST, Wenzel SE Methods for the assessment of endobronchial biopsies in clinical research: application to studies of pathogenesis and the effects of treatment. Am J Respir Crit Care Med 2003, 168:S1-17.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. S1-17
    • Jeffery, P.K.1    Holgate, S.T.2    Wenzel, S.E.3
  • 15
    • 0026567221 scopus 로고
    • New insights into airway inflammation by endobronchial biopsy
    • Holgate ST, Wilson JW, Howarth PH New insights into airway inflammation by endobronchial biopsy. Am Rev Respir Dis 1992, 145:S2-S6.
    • (1992) Am Rev Respir Dis , vol.145 , pp. S2-S6
    • Holgate, S.T.1    Wilson, J.W.2    Howarth, P.H.3
  • 16
    • 0027535474 scopus 로고
    • Airway mucosal inflammation even in patients with newly diagnosed asthma
    • Laitinen LA, Laitinen A, Haahtela T Airway mucosal inflammation even in patients with newly diagnosed asthma. Am Rev Respir Dis 1993, 147:697-704.
    • (1993) Am Rev Respir Dis , vol.147 , pp. 697-704
    • Laitinen, L.A.1    Laitinen, A.2    Haahtela, T.3
  • 17
    • 0025721109 scopus 로고
    • Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness
    • Bradley BL, Azzawi M, Jacobson M, et al. Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol 1991, 88:661-674.
    • (1991) J Allergy Clin Immunol , vol.88 , pp. 661-674
    • Bradley, B.L.1    Azzawi, M.2    Jacobson, M.3
  • 18
    • 0031052842 scopus 로고    scopus 로고
    • Kinetics of the development and recovery of the lung from IgE-mediated inflammation: dissociation of pulmonary eosinophilia, lung injury, and eosinophil-active cytokines
    • Shaver JR, Zangrilli JG, Cho SK, et al. Kinetics of the development and recovery of the lung from IgE-mediated inflammation: dissociation of pulmonary eosinophilia, lung injury, and eosinophil-active cytokines. Am J Respir Crit Care Med 1997, 155:442-448.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 442-448
    • Shaver, J.R.1    Zangrilli, J.G.2    Cho, S.K.3
  • 19
    • 0025037094 scopus 로고
    • Eosinophilic inflammation in asthma
    • Bousquet J, Chanez P, Lacoste JY, et al. Eosinophilic inflammation in asthma. N Engl J Med 1990, 323:1033-1039.
    • (1990) N Engl J Med , vol.323 , pp. 1033-1039
    • Bousquet, J.1    Chanez, P.2    Lacoste, J.Y.3
  • 20
    • 51649092146 scopus 로고    scopus 로고
    • Noninvasive evaluation of airway inflammation in asthmatic patients who smoke: implications for application in clinical practice
    • Bessa V, Tseliou E, Bakakos P, Loukides S Noninvasive evaluation of airway inflammation in asthmatic patients who smoke: implications for application in clinical practice. Ann Allergy Asthma Immunol 2008, 101:226-232.
    • (2008) Ann Allergy Asthma Immunol , vol.101 , pp. 226-232
    • Bessa, V.1    Tseliou, E.2    Bakakos, P.3    Loukides, S.4
  • 21
    • 0028266252 scopus 로고
    • Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways
    • Montefort S, Gratziou C, Goulding D, et al. Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways. J Clin Invest 1994, 93:1411-1421.
    • (1994) J Clin Invest , vol.93 , pp. 1411-1421
    • Montefort, S.1    Gratziou, C.2    Goulding, D.3
  • 22
    • 0025760379 scopus 로고
    • Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma
    • Hamid Q, Azzawi M, Ying S, et al. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest 1991, 87:1541-1546.
    • (1991) J Clin Invest , vol.87 , pp. 1541-1546
    • Hamid, Q.1    Azzawi, M.2    Ying, S.3
  • 23
    • 0029302202 scopus 로고
    • Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects
    • Yung S, Durham SR, Corrigan CJ, et al. Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects. Am J Respir Cell Mol Biol 1995, 12:477-487.
    • (1995) Am J Respir Cell Mol Biol , vol.12 , pp. 477-487
    • Yung, S.1    Durham, S.R.2    Corrigan, C.J.3
  • 24
    • 0027342879 scopus 로고
    • Increases in activated T lymphocytes, eosinophils and cytokine mRNA expression for interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics
    • Bentley AM, Meng Q, Robinson DS, et al. Increases in activated T lymphocytes, eosinophils and cytokine mRNA expression for interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics. Am J Respir Cell Mol Biol 1993, 8:35-42.
    • (1993) Am J Respir Cell Mol Biol , vol.8 , pp. 35-42
    • Bentley, A.M.1    Meng, Q.2    Robinson, D.S.3
  • 25
    • 0027245528 scopus 로고
    • Intraepithelial mast cells in allergic and nonallergic asthma: assessment using bronchial brushings
    • Gibson PG, Allen CJ, Yang JP, et al. Intraepithelial mast cells in allergic and nonallergic asthma: assessment using bronchial brushings. Am Rev Respir Dis 1993, 148:80-86.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 80-86
    • Gibson, P.G.1    Allen, C.J.2    Yang, J.P.3
  • 27
    • 77951672627 scopus 로고    scopus 로고
    • Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma
    • Dougherty RH, Sidhu SS, Raman K, et al. Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma. J Allergy Clin Immunol 2010, 125:1046-1053.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1046-1053
    • Dougherty, R.H.1    Sidhu, S.S.2    Raman, K.3
  • 28
    • 0028432821 scopus 로고
    • Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines
    • Bradding P, Roberts JA, Britten KM, et al. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994, 10:471-480.
    • (1994) Am J Respir Cell Mol Biol , vol.10 , pp. 471-480
    • Bradding, P.1    Roberts, J.A.2    Britten, K.M.3
  • 29
    • 33644845766 scopus 로고    scopus 로고
    • Bronchial matrix and inflammation respond to inhaled steroids despite ongoing allergen exposure in asthma
    • de Kluijver J, Schrumpf JA, Evertse CE, et al. Bronchial matrix and inflammation respond to inhaled steroids despite ongoing allergen exposure in asthma. Clin Exp Allergy 2005, 35:1361-1369.
    • (2005) Clin Exp Allergy , vol.35 , pp. 1361-1369
    • de Kluijver, J.1    Schrumpf, J.A.2    Evertse, C.E.3
  • 30
    • 0037198418 scopus 로고    scopus 로고
    • Mast-cell infiltration of airway smooth muscle in asthma
    • Brightling CE, Bradding P, Symon FA, et al. Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med 2002, 346:1699-1705.
    • (2002) N Engl J Med , vol.346 , pp. 1699-1705
    • Brightling, C.E.1    Bradding, P.2    Symon, F.A.3
  • 31
    • 0036014530 scopus 로고    scopus 로고
    • Distribution and degranulation of airway mast cells in normal and asthmatic subjects
    • Carroll NG, Mutavdzic S, James AL Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 2002, 19:879-885.
    • (2002) Eur Respir J , vol.19 , pp. 879-885
    • Carroll, N.G.1    Mutavdzic, S.2    James, A.L.3
  • 32
    • 36749095585 scopus 로고    scopus 로고
    • Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma
    • Berry M, Morgan A, Shaw DE, et al. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax 2007, 62:1043-1049.
    • (2007) Thorax , vol.62 , pp. 1043-1049
    • Berry, M.1    Morgan, A.2    Shaw, D.E.3
  • 33
    • 33846202881 scopus 로고    scopus 로고
    • Inflammation of bronchial smooth muscle in allergic asthma
    • Begueret H, Berger P, Vernejoux JM, et al. Inflammation of bronchial smooth muscle in allergic asthma. Thorax 2007, 62:8-15.
    • (2007) Thorax , vol.62 , pp. 8-15
    • Begueret, H.1    Berger, P.2    Vernejoux, J.M.3
  • 34
    • 15944362722 scopus 로고    scopus 로고
    • Relationship of small airway chymase-positive mast cells and lung function in severe asthma
    • Balzar S, Chu HW, Strand M, Wenzel S Relationship of small airway chymase-positive mast cells and lung function in severe asthma. Am J Respir Crit Care Med 2005, 171:431-439.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 431-439
    • Balzar, S.1    Chu, H.W.2    Strand, M.3    Wenzel, S.4
  • 35
    • 0031817795 scopus 로고    scopus 로고
    • Inflammatory cell distribution within and along asthmatic airways
    • Haley KJ, Sunday ME, Wiggs BR, et al. Inflammatory cell distribution within and along asthmatic airways. Am J Respir Crit Care Med 1998, 158:565-572.
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 565-572
    • Haley, K.J.1    Sunday, M.E.2    Wiggs, B.R.3
  • 37
    • 1542721566 scopus 로고    scopus 로고
    • Aggregations of lymphoid cells in the airways of nonsmokers, smokers, and subjects with asthma
    • Elliot JG, Jensen CM, Mutavdzic S, et al. Aggregations of lymphoid cells in the airways of nonsmokers, smokers, and subjects with asthma. Am J Respir Crit Care Med 2004, 169:712-718.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 712-718
    • Elliot, J.G.1    Jensen, C.M.2    Mutavdzic, S.3
  • 38
    • 10544256182 scopus 로고    scopus 로고
    • IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity
    • Humbert M, Durham SR, Ying S, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996, 154:1497-1504.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 1497-1504
    • Humbert, M.1    Durham, S.R.2    Ying, S.3
  • 39
    • 0034744489 scopus 로고    scopus 로고
    • Local expression of epsilon germline gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma
    • Ying S, Humbert M, Meng Q, et al. Local expression of epsilon germline gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma. J Allergy Clin Immunol 2001, 107:686-692.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 686-692
    • Ying, S.1    Humbert, M.2    Meng, Q.3
  • 40
    • 69249150516 scopus 로고    scopus 로고
    • T-helper type 2-driven inflammation defines major subphenotypes of asthma
    • Woodruff PG, Modrek B, Choy DF, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009, 180:388-395.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 388-395
    • Woodruff, P.G.1    Modrek, B.2    Choy, D.F.3
  • 41
    • 80053084755 scopus 로고    scopus 로고
    • Lebrikizumab treatment in adults with asthma
    • Corren J, Lemanske RF, Hanania NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011, 365:1088-1098.
    • (2011) N Engl J Med , vol.365 , pp. 1088-1098
    • Corren, J.1    Lemanske, R.F.2    Hanania, N.A.3
  • 42
    • 0026625347 scopus 로고
    • Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma: relationship to symptoms and bronchial responsiveness
    • Bentley AM, Menz G, Storz C, et al. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma: relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis 1992, 146:500-506.
    • (1992) Am Rev Respir Dis , vol.146 , pp. 500-506
    • Bentley, A.M.1    Menz, G.2    Storz, C.3
  • 43
    • 0030983513 scopus 로고    scopus 로고
    • Upregulation of alpha GM-CSF-receptor in nonatopic asthma but not in atopic asthma
    • Kotsimbos AT, Humbert M, Minshall E, et al. Upregulation of alpha GM-CSF-receptor in nonatopic asthma but not in atopic asthma. J Allergy Clin Immunol 1997, 99:666-672.
    • (1997) J Allergy Clin Immunol , vol.99 , pp. 666-672
    • Kotsimbos, A.T.1    Humbert, M.2    Minshall, E.3
  • 44
    • 0036310908 scopus 로고    scopus 로고
    • Non-eosinophilic asthma: importance and possible mechanisms
    • Douwes J, Gibson P, Pekkanen J, et al. Non-eosinophilic asthma: importance and possible mechanisms. Thorax 2002, 57:643-648.
    • (2002) Thorax , vol.57 , pp. 643-648
    • Douwes, J.1    Gibson, P.2    Pekkanen, J.3
  • 45
    • 80053087268 scopus 로고    scopus 로고
    • Non-eosinophilic asthma in children: relation with airway remodeling
    • Baraldo S, Turato G, Bazzan E, et al. Non-eosinophilic asthma in children: relation with airway remodeling. Eur Respir J 2011, 38:575-583.
    • (2011) Eur Respir J , vol.38 , pp. 575-583
    • Baraldo, S.1    Turato, G.2    Bazzan, E.3
  • 46
    • 0034518978 scopus 로고    scopus 로고
    • Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. BHR Group
    • Amin K, Ludviksdottir D, Janson C, et al. Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. BHR Group. Am J Respir Crit Care Med 2000, 162:2295-2301.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 2295-2301
    • Amin, K.1    Ludviksdottir, D.2    Janson, C.3
  • 47
    • 0031831643 scopus 로고    scopus 로고
    • Neutrophil infiltration and release of IL-8 in airway mucosa from subjects with grain dust-induced occupational asthma
    • Park HS, Jung KS, Hwang SC, Nahm DH, Yim HE Neutrophil infiltration and release of IL-8 in airway mucosa from subjects with grain dust-induced occupational asthma. Clin Exp Allergy 1998, 28:724-730.
    • (1998) Clin Exp Allergy , vol.28 , pp. 724-730
    • Park, H.S.1    Jung, K.S.2    Hwang, S.C.3    Nahm, D.H.4    Yim, H.E.5
  • 48
    • 0029057979 scopus 로고
    • Glucocorticoid treatment inhibits apoptosis in human neutrophils: separation of survival and activation outcomes
    • Cox G Glucocorticoid treatment inhibits apoptosis in human neutrophils: separation of survival and activation outcomes. J Immunol 1995, 154:4719-4725.
    • (1995) J Immunol , vol.154 , pp. 4719-4725
    • Cox, G.1
  • 49
    • 0035206065 scopus 로고    scopus 로고
    • Understanding airway wall remodeling in asthma: a basis for improvements in therapy?
    • Kumar RK Understanding airway wall remodeling in asthma: a basis for improvements in therapy?. Pharmacol Ther 2001, 91:93-104.
    • (2001) Pharmacol Ther , vol.91 , pp. 93-104
    • Kumar, R.K.1
  • 50
    • 0035891664 scopus 로고    scopus 로고
    • Remodelling in asthma and chronic obstructive lung disease
    • Jeffery PK Remodelling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med 2001, 164:S28-S38.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. S28-S38
    • Jeffery, P.K.1
  • 52
    • 0031753315 scopus 로고    scopus 로고
    • Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation
    • Hoshino M, Nakamura Y, Sim J, Shimojo J, Isogai S Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation. J Allergy Clin Immunol 1998, 102:783-788.
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 783-788
    • Hoshino, M.1    Nakamura, Y.2    Sim, J.3    Shimojo, J.4    Isogai, S.5
  • 53
    • 33747811511 scopus 로고    scopus 로고
    • Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants
    • Saglani S, Molyneux C, Gong H, et al. Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants. Eur Respir J 2006, 28:505-512.
    • (2006) Eur Respir J , vol.28 , pp. 505-512
    • Saglani, S.1    Molyneux, C.2    Gong, H.3
  • 54
    • 0030267704 scopus 로고    scopus 로고
    • Expression of laminins in the airways in various types of asthmatic patients: a morphometric study
    • Altraja A, Laitinen A, Virtanen I, et al. Expression of laminins in the airways in various types of asthmatic patients: a morphometric study. Am J Respir Cell Mol Biol 1996, 15:482-488.
    • (1996) Am J Respir Cell Mol Biol , vol.15 , pp. 482-488
    • Altraja, A.1    Laitinen, A.2    Virtanen, I.3
  • 55
    • 0030870119 scopus 로고    scopus 로고
    • Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid
    • Laitinen A, Altraja A, Kampe M, et al. Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid. Am J Respir Crit Care Med 1997, 156:951-958.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 951-958
    • Laitinen, A.1    Altraja, A.2    Kampe, M.3
  • 56
    • 33745394558 scopus 로고    scopus 로고
    • Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals
    • Takayama G, Arima K, Kanaji T, et al. Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. J Allergy Clin Immunol 2006, 118:98-104.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 98-104
    • Takayama, G.1    Arima, K.2    Kanaji, T.3
  • 58
    • 0035135666 scopus 로고    scopus 로고
    • Basement membrane pores in human bronchial epithelium: a conduit for infiltrating cells?
    • Howat WJ, Holmes JA, Holgate ST, Lackie PM Basement membrane pores in human bronchial epithelium: a conduit for infiltrating cells?. Am J Pathol 2001, 158:673-680.
    • (2001) Am J Pathol , vol.158 , pp. 673-680
    • Howat, W.J.1    Holmes, J.A.2    Holgate, S.T.3    Lackie, P.M.4
  • 60
    • 0033258479 scopus 로고    scopus 로고
    • The attenuated fibroblast sheath of the respiratory tract epithelial-mesenchymal trophic unit
    • Evans MJ, Van Winkle LS, Fanucchi MV, Plopper CG The attenuated fibroblast sheath of the respiratory tract epithelial-mesenchymal trophic unit. Am J Respir Cell Mol Biol 1999, 21:655-657.
    • (1999) Am J Respir Cell Mol Biol , vol.21 , pp. 655-657
    • Evans, M.J.1    Van Winkle, L.S.2    Fanucchi, M.V.3    Plopper, C.G.4
  • 61
    • 0034802397 scopus 로고    scopus 로고
    • The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma
    • Richter A, Puddicombe SM, Lordan JL, et al. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol 2001, 25:385-391.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 385-391
    • Richter, A.1    Puddicombe, S.M.2    Lordan, J.L.3
  • 63
    • 9744248235 scopus 로고    scopus 로고
    • Acute allergen-induced airway remodeling in atopic asthma
    • Phipps S, Benyahia F, Ou TT, et al. Acute allergen-induced airway remodeling in atopic asthma. Am J Respir Cell Mol Biol 2004, 31:626-632.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 626-632
    • Phipps, S.1    Benyahia, F.2    Ou, T.T.3
  • 64
    • 79957512933 scopus 로고    scopus 로고
    • Effect of bronchoconstriction on airway remodeling in asthma
    • Grainge CL, Lau LC, Ward JA, et al. Effect of bronchoconstriction on airway remodeling in asthma. N Engl J Med 2011, 364:2006-2015.
    • (2011) N Engl J Med , vol.364 , pp. 2006-2015
    • Grainge, C.L.1    Lau, L.C.2    Ward, J.A.3
  • 66
    • 0035132115 scopus 로고    scopus 로고
    • Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression
    • Ordonez CL, Khashayar R, Wong HH, et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 2001, 163:517-523.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 517-523
    • Ordonez, C.L.1    Khashayar, R.2    Wong, H.H.3
  • 67
    • 0028343354 scopus 로고
    • Cell proliferation in the bronchial mucosa of asthmatics and chronic bronchitics
    • Demoly P, Simony-Lafontaine J, Chanez P, et al. Cell proliferation in the bronchial mucosa of asthmatics and chronic bronchitics. Am J Respir Crit Care Med 1994, 150:214-217.
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 214-217
    • Demoly, P.1    Simony-Lafontaine, J.2    Chanez, P.3
  • 68
    • 0024828192 scopus 로고
    • Bronchial biopsies in asthma: an ultrastructural, quantitative study and correlation with hyperreactivity
    • Jeffery PK, Wardlaw AJ, Nelson FC, Collins JV, Kay AB Bronchial biopsies in asthma: an ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 1989, 140:1745-1753.
    • (1989) Am Rev Respir Dis , vol.140 , pp. 1745-1753
    • Jeffery, P.K.1    Wardlaw, A.J.2    Nelson, F.C.3    Collins, J.V.4    Kay, A.B.5
  • 69
    • 0024545977 scopus 로고
    • Cellular events in the bronchi in mild asthma and after bronchial provocation
    • Beasley R, Roche WR, Roberts JA, Holgate ST Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 1989, 139:806-817.
    • (1989) Am Rev Respir Dis , vol.139 , pp. 806-817
    • Beasley, R.1    Roche, W.R.2    Roberts, J.A.3    Holgate, S.T.4
  • 70
    • 33750592575 scopus 로고    scopus 로고
    • Epithelial damage and angiogenesis in the airways of children with asthma
    • Barbato A, Turato G, Baraldo S, et al. Epithelial damage and angiogenesis in the airways of children with asthma. Am J Respir Crit Care Med 2006, 174:975-981.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 975-981
    • Barbato, A.1    Turato, G.2    Baraldo, S.3
  • 72
    • 80052219553 scopus 로고    scopus 로고
    • Defective epithelial barrier function in asthma
    • Xiao C, Puddicombe SM, Field S, et al. Defective epithelial barrier function in asthma. J Allergy Clin Immunol 2011, 128:549-556.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 549-556
    • Xiao, C.1    Puddicombe, S.M.2    Field, S.3
  • 73
    • 73449099989 scopus 로고    scopus 로고
    • Increased myoepithelial cells of bronchial submucosal glands in fatal asthma
    • Green FH, Williams DJ, James A, et al. Increased myoepithelial cells of bronchial submucosal glands in fatal asthma. Thorax 2010, 65:32-38.
    • (2010) Thorax , vol.65 , pp. 32-38
    • Green, F.H.1    Williams, D.J.2    James, A.3
  • 74
    • 0034077676 scopus 로고    scopus 로고
    • Airway smooth muscle in health and disease: methods of measurement and relation to function
    • James A, Carroll N Airway smooth muscle in health and disease: methods of measurement and relation to function. Eur Respir J 2000, 15:782-789.
    • (2000) Eur Respir J , vol.15 , pp. 782-789
    • James, A.1    Carroll, N.2
  • 75
    • 70349146860 scopus 로고    scopus 로고
    • Airway smooth muscle thickness in asthma is related to severity but not duration of asthma
    • James AL, Bai TR, Mauad T, et al. Airway smooth muscle thickness in asthma is related to severity but not duration of asthma. Eur Respir J 2009, 34:1040-1045.
    • (2009) Eur Respir J , vol.34 , pp. 1040-1045
    • James, A.L.1    Bai, T.R.2    Mauad, T.3
  • 76
    • 0027181166 scopus 로고
    • Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: a 3-D morphometric study
    • Ebina M, Takahashi T, Chiba T, Motomiya M Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: a 3-D morphometric study. Am Rev Respir Dis 1993, 148:720-726.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 720-726
    • Ebina, M.1    Takahashi, T.2    Chiba, T.3    Motomiya, M.4
  • 77
  • 78
    • 11144358047 scopus 로고    scopus 로고
    • Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression
    • Woodruff PG, Dolganov GM, Ferrando RE, et al. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med 2004, 169:1001-1006.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 1001-1006
    • Woodruff, P.G.1    Dolganov, G.M.2    Ferrando, R.E.3
  • 79
    • 33846262518 scopus 로고    scopus 로고
    • Differences in proteoglycan deposition in the airways of moderate and severe asthmatics
    • Pini L, Hamid Q, Shannon J, et al. Differences in proteoglycan deposition in the airways of moderate and severe asthmatics. Eur Respir J 2007, 29:71-77.
    • (2007) Eur Respir J , vol.29 , pp. 71-77
    • Pini, L.1    Hamid, Q.2    Shannon, J.3
  • 80
    • 77951695782 scopus 로고    scopus 로고
    • Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma
    • Hassan M, Jo T, Risse PA, et al. Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma. J Allergy Clin Immunol 2010, 125:1037-1045.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1037-1045
    • Hassan, M.1    Jo, T.2    Risse, P.A.3
  • 81
    • 0030841721 scopus 로고    scopus 로고
    • Increased vascularity of the bronchial mucosa in mild asthma
    • Li X, Wilson JW Increased vascularity of the bronchial mucosa in mild asthma. Am J Respir Crit Care Med 1997, 156:229-233.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 229-233
    • Li, X.1    Wilson, J.W.2
  • 82
    • 0035186301 scopus 로고    scopus 로고
    • Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects
    • Salvato G Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects. Thorax 2001, 56:902-906.
    • (2001) Thorax , vol.56 , pp. 902-906
    • Salvato, G.1
  • 83
    • 15844401603 scopus 로고    scopus 로고
    • Quantitative analysis of bronchial wall vascularity in the medium and small airways of patients with asthma and COPD
    • Hashimoto M, Tanaka H, Abe S Quantitative analysis of bronchial wall vascularity in the medium and small airways of patients with asthma and COPD. Chest 2005, 127:965-972.
    • (2005) Chest , vol.127 , pp. 965-972
    • Hashimoto, M.1    Tanaka, H.2    Abe, S.3
  • 84
    • 33744912533 scopus 로고    scopus 로고
    • Increased vascular endothelial growth factor and receptors: relationship to angiogenesis in asthma
    • Feltis BN, Wignarajah D, Zheng L, et al. Increased vascular endothelial growth factor and receptors: relationship to angiogenesis in asthma. Am J Respir Crit Care Med 2006, 173:1201-1207.
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 1201-1207
    • Feltis, B.N.1    Wignarajah, D.2    Zheng, L.3
  • 85
    • 70350320406 scopus 로고    scopus 로고
    • Increased vascular permeability precedes cellular inflammation as asthma control deteriorates
    • Khor YH, Teoh AK, Lam SM, et al. Increased vascular permeability precedes cellular inflammation as asthma control deteriorates. Clin Exp Allergy 2009, 39:1659-1667.
    • (2009) Clin Exp Allergy , vol.39 , pp. 1659-1667
    • Khor, Y.H.1    Teoh, A.K.2    Lam, S.M.3
  • 86
    • 76149146032 scopus 로고    scopus 로고
    • Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
    • Moore WC, Meyers DA, Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010, 181:315-323.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 315-323
    • Moore, W.C.1    Meyers, D.A.2    Wenzel, S.E.3
  • 87
    • 78049457548 scopus 로고    scopus 로고
    • Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma
    • Bousquet J, Mantzouranis E, Cruz AA, et al. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol 2010, 126:926-938.
    • (2010) J Allergy Clin Immunol , vol.126 , pp. 926-938
    • Bousquet, J.1    Mantzouranis, E.2    Cruz, A.A.3
  • 89
    • 0002543851 scopus 로고
    • The pathology of asthma, with special reference to changes in the bronchial mucosa
    • Dunnill MS The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol 1960, 13:27-33.
    • (1960) J Clin Pathol , vol.13 , pp. 27-33
    • Dunnill, M.S.1
  • 90
    • 0037812532 scopus 로고    scopus 로고
    • Characterization of airway plugging in fatal asthma
    • Kuyper LM, Pare PD, Hogg JC, et al. Characterization of airway plugging in fatal asthma. Am J Med 2003, 115:6-11.
    • (2003) Am J Med , vol.115 , pp. 6-11
    • Kuyper, L.M.1    Pare, P.D.2    Hogg, J.C.3
  • 91
    • 0027216415 scopus 로고
    • Sudden-onset fatal asthma: a distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa?
    • Sur S, Crotty TB, Kephart GM, et al. Sudden-onset fatal asthma: a distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa?. Am Rev Respir Dis 1993, 148:713-719.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 713-719
    • Sur, S.1    Crotty, T.B.2    Kephart, G.M.3
  • 92
    • 0029893414 scopus 로고    scopus 로고
    • Airway structure and inflammatory cells in fatal attacks of asthma
    • Carroll N, Carello S, Cooke C, James A Airway structure and inflammatory cells in fatal attacks of asthma. Eur Respir J 1996, 9:709-715.
    • (1996) Eur Respir J , vol.9 , pp. 709-715
    • Carroll, N.1    Carello, S.2    Cooke, C.3    James, A.4
  • 93
    • 24644468131 scopus 로고    scopus 로고
    • Time to death, airway wall inflammation and remodelling in fatal asthma
    • James AL, Elliot JG, Abramson MJ, Walters EH Time to death, airway wall inflammation and remodelling in fatal asthma. Eur Respir J 2005, 26:429-434.
    • (2005) Eur Respir J , vol.26 , pp. 429-434
    • James, A.L.1    Elliot, J.G.2    Abramson, M.J.3    Walters, E.H.4
  • 95
    • 55849115586 scopus 로고    scopus 로고
    • Slow-onset asthma deaths have more eosinophils and health care utilization than rapid-onset deaths
    • Hyzy RC, Travis WD, Hanna E, et al. Slow-onset asthma deaths have more eosinophils and health care utilization than rapid-onset deaths. Respir Med 2008, 102:1819-1826.
    • (2008) Respir Med , vol.102 , pp. 1819-1826
    • Hyzy, R.C.1    Travis, W.D.2    Hanna, E.3
  • 96
    • 39449123817 scopus 로고    scopus 로고
    • Differences in airway cytokine profile in severe asthma compared to moderate asthma
    • Shannon J, Ernst P, Yamauchi Y, et al. Differences in airway cytokine profile in severe asthma compared to moderate asthma. Chest 2008, 133:420-426.
    • (2008) Chest , vol.133 , pp. 420-426
    • Shannon, J.1    Ernst, P.2    Yamauchi, Y.3
  • 97
    • 67349203306 scopus 로고    scopus 로고
    • T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma
    • Al-Ramli W, Prefontaine D, Chouiali F, et al. T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma. J Allergy Clin Immunol 2009, 123:1185-1187.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 1185-1187
    • Al-Ramli, W.1    Prefontaine, D.2    Chouiali, F.3
  • 98
    • 78349269946 scopus 로고    scopus 로고
    • Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD
    • Doe C, Bafadhel M, Siddiqui S, et al. Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. Chest 2010, 138:1140-1147.
    • (2010) Chest , vol.138 , pp. 1140-1147
    • Doe, C.1    Bafadhel, M.2    Siddiqui, S.3
  • 99
    • 12144261115 scopus 로고    scopus 로고
    • Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma
    • Nguyen LT, Lim S, Oates T, Chung KF Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma. Respir Med 2005, 99:200-207.
    • (2005) Respir Med , vol.99 , pp. 200-207
    • Nguyen, L.T.1    Lim, S.2    Oates, T.3    Chung, K.F.4
  • 100
    • 79551511756 scopus 로고    scopus 로고
    • Mast cell phenotype, location, and activation in severe asthma: data from the Severe Asthma Research Program
    • Balzar S, Fajt ML, Comhair SA, et al. Mast cell phenotype, location, and activation in severe asthma: data from the Severe Asthma Research Program. Am J Respir Crit Care Med 2011, 183:299-309.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 299-309
    • Balzar, S.1    Fajt, M.L.2    Comhair, S.A.3
  • 101
    • 0036174758 scopus 로고    scopus 로고
    • Therapeutic significance of distal airway inflammation in asthma
    • Martin RJ Therapeutic significance of distal airway inflammation in asthma. J Allergy Clin Immunol 2002, 109:S447-S460.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. S447-S460
    • Martin, R.J.1
  • 102
    • 0026026853 scopus 로고
    • Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma
    • Saetta M, Di Stefano A, Rosina C, Thiene G, Fabbri LM Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Respir Dis 1991, 143:138-143.
    • (1991) Am Rev Respir Dis , vol.143 , pp. 138-143
    • Saetta, M.1    Di Stefano, A.2    Rosina, C.3    Thiene, G.4    Fabbri, L.M.5
  • 103
    • 70349099137 scopus 로고    scopus 로고
    • Pul-monary periarterial inflammation in fatal asthma
    • Shiang C, Mauad T, Senhorini A, et al. Pul-monary periarterial inflammation in fatal asthma. Clin Exp Allergy 2009, 39:1499-1507.
    • (2009) Clin Exp Allergy , vol.39 , pp. 1499-1507
    • Shiang, C.1    Mauad, T.2    Senhorini, A.3
  • 104
    • 79953670244 scopus 로고    scopus 로고
    • Mast cell-associated alveolar inflammation in patients with atopic uncontrolled asthma
    • Andersson CK, Bergqvist A, Mori M, et al. Mast cell-associated alveolar inflammation in patients with atopic uncontrolled asthma. J Allergy Clin Immunol 2011, 127:905-912.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 905-912
    • Andersson, C.K.1    Bergqvist, A.2    Mori, M.3
  • 105
    • 67649805319 scopus 로고    scopus 로고
    • An official American Thoracic Society/European Respiratory Society statement. Asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice
    • Reddel HK, Taylor DR, Bateman ED, et al. An official American Thoracic Society/European Respiratory Society statement. Asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009, 180:59-99.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 59-99
    • Reddel, H.K.1    Taylor, D.R.2    Bateman, E.D.3
  • 106
    • 26944489955 scopus 로고    scopus 로고
    • Exacerbations: the asthma paradox
    • Holgate ST Exacerbations: the asthma paradox. Am J Respir Crit Care Med 2005, 172:941-943.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 941-943
    • Holgate, S.T.1
  • 107
    • 58849162826 scopus 로고    scopus 로고
    • Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype
    • Dougherty RH, Fahy JV Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype. Clin Exp Allergy 2009, 39:193-202.
    • (2009) Clin Exp Allergy , vol.39 , pp. 193-202
    • Dougherty, R.H.1    Fahy, J.V.2
  • 108
    • 71749120427 scopus 로고    scopus 로고
    • Recent asthma exacerbations predict future exacerbations in children with severe or difficult-to-treat asthma
    • Haselkorn T, Zeiger RS, Chipps BE, et al. Recent asthma exacerbations predict future exacerbations in children with severe or difficult-to-treat asthma. J Allergy Clin Immunol 2009, 124:921-927.
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 921-927
    • Haselkorn, T.1    Zeiger, R.S.2    Chipps, B.E.3
  • 109
    • 0028990124 scopus 로고
    • Community study of role of viral infections in exacerbations of asthma in 9-11 year old children
    • Johnston SL, Pattemore PK, Sanderson G, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 1995, 310:1225-1229.
    • (1995) BMJ , vol.310 , pp. 1225-1229
    • Johnston, S.L.1    Pattemore, P.K.2    Sanderson, G.3
  • 110
    • 79955674573 scopus 로고    scopus 로고
    • Association between human rhinovirus C and severity of acute asthma in children
    • Bizzintino J, Lee WM, Laing IA, et al. Association between human rhinovirus C and severity of acute asthma in children. Eur Respir J 2011, 37:1037-1042.
    • (2011) Eur Respir J , vol.37 , pp. 1037-1042
    • Bizzintino, J.1    Lee, W.M.2    Laing, I.A.3
  • 111
    • 33646555487 scopus 로고    scopus 로고
    • Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children
    • Murray CS, Poletti G, Kebadze T, et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax 2006, 61:376-382.
    • (2006) Thorax , vol.61 , pp. 376-382
    • Murray, C.S.1    Poletti, G.2    Kebadze, T.3
  • 112
    • 77951665504 scopus 로고    scopus 로고
    • Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbations
    • Holt PG, Strickland DH Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbations. J Allergy Clin Immunol 2010, 125:963-972.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 963-972
    • Holt, P.G.1    Strickland, D.H.2
  • 113
    • 77953073669 scopus 로고    scopus 로고
    • IL-4 and IL-13 dual antagonism: a promising approach to the dilemma of generating effective asthma biotherapeutics
    • Borish L IL-4 and IL-13 dual antagonism: a promising approach to the dilemma of generating effective asthma biotherapeutics. Am J Respir Crit Care Med 2010, 181:769-770.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 769-770
    • Borish, L.1
  • 114
    • 34250370360 scopus 로고    scopus 로고
    • Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthma
    • Qiu Y, Zhu J, Bandi V, et al. Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthma. Thorax 2007, 62:475-482.
    • (2007) Thorax , vol.62 , pp. 475-482
    • Qiu, Y.1    Zhu, J.2    Bandi, V.3
  • 115
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    • Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009, 360:985-993.
    • (2009) N Engl J Med , vol.360 , pp. 985-993
    • Nair, P.1    Pizzichini, M.M.2    Kjarsgaard, M.3
  • 116
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009, 360:973-984.
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3
  • 117
    • 12144289339 scopus 로고    scopus 로고
    • Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway
    • Castro M, Bloch SR, Jenkerson MV, et al. Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway. Am J Respir Crit Care Med 2004, 169:842-849.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 842-849
    • Castro, M.1    Bloch, S.R.2    Jenkerson, M.V.3
  • 118
    • 77951142669 scopus 로고    scopus 로고
    • Morphological and molecular characteristics of "difficult" asthma
    • Selivanova PA, Kulikov ES, Kozina OV, et al. Morphological and molecular characteristics of "difficult" asthma. J Asthma 2010, 47:269-275.
    • (2010) J Asthma , vol.47 , pp. 269-275
    • Selivanova, P.A.1    Kulikov, E.S.2    Kozina, O.V.3
  • 119
    • 34447318645 scopus 로고    scopus 로고
    • Epithelial cell proliferation contributes to airway remodeling in severe asthma
    • Cohen L, E X, Tarsi J, et al. Epithelial cell proliferation contributes to airway remodeling in severe asthma. Am J Respir Crit Care Med 2007, 176:138-145.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 138-145
    • Cohen, L.E.X.1    Tarsi, J.2
  • 120
    • 0014491275 scopus 로고
    • A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema
    • Dunnill MS, Massarella GR, Anderson JA A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax 1969, 24:176-179.
    • (1969) Thorax , vol.24 , pp. 176-179
    • Dunnill, M.S.1    Massarella, G.R.2    Anderson, J.A.3
  • 122
    • 67349109921 scopus 로고    scopus 로고
    • The outer wall of small airways is a major site of remodeling in fatal asthma
    • Dolhnikoff M, da Silva LF, de Araujo BB, et al. The outer wall of small airways is a major site of remodeling in fatal asthma. J Allergy Clin Immunol 2009, 123:1090-1097.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 1090-1097
    • Dolhnikoff, M.1    da Silva, L.F.2    de Araujo, B.B.3
  • 123
    • 5144221335 scopus 로고    scopus 로고
    • Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma
    • Mauad T, Silva LF, Santos MA, et al. Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. Am J Respir Crit Care Med 2004, 170:857-862.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 857-862
    • Mauad, T.1    Silva, L.F.2    Santos, M.A.3
  • 124
    • 0024596810 scopus 로고
    • Bronchial hyperresponsiveness: the need for a distinction between hypersensitivity and excessive airway narrowing
    • Sterk PJ, Bel EH Bronchial hyperresponsiveness: the need for a distinction between hypersensitivity and excessive airway narrowing. Eur Respir J 1989, 2:267-274.
    • (1989) Eur Respir J , vol.2 , pp. 267-274
    • Sterk, P.J.1    Bel, E.H.2
  • 125
    • 0030010572 scopus 로고    scopus 로고
    • Relationship between the inflammatory infiltrate in bronchial biopsy specimens and clinical severity of asthma in patients treated with inhaled steroids
    • Sont JK, Han J, van Krieken JM, et al. Relationship between the inflammatory infiltrate in bronchial biopsy specimens and clinical severity of asthma in patients treated with inhaled steroids. Thorax 1996, 51:496-502.
    • (1996) Thorax , vol.51 , pp. 496-502
    • Sont, J.K.1    Han, J.2    van Krieken, J.M.3
  • 126
    • 0031917809 scopus 로고    scopus 로고
    • Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma
    • Crimi E, Spanevello A, Neri M, et al. Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma. Am J Respir Crit Care Med 1998, 157:4-9.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 4-9
    • Crimi, E.1    Spanevello, A.2    Neri, M.3
  • 128
    • 0029923640 scopus 로고    scopus 로고
    • Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma
    • Chetta A, Foresi A, Del Donno M, et al. Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma. Am J Respir Crit Care Med 1996, 153:910-917.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 910-917
    • Chetta, A.1    Foresi, A.2    Del Donno, M.3
  • 129
    • 67649224092 scopus 로고    scopus 로고
    • Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction
    • Kaminska M, Foley S, Maghni K, et al. Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction. J Allergy Clin Immunol 2009, 124:45-51.
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 45-51
    • Kaminska, M.1    Foley, S.2    Maghni, K.3
  • 130
    • 58349121851 scopus 로고    scopus 로고
    • Severe exacerbations and decline in lung function in asthma
    • O'Byrne PM, Pedersen S, Lamm CJ, et al. Severe exacerbations and decline in lung function in asthma. Am J Respir Crit Care Med 2009, 179:19-24.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 19-24
    • O'Byrne, P.M.1    Pedersen, S.2    Lamm, C.J.3
  • 131
    • 35949002726 scopus 로고    scopus 로고
    • Severe exacerbations predict excess lung function decline in asthma
    • Bai TR, Vonk JM, Postma DS, Boezen HM Severe exacerbations predict excess lung function decline in asthma. Eur Respir J 2007, 30:452-456.
    • (2007) Eur Respir J , vol.30 , pp. 452-456
    • Bai, T.R.1    Vonk, J.M.2    Postma, D.S.3    Boezen, H.M.4
  • 132
    • 0024578295 scopus 로고
    • The mechanics of airway narrowing in asthma
    • James AL, Pare PD, Hogg JC The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989, 139:242-246.
    • (1989) Am Rev Respir Dis , vol.139 , pp. 242-246
    • James, A.L.1    Pare, P.D.2    Hogg, J.C.3
  • 133
    • 34447572685 scopus 로고    scopus 로고
    • Clinical relevance of airway remodelling in airway diseases
    • James AL, Wenzel S Clinical relevance of airway remodelling in airway diseases. Eur Respir J 2007, 30:134-155.
    • (2007) Eur Respir J , vol.30 , pp. 134-155
    • James, A.L.1    Wenzel, S.2
  • 134
    • 0025027796 scopus 로고
    • A theoretical study of the effect of airway smooth muscle orientation on bronchoconstriction
    • Bates JH, Martin JG A theoretical study of the effect of airway smooth muscle orientation on bronchoconstriction. J Appl Physiol 1990, 69:995-1001.
    • (1990) J Appl Physiol , vol.69 , pp. 995-1001
    • Bates, J.H.1    Martin, J.G.2
  • 135
    • 0034131479 scopus 로고    scopus 로고
    • Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes
    • in't Veen JC, Beekman AJ, Bel EH, Sterk PJ Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med 2000, 161:1902-1906.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 1902-1906
    • in't Veen, J.C.1    Beekman, A.J.2    Bel, E.H.3    Sterk, P.J.4
  • 136
    • 0032989315 scopus 로고    scopus 로고
    • Dysfunction of pulmonary surfactant in asthmatics after segmental allergen challenge
    • Hohlfeld JM, Ahlf K, Enhorning G, et al. Dysfunction of pulmonary surfactant in asthmatics after segmental allergen challenge. Am J Respir Crit Care Med 1999, 159:1803-1809.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1803-1809
    • Hohlfeld, J.M.1    Ahlf, K.2    Enhorning, G.3
  • 137
    • 0032766394 scopus 로고    scopus 로고
    • Antigen-induced airway inflammation in atopic subjects generates dysfunction of pulmonary surfactant
    • Jarjour NN, Enhorning G Antigen-induced airway inflammation in atopic subjects generates dysfunction of pulmonary surfactant. Am J Respir Crit Care Med 1999, 160:336-341.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 336-341
    • Jarjour, N.N.1    Enhorning, G.2
  • 138
    • 47149104046 scopus 로고    scopus 로고
    • Mechanisms of airway hyperresponsiveness in asthma
    • Berend N, Salome CM, King GG Mechanisms of airway hyperresponsiveness in asthma. Respirology 2008, 13:624-631.
    • (2008) Respirology , vol.13 , pp. 624-631
    • Berend, N.1    Salome, C.M.2    King, G.G.3
  • 139
    • 0027404742 scopus 로고
    • The structure of large and small airways in nonfatal and fatal asthma
    • Carroll N, Elliot J, Morton A, James A The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 1993, 147:405-410.
    • (1993) Am Rev Respir Dis , vol.147 , pp. 405-410
    • Carroll, N.1    Elliot, J.2    Morton, A.3    James, A.4
  • 141
    • 0022215569 scopus 로고
    • Irreversible airflow obstruction: evolution in asthma
    • Finucane KE, Greville HW, Brown PJE Irreversible airflow obstruction: evolution in asthma. Med J Aust 1985, 142:602-604.
    • (1985) Med J Aust , vol.142 , pp. 602-604
    • Finucane, K.E.1    Greville, H.W.2    Brown, P.J.E.3
  • 143
    • 14644412828 scopus 로고    scopus 로고
    • Markers of eosinophilic inflammation and tissue re-modelling in children before clinically diagnosed bronchial asthma
    • Pohunek P, Warner JO, Turzikova J, Kudrmann J, Toche WR Markers of eosinophilic inflammation and tissue re-modelling in children before clinically diagnosed bronchial asthma. Pediatr Allergy Immunol 2005, 16:43-51.
    • (2005) Pediatr Allergy Immunol , vol.16 , pp. 43-51
    • Pohunek, P.1    Warner, J.O.2    Turzikova, J.3    Kudrmann, J.4    Toche, W.R.5
  • 144
    • 36049007283 scopus 로고    scopus 로고
    • Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers
    • Saglani S, Payne DN, Zhu J, et al. Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers. Am J Respir Crit Care Med 2007, 176:858-864.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 858-864
    • Saglani, S.1    Payne, D.N.2    Zhu, J.3
  • 145
    • 0037214337 scopus 로고    scopus 로고
    • Early thickening of the reticular basement membrane in children with difficult asthma
    • Payne DN, Rogers AV, Adelroth E, et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med 2003, 167:78-82.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 78-82
    • Payne, D.N.1    Rogers, A.V.2    Adelroth, E.3
  • 146
    • 18844401152 scopus 로고    scopus 로고
    • Epithelial stress and structural remodelling in childhood asthma
    • Fedorov IA, Wilson SJ, Davies DE, Holgate ST Epithelial stress and structural remodelling in childhood asthma. Thorax 2005, 60:389-394.
    • (2005) Thorax , vol.60 , pp. 389-394
    • Fedorov, I.A.1    Wilson, S.J.2    Davies, D.E.3    Holgate, S.T.4
  • 147
    • 42649096323 scopus 로고    scopus 로고
    • Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis
    • Regamey N, Ochs M, Hilliard TN, et al. Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2008, 177:837-843.
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 837-843
    • Regamey, N.1    Ochs, M.2    Hilliard, T.N.3
  • 148
    • 0032826640 scopus 로고    scopus 로고
    • Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodelling
    • Laprise C, Laviolette M, Boutet M, Boulry LP Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodelling. Eur Respir J 1999, 14:63-73.
    • (1999) Eur Respir J , vol.14 , pp. 63-73
    • Laprise, C.1    Laviolette, M.2    Boutet, M.3    Boulry, L.P.4
  • 149
    • 20144387227 scopus 로고    scopus 로고
    • Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction
    • Saglani S, Malmstrom K, Pelkonen AS, et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am J Respir Crit Care Med 2005, 171:722-727.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 722-727
    • Saglani, S.1    Malmstrom, K.2    Pelkonen, A.S.3
  • 150
    • 0030048946 scopus 로고    scopus 로고
    • Prednisolone treatment in asthma: reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa
    • Bentley AM, Hamid Q, Robinson DS, et al. Prednisolone treatment in asthma: reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. Am J Respir Crit Care Med 1996, 153:551-556.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 551-556
    • Bentley, A.M.1    Hamid, Q.2    Robinson, D.S.3
  • 151
    • 0036216744 scopus 로고    scopus 로고
    • Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma
    • Ward C, Pais M, Bish R, et al. Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma. Thorax 2002, 57:309-316.
    • (2002) Thorax , vol.57 , pp. 309-316
    • Ward, C.1    Pais, M.2    Bish, R.3
  • 152
    • 0030859389 scopus 로고    scopus 로고
    • Bronchoscopic evaluation of severe asthma: persistent inflammation associated with high dose glucocorticoids
    • Wenzel SE, Szefler SJ, Leung DYM, et al. Bronchoscopic evaluation of severe asthma: persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med 1997, 156:737-743.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 737-743
    • Wenzel, S.E.1    Szefler, S.J.2    Leung, D.Y.M.3
  • 153
    • 77955659342 scopus 로고    scopus 로고
    • Airway eosinophilia in remission and progression of asthma: accumulation with a fast decline of FEV(1)
    • Broekema M, Volbeda F, Timens W, et al. Airway eosinophilia in remission and progression of asthma: accumulation with a fast decline of FEV(1). Respir Med 2010, 104:1254-1262.
    • (2010) Respir Med , vol.104 , pp. 1254-1262
    • Broekema, M.1    Volbeda, F.2    Timens, W.3
  • 154
  • 155
    • 0035402361 scopus 로고    scopus 로고
    • Effect of a long-acting beta2-agonist over three months on airway wall vascular remodeling in asthma
    • Orsida BE, Ward C, Li X, et al. Effect of a long-acting beta2-agonist over three months on airway wall vascular remodeling in asthma. Am J Respir Crit Care Med 2001, 164:117-121.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 117-121
    • Orsida, B.E.1    Ward, C.2    Li, X.3
  • 156
    • 67349269860 scopus 로고    scopus 로고
    • Airway inflammation in patients with asthma with high-fixed or low-fixed plus as-needed budesonide/formoterol
    • Pavord ID, Jeffery PK, Qiu Y, et al. Airway inflammation in patients with asthma with high-fixed or low-fixed plus as-needed budesonide/formoterol. J Allergy Clin Immunol 2009, 123:1083-1089.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 1083-1089
    • Pavord, I.D.1    Jeffery, P.K.2    Qiu, Y.3
  • 158
    • 0026333085 scopus 로고
    • Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity
    • Walker C, Kaegi MK, Braun P, Blaser K Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity. J Allergy Clin Immunol 1991, 88:935-942.
    • (1991) J Allergy Clin Immunol , vol.88 , pp. 935-942
    • Walker, C.1    Kaegi, M.K.2    Braun, P.3    Blaser, K.4
  • 159
    • 0028937777 scopus 로고
    • T cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma
    • Virchow JC, Walker C, Hafner D, et al. T cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma. Am J Respir Crit Care Med 1995, 151:960-968.
    • (1995) Am J Respir Crit Care Med , vol.151 , pp. 960-968
    • Virchow, J.C.1    Walker, C.2    Hafner, D.3
  • 160
    • 0033845865 scopus 로고    scopus 로고
    • CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus: potential implication in eosinophil recruitment
    • Tillie-Leblond I, Hammad H, Desurmont S, et al. CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus: potential implication in eosinophil recruitment. Am J Respir Crit Care Med 2000, 162:586-592.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 586-592
    • Tillie-Leblond, I.1    Hammad, H.2    Desurmont, S.3
  • 161
    • 0034914913 scopus 로고    scopus 로고
    • Cytokine profile of bronchoalveolar lavage-derived CD4+, CD8+, and gamma-delta T cells in people with asthma after segmental allergen challenge
    • Krug N, Erpenbeck VJ, Balke K, et al. Cytokine profile of bronchoalveolar lavage-derived CD4+, CD8+, and gamma-delta T cells in people with asthma after segmental allergen challenge. Am J Respir Cell Mol Biol 2001, 25:125-131.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 125-131
    • Krug, N.1    Erpenbeck, V.J.2    Balke, K.3
  • 162
    • 38149049065 scopus 로고    scopus 로고
    • Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines
    • Brasier AR, Victor S, Boetticher G, et al. Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines. J Allergy Clin Immunol 2008, 121:30-37.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 30-37
    • Brasier, A.R.1    Victor, S.2    Boetticher, G.3
  • 163
    • 34047261246 scopus 로고    scopus 로고
    • Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease
    • Vijayanand P, Seumois G, Pickard C, et al. Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease. N Engl J Med 2007, 356:1410-1422.
    • (2007) N Engl J Med , vol.356 , pp. 1410-1422
    • Vijayanand, P.1    Seumois, G.2    Pickard, C.3
  • 164
    • 77957843236 scopus 로고    scopus 로고
    • Increased airway T regulatory cells in asthmatic subjects
    • Smyth LJ, Eustace A, Kolsum U, Blaikely J, Singh D Increased airway T regulatory cells in asthmatic subjects. Chest 2010, 138:905-912.
    • (2010) Chest , vol.138 , pp. 905-912
    • Smyth, L.J.1    Eustace, A.2    Kolsum, U.3    Blaikely, J.4    Singh, D.5
  • 165
    • 84860655039 scopus 로고    scopus 로고
    • Innate and adaptive immune responses in asthma
    • Holgate ST Innate and adaptive immune responses in asthma. Nat Med 2012, 18:673-683.
    • (2012) Nat Med , vol.18 , pp. 673-683
    • Holgate, S.T.1
  • 166
    • 0029759171 scopus 로고    scopus 로고
    • Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements
    • Pizzichini E, Pizzichini MM, Efthimiadis A, et al. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. Am J Respir Crit Care Med 1996, 154:308-317.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 308-317
    • Pizzichini, E.1    Pizzichini, M.M.2    Efthimiadis, A.3
  • 167
    • 0031782865 scopus 로고    scopus 로고
    • Use of induced sputum to examine airway inflammation in childhood asthma
    • Gibson PG Use of induced sputum to examine airway inflammation in childhood asthma. J Allergy Clin Immunol 1998, 102:S100-S101.
    • (1998) J Allergy Clin Immunol , vol.102 , pp. S100-S101
    • Gibson, P.G.1
  • 168
    • 0036208838 scopus 로고    scopus 로고
    • A comparison of the validity of different diagnostic tests in adults with asthma
    • Hunter CJ, Brightling CE, Woltmann G, Wardlaw AJ, Pavord ID A comparison of the validity of different diagnostic tests in adults with asthma. Chest 2002, 121:1051-1057.
    • (2002) Chest , vol.121 , pp. 1051-1057
    • Hunter, C.J.1    Brightling, C.E.2    Woltmann, G.3    Wardlaw, A.J.4    Pavord, I.D.5
  • 169
    • 0033954741 scopus 로고    scopus 로고
    • The relationship between airways inflammation and asthma severity
    • Louis R, Lau LCK, Bron AO, et al. The relationship between airways inflammation and asthma severity. Am J Respir Crit Care Med 2000, 161:9-16.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 9-16
    • Louis, R.1    Lau, L.C.K.2    Bron, A.O.3
  • 170
    • 38149069331 scopus 로고    scopus 로고
    • Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults
    • Petsky HL, Kynaston JA, Turner C, et al. Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults. Cochrane Database Syst Rev 2007, (2).
    • (2007) Cochrane Database Syst Rev , Issue.2
    • Petsky, H.L.1    Kynaston, J.A.2    Turner, C.3
  • 171
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie MJ, ten Brinke A, Khan J, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000, 356:2144-2148.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    ten Brinke, A.2    Khan, J.3
  • 172
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    • Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003, 167:199-204.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 173
    • 0036795111 scopus 로고    scopus 로고
    • Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    • Green RH, Brightling CE, Woltmann G, et al. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002, 57:875-879.
    • (2002) Thorax , vol.57 , pp. 875-879
    • Green, R.H.1    Brightling, C.E.2    Woltmann, G.3
  • 174
    • 67049144615 scopus 로고    scopus 로고
    • Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies
    • Fahy JV Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc 2009, 6:256-259.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 256-259
    • Fahy, J.V.1
  • 175
    • 77951979415 scopus 로고    scopus 로고
    • Effects of steroid therapy on inflammatory cell subtypes in asthma
    • Cowan DC, Cowan JO, Palmay R, Williamson A, Taylor DR Effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax 2010, 65:384-390.
    • (2010) Thorax , vol.65 , pp. 384-390
    • Cowan, D.C.1    Cowan, J.O.2    Palmay, R.3    Williamson, A.4    Taylor, D.R.5
  • 176
    • 70349241725 scopus 로고    scopus 로고
    • Inflammatory phenotypes in adult asthma: clinical applications
    • Gibson PG Inflammatory phenotypes in adult asthma: clinical applications. Clin Respir J 2009, 3:198-206.
    • (2009) Clin Respir J , vol.3 , pp. 198-206
    • Gibson, P.G.1
  • 177
    • 33645101537 scopus 로고    scopus 로고
    • Inflammatory subtypes in asthma: assessment and identification using induced sputum
    • Simpson JL, Scott R, Boyle MJ, Gibson PG Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology 2006, 11:54-61.
    • (2006) Respirology , vol.11 , pp. 54-61
    • Simpson, J.L.1    Scott, R.2    Boyle, M.J.3    Gibson, P.G.4
  • 178
    • 68849086058 scopus 로고    scopus 로고
    • Inflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NO
    • Porsbjerg C, Lund TK, Pedersen L, Backer V Inflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NO. J Asthma 2009, 46:606-612.
    • (2009) J Asthma , vol.46 , pp. 606-612
    • Porsbjerg, C.1    Lund, T.K.2    Pedersen, L.3    Backer, V.4
  • 179
    • 15944422151 scopus 로고    scopus 로고
    • Induced sputum 8-isoprostane concentrations in inflammatory airway diseases
    • Wood LG, Garg ML, Simpson JL, et al. Induced sputum 8-isoprostane concentrations in inflammatory airway diseases. Am J Respir Crit Care Med 2005, 171:426-430.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 426-430
    • Wood, L.G.1    Garg, M.L.2    Simpson, J.L.3
  • 180
    • 0035051851 scopus 로고    scopus 로고
    • Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment
    • Redington AE, Meng QH, Springall DR, et al. Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. Thorax 2001, 56:351-357.
    • (2001) Thorax , vol.56 , pp. 351-357
    • Redington, A.E.1    Meng, Q.H.2    Springall, D.R.3
  • 181
    • 77956791391 scopus 로고    scopus 로고
    • Exhaled nitric oxide in pulmonary diseases: a comprehensive review
    • Barnes PJ, Dweik RA, Gelb AF, et al. Exhaled nitric oxide in pulmonary diseases: a comprehensive review. Chest 2010, 138:682-692.
    • (2010) Chest , vol.138 , pp. 682-692
    • Barnes, P.J.1    Dweik, R.A.2    Gelb, A.F.3
  • 182
    • 80052755474 scopus 로고    scopus 로고
    • Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial
    • Powell H, Murphy VE, Taylor DR, et al. Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. Lancet 2011, 378:983-990.
    • (2011) Lancet , vol.378 , pp. 983-990
    • Powell, H.1    Murphy, V.E.2    Taylor, D.R.3
  • 183
    • 33749582774 scopus 로고    scopus 로고
    • Exhaled breath condensate nitrite/nitrate and pH in relation to pediatric asthma control and exhaled nitric oxide
    • Ratnawati, Morton J, Henry RL, Thomas PS Exhaled breath condensate nitrite/nitrate and pH in relation to pediatric asthma control and exhaled nitric oxide. Pediatr Pulmonol 2006, 41:929-936.
    • (2006) Pediatr Pulmonol , vol.41 , pp. 929-936
    • Ratnawati1    Morton, J.2    Henry, R.L.3    Thomas, P.S.4
  • 184
    • 33745479516 scopus 로고    scopus 로고
    • Airway cytokine expression measured by means of protein array in exhaled breath condensate: correlation with physiologic properties in asthmatic patients
    • Matsunaga K, Yanagisawa S, Ichikawa T, et al. Airway cytokine expression measured by means of protein array in exhaled breath condensate: correlation with physiologic properties in asthmatic patients. J Allergy Clin Immunol 2006, 118:84-90.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 84-90
    • Matsunaga, K.1    Yanagisawa, S.2    Ichikawa, T.3
  • 185
    • 72749090104 scopus 로고    scopus 로고
    • Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma
    • Fens N, Zwinderman AH, van der Schee MP, et al. Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma. Am J Respir Crit Care Med 2009, 180:1076-1082.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 1076-1082
    • Fens, N.1    Zwinderman, A.H.2    van der Schee, M.P.3
  • 186
    • 84858322573 scopus 로고    scopus 로고
    • Clinical update on the use of biomarkers of airway inflammation in the management of asthma
    • Wadsworth S, Sin D, Dorscheid D Clinical update on the use of biomarkers of airway inflammation in the management of asthma. J Asthma Allergy 2011, 4:77-86.
    • (2011) J Asthma Allergy , vol.4 , pp. 77-86
    • Wadsworth, S.1    Sin, D.2    Dorscheid, D.3
  • 187
    • 76149098409 scopus 로고    scopus 로고
    • Noninvasive markers of airway inflammation in asthma
    • Wedes SH, Khatri SB, Zhang R, et al. Noninvasive markers of airway inflammation in asthma. Clin Transl Sci 2009, 2:112-117.
    • (2009) Clin Transl Sci , vol.2 , pp. 112-117
    • Wedes, S.H.1    Khatri, S.B.2    Zhang, R.3
  • 188
    • 79960715523 scopus 로고    scopus 로고
    • Serum OX40 ligand levels in asthmatic children: a potential biomarker of severity and persistence
    • Ezzat MH, Imam SS, Shaheen KY, Elbrhami Em Serum OX40 ligand levels in asthmatic children: a potential biomarker of severity and persistence. Allergy Asthma Proc 2011, 32:313-318.
    • (2011) Allergy Asthma Proc , vol.32 , pp. 313-318
    • Ezzat, M.H.1    Imam, S.S.2    Shaheen, K.Y.3    Elbrhami, E.4
  • 189
    • 0033773941 scopus 로고    scopus 로고
    • Airway wall thickness in asthma assessed by computed tomography: relation to clinical indices
    • Niimi A, Matsumoto H, Amitani R, et al. Airway wall thickness in asthma assessed by computed tomography: relation to clinical indices. Am J Respir Crit Care Med 2000, 162:1518-1523.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 1518-1523
    • Niimi, A.1    Matsumoto, H.2    Amitani, R.3
  • 190
    • 57349134464 scopus 로고    scopus 로고
    • Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology
    • Aysola RS, Hoffman EA, Gierada D, et al. Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. Chest 2008, 134:1183-1191.
    • (2008) Chest , vol.134 , pp. 1183-1191
    • Aysola, R.S.1    Hoffman, E.A.2    Gierada, D.3
  • 191
    • 73949132114 scopus 로고    scopus 로고
    • Bronchial measurements in patients with asthma: comparison of quantitative thin-section CT findings with those in healthy subjects and correlation with pathologic findings
    • Montaudon M, Lederlin M, Reich S, et al. Bronchial measurements in patients with asthma: comparison of quantitative thin-section CT findings with those in healthy subjects and correlation with pathologic findings. Radiology 2009, 253:844-853.
    • (2009) Radiology , vol.253 , pp. 844-853
    • Montaudon, M.1    Lederlin, M.2    Reich, S.3
  • 192
    • 34447318897 scopus 로고    scopus 로고
    • Airway distensibility in adults with asthma and healthy adults, measured by forced oscillation technique
    • Brown NJ, Salome CM, Berend N, Thorpe CW, King GG Airway distensibility in adults with asthma and healthy adults, measured by forced oscillation technique. Am J Respir Crit Care Med 2007, 176:129-137.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 129-137
    • Brown, N.J.1    Salome, C.M.2    Berend, N.3    Thorpe, C.W.4    King, G.G.5
  • 193
    • 0027181170 scopus 로고
    • The lack of distensibility of asthmatic airways
    • Wilson JW, Li X, Pain MC The lack of distensibility of asthmatic airways. Am Rev Respir Dis 1993, 148:806-809.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 806-809
    • Wilson, J.W.1    Li, X.2    Pain, M.C.3
  • 194
    • 0035509050 scopus 로고    scopus 로고
    • Reduced airway distensibility, fixed airflow limitation, and airway wall remodeling in asthma
    • Ward C, Johns DP, Bish R, et al. Reduced airway distensibility, fixed airflow limitation, and airway wall remodeling in asthma. Am J Respir Crit Care Med 2001, 164:1718-1721.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1718-1721
    • Ward, C.1    Johns, D.P.2    Bish, R.3
  • 195
    • 69249085744 scopus 로고    scopus 로고
    • Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques
    • Williamson JP, James AL, Phillips MJ, et al. Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques. Eur Respir J 2009, 34:42-55.
    • (2009) Eur Respir J , vol.34 , pp. 42-55
    • Williamson, J.P.1    James, A.L.2    Phillips, M.J.3
  • 196
    • 70049093185 scopus 로고    scopus 로고
    • The use of endobronchial ultrasonography in assessment of bronchial wall remodeling in patients with asthma
    • Soja J, Grzanka P, Sladek K, et al. The use of endobronchial ultrasonography in assessment of bronchial wall remodeling in patients with asthma. Chest 2009, 136:797-804.
    • (2009) Chest , vol.136 , pp. 797-804
    • Soja, J.1    Grzanka, P.2    Sladek, K.3
  • 197
    • 0030753766 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 in asthma: measurement in bronchoalveolar lavage fluid
    • Redington AE, Madden J, Frew AJ, et al. Transforming growth factor-beta1 in asthma: measurement in bronchoalveolar lavage fluid. Am J Respir Crit Care Med 1997, 156:642-647.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 642-647
    • Redington, A.E.1    Madden, J.2    Frew, A.J.3
  • 198
    • 71849090786 scopus 로고    scopus 로고
    • Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack
    • Enomoto Y, Orihara K, Takamasu T, et al. Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack. J Allergy Clin Immunol 2009, 124:913-920.
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 913-920
    • Enomoto, Y.1    Orihara, K.2    Takamasu, T.3
  • 199
    • 80051670719 scopus 로고    scopus 로고
    • Animal models of asthma: value, limitations and opportunities for alternative approaches
    • Holmes AM, Solari R, Holgate ST Animal models of asthma: value, limitations and opportunities for alternative approaches. Drug Discov Today 2011, 16:659-670.
    • (2011) Drug Discov Today , vol.16 , pp. 659-670
    • Holmes, A.M.1    Solari, R.2    Holgate, S.T.3
  • 200
    • 22344457252 scopus 로고    scopus 로고
    • No audible wheezing: nuggets and conundrums from mouse asthma models
    • Boyce JA, Austen KF No audible wheezing: nuggets and conundrums from mouse asthma models. J Exp Med 2005, 201:1869-1873.
    • (2005) J Exp Med , vol.201 , pp. 1869-1873
    • Boyce, J.A.1    Austen, K.F.2
  • 201
    • 33845540077 scopus 로고    scopus 로고
    • Animal models of asthma-Pro: Allergic avoidance of animal (model[s]) is not an option
    • Shapiro SD Animal models of asthma-Pro: Allergic avoidance of animal (model[s]) is not an option. Am J Respir Crit Care Med 2006, 174:1171-1173.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1171-1173
    • Shapiro, S.D.1
  • 202
    • 33845543076 scopus 로고    scopus 로고
    • The mouse trap: it still yields few answers in asthma
    • Wenzel S, Holgate ST The mouse trap: it still yields few answers in asthma. Am J Respir Crit Care Med 2006, 174:1173-1176.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1173-1176
    • Wenzel, S.1    Holgate, S.T.2


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