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Volumn 172, Issue 2, 2005, Pages 149-160

Severe asthma in adults

Author keywords

Asthma; Inflammation; Phenotypes; Physiology; Remodeling; Treatment

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; CYCLOSPORIN; IMATINIB; IMMUNOGLOBULIN E ANTIBODY; IMMUNOMODULATING AGENT; LIPOXYGENASE INHIBITOR; MEPOLIZUMAB; METHACHOLINE; METHOTREXATE;

EID: 22144452574     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200409-1181PP     Document Type: Review
Times cited : (260)

References (120)
  • 3
    • 0003736036 scopus 로고    scopus 로고
    • Bethesda, MD: National Institutes of Health, National Heart, Lung, and Blood Institute
    • Global Initiative for Asthma. Global strategy for asthma management and prevention. Bethesda, MD: National Institutes of Health, National Heart, Lung, and Blood Institute; 2002.
    • (2002) Global Strategy for Asthma Management and Prevention
  • 5
    • 0033025989 scopus 로고    scopus 로고
    • Difficult/therapy-resistant asthma: The need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies
    • ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society
    • Chung KF, Godard P, Adelroth E, Ayres J, Barnes N, Barnes P, Bel E, Burney P, Chanez P, Connett G, et al. Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society. Eur Respir J 1999;13:1198-1208.
    • (1999) Eur Respir J , vol.13 , pp. 1198-1208
    • Chung, K.F.1    Godard, P.2    Adelroth, E.3    Ayres, J.4    Barnes, N.5    Barnes, P.6    Bel, E.7    Burney, P.8    Chanez, P.9    Connett, G.10
  • 6
    • 0034526865 scopus 로고    scopus 로고
    • Proceedings of the ATS Workshop on Refractory Asthma: Current understanding, recommendations and unanswered questions
    • Wenzel SE, Fahv JV, Irvin CG, Peters SP, Spector S, Szefler SJ. Proceedings of the ATS Workshop on Refractory Asthma: current understanding, recommendations and unanswered questions. Am J Respir Crit Care Med 2000;162:2341-2351.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 2341-2351
    • Wenzel, S.E.1    Fahv, J.V.2    Irvin, C.G.3    Peters, S.P.4    Spector, S.5    Szefler, S.J.6
  • 7
    • 10744231300 scopus 로고    scopus 로고
    • The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma
    • European Network for Understanding Mechanisms of Severe Asthma. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. Eur Respir J 2003;22(3): 470-477.
    • (2003) Eur Respir J , vol.22 , Issue.3 , pp. 470-477
  • 8
    • 9144268928 scopus 로고    scopus 로고
    • Design and baseline characteristics of the Epidemiology and Natural history of asthma: Outcomes and treatment Regimens (TENOR) study: A large cohort of patients with severe or difficult-to-treat asthma
    • Dolan CM, Fraher KE, Bleecker ER, Borish L, Chipps B, Hayden ML, Weiss S, Zheng B, Johnson C, Wenzel S. Design and baseline characteristics of The Epidemiology and Natural history of asthma: Outcomes and treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol 2004;92:32-39.
    • (2004) Ann Allergy Asthma Immunol , vol.92 , pp. 32-39
    • Dolan, C.M.1    Fraher, K.E.2    Bleecker, E.R.3    Borish, L.4    Chipps, B.5    Hayden, M.L.6    Weiss, S.7    Zheng, B.8    Johnson, C.9    Wenzel, S.10
  • 11
    • 0032558685 scopus 로고    scopus 로고
    • A 15-year followup study of ventilatory function in adults with asthma
    • Lange P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15-year followup study of ventilatory function in adults with asthma. N Engl J Med 1998;339:1194-1200.
    • (1998) N Engl J Med , vol.339 , pp. 1194-1200
    • Lange, P.1    Parner, J.2    Vestbo, J.3    Schnohr, P.4    Jensen, G.5
  • 12
    • 0028064310 scopus 로고
    • Decline of lung function in adults with bronchial asthma
    • Ulrik CS, Lange P. Decline of lung function in adults with bronchial asthma. Am J Respir Crit Care Med 1994;150:629-634.
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 629-634
    • Ulrik, C.S.1    Lange, P.2
  • 13
    • 0035093489 scopus 로고    scopus 로고
    • Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection
    • ten Brinke A, van Dissel JT, Sterk PJ, Zwinderman AH, Rabe KF, Bel EH. Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection. J Allergy Clin Immunol 2001;107:449-454.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 449-454
    • Ten Brinke, A.1    Van Dissel, J.T.2    Sterk, P.J.3    Zwinderman, A.H.4    Rabe, K.F.5    Bel, E.H.6
  • 14
    • 0346041503 scopus 로고    scopus 로고
    • Distinguishing severe asthma phenotypes: Role of age at onset and eosinophilic inflammation
    • Miranda C, Busacker A, Balzar S, Trudeau J, Wenzel SE. Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. J Allergy Clin Immunol 2004;113:101-108.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 101-108
    • Miranda, C.1    Busacker, A.2    Balzar, S.3    Trudeau, J.4    Wenzel, S.E.5
  • 19
  • 23
    • 6344291534 scopus 로고    scopus 로고
    • Reconcilable differences: A cross-sectional study of the relationship between socioeconomic status and the magnitude of short-acting beta-agonist use in asthma
    • Lynd LD, Sandford AJ, Kelly EM, Pare PD, Bai TR, Fitzgerald JM, Anis AH. Reconcilable differences: a cross-sectional study of the relationship between socioeconomic status and the magnitude of short-acting beta-agonist use in asthma. Chest 2004;126:1161-1168.
    • (2004) Chest , vol.126 , pp. 1161-1168
    • Lynd, L.D.1    Sandford, A.J.2    Kelly, E.M.3    Pare, P.D.4    Bai, T.R.5    Fitzgerald, J.M.6    Anis, A.H.7
  • 24
    • 0031436130 scopus 로고    scopus 로고
    • Sensitization to dust mites as a dominant risk factor for asthma among adolescents living in central Virginia: Multiple regression analysis of a population-based study
    • Squillace SP, Sporik RB, Rakes G, Couture N, Lawrence A, Merriam S, Zhang J, Plaits-Mills AE. Sensitization to dust mites as a dominant risk factor for asthma among adolescents living in central Virginia: multiple regression analysis of a population-based study. Am J Respir Crit Care Med 1997;156:1760-1764.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 1760-1764
    • Squillace, S.P.1    Sporik, R.B.2    Rakes, G.3    Couture, N.4    Lawrence, A.5    Merriam, S.6    Zhang, J.7    Plaits-Mills, A.E.8
  • 27
    • 0034017303 scopus 로고    scopus 로고
    • Relationships of active smoking to asthma and asthma severity in the EGEA study. Epidemiological study on the Genetics and Environment of Asthma
    • Siroux V, Pin I, Oryszczyn MP, Le Moual N, Kauffmann F. Relationships of active smoking to asthma and asthma severity in the EGEA study. Epidemiological study on the Genetics and Environment of Asthma. Eur Respir J 2000;15:470-477.
    • (2000) Eur Respir J , vol.15 , pp. 470-477
    • Siroux, V.1    Pin, I.2    Oryszczyn, M.P.3    Le Moual, N.4    Kauffmann, F.5
  • 28
  • 33
    • 0036606194 scopus 로고    scopus 로고
    • Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin
    • Wenzel SE, Gibbs RL, Lehr MV, Simoes EA. Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin. Am J Med 2002;112:627-633.
    • (2002) Am J Med , vol.112 , pp. 627-633
    • Wenzel, S.E.1    Gibbs, R.L.2    Lehr, M.V.3    Simoes, E.A.4
  • 35
    • 32744472706 scopus 로고    scopus 로고
    • Body mass index linked to severity in a large cohort of severe or difficult to treat asthma subjects
    • Weiss S, Dolan CM, Zheng B, Johnson C. Body mass index linked to severity in a large cohort of severe or difficult to treat asthma subjects [abstract]. Am J Respir Crit Care Med 2002;165:A435.
    • (2002) Am J Respir Crit Care Med , vol.165
    • Weiss, S.1    Dolan, C.M.2    Zheng, B.3    Johnson, C.4
  • 36
    • 0033728998 scopus 로고    scopus 로고
    • Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma
    • Hakala K, Stenius-Aarniala B, Sovijarvi A. Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma. Chest 2000;118:1315-1321.
    • (2000) Chest , vol.118 , pp. 1315-1321
    • Hakala, K.1    Stenius-Aarniala, B.2    Sovijarvi, A.3
  • 37
    • 2942733178 scopus 로고    scopus 로고
    • Effect of weight reduction on respiratory function and airway reactivity in obese women
    • Aaron SD, Fergusson D, Dent R, Chen Y, Vandemheen KL, Dales RE. Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest 2004;125:2046-2052.
    • (2004) Chest , vol.125 , pp. 2046-2052
    • Aaron, S.D.1    Fergusson, D.2    Dent, R.3    Chen, Y.4    Vandemheen, K.L.5    Dales, R.E.6
  • 38
    • 0027173757 scopus 로고
    • Psychiatric and social aspects of brittle asthma
    • Garden GM, Ayres JG. Psychiatric and social aspects of brittle asthma. Thorax 1993;48:501-505.
    • (1993) Thorax , vol.48 , pp. 501-505
    • Garden, G.M.1    Ayres, J.G.2
  • 39
    • 0021815139 scopus 로고
    • Physiologic and psychological characteristics associated with deaths due to asthma in childhood: A case-controlled study
    • Strunk RC, Mrazek DA, Fuhrmann GS, LaBrecque JF. Physiologic and psychological characteristics associated with deaths due to asthma in childhood: a case-controlled study. JAMA 1985;254:1193-1198.
    • (1985) JAMA , vol.254 , pp. 1193-1198
    • Strunk, R.C.1    Mrazek, D.A.2    Fuhrmann, G.S.3    Labrecque, J.F.4
  • 42
    • 0036221632 scopus 로고    scopus 로고
    • Case-control study of severe life threatening asthma (SLTA) in adults: Psychological factors
    • Kolbe J, Fergusson W, Vamos M, Garrett J. Case-control study of severe life threatening asthma (SLTA) in adults: psychological factors. Thorax 2002;57:317-322.
    • (2002) Thorax , vol.57 , pp. 317-322
    • Kolbe, J.1    Fergusson, W.2    Vamos, M.3    Garrett, J.4
  • 44
    • 1142309474 scopus 로고    scopus 로고
    • Improved refill persistence with fluticasone propionate and salmeterol in a single inhaler compared with other controller therapies
    • Stoloff SW, Stempel DA, Meyer J, Stanford RH, Carranza Rosenzweig JR. Improved refill persistence with fluticasone propionate and salmeterol in a single inhaler compared with other controller therapies. J Allergy Clin Immunol 2004;113:245-251.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 245-251
    • Stoloff, S.W.1    Stempel, D.A.2    Meyer, J.3    Stanford, R.H.4    Carranza Rosenzweig, J.R.5
  • 45
    • 0038206447 scopus 로고    scopus 로고
    • "Real-world" effectiveness of daily controller medicine in children with mild persistent asthma
    • Bukstein DA, Luskin AT, Bernstein A. "Real-world" effectiveness of daily controller medicine in children with mild persistent asthma. Ann Allergy Asthma Immunol 2003;90:543-549.
    • (2003) Ann Allergy Asthma Immunol , vol.90 , pp. 543-549
    • Bukstein, D.A.1    Luskin, A.T.2    Bernstein, A.3
  • 48
    • 0036083170 scopus 로고    scopus 로고
    • Adherence to asthma self-management plans with inhaled corticosteroid and oral prednisone: A descriptive analysis
    • Wraight JM, Cowan JO, Flannery EM, Town GI, Taylor DR. Adherence to asthma self-management plans with inhaled corticosteroid and oral prednisone: a descriptive analysis. Respirology 2002;7:133-139.
    • (2002) Respirology , vol.7 , pp. 133-139
    • Wraight, J.M.1    Cowan, J.O.2    Flannery, E.M.3    Town, G.I.4    Taylor, D.R.5
  • 49
    • 0028827729 scopus 로고
    • Single, high-dose intramuscular triamcinolone acetonide versus weekly oral methotrexate in life-threatening asthma: A double-blind study
    • Ogirala RG, Sturm TM, Aldrich TK, Meller FF, Pacia EB, Keane AM, Finkel RI. Single, high-dose intramuscular triamcinolone acetonide versus weekly oral methotrexate in life-threatening asthma: a double-blind study. Am J Respir Crit Care Med 1995;152:1461-1466.
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 1461-1466
    • Ogirala, R.G.1    Sturm, T.M.2    Aldrich, T.K.3    Meller, F.F.4    Pacia, E.B.5    Keane, A.M.6    Finkel, R.I.7
  • 50
    • 4444221246 scopus 로고    scopus 로고
    • "Refractory" eosinophilic airway inflammation in severe asthma: Effect of patenteral corticosteroids
    • ten Brinke A, Zwinderman AH, Sterk PJ, Rabe KF, Bel EH. "Refractory" eosinophilic airway inflammation in severe asthma: effect of patenteral corticosteroids. Am J Respir Crit Care Med 2004;170:601-605.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 601-605
    • Ten Brinke, A.1    Zwinderman, A.H.2    Sterk, P.J.3    Rabe, K.F.4    Bel, E.H.5
  • 51
    • 0031911619 scopus 로고    scopus 로고
    • Relationship between airway obstruction and respiratory symptoms in adult asthmatics
    • Teeter JG, Bleecker ER. Relationship between airway obstruction and respiratory symptoms in adult asthmatics. Chest 1998;113:272-277.
    • (1998) Chest , vol.113 , pp. 272-277
    • Teeter, J.G.1    Bleecker, E.R.2
  • 53
    • 0033940777 scopus 로고    scopus 로고
    • Relationship between increased airway responsiveness and asthma severity in the childhood asthma management program
    • Weiss ST, Van Natta ML, Zeiger RS. Relationship between increased airway responsiveness and asthma severity in the childhood asthma management program. Am J Respir Crit Care Med 2000;162:50-56.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 50-56
    • Weiss, S.T.1    Van Natta, M.L.2    Zeiger, R.S.3
  • 54
    • 0031981957 scopus 로고    scopus 로고
    • Difficult-to-control asthma: Clinical characteristics of steroid-insensitive asthma
    • Chan MT, Leung DY, Szefler SJ, Spahn JD. Difficult-to-control asthma: clinical characteristics of steroid-insensitive asthma. J Allergy Clin Immunol 1998;101:594-601.
    • (1998) J Allergy Clin Immunol , vol.101 , pp. 594-601
    • Chan, M.T.1    Leung, D.Y.2    Szefler, S.J.3    Spahn, J.D.4
  • 55
    • 0015153467 scopus 로고
    • Lung volume changes in asthma measured concurrently by two methods
    • Woolcock AJ, Rebuck AS, Cade JF, Read J. Lung volume changes in asthma measured concurrently by two methods. Am Rev Respir Dis 1971;104:703-709.
    • (1971) Am Rev Respir Dis , vol.104 , pp. 703-709
    • Woolcock, A.J.1    Rebuck, A.S.2    Cade, J.F.3    Read, J.4
  • 56
    • 0014359330 scopus 로고
    • The static elastic properties in the lungs in asthma
    • Woolcock AJ, Read J. The static elastic properties in the lungs in asthma. Am Rev Respir Dis 1968;98:788-794.
    • (1968) Am Rev Respir Dis , vol.98 , pp. 788-794
    • Woolcock, A.J.1    Read, J.2
  • 57
    • 0033694849 scopus 로고    scopus 로고
    • Unsuspected pseudophysiologic emphysema in chronic persistent asthma
    • Gelb AF, Zamel N. Unsuspected pseudophysiologic emphysema in chronic persistent asthma. Am J Respir Crit Care Med 2000;162:1778-1782.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 1778-1782
    • Gelb, A.F.1    Zamel, N.2
  • 60
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, Chu HW. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999;160: 1001-1008.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1001-1008
    • Wenzel, S.E.1    Schwartz, L.B.2    Langmack, E.L.3    Halliday, J.L.4    Trudeau, J.B.5    Gibbs, R.L.6    Chu, H.W.7
  • 61
    • 0034131479 scopus 로고    scopus 로고
    • Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes
    • in't Veen JC, Beekman AJ, Bel EH, Sterk PJ. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med 2000;161:1902-1906.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 1902-1906
    • In't Veen, J.C.1    Beekman, A.J.2    Bel, E.H.3    Sterk, P.J.4
  • 63
    • 0028280428 scopus 로고
    • Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma
    • Kikuchi Y, Okabe S, Tamura G, Hida W, Homma M, Shirato K, Takishima T. Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma. N Engl J Med 1994;330:1329-1334.
    • (1994) N Engl J Med , vol.330 , pp. 1329-1334
    • Kikuchi, Y.1    Okabe, S.2    Tamura, G.3    Hida, W.4    Homma, M.5    Shirato, K.6    Takishima, T.7
  • 64
    • 4344659228 scopus 로고    scopus 로고
    • Dyspnoea at rest and at the end of different exercises in patients with near-fatal asthma
    • Barreiro E, Gea J, Sanjuas C, Marcos R, Broquetas J, Milic-Emili J. Dyspnoea at rest and at the end of different exercises in patients with near-fatal asthma. Eur Respir J 2004;24:219-225.
    • (2004) Eur Respir J , vol.24 , pp. 219-225
    • Barreiro, E.1    Gea, J.2    Sanjuas, C.3    Marcos, R.4    Broquetas, J.5    Milic-Emili, J.6
  • 67
    • 0001037769 scopus 로고
    • A working classification of asthma
    • Rackeman FM. A working classification of asthma. Am J Med 1947;33: 601-606.
    • (1947) Am J Med , vol.33 , pp. 601-606
    • Rackeman, F.M.1
  • 68
    • 0035888740 scopus 로고    scopus 로고
    • Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone
    • Payne DN, Adcock IM, Wilson NM, Gates T, Scallan M, Bush A. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. Am J Respir Crit Care Med 2001;164:1376-1381.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1376-1381
    • Payne, D.N.1    Adcock, I.M.2    Wilson, N.M.3    Gates, T.4    Scallan, M.5    Bush, A.6
  • 70
    • 15944362722 scopus 로고    scopus 로고
    • Relationship of small airway chymase-positive mast cells and lung function in severe asthma
    • Balzar S, Chu HW, Strand M, Wenzel S. Relationship of small airway chymase-positive mast cells and lung function in severe asthma. Am J Respir Crit Care Med 2005;171:431-439.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 431-439
    • Balzar, S.1    Chu, H.W.2    Strand, M.3    Wenzel, S.4
  • 71
    • 0034541314 scopus 로고    scopus 로고
    • Peripheral blood and airway tissue expression of transforming growth factor beta by neutrophils in asthmatic subjects and normal control subjects
    • Chu HW, Trudeau JB, Balzar S, Wenzel S. Peripheral blood and airway tissue expression of transforming growth factor beta by neutrophils in asthmatic subjects and normal control subjects. J Allergy Clin Immunol 2000;106:1115-1123.
    • (2000) J Allergy Clin Immunol , vol.106 , pp. 1115-1123
    • Chu, H.W.1    Trudeau, J.B.2    Balzar, S.3    Wenzel, S.4
  • 72
    • 0036434681 scopus 로고    scopus 로고
    • Expression and activation of 15-lipoxygenase pathway in severe asthma: Relationship to eosinophilic phenotype and collagen deposition
    • Chu HW, Balzar S, Westcott JY, Trudeau JB, Sun Y, Conrad DJ, Wenzel SE. Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition. Clin Exp Allergy 2002;32:1558-1565.
    • (2002) Clin Exp Allergy , vol.32 , pp. 1558-1565
    • Chu, H.W.1    Balzar, S.2    Westcott, J.Y.3    Trudeau, J.B.4    Sun, Y.5    Conrad, D.J.6    Wenzel, S.E.7
  • 74
    • 32744469974 scopus 로고    scopus 로고
    • The phenotype of steroid dependent severe asthma is not associated with incresaed lung levels of TH-2 cytokines
    • Bornholm, Denmark
    • Wenzel SE, Balzar S, Chu HW, Cundall M. The phenotype of steroid dependent severe asthma is not associated with incresaed lung levels of TH-2 cytokines. Presented at the Collegium Internationale Allergolicum, Bornholm, Denmark, 2004
    • (2004) Collegium Internationale Allergolicum
    • Wenzel, S.E.1    Balzar, S.2    Chu, H.W.3    Cundall, M.4
  • 78
    • 0036903388 scopus 로고    scopus 로고
    • High-resolution CT features of severe asthma and bronchiolitis obliterans
    • Jensen SP, Lynch DA, Brown KK, Wenzel SE, Newell JD. High-resolution CT features of severe asthma and bronchiolitis obliterans. Clin Radiol 2002;57:1078-1085.
    • (2002) Clin Radiol , vol.57 , pp. 1078-1085
    • Jensen, S.P.1    Lynch, D.A.2    Brown, K.K.3    Wenzel, S.E.4    Newell, J.D.5
  • 79
    • 0029057979 scopus 로고
    • Glucocorticoid treatment inhibits apoptosis in human neutrophils: Separation of survival and activation outcomes
    • Cox G. Glucocorticoid treatment inhibits apoptosis in human neutrophils: separation of survival and activation outcomes. J Immunol 1995; 154:4719-4725.
    • (1995) J Immunol , vol.154 , pp. 4719-4725
    • Cox, G.1
  • 80
    • 0037504020 scopus 로고    scopus 로고
    • Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: Association with asthma severity, neutrophilic inflammation, and wound repair
    • Wenzel SE, Balzar S, Cundall M, Chu HW. Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: Association with asthma severity, neutrophilic inflammation, and wound repair. J Allergy Clin Immunol 2003;111:1345-1352.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1345-1352
    • Wenzel, S.E.1    Balzar, S.2    Cundall, M.3    Chu, H.W.4
  • 81
    • 0345734195 scopus 로고    scopus 로고
    • Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids
    • Cundall M, Sun Y, Miranda C, Trudeau JB, Barnes S, Wenzel SE. Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids. J Allergy Clin Immunol 2003;112:1064-1071.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 1064-1071
    • Cundall, M.1    Sun, Y.2    Miranda, C.3    Trudeau, J.B.4    Barnes, S.5    Wenzel, S.E.6
  • 82
    • 0142010551 scopus 로고    scopus 로고
    • A comparison of the clinical characteristics of children and adults with severe asthma
    • Jenkins HA, Cherniack R, Szefler SJ, Covar R, Gelfand EW, Spahn JD. A comparison of the clinical characteristics of children and adults with severe asthma. Chest 2003;124:1318-1324.
    • (2003) Chest , vol.124 , pp. 1318-1324
    • Jenkins, H.A.1    Cherniack, R.2    Szefler, S.J.3    Covar, R.4    Gelfand, E.W.5    Spahn, J.D.6
  • 86
    • 0028079557 scopus 로고
    • Steroid-resistant asthma: Cellular mechanisms contributing to inadequate response to glucocorticoid therapy
    • Sher E, Leung DYM, Surs W, Kam JC, Zieg G, Kamada AK, Szefler SJ. Steroid-resistant asthma: cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 1994;93: 33-39.
    • (1994) J Clin Invest , vol.93 , pp. 33-39
    • Sher, E.1    Leung, D.Y.M.2    Surs, W.3    Kam, J.C.4    Zieg, G.5    Kamada, A.K.6    Szefler, S.J.7
  • 87
    • 0036795111 scopus 로고    scopus 로고
    • Analysis of induced sputum in adults with asthma: Identification of a subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    • Green RH, Brightling CE, Weltmann G, Parker D, Wardlaw AJ, Pavord ID. Analysis of induced sputum in adults with asthma: identification of a subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002;57:875-879.
    • (2002) Thorax , vol.57 , pp. 875-879
    • Green, R.H.1    Brightling, C.E.2    Weltmann, G.3    Parker, D.4    Wardlaw, A.J.5    Pavord, I.D.6
  • 88
    • 0027242280 scopus 로고
    • Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids
    • Kam JC, Szefler SJ, Surs W, Sher ER, Leung DY. Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J Immunol 1993;151:3460-3466.
    • (1993) J Immunol , vol.151 , pp. 3460-3466
    • Kam, J.C.1    Szefler, S.J.2    Surs, W.3    Sher, E.R.4    Leung, D.Y.5
  • 89
    • 0032535369 scopus 로고    scopus 로고
    • Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes
    • Lane SJ, Adcock IM, Richards D, Hawrylowicz C, Barnes PJ, Lee TH. Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes. J Clin Invest 1998; 102:2156-2164.
    • (1998) J Clin Invest , vol.102 , pp. 2156-2164
    • Lane, S.J.1    Adcock, I.M.2    Richards, D.3    Hawrylowicz, C.4    Barnes, P.J.5    Lee, T.H.6
  • 93
    • 0027404742 scopus 로고
    • The structure of large and small airways in nonfatal and fatal asthma
    • Carroll NG, Elliot J, Morion AR, James AL. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 1993;147:405-410.
    • (1993) Am Rev Respir Dis , vol.147 , pp. 405-410
    • Carroll, N.G.1    Elliot, J.2    Morion, A.R.3    James, A.L.4
  • 94
    • 0036014530 scopus 로고    scopus 로고
    • Distribution and degranulation of airway mast cells in normal and asthmatic subjects
    • Carroll NG, Mutavdzic S, James AL. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 2002;19:879-885.
    • (2002) Eur Respir J , vol.19 , pp. 879-885
    • Carroll, N.G.1    Mutavdzic, S.2    James, A.L.3
  • 96
    • 0035989738 scopus 로고    scopus 로고
    • Transbronchial biopsy as a tool to evaluate small airways in asthma
    • Balzar S, Wenzel SE, Chu HW. Transbronchial biopsy as a tool to evaluate small airways in asthma. Eur Respir J 2002;20:254-259.
    • (2002) Eur Respir J , vol.20 , pp. 254-259
    • Balzar, S.1    Wenzel, S.E.2    Chu, H.W.3
  • 97
    • 0032438394 scopus 로고    scopus 로고
    • Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone
    • Leach CL, Davidson PJ, Boudreau RJ. Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. Eur Respir J 1998;12:1346-1353.
    • (1998) Eur Respir J , vol.12 , pp. 1346-1353
    • Leach, C.L.1    Davidson, P.J.2    Boudreau, R.J.3
  • 100
    • 0010875759 scopus 로고    scopus 로고
    • TGF-beta + IL-13 increases eotaxin in a cell and mediator specific manner associated with increases in procollagen
    • Wenzel S, Barnes S, Westcott J, Gibbs R, Miranda C, Chu HW, Trudeau J. TGF-beta + IL-13 increases eotaxin in a cell and mediator specific manner associated with increases in procollagen [abstract]. Am J Respir Crit Care Med 2002;165:A730.
    • (2002) Am J Respir Crit Care Med , vol.165
    • Wenzel, S.1    Barnes, S.2    Westcott, J.3    Gibbs, R.4    Miranda, C.5    Chu, H.W.6    Trudeau, J.7
  • 103
    • 0035131224 scopus 로고    scopus 로고
    • Relationship of epidermal growth factor receptors to goblet cell production in human bronchi
    • Takeyama K, Fahy JV, Nadel JA. Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. Am J Respir Crit Care Med 2001;163:511-516.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 511-516
    • Takeyama, K.1    Fahy, J.V.2    Nadel, J.A.3
  • 104
    • 0036083181 scopus 로고    scopus 로고
    • TGF-beta isoform release and activation during in vitro bronchial epithelial wound repair
    • Howat WJ, Holgate ST, Lackie PM. TGF-beta isoform release and activation during in vitro bronchial epithelial wound repair. Am J Physiol Lung Cell Mol Physiol 2002;282:L115-L123.
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.282
    • Howat, W.J.1    Holgate, S.T.2    Lackie, P.M.3
  • 107
    • 0024578295 scopus 로고
    • The mechanics of airway narrowing in asthma
    • James AL, Pare PD, Hogg JC. The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989;139:242-246.
    • (1989) Am Rev Respir Dis , vol.139 , pp. 242-246
    • James, A.L.1    Pare, P.D.2    Hogg, J.C.3
  • 113
    • 0036923819 scopus 로고    scopus 로고
    • Vocal cord dysfunction induced by methacholine challenge testing
    • Perkins PJ, Morris MJ. Vocal cord dysfunction induced by methacholine challenge testing. Chest 2002;122:1988-1993.
    • (2002) Chest , vol.122 , pp. 1988-1993
    • Perkins, P.J.1    Morris, M.J.2
  • 116
    • 0012326185 scopus 로고    scopus 로고
    • Initial demographic information from an extensive data base of severe, steroid dependent asthmatics studied at National Jewish
    • Gibbs R, Miranda C, Wenzel S. Initial demographic information from an extensive data base of severe, steroid dependent asthmatics studied at National Jewish [abstract]. Am J Respir Crit Care Med 2002;165: A119.
    • (2002) Am J Respir Crit Care Med , vol.165
    • Gibbs, R.1    Miranda, C.2    Wenzel, S.3
  • 117
    • 4244024468 scopus 로고    scopus 로고
    • A pilot study to evaluate the bronchodilator response pattern to salmeterol in refractory asthma
    • Guyer B, Gibbs R, Feldsien D, Wenzel S. A pilot study to evaluate the bronchodilator response pattern to salmeterol in refractory asthma. J Allergy Clin Immunol 2002;109:S244.
    • (2002) J Allergy Clin Immunol , vol.109
    • Guyer, B.1    Gibbs, R.2    Feldsien, D.3    Wenzel, S.4
  • 118
    • 0036257390 scopus 로고    scopus 로고
    • Comparison of the effects of salmeterol and formoterol in patients with severe asthma
    • Nightingale JA, Rogers DF, Barnes PJ. Comparison of the effects of salmeterol and formoterol in patients with severe asthma. Chest 2002; 121:1401-1406.
    • (2002) Chest , vol.121 , pp. 1401-1406
    • Nightingale, J.A.1    Rogers, D.F.2    Barnes, P.J.3
  • 119
    • 0030071686 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled study of cyclosporin a as a corticosteroid-sparing agent in corticosteroid-dependent asthma
    • Lock SH, Kay AB, Barnes NC. Double-blind, placebo-controlled study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma. Am J Respir Crit Care Med 1996;153:509-514.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 509-514
    • Lock, S.H.1    Kay, A.B.2    Barnes, N.C.3


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